摘要:
An electromagnetic device includes an electromagnet having one electrical coil and an annular member of high permeability having a pair of radially spaced first and second circumferential magnetic resistance portions. The first and second armatures are disposed in opposed relation to the first and second magnetic resistance portions, respectively. At least one of the first and second magnetic resistance portions is interrupted by circumferentially spaced magnetic bridge portions having such a size as to allow a predetermined amount of magnetic flux to pass therethrough to attract the one of the first and second armatures, disposed in opposed relation to the other of the first and second magnetic resistance portions, into contact with the annular member when excitation current of lower magnitude is applied to the coil. When excitation current of higher magnitude is applied to the coil, the magnetic flux passes through the first and second armatures, thereby attracting them into contact with the annular member.
摘要:
The invention provides novel XAF nucleic acid sequences. Also provided are XAF polypeptides, anti-XAF antibodies, and methods for modulating apoptosis and detecting compounds which modulate apoptosis.
摘要:
Intake and exhaust ports of an internal combustion engine possess respective turbine impellers, and an electrical rotary machine is formed on a rotary shaft connecting the impellers. Sensors are provided for sensing the loaded state of the engine at all times based on engine rpm and the amount of fuel supplied to the engine. When the engine is overloaded, the electrical rotary machine is made to operate as a motor to assist in the supercharging of the engine. When the engine load is not excessive, the rotary machine is made to operate as a generator to charge surplus energy, derived from the engine exhaust, in a storage battery.
摘要:
The invention provides novel XAF nucleic acid sequences. Also provided are XAF polypeptides, anti-XAF antibodies, and methods for modulating apoptosis and detecting compounds which modulate apoptosis.
摘要:
The acetylation level of a peptide is determined utilizing the fact that the changes in the acetylation level are reflected in the sensitivity of the substrate peptide to a peptidase. This method can be used for measuring activities of deacetylase and acetylase, and also enables screening for substances that influence the activity of these enzymes. The deacetylase activity can be measured by a simple procedure according to the present invention.
摘要:
The invention provides novel XAF nucleic acid sequences. Also provided are XAF polypeptides, anti-XAF antibodies, and methods for modulating apoptosis and detecting compounds which modulate apoptosis.
摘要:
The acetylation level of a peptide is determined utilizing the fact that the changes in the acetylation level are reflected in the sensitivity of the substrate peptide to a peptidase. This method can be used for measuring activities of deacetylase and acetylase, and also enables screening for substances that influence the activity of these enzymes. The deacetylase activity can be measured by a simple procedure according to the present invention.
摘要:
A method for simply and conveniently detecting acetyltransferase and deacetylase activities of proteins by executing an acetylation reaction of a peptide substrate with an acetyltransferase, or a deacetylation reaction of an acetylated peptide substrate with a deacetylase, and after the completion of these reactions, detecting the acetyl group bound to the peptide substrate by using an anti-acetylated peptide antibody. This system for detecting acetyltransferase and deacetylase activities using the anti-acetylated peptide antibody enables screening inhibitors or enhancers of acetyltransferase and deacetylase. A system for screening deacetylase inhibitors or acetyltransferase enhancers using cultured cells is also provided.
摘要:
The acetylation level of a peptide is determined utilizing the fact that the changes in the acetylation level are reflected in the sensitivity of the substrate peptide to a peptidase. This method can be used for measuring activities of deacetylase and acetylase, and also enables screening for substances that influence the activity of these enzymes. The deacetylase activity can be measured by a simple procedure according to the present invention.
摘要:
The present invention provides methods for measuring the phosphorylation activity of Cdc7-ASK kinase complex by using as an indicator the level of phosphorylation at a phosphorylation site of MCM, which is a substrate of Cdc7-ASK kinase complex. The effects of test compounds on the phosphorylation activity of Cdc7-ASK kinase complex can also be evaluated based on these measurement methods. Compounds that inhibit this phosphorylation activity are useful as anti-cancer agents having superior specificity for cancer.