公开(公告)号：US3940479A

公开(公告)日：1976-02-24

申请号：US489104

申请日：1974-07-17

申请人： Takashi Shomura ,  Shoji Omoto ,  Shinji Miyado ,  Hiroshi Watanabe ,  Shigeharu Inouye ,  Yujiro Yamada ,  Taro Niida

发明人： Takashi Shomura ,  Shoji Omoto ,  Shinji Miyado ,  Hiroshi Watanabe ,  Shigeharu Inouye ,  Yujiro Yamada ,  Taro Niida

IPC分类号： C07G11/00 ,  A61K35/00

CPC分类号： C07G11/00 ,  Y10S435/838

摘要： A BN-109 substance producing strain of the genus Bacillus is cultivated under an aerobic condition to produce and accumulate BN-109 substance in a culture medium. The BN-109 substance is isolated from the culture broth and purified, and proved to be a novel antibiotic. The BN-109 is effective in the treatment and prevention of swine scours.

摘要翻译： 在需氧条件下培养芽孢杆菌属的BN-109物质产生菌株，以在培养基中产生并积累BN-109物质。 BN-109物质从培养液中分离纯化，证明是一种新型抗生素。 BN-109可有效治疗和预防猪流感。

公开(公告)号：US4010155A

公开(公告)日：1977-03-01

申请号：US526731

申请日：1974-11-25

申请人： Shigeharu Inouye ,  Takashi Shomura ,  Michio Kojima ,  Yasuaki Ogawa ,  Hiroshi Watanabe ,  Yasumitsu Kondo ,  Kazuo Saito, deceased ,  Yujiro Yamada ,  Taro Niida

发明人： Shigeharu Inouye ,  Takashi Shomura ,  Michio Kojima ,  Yasuaki Ogawa ,  Hiroshi Watanabe ,  Yasumitsu Kondo ,  Kazuo Saito, deceased ,  Yujiro Yamada ,  Taro Niida

IPC分类号： A61K35/74 ,  C07D501/36 ,  C07D501/57 ,  C12P1/06 ,  C12P35/08 ,  C12D9/00

CPC分类号： C12P35/08 ,  Y10S435/803 ,  Y10S435/893 ,  Y10S435/929

摘要： A new antibiotic designated as SF-1623 substance exhibiting a useful antibacterial activity against gram-negative bacteria is now produced by cultivating a new strain ATCC 21999 of the known species Streptomyces chartreusis. The SF-1623 substance in the form of its an alkali metal salt may be recovered from the culture when the cultivation is effected under aerobic conditions in the presence of an alkali metal thiosulfate.

摘要翻译： 现在通过培育已知种类的链霉菌Streptomyces chartreusis的新菌株ATCC 21999，产生一种被指定为对革兰氏阴性细菌有用的抗菌活性的SF-1623物质的新抗生素。 当在有氧条件下在碱金属硫代硫酸盐存在下进行培养时，可以从培养物中回收其碱金属盐形式的SF-1623物质。

公开(公告)号：US4076588A

公开(公告)日：1978-02-28

申请号：US703589

申请日：1976-07-08

申请人： Shigeharu Inouye ,  Takashi Shomura ,  Michio Kojima ,  Yasuaki Ogawa ,  Hiroshi Watanabe ,  Yasumitsu Kondo ,  Kazuo Saito, deceased ,  Yujiro Yamada ,  Taro Niida

发明人： Shigeharu Inouye ,  Takashi Shomura ,  Michio Kojima ,  Yasuaki Ogawa ,  Hiroshi Watanabe ,  Yasumitsu Kondo ,  Kazuo Saito, deceased ,  Yujiro Yamada ,  Taro Niida

IPC分类号： A61K35/74 ,  C07D501/36 ,  C07D501/57 ,  C12P1/06 ,  C12P35/08 ,  C12D9/14

CPC分类号： C12P35/08 ,  Y10S435/803 ,  Y10S435/893 ,  Y10S435/929

摘要： A new antibiotic designated as SF-1623 substance exhibiting a useful antibacterial activity against gram-negative bacteria is now produced by cultivating a new strain ATCC 21999 of the known species Streptomyces chartreusis. The SF-1623 substance in the form of its an alkali metal salt may be recovered from the culture when the cultivation is effected under aerobic conditions in the presence of an alkali metal thiosulfate.

摘要翻译： 现在通过培育已知种类的链霉菌Streptomyces chartreusis的新菌株ATCC 21999，产生一种被指定为对革兰氏阴性细菌有用的抗菌活性的SF-1623物质的新抗生素。 当在有氧条件下在碱金属硫代硫酸盐存在下进行培养时，可以从培养物中回收其碱金属盐形式的SF-1623物质。

公开(公告)号：US4181715A

公开(公告)日：1980-01-01

申请号：US908983

申请日：1978-05-24

申请人： Yasumitsu Kondo ,  Takashi Shomura ,  Hiroshi Watanabe ,  Tetsuro Watanabe ,  Shigeharu Inouye ,  Taro Niida

发明人： Yasumitsu Kondo ,  Takashi Shomura ,  Hiroshi Watanabe ,  Tetsuro Watanabe ,  Shigeharu Inouye ,  Taro Niida

IPC分类号： A61K35/00 ,  A61K35/74 ,  A61K35/742

CPC分类号： A61K35/742 ,  Y10S435/898

摘要： A novel antibiotic substance SF-1540 and a process for preparing the same which comprises culturing a substance SF-1540-producing microorganism belonging to the genus Streptomyces in a medium and isolating and recovering the substance SF-1540 from a cultured broth; a novel derivative of the substance SF-1540 and a process for preparing the same which comprises treating said antibiotic substance SF-1540 with methanol to form the corresponding antibiotic substance SF-1540 derivative.

摘要翻译： 一种新型抗生素物质SF-1540及其制备方法，其包括在培养基中培养属于链霉菌属的SF-1540生物微生物，并从培养液中分离回收物质SF-1540; 物质SF-1540的新衍生物及其制备方法，其包括用甲醇处理所述抗生素物质SF-1540以形成相应的抗生素物质SF-1540衍生物。

公开(公告)号：US4169140A

公开(公告)日：1979-09-25

申请号：US736143

申请日：1976-10-27

申请人： Kazunori Ohba ,  Takashi Shomura ,  Hiroshi Watanabe ,  Kunikazu Totsukawa ,  Michio Kojima ,  Shoji Omoto ,  Takashi Tsuruoka ,  Shigeharu Inoue ,  Taro Niida

发明人： Kazunori Ohba ,  Takashi Shomura ,  Hiroshi Watanabe ,  Kunikazu Totsukawa ,  Michio Kojima ,  Shoji Omoto ,  Takashi Tsuruoka ,  Shigeharu Inoue ,  Taro Niida

IPC分类号： A61K35/74 ,  A61P31/04 ,  C07G11/00 ,  C12P1/06 ,  C12R1/465 ,  A61K35/00

CPC分类号： C12P1/06

摘要： A new antibiotic SF-1771 substance is produced by cultivating a new strain, Streptomyces toyocaensis SF-1771, in a liquid culture medium under aerobic conditions. This antibiotic may be isolated from the fermentation broth by treating the broth filtrate with a synthetic adsorbent resin for adsorption of the active compound and eluting the resin with an aqueous alcohol or aqueous acetone, followed by chromatographic purification. SF-1771 substance is a copper-containing antibiotic which shows antibacterial activity against Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus subtilis. Removal of the copper component from SF-1771 substance by treatment with hydrogen sulfide, an alkali metal sulfide or a copper-chelating agent gives SF-1771-B substance containing no copper component which shows antibacterial activity as high as but a toxicity lower than SF-1771 substance.

摘要翻译： 通过在有氧条件下在液体培养基中培养新的菌株Streptomyces toyocaensis SF-1771来生产新的抗生素SF-1771物质。 通过用合成吸附剂树脂处理肉汤滤液以吸附活性化合物并用含水醇或丙酮水溶液洗脱树脂，然后进行色谱纯化，从发酵液中分离出该抗生素。 SF-1771物质是对大肠杆菌，伤寒沙门氏菌，铜绿假单胞菌，金黄色葡萄球菌和枯草芽孢杆菌具有抗菌活性的含铜抗生素。 通过用硫化氢，碱金属硫化物或铜螯合剂处理从SF-1771物质中除去铜成分得到不含铜成分的SF-1771-B物质，其抗菌活性高于但低于SF的毒性 -1771物质。

公开(公告)号：US4160026A

公开(公告)日：1979-07-03

申请号：US826766

申请日：1977-08-22

申请人： Katsuyoshi Iwamatsu ,  Shoji Omoto ,  Takashi Shomura ,  Hiroshi Watanabe ,  Michio Kojima ,  Shigeharu Inoue ,  Taro Niida ,  Takashi Hisamatsu ,  Shingo Uchida

发明人： Katsuyoshi Iwamatsu ,  Shoji Omoto ,  Takashi Shomura ,  Hiroshi Watanabe ,  Michio Kojima ,  Shigeharu Inoue ,  Taro Niida ,  Takashi Hisamatsu ,  Shingo Uchida

IPC分类号： C12P13/00 ,  A61K35/74 ,  A61P31/04 ,  A61P37/04 ,  C07G11/00 ,  C07H5/06 ,  C12P1/06 ,  C12P19/04 ,  C12D9/14

CPC分类号： C07H5/06 ,  C07G11/00 ,  C12P1/06 ,  Y10S435/886

摘要： New antibiotics SF-1130-x.sub.1 substance and SF-1130-x.sub.2 substance are produced by cultivating a microorganism Streptomyces myxogenes SF-1130 now deposited under FERM-P. 676 and ATCC. 31305 in a liquid culture medium under aerobic conditions, and these antibiotics may be isolated from the fermentation broth and are useful as an activator for enhancing the host defense system in living animals. The activity of these antibiotics may be improved when used in combination with one or more of maltose, maltotriose, maltotetraose, maltopentaose, maltohexaose and maltoheptaose.

摘要翻译： 新型抗生素SF-1130-x1物质和SF-1130-x2物质是通过培养现在以FERM-P沉积的微生物Streptomyces myxogenes SF-1130生产的。 676和ATCC。 31305在有氧条件下在液体培养基中，这些抗生素可以从发酵液中分离出来，可用作增强活体动物宿主防御系统的活化剂。 当与麦芽糖，麦芽三糖，麦芽四糖，麦芽五糖，麦芽六糖和麦芽七糖中的一种或多种组合使用时，可以改善这些抗生素的活性。

公开(公告)号：US3974035A

公开(公告)日：1976-08-10

申请号：US552281

申请日：1975-02-24

申请人： Takashi Shomura ,  Hiroshi Watanabe ,  Yasuaki Ogawa ,  Kazunori Ohba ,  Yasumitsu Kondo ,  Michio Kojima ,  Shigeharu Inoje ,  Taro Niida

发明人： Takashi Shomura ,  Hiroshi Watanabe ,  Yasuaki Ogawa ,  Kazunori Ohba ,  Yasumitsu Kondo ,  Michio Kojima ,  Shigeharu Inoje ,  Taro Niida

IPC分类号： A61K31/545 ,  A61P31/04 ,  C12P35/08 ,  C12D9/14

CPC分类号： C12P35/08 ,  Y10S435/893

摘要： This invention relates to a process for preparing a cephamycin type antibiotic substance which comprises cultivating a microorganism belonging to the genus Streptomyces under aerobic conditions and a primary object of this invention is to provide a process for preparing the said product on a simple and industrial scale.

摘要翻译： 本发明涉及一种制备头孢霉素型抗生素物质的方法，该方法包括在需氧条件下培养属于链霉菌属的微生物，本发明的主要目的是提供以简单和工业规模制备所述产品的方法。

公开(公告)号：US4202886A

公开(公告)日：1980-05-13

申请号：US902137

申请日：1978-05-02

申请人： Kazunori Ohba ,  Takashi Shomura ,  Yasuaki Ogawa ,  Takashi Tsuruoka ,  Hiroshi Watanabe ,  Takashi Hisamatsu ,  Shingo Uchida ,  Michio Kojima ,  Shigeharu Inouye

发明人： Kazunori Ohba ,  Takashi Shomura ,  Yasuaki Ogawa ,  Takashi Tsuruoka ,  Hiroshi Watanabe ,  Takashi Hisamatsu ,  Shingo Uchida ,  Michio Kojima ,  Shigeharu Inouye

IPC分类号： C07G11/00 ,  A61K35/74 ,  A61P31/00 ,  A61P31/04 ,  A61P35/00 ,  C12P1/06 ,  C12R1/465

CPC分类号： C12P1/06

摘要： An antibiotic SF-1942 substance produced by cultivating an SF-1942 substance producing strain of the genus Streptomyces in a nutrient medium under aerobic conditions to produce and accumulate the SF-1942 substance in the nutrient medium and isolating the SF-1942 substance from the fermentation broth followed by purification and a process for the production of the antibiotic SF-1942 substance. The SF-1942 substance is effective as an antimicrobial agent and an antitumor agent against Sarcoma 180 tumor cells in mice.

摘要翻译： 通过在营养培养基中在需氧条件下培养产生链霉菌属的SF-1942物质的菌株而产生的抗生素SF-1942物质，以在营养培养基中产生并积累SF-1942物质并从发酵中分离出SF-1942物质 肉汤，然后进行纯化和生产抗生素SF-1942物质的方法。 SF-1942物质作为抗微生物剂和抗小鼠肉瘤180肿瘤细胞的抗肿瘤剂是有效的。

公开(公告)号：US20190114273A1

公开(公告)日：2019-04-18

申请号：US16218600

申请日：2018-12-13

申请人： Hiroshi Watanabe

发明人： Hiroshi Watanabe

IPC分类号： G06F13/20 ,  G06F13/16 ,  H04L29/06 ,  H04L9/32 ,  H04L9/06 ,  H01L29/861 ,  H01L29/788 ,  H01L29/78 ,  H01L49/02 ,  H01L27/112 ,  H01L27/06 ,  H01L23/525 ,  H01L23/522 ,  H01L23/528 ,  G06F21/73 ,  G06F21/44 ,  G06F13/40

CPC分类号： G06F13/20 ,  G06F13/1673 ,  G06F13/4068 ,  G06F21/44 ,  G06F21/73 ,  H01L23/5226 ,  H01L23/5256 ,  H01L23/528 ,  H01L27/0629 ,  H01L27/11286 ,  H01L28/60 ,  H01L29/78 ,  H01L29/7883 ,  H01L29/861 ,  H04L9/0662 ,  H04L9/3278 ,  H04L63/083 ,  H04L63/0876

摘要： A method of using a chip identification device is jointly performed by a chip mass-produced by a semiconductor manufacturing process, a first chip manufacturer making the chip, and a chip user assembling a product by using the chip. The method includes inputting a first published passcode, published by the first chip manufacturer, inputting a second published passcode published by a second chip manufacturer, inputting the first published passcode to the chip by the chip user, reading an aggregate of electronic output signals as a read code, sending the read code to the first chip manufacturer to compare the first output code and the read code. The chip is regarded as a counterfeit if the comparison is consistent.

公开(公告)号：US09894095B2

公开(公告)日：2018-02-13

申请号：US15064693

申请日：2016-03-09

申请人： Hiroshi Watanabe

发明人： Hiroshi Watanabe

IPC分类号： H04L9/32 ,  H04L29/06 ,  G06F21/73 ,  G09C1/00 ,  G06F21/44 ,  G11C16/08 ,  G11C16/10 ,  G11C16/16 ,  G11C16/26 ,  G11C16/34 ,  H01L21/02 ,  H01L23/528

CPC分类号： H04L63/1441 ,  G06F21/44 ,  G06F21/73 ,  G06F2221/2129 ,  G09C1/00 ,  G11C16/08 ,  G11C16/10 ,  G11C16/16 ,  G11C16/26 ,  G11C16/34 ,  H01L21/02236 ,  H01L21/02255 ,  H01L23/528 ,  H04L9/3278 ,  H04L63/083 ,  H04L65/1073

摘要： A technology precluding attacks through peripheral devices thefts to a network of electronic appliance, by utilizing physical chip identification devices, is disclosed. The electronic appliance in the network are divided into the peripheral devices and stem servers managing registration information of the peripheral devices, wherein the stem servers serve as central control using software, and the peripheral devices are managed at device-level by having physical chip identification devices, thus the security of the whole network is efficiently reinforced.