公开(公告)号：US20060167230A1

公开(公告)日：2006-07-27

申请号：US10542682

申请日：2004-01-20

申请人： Takaki Koga ,  Naoki Kimura ,  Takeshi Yoshino ,  Koichiro Ono

发明人： Takaki Koga ,  Naoki Kimura ,  Takeshi Yoshino ,  Koichiro Ono

IPC分类号： C07K16/44 ,  C07K16/40

CPC分类号： C07K16/38 ,  C07K14/8121 ,  C07K2317/50 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention provides anti-PCI antibodies having Protein C inhibitor (PCI)-neutralizing activity, and the uses thereof. Through the generation and screening of anti-PCI antibodies, the inventors successfully isolated anti-PCI antibodies which inhibit PCI's inhibitory effect on the production and activity of activated Protein C (aPC). The antibodies of the present invention suppress PCI's inhibitory effect on aPC production and/or the aPC inactivation by PCI, and thus can be used to maintain aPC activity and sustain the effects of aPC physiological activities, such as suppression of the activation of blood coagulation system and anti-inflammatory functions. The present invention also provides uses of the antibodies of the present invention in treating diseases such as thrombosis and sepsis using aPC. In treatments by aPC administration, the therapeutic effect of aPC can be sustained by administering an antibody of the present invention. The antibodies of the present invention can be used in the treatment and prevention of diseases such as thrombosis and sepsis.

摘要翻译： 本发明提供具有蛋白C抑制剂（PCI） - 中和活性的抗PCI抗体及其用途。 通过抗PCI抗体的产生和筛选，本发明人成功地分离了抗PCI抗体，其抑制PCI对活化蛋白C（aPC）的产生和活性的抑制作用。 本发明的抗体抑制PCI对aPC生成的抑制作用和/或PCI的aPC失活，因此可用于维持aPC活性并维持aPC生理活性的作用，例如抑制血液凝固系统的活化 和抗炎功能。 本发明还提供了本发明的抗体在使用aPC治疗诸如血栓形成和败血症的疾病中的用途。 在通过aPC施用的治疗中，通过施用本发明的抗体可以维持aPC的治疗效果。 本发明的抗体可用于治疗和预防诸如血栓形成和败血症等疾病。

公开(公告)号：US09013020B2

公开(公告)日：2015-04-21

申请号：US13982063

申请日：2012-03-09

申请人： Takeshi Takeuchi ,  Naoki Kimura

发明人： Takeshi Takeuchi ,  Naoki Kimura

IPC分类号： H01L27/144 ,  G01J1/04 ,  H01L31/0203 ,  H05K1/18 ,  H01L31/02 ,  H05K1/03

CPC分类号： H01L27/1446 ,  G01J1/0403 ,  H01L31/02005 ,  H01L31/0203 ,  H01L2224/48091 ,  H01L2224/48137 ,  H05K1/0313 ,  H05K1/181 ,  H05K2201/10015 ,  H05K2201/10121 ,  Y02P70/611 ,  H01L2924/00014

摘要： Disclosed is a photodiode carrier which can equalize the frequency response characteristics of a plurality of mounted photodiodes. A photodiode carrier as disclosed includes a diode array connection region, first and second signal side electrodes connected to the diode array connection region, first and second bias side electrodes connected to the diode array connection region, and first and second condensers connected between the electrode disposed on the way of the first and the second bias side electrodes and the ground electrode, wherein the electrodes disposed on the way of the first and the second bias side electrodes are located in the about equal distance from the diode array connection region 7 as a start point.

摘要翻译： 公开了可以使多个安装的光电二极管的频率响应特性相等的光电二极管载体。 所公开的光电二极管载体包括二极管阵列连接区域，连接到二极管阵列连接区域的第一和第二信号侧电极，连接到二极管阵列连接区域的第一和第二偏置侧电极以及连接在所设置的电极之间的第一和第二电容器 在第一和第二偏置侧电极和接地电极的路径上，其中设置在第一和第二偏置侧电极途中的电极位于与二极管阵列连接区域7大致相等的距离处，作为起始点 点。

公开(公告)号：US20120282173A1

公开(公告)日：2012-11-08

申请号：US13391171

申请日：2010-08-17

申请人： Naoki Kimura

发明人： Naoki Kimura

IPC分类号： A61K39/395 ,  A61P35/00 ,  G01N33/574 ,  C12N5/09 ,  C07K1/107 ,  C07K16/22 ,  A61K51/10

CPC分类号： C07K16/22 ,  C07K2317/24 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/57407 ,  G01N33/577

摘要： An anti-HB-EGF antibody having an internalizing activity is disclosed. A cytotoxic substance is preferably bound to the anti-HB-EGF antibody of the present invention. Also provided are an anti-cancer agent and a cell proliferation inhibitor, which comprise the antibody of the present invention as an active ingredient, a method of treating cancer and a method of diagnosing cancer, which comprise the administration of the antibody of the present invention. Cancers that can be treated by the anti-cancer agent of the present invention include pancreatic cancer, liver cancer, esophageal cancer, melanoma, colorectal cancer, gastric cancer, ovarian cancer, uterine cervical cancer, breast cancer, bladder cancer, brain tumors, and hematological cancers.

摘要翻译： 公开了具有内在活性的抗HB-EGF抗体。 细胞毒性物质优选与本发明的抗HB-EGF抗体结合。 还提供了包含本发明的抗体作为活性成分的抗癌剂和细胞增殖抑制剂，治疗癌症的方法和诊断癌症的方法，其包括施用本发明的抗体 。 可以用本发明的抗癌剂治疗的癌症包括胰腺癌，肝癌，食管癌，黑素瘤，结肠直肠癌，胃癌，卵巢癌，子宫颈癌，乳腺癌，膀胱癌，脑肿瘤和 血液癌。

公开(公告)号：US20120235141A1

公开(公告)日：2012-09-20

申请号：US13418619

申请日：2012-03-13

申请人： Hayato MASUBUCHI ,  Naoki Kimura ,  Manabu Matsumoto ,  Toyota Morimoto

发明人： Hayato MASUBUCHI ,  Naoki Kimura ,  Manabu Matsumoto ,  Toyota Morimoto

IPC分类号： H01L23/58 ,  H01L23/48

CPC分类号： H01L25/18 ,  G11C5/02 ,  H01L23/3121 ,  H01L23/3142 ,  H01L23/49822 ,  H01L23/49838 ,  H01L23/5286 ,  H01L23/552 ,  H01L23/562 ,  H01L25/0655 ,  H01L25/50 ,  H01L27/115 ,  H01L2924/0002 ,  H05K1/0225 ,  H05K1/0271 ,  H05K1/0298 ,  H05K1/181 ,  H05K3/305 ,  H05K2201/09136 ,  H05K2201/09681 ,  H05K2201/10159 ,  Y02P70/613 ,  H01L2924/00

摘要： According to one embodiment, a semiconductor memory system includes a substrate, a plurality of elements and an adhesive portion. The substrate has a multilayer structure in which wiring patterns are formed, and has a substantially rectangle shape in a planar view. The elements are provided and arranged along the long-side direction of a surface layer side of the substrate. The adhesive portion is filled in a gap between the elements and in a gap between the elements and the substrate, where surfaces of the elements are exposed.

摘要翻译： 根据一个实施例，半导体存储器系统包括衬底，多个元件和粘合剂部分。 基板具有其中形成布线图案并且在平面图中具有大致矩形形状的多层结构。 元件沿着衬底的表面层侧的长边方向设置和布置。 粘合剂部分填充在元件之间的间隙中，并且在元件和基板之间的间隙中填充元件的表面。

公开(公告)号：US20120212988A1

公开(公告)日：2012-08-23

申请号：US13052425

申请日：2011-03-21

申请人： Masato Sugita ,  Naoki Kimura ,  Daisuke Kimura

发明人： Masato Sugita ,  Naoki Kimura ,  Daisuke Kimura

IPC分类号： G11C5/02

CPC分类号： G11C5/04 ,  G06F13/4282 ,  G06F17/30867 ,  G06F2213/0032 ,  G11C5/02 ,  G11C5/06 ,  G11C5/063 ,  G11C14/0018 ,  G11C16/04

摘要： According to an embodiment, a semiconductor device includes a substrate, a connector, a volatile semiconductor memory element, multiple nonvolatile semiconductor memory elements, and a controller. A wiring pattern includes a signal line that is formed between the connector and the controller and that connects the connector to the controller. On the opposite side of the controller to the signal line, the multiple nonvolatile semiconductor memory elements are aligned along the longitudinal direction of the substrate.

摘要翻译： 根据实施例，半导体器件包括衬底，连接器，易失性半导体存储器元件，多个非易失性半导体存储器元件和控制器。 布线图案包括在连接器和控制器之间形成并将连接器连接到控制器的信号线。 在信号线的控制器的相反侧，多个非易失性半导体存储元件沿着基板的纵向排列。

公开(公告)号：US20120202097A1

公开(公告)日：2012-08-09

申请号：US13394909

申请日：2010-08-11

申请人： Naoki Kimura ,  Takenori Ishizu

发明人： Naoki Kimura ,  Takenori Ishizu

IPC分类号： H01M10/04 ,  H01M10/02 ,  H01M2/02

CPC分类号： H01M10/0587 ,  H01M10/0525 ,  Y02T10/7011

摘要： In a lithium ion secondary cell including a wound group 20 in which a positive electrode 24 including a positive electrode mixture layer 5 and a negative electrode 22 including a negative electrode mixture layer 6 are wound with the interposition of separators 21, 23, a winding starting edge 22S is disposed more towards an inner peripheral side than the positive electrode 24; a winding ending edge 22E is disposed more towards an outer peripheral side than a winding ending edge 24E; the winding starting edges 24S, 22S, and the winding ending edges 24S, 22E are disposed within a flat portion of the wound group 20; and the negative electrode mixture layer 6 covering a surface of the positive electrode mixture layer 5 is disposed on an inner and an outer circumferential surface of the positive electrode mixture layer 5.

摘要翻译： 在包括卷绕组20的锂离子二次电池中，其中包括正极合剂层5的正极24和包含负极混合物层6的负极22缠绕有隔离层21,23，绕组起始 边缘22S更靠近正极24的内周侧设置; 卷绕结束边缘22E比卷绕结束边缘24E更靠外侧设置; 卷绕起始边缘24S，22S和卷绕终止边缘24S，22E设置在卷绕组20的平坦部分内; 覆盖正极复合层5的表面的负极合剂层6配置在正极合剂层5的内周面和外周面上。

公开(公告)号：US20070154945A1

公开(公告)日：2007-07-05

申请号：US10591720

申请日：2005-02-09

申请人： Megumi Akiyama ,  Naoki Kimura

发明人： Megumi Akiyama ,  Naoki Kimura

IPC分类号： G01N33/53 ,  G01N1/28 ,  C12N9/00 ,  C07K16/18 ,  C12M3/00 ,  B05D3/02

CPC分类号： G01N33/54353

摘要： It is an object of the present invention to provide a method of conveniently efficiently and easily immobilizing a protein on a substrate, a method of detecting a substance capable of interacting with the protein at a high sensitivity, and a protein and a protein-immobilized substrate which are used in these methods. In the method of detecting a substance capable of interacting with a protein using the immobilized protein of the present invention, a protein bound to a compound having a group capable of binding onto a substrate for immobilizing a biomolecule or a carrier provided on the substrate and immobilized onto the substrate, is used as the immobilized protein.

摘要翻译： 本发明的目的是提供一种方便地有效且容易地将蛋白质固定在底物上的方法，检测能够以高灵敏度与蛋白质相互作用的物质的方法以及蛋白质和固定蛋白质的底物 在这些方法中使用。 在使用本发明的固定化蛋白质检测能够与蛋白质相互作用的物质的方法中，结合到具有能够结合到基底上的基团的化合物的蛋白质用于固定生物分子或设置在基底上的载体并被固定 用作固定化蛋白质。

公开(公告)号：US20070087379A1

公开(公告)日：2007-04-19

申请号：US11643069

申请日：2006-12-20

申请人： Tetsuya Taga ,  Naoki Kimura

发明人： Tetsuya Taga ,  Naoki Kimura

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

CPC分类号： C07K14/47 ,  A61K38/00

摘要： A novel gene, dubbed “YS68”, involved in primitive hematopoiesis was successfully isolated from cDNA derived from mouse yolk sacs. In addition, a human gene corresponding to this gene was successfully isolated. Expression characteristics of these genes suggested their involvement in primitive hematopoiesis. The proteins of this invention and genes encoding the proteins may be utilized as tools for drug development against diseases, such as hematological disorders.

摘要翻译： 从源自小鼠卵黄囊的cDNA中成功分离了一种称为“YS68”的新基因，涉及原始造血。 此外，成功分离了与该基因相对应的人类基因。 这些基因的表达特征表明它们参与原始造血。 本发明的蛋白质和编码蛋白质的基因可以用作针对疾病如血液学疾病的药物开发的工具。

公开(公告)号：US07140131B2

公开(公告)日：2006-11-28

申请号：US11011446

申请日：2004-12-15

申请人： Naoki Kimura

发明人： Naoki Kimura

IPC分类号： G02B6/26

CPC分类号： G02B6/29361 ,  G02B6/12007 ,  G02B6/29368 ,  G02B6/4214 ,  G02B6/423 ,  G02B6/4246 ,  G02B2006/12109

摘要： An optical communication module for communicating a light signal including a groove portion whose section is V-shaped and provided on the surface of an optical waveguide substrate, on one of two surfaces of which groove portion a mirror is formed by the coating with a metal film and in the vicinity of the other surface of which groove portion, a tip of an optical waveguide on the optical waveguide substrate is provided, whereby a signal light guided by the optical waveguide is reflected by the mirror of the metal film so as to be incident on a light-receiving element disposed on the surface of the optical waveguide substrate.

公开(公告)号：US06973239B2

公开(公告)日：2005-12-06

申请号：US10067337

申请日：2002-02-07

申请人： Naoki Kimura

发明人： Naoki Kimura

IPC分类号： G02B6/12 ,  G02B6/42 ,  H01L31/0232 ,  H01L31/12 ,  H01S5/022 ,  H01S5/026 ,  G02B6/30

CPC分类号： H01S5/0264 ,  G02B6/42 ,  G02B6/423 ,  G02B6/4246 ,  G02B2006/12126

摘要： Transmission signal light emitted from a light emitting element is coupled to an optical waveguide and guided into a transmission line. A light monitor a portion of leakage light, which is used for control of optical output of the light emitting element. The optical semiconductor module is covered with transparent resin that is closely matched to the refractive index of a clad layer covering the optical waveguide. The light leaked to the inside of the clad layer is not reflected at a top surface of the clad layer and is received at a light receiving surface of the light monitor.

摘要翻译： 从发光元件发射的透射信号光耦合到光波导并被引导到传输线中。 光监测用于控制发光元件的光输出的泄漏光的一部分。 光学半导体模块用与覆盖光波导的覆层的折射率紧密匹配的透明树脂覆盖。 泄漏到包覆层内部的光不会在包覆层的顶面被反射，并被接收在光监视器的受光面上。