公开(公告)号：US06883092B2

公开(公告)日：2005-04-19

申请号：US10157992

申请日：2002-05-31

申请人： Takeo Sasaki ,  Koichi Kuroiwa ,  Shoji Taniguchi ,  Takanobu Kashiwagi

发明人： Takeo Sasaki ,  Koichi Kuroiwa ,  Shoji Taniguchi ,  Takanobu Kashiwagi

IPC分类号： G06F11/10 ,  G06F1/32 ,  G06F9/445 ,  G06F11/00

CPC分类号： G06F9/4401

摘要： A processor and method of booting the processor in which dispensable circuit operation is eliminated to reduce power consumption. A first expected check-sum value relating to instructions and table data and a second expected check-sum value relating only to instructions are held in a boot ROM. When power is turned on, if a power-on determination circuit determines that the power has been turned on for a system, a read selection circuit loads instructions and the table data into an instruction storage memory and a table data storage memory and a check-sum performing circuit performs check-sum using the first expected check-sum value. In the case where the power has been turned on for periodic operation, instructions are loaded into the instruction storage memory, check-sum is performed using the second expected check-sum value, and table data that was saved in a backup memory is loaded into the table data storage memory. Thus, the time required for loading from the boot ROM for the periodic operation decreases.

摘要翻译： 引导处理器的处理器和方法，其中消除了可分配的电路操作以降低功耗。 与指令和表数据相关的第一预期校验和值和仅与指令相关的第二预期校验和值被保存在引导ROM中。 当电源接通时，如果上电确定电路确定系统的电源已经接通，则读选择电路将指令和表数据加载到指令存储存储器和表数据存储存储器中， 总和执行电路使用第一预期校验和值来执行校验和。 在电源已经接通周期性操作的情况下，指令被加载到指令存储器中，使用第二预期校验和值进行校验和，并将保存在备用存储器中的表数据加载到 表数据存储内存。 因此，用于周期性操作的从引导ROM加载所需的时间减少。

公开(公告)号：US07935815B2

公开(公告)日：2011-05-03

申请号：US12200731

申请日：2008-08-28

申请人： Teiji Kimura ,  Noritaka Kitazawa ,  Toshihiko Kaneko ,  Nobuaki Sato ,  Koki Kawano ,  Koichi Ito ,  Mamoru Takaishi ,  Takeo Sasaki ,  Yu Yoshida ,  Toshiyuki Uemura ,  Takashi Doko ,  Daisuke Shinmyo ,  Daiju Hasegawa ,  Takehiko Miyagawa ,  Hiroaki Hagiwara

发明人： Teiji Kimura ,  Noritaka Kitazawa ,  Toshihiko Kaneko ,  Nobuaki Sato ,  Koki Kawano ,  Koichi Ito ,  Mamoru Takaishi ,  Takeo Sasaki ,  Yu Yoshida ,  Toshiyuki Uemura ,  Takashi Doko ,  Daisuke Shinmyo ,  Daiju Hasegawa ,  Takehiko Miyagawa ,  Hiroaki Hagiwara

IPC分类号： C07D491/00 ,  C07D513/00 ,  C07D515/00 ,  C07D265/36 ,  C07D498/02 ,  C07D487/00 ,  C07D513/02 ,  C07D515/02 ,  C07D401/00

CPC分类号： C07D403/10 ,  C07D401/14 ,  C07D403/14 ,  C07D409/14

摘要： A compound represented by the formula (I): or a pharmacologically acceptable salt thereof, wherein Ar1 represents an imidazolyl group or the like which may be substituted with a C1-6 alkyl group, Ar2 represents a phenyl group or the like which may be substituted with a C1-6 alkoxy group, X1 represents a double bond or the like and Het represents a triazolyl group or the like which may be substituted with a C1-6 alkyl group or the like, is effective as a therapeutic or prophylactic agent for a disease caused by Aβ.

摘要翻译： 由式（I）表示的化合物或其药理学上可接受的盐，其中Ar 1表示可被C 1-6烷基取代的咪唑基等，Ar 2表示可被取代的苯基等 具有C 1-6烷氧基，X 1表示双键等，Het表示可以被C 1-6烷基等取代的三唑基等，作为治疗或预防药物是有效的 A＆BGR引起的疾病

公开(公告)号：US20090203697A1

公开(公告)日：2009-08-13

申请号：US12301421

申请日：2007-05-18

申请人： Teiji Kimura ,  Koki Kawano ,  Eriko Doi ,  Noritaka Kitazawa ,  Takehiko Miyagawa ,  Nobuaki Sato ,  Toshihiko Kaneko ,  Kogyoku Shin ,  Koichi Ito ,  Mamoru Takaishi ,  Takeo Sasaki ,  Hiroaki Hagiwara

发明人： Teiji Kimura ,  Koki Kawano ,  Eriko Doi ,  Noritaka Kitazawa ,  Takehiko Miyagawa ,  Nobuaki Sato ,  Toshihiko Kaneko ,  Kogyoku Shin ,  Koichi Ito ,  Mamoru Takaishi ,  Takeo Sasaki ,  Hiroaki Hagiwara

IPC分类号： A61K31/5377 ,  A61K31/4353 ,  A61K31/4439 ,  C07D413/10 ,  C07D455/02 ,  C07D401/10 ,  C07D413/14 ,  C07D401/14

CPC分类号： C07D249/08 ,  C07D401/10 ,  C07D401/14 ,  C07D413/10 ,  C07D413/14 ,  C07D471/04

摘要： Disclosed is a compound represented by the formula (I) below or a pharmacologically acceptable salt thereof. Also disclosed is a use of the compound or salt as a pharmaceutical product. (In the formula, Ar1 represents a triazolyl group or the like which may be substituted with a C1-6 alkyl group or the like; Ar2 represents a phenyl group or the like which may be substituted with a C1-6 alkoxy group or the like; X1 represents —CR3═CR4— (wherein R3 and R4 respectively represent a C1-6 alkyl group or the like); and R1 and R2 respectively represent a C1-6 alkyl group or the like.)

摘要翻译： 公开了由下式（I）表示的化合物或其药理学上可接受的盐。 还公开了化合物或盐作为药物产品的用途。 （式中，Ar 1表示可被C 1-6烷基等取代的三唑基等，Ar 2表示可被C 1-6烷氧基等取代的苯基等） ; X1表示-CR3-CR4-（其中R3和R4分别表示C1-6烷基等），R1和R2分别表示C1-6烷基等）。

公开(公告)号：US20090181945A1

公开(公告)日：2009-07-16

申请号：US12403565

申请日：2009-03-13

申请人： Teiji Kimura ,  Koki Kawano ,  Eriko Doi ,  Noritaka Kitazawa ,  Mamoru Takaishi ,  Koichi Ito ,  Toshihiko Kaneko ,  Takeo Sasaki ,  Takehiko Miyagawa ,  Hiroaki Hagiwara ,  Yu Yoshida

发明人： Teiji Kimura ,  Koki Kawano ,  Eriko Doi ,  Noritaka Kitazawa ,  Mamoru Takaishi ,  Koichi Ito ,  Toshihiko Kaneko ,  Takeo Sasaki ,  Takehiko Miyagawa ,  Hiroaki Hagiwara ,  Yu Yoshida

IPC分类号： A61K31/4375 ,  C07D455/02 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  A61K31/437 ,  A61K31/55 ,  A61K31/4178 ,  A61K31/5365 ,  A61K31/4985 ,  A61P25/00

CPC分类号： C07D471/04 ,  C07D487/04

摘要： The present invention relates to a novel two cyclic cinnamide compound and a pharmaceutical agent comprising the compound as an active ingredient. The two cyclic cinnamide compound represented by the general formula (I): wherein represents a single bond or a double bond; Ar1 represents a phenyl group or pyridinyl group that may be substituted with 1 to 3 substituents; R1 and R2 each represent a C1-6 alkyl group, a hydroxyl group, or the like; Z1 represents a methylene group or vinylene group, which may be substituted with 1 or 2 substituents selected from Substituent Group A1, an oxygen atom, or an imino group that may be substituted with a substituent selected from Substituent Group A1; and p, q, and r each represent an integer of 0 to 2, which has an effect of reducing Aβ40 and Aβ42 production, and thus is particularly useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ such as Alzheimer's disease or Down's syndrome.

摘要翻译： 本发明涉及一种新型的两种环状肉桂酰胺化合物和包含该化合物作为活性成分的药剂。 由通式（I）表示的两种环状肉桂酰胺化合物：其中表示单键或双键; Ar 1表示可被1〜3个取代基取代的苯基或吡啶基; R1和R2各自表示C1-6烷基，羟基等; Z1表示亚甲基或亚乙烯基，其可以被1或2个选自取代基组A1，氧原子或可被选自取代基组A1的取代基取代的亚氨基取代基取代; 并且p，q和r各自表示0〜2的整数，其具有降低Abeta40和Abeta42产生的作用，因此特别可用作由Abeta如阿尔茨海默病或阿尔茨海默病引起的神经变性疾病的预防或治疗剂 唐氏综合症。

公开(公告)号：US20080207900A1

公开(公告)日：2008-08-28

申请号：US12037315

申请日：2008-02-26

申请人： Teiji KIMURA ,  Koki Kawano ,  Eriko Doi ,  Noritaka Kitazawa ,  Mamoru Takaishi ,  Koichi Ito ,  Toshihiko Kaneko ,  Takeo Sasaki ,  Nobuaki Sato ,  Takehiko Miyagawa ,  Hiroaki Hagiwara

发明人： Teiji KIMURA ,  Koki Kawano ,  Eriko Doi ,  Noritaka Kitazawa ,  Mamoru Takaishi ,  Koichi Ito ,  Toshihiko Kaneko ,  Takeo Sasaki ,  Nobuaki Sato ,  Takehiko Miyagawa ,  Hiroaki Hagiwara

IPC分类号： C07D498/04

CPC分类号： C07D498/04

摘要： The present invention relates to a compound represented by formula (I): wherein R1 represents a C1-3 alkyl group, R2 represents a hydrogen atom or a C1-3 alkyl group, Ar represents a phenyl group or the like which may be substituted with 1 to 3 substituents, X represents an oxygen atom or the like, n and m are the same or different and integers of 0 to 2, or a pharmacologically acceptable salt, and use thereof as a medicament.

摘要翻译： 本发明涉及由式（I）表示的化合物：其中R 1表示C 1-3烷基，R 2表示氢原子或C1-3 烷基，Ar表示可被1〜3个取代基取代的苯基等，X表示氧原子等，n和m相同或不同，整数为0〜2，或药理学上可接受的盐 ，及其作为药物的用途。

公开(公告)号：US20080070902A1

公开(公告)日：2008-03-20

申请号：US11596723

申请日：2005-05-25

申请人： Teiji Kimura ,  Koki Kawano ,  Eriko Doi ,  Noritaka Kitazawa ,  Kogyoku Shin ,  Takehiko Miyagawa ,  Toshihiko Kaneko ,  Koichi Ito ,  Mamoru Takaishi ,  Takeo Sasaki ,  Hiroaki Hagiwara

发明人： Teiji Kimura ,  Koki Kawano ,  Eriko Doi ,  Noritaka Kitazawa ,  Kogyoku Shin ,  Takehiko Miyagawa ,  Toshihiko Kaneko ,  Koichi Ito ,  Mamoru Takaishi ,  Takeo Sasaki ,  Hiroaki Hagiwara

IPC分类号： A61K31/4164 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/535 ,  A61K31/55 ,  A61P25/28 ,  A61P3/00 ,  A61P43/00 ,  C07D233/66 ,  C07D401/10 ,  C07D403/10 ,  C07D413/10

CPC分类号： C07D401/10 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14 ,  C07D487/04

摘要： The present invention relates to a compound represented by Formula (I): (wherein Ar1 represents an imidazolyl group which may be substituted with 1 to 3 substituents; Ar2 represents a pyridinyl group, a pyrimidinyl group, or a phenyl group which may be substituted with 1 to 3 substituents; X1 represents (1) —C≡C— or (2) a double bond etc. which may be substituted; R1 and R2 represent, for example, a C1-6 alkyl group or C3-8 cycloalkyl group which may be substituted) or a pharmacologically acceptable salt thereof and to the use thereof as pharmaceutical agents.

摘要翻译： 本发明涉及由式（I）表示的化合物：（其中Ar 1代表可被1至3个取代基取代的咪唑基; Ar 2表示 吡啶基，嘧啶基或可被1至3个取代基取代的苯基; X 1表示（1）-C≡C-或（2）双键等，其可以 被取代; R 1和R 2表示例如可以被取代的C 1-6烷基或C 3-8环烷基）或其药理学上可接受的盐 以及作为药剂的用途。

公开(公告)号：US06495845B1

公开(公告)日：2002-12-17

申请号：US09588232

申请日：2000-06-06

申请人： Kenichi Tsunota ,  Nobuyuki Yamada ,  Shinji Furuichi ,  Takeo Sasaki

发明人： Kenichi Tsunota ,  Nobuyuki Yamada ,  Shinji Furuichi ,  Takeo Sasaki

IPC分类号： G01T120

CPC分类号： G01T1/2018 ,  G01T1/2002

摘要： Sintered ceramics having such high radiation shielding capability and so easy to machine that they can be used as a radiation shield for radiation detectors are disclosed. The ceramics show a radiation shielding capability more than 90% and preferably have high light reflecting performance. They may comprises rare-earth oxides such as gadolinium oxide, oxide of at least one of vanadium, tantalum and niobium and alkali-earth oxide which is used for a sintering agent. They can be used as a radiation shield in place of a molybdenum or tungsten radiation shielding plate and also as a light reflecting film instead of titanium dioxide film in a radiation detector for radiation CT equipment.

摘要翻译： 公开了具有这样高的辐射屏蔽能力并且容易加工的烧结陶瓷，以使它们可以用作辐射探测器的辐射屏蔽。 陶瓷的辐射屏蔽能力大于90％，优选具有高的光反射性能。 它们可以包括稀土氧化物，例如氧化钆，钒，钽和铌中的至少一种的氧化物和用于烧结剂的碱土金属氧化物。 它们可以用作辐射屏蔽来代替钼或钨辐射屏蔽板，并且还可以用作辐射CT设备的辐射检测器中的二氧化钛膜的光反射膜。

公开(公告)号：US06461159B1

公开(公告)日：2002-10-08

申请号：US09500166

申请日：2000-02-08

申请人： Akiyoshi Kotaka ,  Takeo Sasaki ,  Makoto Michiaki

发明人： Akiyoshi Kotaka ,  Takeo Sasaki ,  Makoto Michiaki

IPC分类号： A61C1900

CPC分类号： A61C19/003

摘要： A dental mixing pad whose mixing surface side is constituted by a color having a low reflectance of a light having a wavelength of 470 nm±80 nm, is disclosed. It is preferred that the color having a low reflectance of a light having a wavelength of 470 nm±80 nm, which constitutes the mixing surface side of the dental mixing pad, is satisfied with at least one of the following requirements: that is, in a standard illuminant D65, L* is 80 or less, and C* is less than 20; L* is 80 or less, and h is 50°±80°; and L* is 30 or less, when expressed by an L*C*h color space. The dental mixing pad of the present invention to be used as a substrate in mixing and kneading a dental material such as a dental cement or a resin-based material, using for dental adhesives or dental filling materials, on its mixing surface in the dental remedy, can readily suppress an unnecessary polymerization reaction with a illumination of circumferential lights without applying excessive operations or using a special device.

摘要翻译： 公开了一种混合表面侧由具有470nm±80nm波长的光的低反射率的颜色构成的牙齿混合垫。 优选构成混合垫的混合面侧的波长为470nm±80nm的光的低反射率的颜色满足以下要求中的至少一个：也就是说，在 标准光源D65，L *为80以下，C *小于20; L *为80以下，h为50°±80°; 当L * C * h颜色空间表示时，L *为30以下。 本发明的牙科混合垫在牙科治疗中的混合表面上混合和捏合诸如牙科粘固剂或树脂基材料的牙科材料（用于牙科粘合剂或牙科填充材料）用作基底 可以在不施加过度的操作或使用特殊装置的情况下容易地抑制周围光的照射而引起的不必要的聚合反应。

公开(公告)号：US06365029B1

公开(公告)日：2002-04-02

申请号：US09309585

申请日：1999-05-11

申请人： Kiyoharu Fujita ,  Shinji Furuichi ,  Takeo Sasaki

发明人： Kiyoharu Fujita ,  Shinji Furuichi ,  Takeo Sasaki

IPC分类号： C25D502

CPC分类号： C25D3/38 ,  C23C28/00 ,  C25D7/001 ,  G11B5/17 ,  G11B5/313 ,  G11B5/3163 ,  G11B5/3967

摘要： A thin film magnetic head comprising a lower magnetic core, an upper magnetic core, and a thin film copper coil wound between magnetic poles of the lower and upper magnetic cores, the time constant of which can be reduced by reducing the specific resistance of the thin film coil and reducing insulating resin layers between the thin film coil conductors and between the coil layers, thereby allowing writing information at higher frequencies. The average crystal grain size of the thin film copper coil is made to be not more than 0.5 &mgr;m. More preferably, the average crystal grain size should be not more than 0.2 &mgr;m. In the thin film magnetic head, the surface roughness of the thin film copper coil can be reduced to not more than 15 nm.

摘要翻译： 一种薄膜磁头，其包括下磁芯，上磁芯和缠绕在下磁芯和上磁芯的磁极之间的薄膜铜线圈，其时间常数可以通过降低薄磁芯的电阻而减小 薄膜线圈，并且在薄膜线圈导体之间和线圈层之间减少绝缘树脂层，从而允许以较高频率写入信息。 薄膜铜线圈的平均晶粒尺寸不大于0.5μm。 更优选地，平均晶粒尺寸应不大于0.2μm。 在薄膜磁头中，薄膜铜线圈的表面粗糙度可以降低到不超过15nm。

公开(公告)号：US06202289B1

公开(公告)日：2001-03-20

申请号：US09330992

申请日：1999-06-14

申请人： Kuniaki Yoshimura ,  Shinji Furuichi ,  Takeo Sasaki

发明人： Kuniaki Yoshimura ,  Shinji Furuichi ,  Takeo Sasaki

IPC分类号： G11B5127

CPC分类号： G11B5/3106 ,  Y10T29/49041 ,  Y10T29/49046

摘要： A manufacturing method that can manufacture small thin film magnetic head sliders with high dimensional accuracy and high manufacturing yield is disclosed. This manufacturing method uses 5 inch- or 6 inch-dia. substrate wafers having a thickness sufficient to keep wafer bending to a minimum level even after thin film magnetic head elements have been formed on it. On the front side surface of the substrate wafer formed are thin film magnetic elements. After a protective layer covered on the surface of the thin film magnetic head elements has been ground and/or lapped, the back side surface of the substrate wafer is ground and/or lapped to a thickness equal to a desired slider length.

摘要翻译： 公开了一种能够制造高尺寸精度和高制造成品率的小型薄膜磁头滑块的制造方法。 该制造方法使用5英寸或6英寸直径。 即使在其上形成薄膜磁头元件之后，具有足以将晶片弯曲保持在最小水平的厚度的衬底晶片。 在形成的基板晶片的正面上是薄膜磁性元件。 在覆盖在薄膜磁头元件表面上的保护层已经被研磨和/或研磨之后，将衬底晶片的背侧表面研磨和/或研磨成等于期望的滑块长度的厚度。