公开(公告)号：US20110242485A1

公开(公告)日：2011-10-06

申请号：US13071136

申请日：2011-03-24

申请人： Takuya Kishimoto ,  Sakuya Tamada ,  Akio Yasuda ,  Kyoko Ohno ,  Ikuo Morita

发明人： Takuya Kishimoto ,  Sakuya Tamada ,  Akio Yasuda ,  Kyoko Ohno ,  Ikuo Morita

IPC分类号： A61B3/14 ,  G01J1/58

CPC分类号： A61B3/1225 ,  A61B3/1015

摘要： A fluorescence image acquisition method including: irradiating an eyeground with a short-pulse beam of light for exciting a fluorescent dye; setting the time point of emission of the light as a reference, measuring the intensities of luminescence of the fluorescent dye at two different times which are predetermined periods of time after the reference, determining the ratio between the intensities of luminescence at the two different times, and detecting the intensity of luminescence of the fluorescent dye having marked a target by using the ratio; and generating a fluorescence image of the fluorescent dye having marked the target, based on the results of detection by the detecting step.

摘要翻译： 一种荧光图像获取方法，包括：用短脉冲光束照射眼睛以激发荧光染料; 将发光的时间点设定为参考，测量在参考后预定时间段的两个不同时间的荧光染料的发光强度，确定两个不同时间的发光强度之间的比率， 并通过使用该比例来检测标记有靶标的荧光染料的发光强度; 以及基于检测步骤的检测结果产生标记了目标物的荧光染料的荧光图像。

公开(公告)号：US08556422B2

公开(公告)日：2013-10-15

申请号：US13071136

申请日：2011-03-24

申请人： Takuya Kishimoto ,  Sakuya Tamada ,  Akio Yasuda ,  Kyoko Ohno ,  Ikuo Morita

发明人： Takuya Kishimoto ,  Sakuya Tamada ,  Akio Yasuda ,  Kyoko Ohno ,  Ikuo Morita

IPC分类号： A61B3/14 ,  A61B3/00

CPC分类号： A61B3/1225 ,  A61B3/1015

摘要： A fluorescence image acquisition method including: irradiating an eyeground with a short-pulse beam of light for exciting a fluorescent dye; setting the time point of emission of the light as a reference, measuring the intensities of luminescence of the fluorescent dye at two different times which are predetermined periods of time after the reference, determining the ratio between the intensities of luminescence at the two different times, and detecting the intensity of luminescence of the fluorescent dye having marked a target by using the ratio; and generating a fluorescence image of the fluorescent dye having marked the target, based on the results of detection by the detecting step.

摘要翻译： 一种荧光图像获取方法，包括：用短脉冲光束照射眼睛以激发荧光染料; 将发光的时间点设定为参考，测量在参考后预定时间段的两个不同时间的荧光染料的发光强度，确定两个不同时间的发光强度之间的比率， 并通过使用该比例来检测标记有靶标的荧光染料的发光强度; 以及基于检测步骤的检测结果产生标记了目标物的荧光染料的荧光图像。

公开(公告)号：US20120004856A1

公开(公告)日：2012-01-05

申请号：US13170429

申请日：2011-06-28

申请人： Eriko Matsui ,  Sakuya Tamada ,  Takuya Kishimoto ,  Akio Yasuda

发明人： Eriko Matsui ,  Sakuya Tamada ,  Takuya Kishimoto ,  Akio Yasuda

IPC分类号： G06F19/00

CPC分类号： A61B3/1173 ,  A61B5/0059 ,  A61B5/14546 ,  A61B5/4088 ,  G01N21/65 ,  G01N33/54373 ,  G01N33/6896 ,  G01N2800/2821

摘要： A spectral data analyzer is disclosed. The spectral data analyzer calculates the spectral intensity ratio of a C—H band and an amide I band in a Raman spectrum that corresponds to a substance present in a body tissue; and automatically determines the presence or absence of amyloid beta in the substance based on the calculated ratio.

摘要翻译： 公开了一种光谱数据分析仪。 光谱数据分析器计算对应于存在于身体组织中的物质的拉曼光谱中的C-H波段和酰胺I波段的光谱强度比; 并基于计算的比例自动确定物质中淀粉样蛋白β的存在或不存在。

公开(公告)号：US20120229769A1

公开(公告)日：2012-09-13

申请号：US13398547

申请日：2012-02-16

申请人： Takuya Kishimoto ,  Sakuya Tamada

发明人： Takuya Kishimoto ,  Sakuya Tamada

IPC分类号： A61B3/12

CPC分类号： A61B3/10 ,  A61B3/1015 ,  A61B3/12 ,  A61B5/0071

摘要： Provided is a fundus imaging apparatus including a wavefront adjuster and a detector. The wavefront adjuster is configured to adjust a wavefront of a femtosecond pulsed laser beam incident on an ocular fundus to be examined. The detector is configured to detect fluorescence generated in a multi-photon excitation process by the femtosecond pulsed laser beam incident on the ocular fundus to be examined. The wavefront adjuster is further configured to adjust the wavefront so that an intensity of the fluorescence to be detected by the detector becomes a maximum value.

摘要翻译： 本发明提供一种包括波前调整器和检测器的眼底成像装置。 波前调整器被配置为调整入射到待检查的眼底的飞秒脉冲激光束的波前。 检测器被配置为检测通过入射到待检查的眼底的飞秒脉冲激光束在多光子激发过程中产生的荧光。 波前调整器还被配置为调整波前，使得检测器检测的荧光强度成为最大值。

公开(公告)号：US09066682B2

公开(公告)日：2015-06-30

申请号：US13398547

申请日：2012-02-16

申请人： Takuya Kishimoto ,  Sakuya Tamada

发明人： Takuya Kishimoto ,  Sakuya Tamada

IPC分类号： A61B3/10 ,  A61B3/12 ,  A61B5/00

CPC分类号： A61B3/10 ,  A61B3/1015 ,  A61B3/12 ,  A61B5/0071

摘要： Provided is a fundus imaging apparatus including a wavefront adjuster and a detector. The wavefront adjuster is configured to adjust a wavefront of a femtosecond pulsed laser beam incident on an ocular fundus to be examined. The detector is configured to detect fluorescence generated in a multi-photon excitation process by the femtosecond pulsed laser beam incident on the ocular fundus to be examined. The wavefront adjuster is further configured to adjust the wavefront so that an intensity of the fluorescence to be detected by the detector becomes a maximum value.

摘要翻译： 本发明提供一种包括波前调整器和检测器的眼底成像装置。 波前调整器被配置为调整入射到待检查的眼底的飞秒脉冲激光束的波前。 检测器被配置为检测通过入射到待检查的眼底的飞秒脉冲激光束在多光子激发过程中产生的荧光。 波前调整器还被配置为调整波前，使得检测器检测的荧光强度成为最大值。

公开(公告)号：US07551537B2

公开(公告)日：2009-06-23

申请号：US10498693

申请日：2003-10-14

申请人： Sakuya Tamada

发明人： Sakuya Tamada

IPC分类号： G11B7/00

CPC分类号： B82Y10/00 ,  G11B7/126 ,  G11B7/1378 ,  G11B7/1398 ,  G11B7/261

摘要： An optical recording medium master disc exposure apparatus comprises a modulating means 3 for modulating intensity of light from an exposure light source 1 in response to recording information and a focusing optical system 9 for focusing the light modulated by this modulating means 3 on a photoresist 12 on an optical recording medium master disc 11 to thereby pattern-expose the photoresist 12 in response to recording information. The exposure light source 1 is composed of a ultrashort wave pulse laser with a repetitive frequency of an integral multiple ranging from 1 time to 20 times as high as the clock frequency of recording information. This optical recording medium master disc apparatus includes an external synchronizing mechanism to vary the resonator length of this ultrashort wave pulse laser to mode-lock the repetitive frequency of the ultrashort wave pulse laser in synchronism with the clock frequency to cause the ultrashort wave pulse laser to emit pulses, and hence miniscule pits can be formed with high accuracy.

摘要翻译： 光记录介质母盘曝光装置包括：调制装置3，用于响应于记录信息调制来自曝光光源1的光的强度;以及聚焦光学系统9，用于将由该调制装置3调制的光聚焦到光致抗蚀剂12上 光记录介质母盘11，从而根据记录信息图案曝光光致抗蚀剂12。 曝光光源1由具有从记录信息的时钟频率的1倍到20倍的整数倍的重复频率的超短脉冲激光器组成。 该光记录介质母盘装置包括外部同步机构，用于改变该超短波脉冲激光器的谐振器长度，以与时钟频率同步地模式锁定超短波脉冲激光器的重复频率，以使超短波脉冲激光器 发射脉冲，因此可以高精度地形成微小的凹坑。

公开(公告)号：US07079479B2

公开(公告)日：2006-07-18

申请号：US10006958

申请日：2001-12-04

申请人： Sakuya Tamada ,  Hidetoshi Watanabe

发明人： Sakuya Tamada ,  Hidetoshi Watanabe

IPC分类号： G11B7/24 ,  B32B3/02

CPC分类号： G11B7/2578 ,  G11B7/2403 ,  G11B7/246 ,  G11B7/2472 ,  G11B7/2475 ,  G11B7/2533 ,  G11B7/2534 ,  G11B7/2542 ,  G11B7/256 ,  G11B2007/25708 ,  G11B2007/2571 ,  G11B2007/25713 ,  G11B2007/25715 ,  G11B2007/25718

摘要： A dielectric part 4 comprising a nitride layer 7 and an oxide layer 8, laid one upon the other, is formed on a data-recording layer 3. A light-transmitting layer 5 is boned with adhesive to the dielectric part 4. Since the dielectric part 4 is interposed between the data-recording layer 3 and the light-transmitting layer 5, the organic material of the data-recording layer 3 does not diffuse into the adhesive that bonds the light-emitting layer to the dielectric layer 4. Additionally, the data-recording layer 3 is not deteriorated due to the oxygen plasma generated during the process of forming the oxide layer 8, because the oxide layer 8 is provided on the nitride layer. Since the nitride layer 7 has a thickness of 10 nm or less, it does not influence optical enhancement effect.

摘要翻译： 在数据记录层3上形成包括氮化物层7和氧化物层8的电介质部分4。 透光层5用粘合剂粘合到介质部分4上。 由于电介质部分4介于数据记录层3和透光层5之间，所以数据记录层3的有机材料不扩散到将发光层与电介质层4结合的粘合剂中 。 另外，由于在氮化物层上设置有氧化物层8，所以在形成氧化物层8的过程中由于氧等离子体而使数据记录层3不劣化。 由于氮化物层7的厚度为10nm以下，因此不影响光学增强效果。

公开(公告)号：US20050180302A1

公开(公告)日：2005-08-18

申请号：US10498693

申请日：2003-10-14

申请人： Sakuya Tamada

发明人： Sakuya Tamada

IPC分类号： G11B7/125 ,  G11B7/26 ,  G11B7/24

CPC分类号： B82Y10/00 ,  G11B7/126 ,  G11B7/1378 ,  G11B7/1398 ,  G11B7/261

摘要： An optical recording medium master disc exposure apparatus comprises a modulating means 3 for modulating intensity of light from an exposure light source 1 in response to recording information and a focusing optical system 9 for focusing the light modulated by this modulating means 3 on a photoresist 12 on an optical recording medium master disc 11 to thereby pattern-expose the photoresist 12 in response to recording information. The exposure light source 1 is composed of a ultrashort wave pulse laser with a repetitive frequency of an integral multiple ranging from 1 time to 20 times as high as the clock frequency of recording information. This optical recording medium master disc apparatus includes an external synchronizing mechanism to vary the resonator length of this ultrashort wave pulse laser to mode-lock the repetitive frequency of the ultrashort wave pulse laser in synchronism with the clock frequency to cause the ultrashort wave pulse laser to emit pulses, and hence miniscule pits can be formed with high accuracy.

摘要翻译： 光记录介质母盘曝光装置包括：调制装置3，用于响应于记录信息调制来自曝光光源1的光的强度;以及聚焦光学系统9，用于将由该调制装置3调制的光聚焦到光致抗蚀剂12上 光记录介质母盘11，从而根据记录信息图案曝光光致抗蚀剂12。 曝光光源1由具有从记录信息的时钟频率的1倍到20倍的整数倍的重复频率的超短脉冲激光器组成。 该光记录介质母盘装置包括外部同步机构，用于改变该超短波脉冲激光器的谐振器长度，以与时钟频率同步地模式锁定超短波脉冲激光器的重复频率，以使超短波脉冲激光器 发射脉冲，因此可以高精度地形成微小的凹坑。

公开(公告)号：US20120250013A1

公开(公告)日：2012-10-04

申请号：US13407447

申请日：2012-02-28

申请人： Sakuya Tamada

发明人： Sakuya Tamada

IPC分类号： G01J3/44

CPC分类号： G01N21/65

摘要： A non-linear Raman spectroscopy apparatus includes a light source unit emitting a pulse beam having a pulse width of 0.2 ns to 10 ns, a pulse peak power of 50 W to 5000 W, and a wavelength of 500 nm to 1200 nm, and a single-mode fiber through which continuous white light is generated from the pulse beam. A test sample to be measured is radiated with a pump-cum-probe beam formed of the pulse beam and a Stokes beam formed of the continuous white light to obtain a Raman spectrum.

摘要翻译： 非线性拉曼光谱装置包括发射脉冲宽度为0.2ns至10ns，脉冲峰值功率为50W至5000W，波长为500nm至1200nm的光源单元，以及 单模光纤通过脉冲光束产生连续的白光。 用由脉冲光束形成的泵浦 - 探针光束和由连续白光形成的斯托克斯光束辐射待测量的测试样品以获得拉曼光谱。

公开(公告)号：US20090302223A1

公开(公告)日：2009-12-10

申请号：US12481140

申请日：2009-06-09

申请人： Sakuya Tamada ,  Kazumine Ito

发明人： Sakuya Tamada ,  Kazumine Ito

IPC分类号： G01J5/02 ,  G01J5/00

CPC分类号： G01J3/02 ,  G01J3/021 ,  G01J3/0275 ,  G01J3/0291 ,  G01N21/3581

摘要： A method of measuring a terahertz wave includes the steps of: starting input of a pulse signal showing that scale marks have been detected, which are arranged at equal intervals along a moving direction of a movable stage which can move in a direction in which an optical path length of incident pulse light is contracted or extended; and taking signals outputted at pulse intervals of the pulse light from a terahertz wave detecting section by synchronizing the timing with the pulse signal.

摘要翻译： 一种测量太赫兹波的方法包括以下步骤：启动表示已经检测出刻度标记的脉冲信号的输入，该脉冲信号沿着可移动台的移动方向以相等的间隔布置，所述移动方向可沿光学 入射脉冲光的路径长度缩小或延长; 并且通过使定时与脉冲信号同步，以脉冲间隔从太赫兹波检测部分输出的信号。