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公开(公告)号：US20060167230A1
公开(公告)日：2006-07-27
申请号：US10542682
申请日：2004-01-20
申请人： Takaki Koga , Naoki Kimura , Takeshi Yoshino , Koichiro Ono
发明人： Takaki Koga , Naoki Kimura , Takeshi Yoshino , Koichiro Ono
CPC分类号： C07K16/38 , C07K14/8121 , C07K2317/50 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention provides anti-PCI antibodies having Protein C inhibitor (PCI)-neutralizing activity, and the uses thereof. Through the generation and screening of anti-PCI antibodies, the inventors successfully isolated anti-PCI antibodies which inhibit PCI's inhibitory effect on the production and activity of activated Protein C (aPC). The antibodies of the present invention suppress PCI's inhibitory effect on aPC production and/or the aPC inactivation by PCI, and thus can be used to maintain aPC activity and sustain the effects of aPC physiological activities, such as suppression of the activation of blood coagulation system and anti-inflammatory functions. The present invention also provides uses of the antibodies of the present invention in treating diseases such as thrombosis and sepsis using aPC. In treatments by aPC administration, the therapeutic effect of aPC can be sustained by administering an antibody of the present invention. The antibodies of the present invention can be used in the treatment and prevention of diseases such as thrombosis and sepsis.
摘要翻译： 本发明提供具有蛋白C抑制剂（PCI） - 中和活性的抗PCI抗体及其用途。 通过抗PCI抗体的产生和筛选，本发明人成功地分离了抗PCI抗体，其抑制PCI对活化蛋白C（aPC）的产生和活性的抑制作用。 本发明的抗体抑制PCI对aPC生成的抑制作用和/或PCI的aPC失活，因此可用于维持aPC活性并维持aPC生理活性的作用，例如抑制血液凝固系统的活化 和抗炎功能。 本发明还提供了本发明的抗体在使用aPC治疗诸如血栓形成和败血症的疾病中的用途。 在通过aPC施用的治疗中，通过施用本发明的抗体可以维持aPC的治疗效果。 本发明的抗体可用于治疗和预防诸如血栓形成和败血症等疾病。
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公开(公告)号：US07776329B2
公开(公告)日：2010-08-17
申请号：US10583795
申请日：2005-07-08
申请人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
发明人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
摘要： An antibody capable of binding to a specific region of glypican 3, as well as a humanized antibody created based on that antibody are disclosed. The anti-GPC3 antibody of the invention has a higher ADCC activity and CDC activity compared with those of a conventional antibody. The antibody of the present invention is useful as a cell growth inhibitor, an anticancer agent and an agent for diagnosis of cancers.
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公开(公告)号：US4530582A
公开(公告)日：1985-07-23
申请号：US537423
申请日：1983-09-29
申请人： Hiroshi Hara , Takashi Tobioka , Takeshi Yoshino , Tetuo Nishikawa , Jiro Sekine
发明人： Hiroshi Hara , Takashi Tobioka , Takeshi Yoshino , Tetuo Nishikawa , Jiro Sekine
摘要： An exposure aperture frame defining an exposure aperture includes at least a pivotable partition member with an inclined guide surface on the inner wall thereof which is pivoted by and thereby permits advancement of a film leader to a film take-up chamber so that the film leader can reach a film take-up chamber without any standstill within the exposure aperture frame. The inclined guide surface permits the forward end of the film leader to ride across the partition member. A spring urges the partition member toward a position in which it encloses the exposure aperture frame. That spring also releasably retains the partition member on a shaft on which it is pivoted. The partition member has a platform member extending toward the take-up chamber, which has an opening therethrough that provides access to the spring.
摘要翻译： 限定曝光孔的曝光孔框架包括至少一个可枢转的分隔构件，其在其内壁上具有倾斜的引导表面，所述倾斜的引导表面由其转动并由此允许胶片引导者前进到胶片拾取室，使得胶片引导件 在曝光孔眼框架内没有任何静止的情况下到达胶片吸收室。 倾斜的引导表面允许胶片引导件的前端穿过分隔件。 弹簧将分隔构件推向其包围曝光孔框架的位置。 那个弹簧也可以将分隔件可释放地保持在其上枢转的轴上。 分隔构件具有朝向卷取室延伸的平台构件，该平台构件具有穿过其的开口，其提供通向弹簧的通路。
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公开(公告)号：US07538809B2
公开(公告)日：2009-05-26
申请号：US10780604
申请日：2004-02-19
CPC分类号： H04N5/335
摘要： This invention relates to a CCD pulse generator capable of generating a CCD driving signal and CCD output processing signal at accurate timings. The pulse generator includes a digital delay type pulse control section which finely delays a transfer signal for driving a CCD, thereby generating a plurality of delay signals, and changes selection of these delay signals, thereby generating a CCD driving signal and/or CCD output processing signal corresponding to set rise and fall timings, an inverted/non-inverted signal generating section which generates the inverted signal and non-inverted signal of the generated signal, a selection section which selects the inverted signal and non-inverted signal of the generated signal, a blanking section which temporarily disables the generated signal, an output section which has an output enable function and outputs the signal selected by the selection section, and an output signal condition setting section which sets pieces of condition setting information that determine the operations of the respective sections.
摘要翻译： 本发明涉及能够在精确定时产生CCD驱动信号和CCD输出处理信号的CCD脉冲发生器。 脉冲发生器包括数字延迟型脉冲控制部分，其精细地延迟用于驱动CCD的传送信号，从而产生多个延迟信号，并改变这些延迟信号的选择，从而产生CCD驱动信号和/或CCD输出处理 对应于设定的上升和下降定时的信号;反相/非反相信号产生部分，其产生所生成的信号的反相信号和非反相信号;选择部分，其选择产生的信号的反相信号和非反相信号 ，暂时禁止产生的信号的消隐部分，具有输出使能功能并输出由选择部分选择的信号的输出部分，以及输出信号条件设置部分，其设置条件设置信息， 各部分。
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5.发明授权Camera with orientable taking lens and a device for attaching a flash unit 失效具有可定向拍摄镜头的相机和用于连接闪光灯组件的设备
公开(公告)号：US4771302A
公开(公告)日：1988-09-13
申请号：US920052
申请日：1986-10-20
申请人： Hisashi Hamada , Katsuhiko Yamamoto , Takeshi Yoshino , Masayoshi Hirai , Shiro Hashimoto , Michihiro Shiina , Shigenori Goto
发明人： Hisashi Hamada , Katsuhiko Yamamoto , Takeshi Yoshino , Masayoshi Hirai , Shiro Hashimoto , Michihiro Shiina , Shigenori Goto
CPC分类号： G03B15/05 , G03B5/06 , G03B2215/0514
摘要： A camera of the type in which a taking lens is orientable relative to the camera body comprises a lens holder, a light-impervious member connecting the lens holder and camera body for allowing at least an axial movement of the taking lens, and a supporting member attached to the lens holder for detachably connecting a flash unit.
摘要翻译： 拍摄镜头相对于相机主体可取向的类型的相机包括透镜保持器，连接透镜保持器和照相机主体的不透光部件，用于允许拍摄镜头的至少轴向移动，以及支撑部件 附接到透镜支架，用于可拆卸地连接闪光单元。
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公开(公告)号：US4610522A
公开(公告)日：1986-09-09
申请号：US657689
申请日：1984-10-04
申请人： Takashi Tobioka , Tetuo Nishizawa , Minoru Ishiguro , Toshio Yoshida , Masanoshin Komori , Seiji Asano , Takeshi Yoshino , Hiroshi Hara
发明人： Takashi Tobioka , Tetuo Nishizawa , Minoru Ishiguro , Toshio Yoshida , Masanoshin Komori , Seiji Asano , Takeshi Yoshino , Hiroshi Hara
CPC分类号： G03B17/425
摘要： A mode change-over device for a mode change-over device for a pre-winding type camera in which, after a loading of a film patrone in the camera and before the shooting, a pre-winding of the film is conducted to fully pre-wind the film on a spool and, when the pre-winding is finished, a mode retaining member is unlocked so as to release a mode change-over member thereby operating a mode change-over switch for a shooting mode, such as to allow an unwinding of the film in a frame-by-frame fashion for each shooting exposure, while the mode change-over member is charged by an opening of a back lid of the camera, the mode change-over device comprising; a counter adapted to operate in response to winding and rewinding of the camera; a retaining member for locking the mode retaining member when the back lid has been opened erroneously or accidentally; and a counter engaging member which prevents the retaining member from locking the mode change-over member when the counter is in the initial position, whereas, when the counter is in the counting position, operates the retaining member for making the retaining member lock the mode change-over member.
摘要翻译： 一种用于预卷绕型照相机的模式切换装置的模式切换装置，其中，在将照相机中的胶片照相机加载并且在拍摄之前，将胶片的预卷绕进行到完全预先 - 将卷片卷绕在卷轴上，并且当预卷绕完成时，模式保持部件被解锁，以便释放模式转换部件，从而操作用于拍摄模式的模式转换开关，例如允许 所述模式转换装置包括：模式切换装置，其中所述模式转换部件通过所述相机的后盖的开口被充电; 适于响应于相机的卷绕和倒带操作的计数器; 当后盖被错误地或意外地打开时用于锁定模式保持构件的保持构件; 以及当计数器处于初始位置时防止保持构件锁定模式转换构件的反接合构件，而当计数器处于计数位置时，操作保持构件以使保持构件锁定模式 转换会员
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公开(公告)号：US08120824B2
公开(公告)日：2012-02-21
申请号：US12267002
申请日：2008-11-07
申请人： Daijiro Saito , Takeshi Yoshino
发明人： Daijiro Saito , Takeshi Yoshino
IPC分类号： H04N1/04
CPC分类号： H04N1/506
摘要： An image forming apparatus including: an image forming section which forms an image on a photosensitive drum based on a reference signal which being an image write control signal of a predetermined cycle; a measuring section which detects a rotational velocity of the photosensitive drum and measures a velocity fluctuation distribution in time period of one rotation of the drum; a storage section which stores a correction value as a correction data table for each type of recording sheets, wherein the correction value is obtained based on the velocity fluctuation distribution; and a control section which corrects the cycle of the reference signal by referring the correction data table corresponding to a selected type of recording sheets, and controls the image forming section to form the image on the photosensitive drum based on the reference signal with the corrected cycle.
摘要翻译： 一种图像形成装置，包括：图像形成部，其基于作为预定周期的图像写入控制信号的参考信号在感光鼓上形成图像; 测量部分，其检测感光鼓的旋转速度并测量滚筒的一个旋转的时间段内的速度波动分布; 存储部分，其将校正值存储为每种类型的记录片材的校正数据表，其中基于速度波动分布获得校正值; 以及控制部，其通过参照与所选择的记录纸张类型相对应的校正数据表来校正参考信号的周期，并且基于具有校正周期的参考信号来控制图像形成部分以在感光鼓上形成图像 。
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公开(公告)号：US20070190599A1
公开(公告)日：2007-08-16
申请号：US10583795
申请日：2005-07-08
申请人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
发明人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
CPC分类号： C07K16/28 , C07K7/06 , C07K14/47 , C07K16/303 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： An antibody capable of binding to a specific region of glypican 3, as well as a humanized antibody created based on that antibody are disclosed. The anti-GPC3 antibody of the invention has a higher ADCC activity and CDC activity compared with those of a conventional antibody. The antibody of the present invention is useful as a cell growth inhibitor, an anticancer agent and an agent for diagnosis of cancers.
摘要翻译： 公开了能够结合磷脂酰肌醇蛋白聚糖3的特定区域的抗体以及基于该抗体产生的人源化抗体。 本发明的抗GPC3抗体与常规抗体相比具有较高的ADCC活性和CDC活性。 本发明的抗体可用作细胞生长抑制剂，抗癌剂和癌症诊断剂。
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公开(公告)号：US07110017B2
公开(公告)日：2006-09-19
申请号：US10383048
申请日：2003-03-06
申请人： Takeshi Yoshino , Kenji Izumiya , Kouichi Takaki
发明人： Takeshi Yoshino , Kenji Izumiya , Kouichi Takaki
IPC分类号： B41J2/435
CPC分类号： H03K5/1506 , G06K15/1219 , H03K5/135 , H04N1/053 , H04N2201/04784 , H04N2201/04789
摘要： There is described a signal controlling circuit particularly used in a printer or copier. The circuit includes a delay chain section to generate a plurality of delayed clock signals, a synchronized signal detecting section to detect a number of delay stages, a total delay time of which is equivalent to a single period of the reference clock signal, based on delayed clock signals synchronized with an index signal and are selected from the plurality of delayed clock signals, an index signal counting section to count index signals inputted into the index signal counting section, a phase shift calculating section to calculate a phase shift amount in respect to the reference clock signal, and a delayed clock selecting section to select a specific delayed clock signal out of the plurality of delayed clock signals in an alternative way, so as to output the specific delayed clock signal to an external section.
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公开(公告)号：US4134656A
公开(公告)日：1979-01-16
申请号：US835740
申请日：1977-09-22
申请人： Takeshi Yoshino
发明人： Takeshi Yoshino
摘要： In a collapsible mount type camera, a transmission pin provided in a lens barrel is movable back and forth as a distance ring or aperture size control ring is rotated. The rear end of the transmission pin is projected rearward out of the lens barrel. The rear end of the pin is integrally fixed to a radially extending lever which extends beyond the periphery of the lens barrel. On the outer end of the radially extending lever abuts a rear end of an intermediate lever pivotally mounted in a camera body. When the lens barrel is retracted into the camera body, the lens barrel with the transmission pin is not obstructed by the intermediate lever.
摘要翻译： 在可折叠安装型照相机中，设置在镜筒中的传输销可随着距离环或孔径尺寸控制环旋转而前后移动。 传输销的后端向后突出到镜筒外。 销的后端一体地固定到延伸超过镜筒的周边的径向延伸的杆上。 在径向延伸的杆的外端上与枢轴安装在相机机体中的中间杆的后端相接。 当镜筒缩回相机机身时，带传动销的镜筒不会被中间杆挡住。
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