公开(公告)号：US20110242485A1

公开(公告)日：2011-10-06

申请号：US13071136

申请日：2011-03-24

申请人： Takuya Kishimoto ,  Sakuya Tamada ,  Akio Yasuda ,  Kyoko Ohno ,  Ikuo Morita

发明人： Takuya Kishimoto ,  Sakuya Tamada ,  Akio Yasuda ,  Kyoko Ohno ,  Ikuo Morita

IPC分类号： A61B3/14 ,  G01J1/58

CPC分类号： A61B3/1225 ,  A61B3/1015

摘要： A fluorescence image acquisition method including: irradiating an eyeground with a short-pulse beam of light for exciting a fluorescent dye; setting the time point of emission of the light as a reference, measuring the intensities of luminescence of the fluorescent dye at two different times which are predetermined periods of time after the reference, determining the ratio between the intensities of luminescence at the two different times, and detecting the intensity of luminescence of the fluorescent dye having marked a target by using the ratio; and generating a fluorescence image of the fluorescent dye having marked the target, based on the results of detection by the detecting step.

摘要翻译： 一种荧光图像获取方法，包括：用短脉冲光束照射眼睛以激发荧光染料; 将发光的时间点设定为参考，测量在参考后预定时间段的两个不同时间的荧光染料的发光强度，确定两个不同时间的发光强度之间的比率， 并通过使用该比例来检测标记有靶标的荧光染料的发光强度; 以及基于检测步骤的检测结果产生标记了目标物的荧光染料的荧光图像。

公开(公告)号：US08556422B2

公开(公告)日：2013-10-15

申请号：US13071136

申请日：2011-03-24

申请人： Takuya Kishimoto ,  Sakuya Tamada ,  Akio Yasuda ,  Kyoko Ohno ,  Ikuo Morita

发明人： Takuya Kishimoto ,  Sakuya Tamada ,  Akio Yasuda ,  Kyoko Ohno ,  Ikuo Morita

IPC分类号： A61B3/14 ,  A61B3/00

CPC分类号： A61B3/1225 ,  A61B3/1015

摘要： A fluorescence image acquisition method including: irradiating an eyeground with a short-pulse beam of light for exciting a fluorescent dye; setting the time point of emission of the light as a reference, measuring the intensities of luminescence of the fluorescent dye at two different times which are predetermined periods of time after the reference, determining the ratio between the intensities of luminescence at the two different times, and detecting the intensity of luminescence of the fluorescent dye having marked a target by using the ratio; and generating a fluorescence image of the fluorescent dye having marked the target, based on the results of detection by the detecting step.

摘要翻译： 一种荧光图像获取方法，包括：用短脉冲光束照射眼睛以激发荧光染料; 将发光的时间点设定为参考，测量在参考后预定时间段的两个不同时间的荧光染料的发光强度，确定两个不同时间的发光强度之间的比率， 并通过使用该比例来检测标记有靶标的荧光染料的发光强度; 以及基于检测步骤的检测结果产生标记了目标物的荧光染料的荧光图像。

公开(公告)号：US20120004856A1

公开(公告)日：2012-01-05

申请号：US13170429

申请日：2011-06-28

申请人： Eriko Matsui ,  Sakuya Tamada ,  Takuya Kishimoto ,  Akio Yasuda

发明人： Eriko Matsui ,  Sakuya Tamada ,  Takuya Kishimoto ,  Akio Yasuda

IPC分类号： G06F19/00

CPC分类号： A61B3/1173 ,  A61B5/0059 ,  A61B5/14546 ,  A61B5/4088 ,  G01N21/65 ,  G01N33/54373 ,  G01N33/6896 ,  G01N2800/2821

摘要： A spectral data analyzer is disclosed. The spectral data analyzer calculates the spectral intensity ratio of a C—H band and an amide I band in a Raman spectrum that corresponds to a substance present in a body tissue; and automatically determines the presence or absence of amyloid beta in the substance based on the calculated ratio.

摘要翻译： 公开了一种光谱数据分析仪。 光谱数据分析器计算对应于存在于身体组织中的物质的拉曼光谱中的C-H波段和酰胺I波段的光谱强度比; 并基于计算的比例自动确定物质中淀粉样蛋白β的存在或不存在。

公开(公告)号：US20120229769A1

公开(公告)日：2012-09-13

申请号：US13398547

申请日：2012-02-16

申请人： Takuya Kishimoto ,  Sakuya Tamada

发明人： Takuya Kishimoto ,  Sakuya Tamada

IPC分类号： A61B3/12

CPC分类号： A61B3/10 ,  A61B3/1015 ,  A61B3/12 ,  A61B5/0071

摘要： Provided is a fundus imaging apparatus including a wavefront adjuster and a detector. The wavefront adjuster is configured to adjust a wavefront of a femtosecond pulsed laser beam incident on an ocular fundus to be examined. The detector is configured to detect fluorescence generated in a multi-photon excitation process by the femtosecond pulsed laser beam incident on the ocular fundus to be examined. The wavefront adjuster is further configured to adjust the wavefront so that an intensity of the fluorescence to be detected by the detector becomes a maximum value.

摘要翻译： 本发明提供一种包括波前调整器和检测器的眼底成像装置。 波前调整器被配置为调整入射到待检查的眼底的飞秒脉冲激光束的波前。 检测器被配置为检测通过入射到待检查的眼底的飞秒脉冲激光束在多光子激发过程中产生的荧光。 波前调整器还被配置为调整波前，使得检测器检测的荧光强度成为最大值。

公开(公告)号：US09066682B2

公开(公告)日：2015-06-30

申请号：US13398547

申请日：2012-02-16

申请人： Takuya Kishimoto ,  Sakuya Tamada

发明人： Takuya Kishimoto ,  Sakuya Tamada

IPC分类号： A61B3/10 ,  A61B3/12 ,  A61B5/00

CPC分类号： A61B3/10 ,  A61B3/1015 ,  A61B3/12 ,  A61B5/0071

摘要： Provided is a fundus imaging apparatus including a wavefront adjuster and a detector. The wavefront adjuster is configured to adjust a wavefront of a femtosecond pulsed laser beam incident on an ocular fundus to be examined. The detector is configured to detect fluorescence generated in a multi-photon excitation process by the femtosecond pulsed laser beam incident on the ocular fundus to be examined. The wavefront adjuster is further configured to adjust the wavefront so that an intensity of the fluorescence to be detected by the detector becomes a maximum value.

摘要翻译： 本发明提供一种包括波前调整器和检测器的眼底成像装置。 波前调整器被配置为调整入射到待检查的眼底的飞秒脉冲激光束的波前。 检测器被配置为检测通过入射到待检查的眼底的飞秒脉冲激光束在多光子激发过程中产生的荧光。 波前调整器还被配置为调整波前，使得检测器检测的荧光强度成为最大值。

公开(公告)号：US09361667B2

公开(公告)日：2016-06-07

申请号：US13818027

申请日：2011-08-26

申请人： Kazuki Aisaka ,  Seiji Kobayashi ,  Takuya Kishimoto ,  Tomoyuki Ootsuki

发明人： Kazuki Aisaka ,  Seiji Kobayashi ,  Takuya Kishimoto ,  Tomoyuki Ootsuki

IPC分类号： G06T5/00 ,  A61B3/12 ,  G06T3/40 ,  A61B3/15 ,  G06T5/50 ,  G06T7/00

CPC分类号： A61B3/0025 ,  A61B3/12 ,  A61B3/152 ,  G06T3/4053 ,  G06T5/001 ,  G06T5/002 ,  G06T5/50 ,  G06T2207/20208 ,  H04N1/387 ,  H04N2201/0414

摘要： The present technology relates to an image processing apparatus and an image processing method, and particularly to an image processing apparatus and an image processing method capable of suppressing an increase in a load on a subject and obtaining a captured image of the subject with higher image quality.An imaging unit reduces a light amount and performs a plurality of imagings of the fundus of the eye so as to generate a plurality of fundus images. A biological information alignment processing unit aligns the fundus images by using biological information of a subject. A super-resolution processing unit superimposes an aligned input image on a previous super-resolution result image so as to generate a new super-resolution result image. The super-resolution processing unit stores or outputs the super-resolution result image in a storage unit or from an output unit, and supplies the super-resolution result image to a super-resolution result image buffer so as to be stored. The present technology may be applied to, for example, an image processing apparatus.

摘要翻译： 本技术涉及一种图像处理装置和图像处理方法，特别涉及一种能够抑制对对象的负担增加并获得具有较高图像质量的被摄体的拍摄图像的图像处理装置和图像处理方法 。 成像单元减少光量并执行眼睛的眼底的多个图像，以产生多个眼底图像。 生物信息对齐处理单元通过使用对象的生物信息对准眼底图像。 超分辨率处理单元将对准的输入图像叠加在先前的超分辨率结果图像上，以生成新的超分辨率结果图像。 超分辨率处理单元将超分辨率结果图像存储或输出到存储单元或输出单元中，并将超分辨率结果图像提供给超分辨率结果图像缓冲器以便被存储。 本技术可以应用于例如图像处理装置。

公开(公告)号：US08753898B2

公开(公告)日：2014-06-17

申请号：US12877237

申请日：2010-09-08

申请人： Kenzo Machida ,  Noriyuki Kishii ,  Mari Ichimura ,  Kazumine Ito ,  Takuya Kishimoto ,  Naohisa Sakamoto

发明人： Kenzo Machida ,  Noriyuki Kishii ,  Mari Ichimura ,  Kazumine Ito ,  Takuya Kishimoto ,  Naohisa Sakamoto

IPC分类号： G01N33/543

CPC分类号： G01N33/54366 ,  G01N21/6452

摘要： Provided is a microbead analysis method for a microbead. The microbead is formed in a columnar shape having a top surface and a bottom surface facing each other, as placed almost in parallel, and a side surface extending therefrom, and carries an identification pattern formed on at least one of the top surface and the bottom surface and a substance immobilized on a surface thereof having affinity to an analyte substance. The method includes detecting fluorescence emitted from the microbead surface due to interaction of the analyte substance with the substance having affinity to the analyte substance from a region including a region of the top surface and the bottom surface where there is no identification pattern formed and the side surface.

摘要翻译： 微珠的微珠分析方法。 微珠形成为具有彼此面对的顶表面和底表面的几乎平行的柱状和从其延伸的侧表面，并且携带形成在顶表面和底部中的至少一个上的识别图案 表面和固定在其对分析物质具有亲和性的表面上的物质。 该方法包括检测由于分析物质与对分析物质具有亲和性的物质的相互作用而从微珠表面发射的荧光，该区域包括不形成识别图案的顶表面和底表面的区域，侧面 表面。

公开(公告)号：US08734593B2

公开(公告)日：2014-05-27

申请号：US13044925

申请日：2011-03-10

申请人： Takuya Kishimoto ,  Koji Ando

发明人： Takuya Kishimoto ,  Koji Ando

IPC分类号： B08B3/02 ,  B08B3/04 ,  B08B11/02

CPC分类号： H01L21/02052 ,  H01L21/02087 ,  H01L21/465 ,  H01L21/67051 ,  H01L21/6708 ,  H01L21/6875

摘要： A substrate treatment apparatus includes: substrate holding unit which horizontally holds a substrate; a rotating unit which rotates the substrate held by the substrate holding unit about a vertical axis; and a first nozzle having a first opposing face to be opposed to a region of a lower surface of the substrate inward of a peripheral portion of the substrate in spaced relation to the lower surface of the substrate during rotation of the substrate by the rotating unit and a treatment liquid spout provided in the first opposing face for filling a space defined between the lower surface of the substrate and the first opposing face with a treatment liquid spouted from the treatment liquid spout to keep the space in a liquid filled state.

摘要翻译： 基板处理装置包括：水平保持基板的基板保持单元; 旋转单元，其使由所述基板保持单元保持的所述基板绕垂直轴旋转; 以及第一喷嘴，所述第一喷嘴具有第一相对面，所述第一相对面在所述基板由所述旋转单元旋转期间与所述基板的与所述基板的下表面间隔开的向内的与所述基板的下表面的区域相对的区域相对; 设置在所述第一相对面中的处理液体喷口，用于将从所述处理液喷口喷出的处理液体填充在所述基板的下表面和所述第一相对面之间的空间，以保持所述空间处于液体填充状态。

公开(公告)号：US20080194826A1

公开(公告)日：2008-08-14

申请号：US12077687

申请日：2008-03-20

申请人： Ryuuta Fukutomi ,  Hitoshi Inoue ,  Koji Kawamura ,  Takuya Kishimoto ,  Masashi Suzuki ,  Rie Shibayama ,  Kazuko Kojima ,  Kouichirou Hagihara

发明人： Ryuuta Fukutomi ,  Hitoshi Inoue ,  Koji Kawamura ,  Takuya Kishimoto ,  Masashi Suzuki ,  Rie Shibayama ,  Kazuko Kojima ,  Kouichirou Hagihara

IPC分类号： C07D401/12 ,  C07D211/58

CPC分类号： C07D401/12 ,  C07D211/58 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14

摘要： A compound represented the general formula (V): wherein X is CH or N; and Ya is a group of the general formula selected from:

摘要翻译： 化合物为通式（Ⅴ）：其中X为CH或N; 并且Y a a是选自以下的通式的基团：

公开(公告)号：US20050052553A1

公开(公告)日：2005-03-10

申请号：US10730686

申请日：2003-12-08

申请人： Toshihito Kido ,  Takuya Kishimoto

发明人： Toshihito Kido ,  Takuya Kishimoto

IPC分类号： H04N5/225 ,  H04N5/232 ,  H04N5/907 ,  H04N101/00 ,  H04N3/14 ,  H04N5/335 ,  H04N5/222

CPC分类号： H04N5/23245 ,  H04N5/232 ,  H04N5/23293 ,  H04N5/3456 ,  H04N5/347 ,  H04N9/04511

摘要： A digital camera capable of capturing, displaying and recording images at appropriate frame rates is provided. When a current shooting scene mode is a non-sport mode, a current readout mode and a current display mode are set to a high-definition readout mode and a high-definition display mode, respectively, at the same time. Additionally, when a current operating mode is a moving image capturing mode, a current recording mode is also set to a high-definition recording mode at the same time. When the current shooting scene mode is a sport mode, on the other hand, the current readout mode and the current display mode are set to a high-speed readout mode and a high-speed display mode, respectively, at the same time. Additionally, when the current operating mode is the moving image capturing mode, the current recording mode is also set to a high-speed recording mode. The digital camera increases the image-capturing frame rate, the display frame rate and the recording frame rate in synchronism with each other in response to a change of the current shooting scene mode from the non-sport mode to the sport mode.

摘要翻译： 提供了能够以适当的帧速率捕获，显示和记录图像的数字照相机。 当当前拍摄场景模式是非运动模式时，同时分别将当前读出模式和当前显示模式设置为高清晰度读出模式和高清晰度显示模式。 此外，当当前操作模式是运动图像捕获模式时，当前记录模式也被同时设置为高清晰度记录模式。 另一方面，当当前拍摄场景模式是运动模式时，同时将当前读出模式和当前显示模式分别设置为高速读出模式和高速显示模式。 此外，当当前操作模式是运动图像捕获模式时，当前记录模式也被设置为高速记录模式。 数字照相机响应于当前拍摄场景模式从非运动模式到运动模式的改变而相互同步地增加图像捕获帧速率，显示帧速率和记录帧速率。