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    Pyridopyrimidine nucleotide compounds
    2.
    发明授权
    Pyridopyrimidine nucleotide compounds 失效
    吡啶并嘧啶核苷酸化合物

    公开(公告)号：US4965350A

    公开(公告)日：1990-10-23

    申请号：US351317

    申请日：1989-05-11

    申请人： Hideo Inoue ,  Eiko Ohtsuka ,  Akihiro Imura ,  Kenichi Masuda ,  Takashi Kamimura

    发明人： Hideo Inoue ,  Eiko Ohtsuka ,  Akihiro Imura ,  Kenichi Masuda ,  Takashi Kamimura

    IPC分类号： C07H19/04 ,  C07H19/10 ,  C07H21/00 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/68

    CPC分类号： C07H19/10 ,  C07H21/00

    摘要： Pyridopyrimidine nucleotide derivatives expressed by formula (I), which are fluorescent and capable of forming base pairing with guanine or adenine, and oligo- or polynucleotide which have at least one of these derivatives in their molecules or at their molecular terminals: ##STR1## wherein X.sub.1 and X.sub.1 respectively represent ##STR2## (in which n indicates an integer of 0, 1, 2, or 3; however, in no case X.sub.1 and Y.sub.1 both indicate n=O); Z.sub.1 indicates a hydrogen atom or ##STR3## (in which n indicates an integer of 1, 2, or 3); W.sub.1 indicates a hydrogen atom or a hydroxyl group. As for R.sub.1 and R.sub.2, in case where R.sub.1 is an amino group or halogen, R.sub.2 indicates a single bond between the carbon atom at the 7-position and the nitrogen atom at the 8-position, and in case where R.sub.2 is a hydrogen atom or an lower alkyl group, R.sub.1 indicates a carbonyl bond ##STR4## formed with the carbon atom at the 7-position.

    摘要翻译： 荧光并能够与鸟嘌呤或腺嘌呤形成碱基配对的式（I）表示的吡哆嘧啶核苷酸衍生物以及在其分子或其分子末端具有至少一种这些衍生物的寡核苷酸或多核苷酸：（ I）其中X1和X1分别表示（其中n表示0,1,2或3的整数;然而，在任何情况下，X1和Y1均不表示n = O）; Z1表示氢原子或（其中n表示1,2或3的整数）; W1表示氢原子或羟基。 对于R 1和R 2，在R 1为氨基或卤素的情况下，R 2表示7位的碳原子和8位的氮原子之间的单键，在R 2为氢原子的情况下 或低级烷基，R 1表示与7-位上的碳原子形成的羰基键“IMAGE”。

    Antibody Drug
    3.
    发明申请
    Antibody Drug 审中-公开
    抗体药物

    公开(公告)号：US20090111146A1

    公开(公告)日：2009-04-30

    申请号：US10570143

    申请日：2004-09-02

    申请人： Eiko Ohtsuka ,  Yutaka Tamura

    发明人： Eiko Ohtsuka ,  Yutaka Tamura

    IPC分类号： C12P21/04 ,  C12N15/00 ,  C07K16/18 ,  C12N15/11 ,  C12N5/06

    CPC分类号： C07K14/7155 ,  C07K2319/30

    摘要： Means for effectively performing therapies at a low cost is provided in which an antibody drug including a fusion protein fusing an extracellular region of IL-10 receptor 1 with a human antibody is used. A gene encoding a fusion protein fusing an extracellular region of IL-10 receptor 1 with a constant region of human IgG1 is incorporated into an expression vector to provide an expression vector for gene therapies and vaccines.

    摘要翻译： 提供了以低成本有效进行治疗的方法，其中使用包含融合IL-10受体1的细胞外区域的融合蛋白的抗体药物与人抗体。 将编码融合蛋白质的融合蛋白质融合到表达载体中以提供IL-10受体1的细胞外区域与人IgG1的恒定区域以提供用于基因治疗和疫苗的表达载体。

    Looped, hairpin ribozyme
    4.
    发明授权
    Looped, hairpin ribozyme 失效
    环状发夹核酶

    公开(公告)号：US5631115A

    公开(公告)日：1997-05-20

    申请号：US367175

    申请日：1994-12-29

    申请人： Eiko Ohtsuka ,  Makoto Koizumi

    发明人： Eiko Ohtsuka ,  Makoto Koizumi

    IPC分类号： A61K38/00 ,  C12N15/113 ,  C12P19/34 ,  C07H21/00

    CPC分类号： C12N15/113 ,  A61K38/00 ,  C12N2310/111 ,  C12N2310/122

    摘要： A polyribonucleotide having a thermodynamically stable loop structure and ribozyme activity and a DNA that codes for the polyribonucleotide. The polyribonucleotide has the following structure ##STR1## Direct administration of the ribozyme polyribonucleotide of the present invention into the body of a patient enables a target polyribonucleotide in the body to be efficiently cleaved, thereby allowing it to be used as an anti-AIDS drug.

    摘要翻译： PCT No.PCT / JP93 / 00907 Sec。 371日期1994年12月29日第 102（e）日期1994年12月29日PCT提交1993年7月2日PCT公布。 第WO94 / 01549号公报 日期1994年1月20日具有热力学稳定的环结构和核酶活性的多核糖核苷酸和编码多核糖核苷酸的DNA。 多核糖核苷酸具有以下结构将本发明的核酶多​​核糖核苷酸直接给药到患者体内使得体内的目标多核糖核苷有效地被切割，从而允许其用作抗艾滋病药物。

    Compounds for the cleavage at a specific position of RNA, oligomers employed for the formation of said compounds, and starting materials for the synthesis of said oligomers
    5.
    发明授权
    Compounds for the cleavage at a specific position of RNA, oligomers employed for the formation of said compounds, and starting materials for the synthesis of said oligomers 失效
    用于在特定位置的切割的化合物，用于形成所述化合物的低聚物和用于合成所述低聚物的起始材料

    公开(公告)号：US5013830A

    公开(公告)日：1991-05-07

    申请号：US478741

    申请日：1990-02-12

    申请人： Eiko Ohtsuka ,  Hideo Inoue ,  Hirokazu Morisawa ,  Susumu Shibahara ,  Sachiko Mukai ,  Tohru Nishihara

    发明人： Eiko Ohtsuka ,  Hideo Inoue ,  Hirokazu Morisawa ,  Susumu Shibahara ,  Sachiko Mukai ,  Tohru Nishihara

    IPC分类号： C07H19/06 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20 ,  C07H21/00 ,  C12N15/10

    CPC分类号： C07H19/06 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20 ,  C07H21/00 ,  C12N15/10

    摘要： There is disclosed a compound having a double chain which is composed of an RNA (+chain) and a complementary DNA (-chain), wherein a portion of the DNA (-chain) has been replaced by an RNA or a derivative thereof, and wherein, when the compound is subjected to the action of an enzyme having a ribonuclease H activity, it is possible to preferentially cleave the RNA (+chain) in a position corresponding to the unsubstituted portion of the DNA (-chain). The compound can thus be used for the preferential cleavage of a phosphodiester bond in a specific position of RNA. Accordingly, the invention provides a useful means for preparing, for instance, a deletion mutant. There is also disclosed a mixed oligomer which comprises an oligomer of RNA or a derivative thereof and a DNA oligomer, wherein the RNA oligomer or a derivative thereof is conjugated to the DNA oligomer via a phosphate diester linkage between the 5'-hydroxyl group and the 3'-hydroxyl group in the ribose or deoxyribose moiety. There is further disclosed a nucleoside derivative of a given general formula for use as a starting material.

    摘要翻译： 公开了具有由RNA（+链）和互补DNA（链）构成的双链的化合物，其中DNA（链）的一部分已被RNA或其衍生物所取代，并且 其中，当化合物经受具有核糖核酸酶H活性的酶的作用时，可以在与DNA（链）的未取代部分相对应的位置优先切割RNA（+链）。 因此，该化合物可用于在RNA的特定位置优先切割磷酸二酯键。 因此，本发明提供了制备例如缺失突变体的有用手段。 还公开了包含RNA的低聚物或其衍生物和DNA低聚物的混合低聚物，其中RNA低聚物或其衍生物通过5'-羟基与 核糖或脱氧核糖部分中的3'-羟基。 进一步公开了用作原料的给定通式的核苷衍生物。