公开(公告)号：US07364847B2

公开(公告)日：2008-04-29

申请号：US10482115

申请日：2002-06-27

申请人： Masaya Tohyama ,  Taiichi Katayama ,  Takayuki Manabe ,  Kazunori Imaizumi ,  Yoko Ikeda

发明人： Masaya Tohyama ,  Taiichi Katayama ,  Takayuki Manabe ,  Kazunori Imaizumi ,  Yoko Ikeda

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07H21/00

CPC分类号： C07K14/4711 ,  C12Q1/6883 ,  C12Q2600/156 ,  G01N33/6896 ,  G01N2500/00

摘要： The present invention provides a means for treatment and/or prevention of a disease caused by aberrant splicing, a neurodegenerative disease represented by Alzheimer's disease, or the like. The present invention relates to a nucleic acid which can be associated with generation of a splice variant that lacks exon 5 of presenilin-2 gene, an inhibitor for inhibiting a binding between protein-nucleic acid caused by aberrant splicing, and a method for screening the inhibitor.

摘要翻译： 本发明提供了治疗和/或预防由异常剪接引起的疾病，由阿尔茨海默病代表的神经变性疾病等的方法。 本发明涉及可以与缺少早老素-2基因的外显子5的剪接变体的产生相关联的核酸，抑制由异常剪接引起的蛋白质 - 核酸之间的结合的抑制剂，以及用于筛选 抑制剂。

公开(公告)号：US20050065102A1

公开(公告)日：2005-03-24

申请号：US10482103

申请日：2002-06-27

申请人： Masaya Tohyama ,  Taiichi Katayama ,  Takayuki Manabe ,  Kazunori Imaizumi ,  Yoko Ikeda

发明人： Masaya Tohyama ,  Taiichi Katayama ,  Takayuki Manabe ,  Kazunori Imaizumi ,  Yoko Ikeda

IPC分类号： C12N15/09 ,  A61K31/7105 ,  A61K31/711 ,  A61K38/00 ,  A61K45/00 ,  A61K48/00 ,  A61P9/10 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28 ,  A61P43/00 ,  C07K14/47 ,  C07H21/02

CPC分类号： C07K14/4702 ,  A61K38/00 ,  A61K48/00 ,  C07K14/4711

摘要： To provide a means useful for treating or preventing a disease such as a brain disorder or a neurodegenerative disease even more efficiently and even more sustainedly. The present invention relates to an inhibitor capable of inhibiting a binding between HMG-I protein and exon 5 of presenilin-2 mRNA, an agent for suppressing neuronal death, capable of suppressing neuronal death, a pharmaceutical composition which is useful for treatment or prevention of a disease caused by the generation of a splice variant that lacks exon 5 of presenilin-2 mRNA, a method for treating or preventing the disease and a use of the inhibitor.

摘要翻译： 提供用于更有效地甚至更持久地治疗或预防诸如脑部疾病或神经变性疾病的疾病的方法。 本发明涉及能够抑制HMG-1蛋白与早老蛋白-2 mRNA的外显子5之间的结合的抑制剂，抑制神经元死亡的能力，能够抑制神经元死亡的药剂组合物，其可用于治疗或预防 由缺乏早老素-2 mRNA的外显子5的剪接变体的产生引起的疾病，治疗或预防疾病的方法和抑制剂的使用。

公开(公告)号：US20110207122A1

公开(公告)日：2011-08-25

申请号：US12596462

申请日：2008-04-17

申请人： Shigeru Kinoshita ,  Kei Tashiro ,  Masakazu Nakano ,  Tomohito Yagi ,  Kazuhiko Mori ,  Yoko Ikeda ,  Takazumi Taniguchi ,  Masaaki Kageyama

发明人： Shigeru Kinoshita ,  Kei Tashiro ,  Masakazu Nakano ,  Tomohito Yagi ,  Kazuhiko Mori ,  Yoko Ikeda ,  Takazumi Taniguchi ,  Masaaki Kageyama

IPC分类号： C12Q1/68 ,  C07H21/04

CPC分类号： C12Q1/6886 ,  C12Q1/6883 ,  C12Q2600/156

摘要： A method of determining the presence or the absence of a glaucoma risk, including the steps of detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base sequence is at least one base sequence selected from the group consisting of base sequences shown in SEQ ID NOs: 203 to 752 or a complementary sequence thereto (step A), and comparing the allele and/or the genotype detected in the step A with at least one of an allele and/or a genotype, containing a high-risk allele, in the base sequences shown in SEQ ID NOs: 203 to 752 (step B). According to the method of the present invention, the level of a progressive risk of glaucoma in a sample donor can be determined by analyzing an allele or a genotype of a single nucleotide polymorphism in the present invention in the sample, so that the sample donor can take a preventive measure of glaucoma, or can receive appropriate treatments, on the basis of this risk.

摘要翻译： 一种确定青光眼风险的存在或不存在的方法，包括以下步骤：在位于碱基序列的第31位的单核苷酸多态性的体外检测等位基因和/或基因型， 其中所述碱基序列是选自SEQ ID NO：203至752所示的碱基序列或其互补序列的至少一种碱基序列（步骤A），并比较检测到的等位基因和/或基因型 在SEQ ID NO：203〜752（步骤B）所示的碱基序列中具有含有高风险等位基因的等位基因和/或基因型中的至少一种的步骤A。 根据本发明的方法，可以通过分析样品中本发明的单核苷酸多态性的等位基因或基因型来确定样品供体中青光眼进行性风险的水平，使得样品供体可以 采取预防措施的青光眼，或者可以根据这种风险接受适当的治疗。

公开(公告)号：US5618795A

公开(公告)日：1997-04-08

申请号：US524644

申请日：1995-09-08

申请人： Shinichi Kondo ,  Seiji Shibahara ,  Takayuki Usui ,  Toshiaki Kudo ,  Shuichi Gomi ,  Atsushi Tamura ,  Yoko Ikeda ,  Daishiro Ikeda ,  Tomio Takeuchi

发明人： Shinichi Kondo ,  Seiji Shibahara ,  Takayuki Usui ,  Toshiaki Kudo ,  Shuichi Gomi ,  Atsushi Tamura ,  Yoko Ikeda ,  Daishiro Ikeda ,  Tomio Takeuchi

IPC分类号： C07H15/236 ,  A61K31/70

CPC分类号： C07H15/234

摘要： As new dibekacin derivatives and new arbekacin derivatives are now provided 2"-amino-2"-deoxydibekacin, 2"-amino-5,2"-dideoxydibekacin, 2"-amino-2"-deoxyarbekacin, 2"-amino-5,2"-dideoxyarbekacin, 2"-amino-5,2"-dideoxy-5-epi-fluoroarbekacin and 2"-amino-5,2"-dideoxy-5-epi-aminoarbekacin which all exhibit high antibacterial activity against a wide variety of gram-positive and gram-negative bacteria, including resistant bacteria such as methicillin-resistant Staphylococcus aureus and which are of low toxicity to mammals and are useful as antibacterial agent for treatment of bacterial infections.

摘要翻译： 现在提供新的二卡辛衍生物和新的阿贝卡星衍生物2' - 氨基-2' - 脱氧胆碱，2“ - 氨基-5,2” - 脱氧胆酸，2“ - 氨基-2'-脱氧阿糖胞苷，2 “ - 氨基-5,2” - 双脱氧肉豆蔻素，2“ - 氨基-5,2” - 双脱氧-5-表 - 氟代贝卡星和2“ - 氨基-5,2” - 双脱氧-5-表 所有这些都表现出对各种革兰氏阳性和革兰氏阴性细菌的高抗菌活性，包括耐甲氧西林金黄色葡萄球菌等抗性细菌，对哺乳动物毒性低，可用作细菌治疗的抗菌剂 感染。

公开(公告)号：US20130210668A1

公开(公告)日：2013-08-15

申请号：US13850453

申请日：2013-03-26

申请人： Shigeru KINOSHITA ,  Kei Tashiro ,  Masakazu Nakano ,  Tomohito Yagi ,  Kazuhiko Mori ,  Yoko Ikeda ,  Takazumi Taniguchi ,  Masaaki Kageyama

发明人： Shigeru KINOSHITA ,  Kei Tashiro ,  Masakazu Nakano ,  Tomohito Yagi ,  Kazuhiko Mori ,  Yoko Ikeda ,  Takazumi Taniguchi ,  Masaaki Kageyama

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q1/6883 ,  C12Q2600/156

摘要： A method of determining the presence or the absence of a glaucoma risk, including the steps of detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base sequence is at least one base sequence selected from the group consisting of base sequences shown in SEQ ID NOs: 203 to 752 or a complementary sequence thereto (step A), and comparing the allele and/or the genotype detected in the step A with at least one of an allele and/or a genotype, containing a high-risk allele, in the base sequences shown in SEQ ID NOs: 203 to 752 (step B). According to the method of the present invention, the level of a progressive risk of glaucoma in a sample donor can be determined by analyzing an allele or a genotype of a single nucleotide polymorphism in the present invention in the sample, so that the sample donor can take a preventive measure of glaucoma, or can receive appropriate treatments, on the basis of this risk.

摘要翻译： 一种确定青光眼风险的存在或不存在的方法，包括以下步骤：在位于碱基序列的第31位的单核苷酸多态性的体外检测等位基因和/或基因型， 其中所述碱基序列是选自SEQ ID NO：203至752所示的碱基序列或其互补序列的至少一种碱基序列（步骤A），并比较检测到的等位基因和/或基因型 在SEQ ID NO：203〜752（步骤B）所示的碱基序列中具有含有高风险等位基因的等位基因和/或基因型中的至少一种的步骤A。 根据本发明的方法，可以通过分析样品中本发明的单核苷酸多态性的等位基因或基因型来确定样品供体中青光眼进行性风险的水平，使得样品供体可以 采取预防措施的青光眼，或者可以根据这种风险接受适当的治疗。

公开(公告)号：US07759072B2

公开(公告)日：2010-07-20

申请号：US11817515

申请日：2006-03-02

申请人： Koji Ushizawa ,  Michiko Kawamoto ,  Shoko Yamamoto ,  Kumiko Yuki ,  Yoko Ikeda ,  Mitsuaki Yamamoto

发明人： Koji Ushizawa ,  Michiko Kawamoto ,  Shoko Yamamoto ,  Kumiko Yuki ,  Yoko Ikeda ,  Mitsuaki Yamamoto

IPC分类号： G01N33/53

CPC分类号： G01N33/581 ,  G01N33/5306 ,  G01N33/542 ,  G01N33/54393

摘要： The present invention provides a novel immunoassay method with high reaction specificity and high sensitivity. The present invention also provides a method for immunoassaying a target antigen utilizing reactivation of an apoenzyme, which includes simultaneously or sequentially adding a test sample to an antibody specific to the target antigen, the target antigen labeled with a coenzyme, an apo-D-amino acid oxidase, a D-amino acid, and a reagent for detecting a hydrogen peroxide produced by the oxidase.

摘要翻译： 本发明提供了具有高反应特异性和高灵敏度的新型免疫测定方法。 本发明还提供了使用辅酶的再活化来免疫测定靶抗原的方法，其包括同时或依次将测试样品加入到靶抗原特异性抗体中，用辅酶标记的靶抗原，载脂蛋白-D-氨基 酸性氧化酶，D-氨基酸和用于检测由氧化酶产生的过氧化氢的试剂。

公开(公告)号：US20060274932A1

公开(公告)日：2006-12-07

申请号：US11431709

申请日：2006-05-11

申请人： Yoko Ikeda ,  Junko Konishi ,  Hisafumi Iwata ,  Yuji Takagi ,  Kenji Obara ,  Ryo Nakagaki ,  Seiji Isogai ,  Yasuhiko Ozawa

发明人： Yoko Ikeda ,  Junko Konishi ,  Hisafumi Iwata ,  Yuji Takagi ,  Kenji Obara ,  Ryo Nakagaki ,  Seiji Isogai ,  Yasuhiko Ozawa

IPC分类号： G06K9/00 ,  G06K9/62 ,  G06K9/46

CPC分类号： G06F3/0486 ,  G06F2203/04803 ,  G06T7/0004 ,  G06T2200/24 ,  G06T2207/30148

摘要： A method for classifying defects, including: calculating feature quantifies of defect image which is obtained by imaging a defect on a sample; classifying the defect image into a classified category by using information on the calculated feature quantities; displaying the classified defect image in a region on a display screen which is defined to the classified category; adding information on the classified category to the displayed defect image; transferring the displayed defect image which is added the information on the classified category to one of the other categories and displaying the transferred defect image in a region on the display screen which is defined to the one of the other categories; and changing information on the category.

公开(公告)号：US5488038A

公开(公告)日：1996-01-30

申请号：US154002

申请日：1993-11-18

申请人： Shinichi Kondo ,  Seiji Shibahara ,  Takayuki Usui ,  Toshiaki Kudo ,  Shuichi Gomi ,  Atsushi Tamura ,  Yoko Ikeda ,  Daishiro Ikeda ,  Tomio Takeuchi

发明人： Shinichi Kondo ,  Seiji Shibahara ,  Takayuki Usui ,  Toshiaki Kudo ,  Shuichi Gomi ,  Atsushi Tamura ,  Yoko Ikeda ,  Daishiro Ikeda ,  Tomio Takeuchi

IPC分类号： C07H15/236 ,  A61K31/70 ,  C07H15/22

CPC分类号： C07H15/234

摘要： As new dibekacin derivatives and new arbekacin derivatives are now provided 2"-amino-2"-deoxydibekacin, 2"-amino-5,2"-dideoxydibekacin, 2"-amino-2"-deoxyarbekacin, 2"-amino-5,2"-dideoxyarbekacin, 2"-amino-5,2"-dideoxy-5-epi-fluoroarbekacin and 2"-amino-5,2"-dideoxy-5-epi-aminoarbekacin which all exhibit high antibacterial activity against a wide variety of gram-positive and gram-negative bacteria, including resistant bacteria such as methicillin-resistant Staphylococcus aureus and which are of low toxicity to mammals and are useful as antibacterial agent for treatment of bacterial infections.

摘要翻译： 现在提供新的二卡辛衍生物和新的阿贝卡星衍生物2' - 氨基-2' - 脱氧胆碱，2“ - 氨基-5,2” - 脱氧胆酸，2“ - 氨基-2'-脱氧阿糖胞苷，2 “ - 氨基-5,2” - 双脱氧肉豆蔻素，2“ - 氨基-5,2” - 双脱氧-5-表 - 氟代贝卡星和2“ - 氨基-5,2” - 双脱氧-5-表 所有这些都表现出对各种革兰氏阳性和革兰氏阴性细菌的高抗菌活性，包括耐甲氧西林金黄色葡萄球菌等抗性细菌，对哺乳动物毒性低，可用作细菌治疗的抗菌剂 感染。

公开(公告)号：US08428336B2

公开(公告)日：2013-04-23

申请号：US11431709

申请日：2006-05-11

申请人： Yoko Ikeda ,  Junko Konishi ,  Hisafumi Iwata ,  Yuji Takagi ,  Kenji Obara ,  Ryo Nakagaki ,  Seiji Isogai ,  Yasuhiko Ozawa

发明人： Yoko Ikeda ,  Junko Konishi ,  Hisafumi Iwata ,  Yuji Takagi ,  Kenji Obara ,  Ryo Nakagaki ,  Seiji Isogai ,  Yasuhiko Ozawa

IPC分类号： G06K9/00

CPC分类号： G06F3/0486 ,  G06F2203/04803 ,  G06T7/0004 ,  G06T2200/24 ,  G06T2207/30148

摘要： A method for classifying defects, including: calculating feature quantifies of defect image which is obtained by imaging a defect on a sample; classifying the defect image into a classified category by using information on the calculated feature quantities; displaying the classified defect image in a region on a display screen which is defined to the classified category; adding information on the classified category to the displayed defect image; transferring the displayed defect image which is added the information on the classified category to one of the other categories and displaying the transferred defect image in a region on the display screen which is defined to the one of the other categories; and changing information on the category.

摘要翻译： 一种用于对缺陷进行分类的方法，包括：通过对样品上的缺陷进行成像而获得的缺陷图像的特征量化计算; 通过使用关于计算的特征量的信息将缺陷图像分类成分类的类别; 在分类的类别的显示屏幕上的区域中显示分类的缺陷图像; 将分类类别的信息添加到所显示的缺陷图像; 将所述分类类别中的信息添加到所述其他类别中的所显示的缺陷图像，并且将所传送的缺陷图像显示在所述显示屏幕上定义为所述其他类别之一的区域中; 并更改关于该类别的信息。

公开(公告)号：US20130012408A1

公开(公告)日：2013-01-10

申请号：US13546674

申请日：2012-07-11

申请人： Shigeru KINOSHITA ,  Kei Tashiro ,  Masakazu Nakano ,  Tomohito Yagi ,  Kazuhiko Mori ,  Yoko Ikeda ,  Takazumi Taniguchi ,  Masaaki Kageyama

发明人： Shigeru KINOSHITA ,  Kei Tashiro ,  Masakazu Nakano ,  Tomohito Yagi ,  Kazuhiko Mori ,  Yoko Ikeda ,  Takazumi Taniguchi ,  Masaaki Kageyama

IPC分类号： C40B30/04 ,  C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q1/6883 ,  C12Q2600/156

摘要： A method of determining the presence or the absence of a glaucoma risk by detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism, comparing the allele and/or the genotype detected with at least one of an allele and/or a genotype with a high-risk allele, wherein the presence of a glaucoma risk is determined in a case where the allele detected is the high-risk allele, or the presence of a glaucoma risk is determined in a case where the genotype detected is a homozygote of the genotype comprising the high-risk allele or a heterozygote when the high-risk allele complies with a dominant genetic model, or the presence of a glaucoma risk is determined in a case where the genotype detected is a homozygote of the genotype comprising the high-risk allele when the high-risk allele complies with a recessive genetic model.

摘要翻译： 通过体外检测单核苷酸多态性的等位基因和/或基因型来确定青光眼存在或不存在青光眼风险的方法，比较检测到的等位基因和/或基因型与等位基因和/或 具有高风险等位基因的基因型，其中在检测到的等位基因是高风险等位基因的情况下确定青光眼风险的存在，或者在检测到的基因型是纯合子的情况下确定青光眼风险的存在 在高风险等位基因符合显性遗传模型的情况下，包括高风险等位基因或杂合子的基因型的基因型，或者在检测到的基因型是包含高表达的基因型的纯合子的情况下，确定青光眼风险的存在 当高风险等位基因符合隐性遗传模型时，这种等位基因是错误的。