公开(公告)号：US20110136246A1

公开(公告)日：2011-06-09

申请号：US13055697

申请日：2009-07-15

申请人： Tatsuhiro Shibata ,  Shigeru Saito

发明人： Tatsuhiro Shibata ,  Shigeru Saito

IPC分类号： G01N33/00 ,  C07H21/00 ,  C07K16/00

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  Y10T436/143333

摘要： The present invention provides a marker which can be used as an indicator for efficacy prediction of an mTOR related anticancer agent or prognostic prediction, and a novel anticancer agent. The present invention provides a method for efficacy evaluation of a cancer drug, and, specifically, a prediction method for the efficacy of an mTOR-related cancer drug by detecting NRF2 abnormality. In addition, the present invention provides a prognostic prediction method for cancer, and, specifically, a prediction method for the prognosis of cancer by detecting NRF2 abnormality. Furthermore, the present invention provides a novel anticancer agent that targets NRF2.

摘要翻译： 本发明提供可用作mTOR相关抗癌剂或预后预测的功效预测指标的标记物和新型抗癌剂。 本发明提供了癌症药物的功效评价方法，具体地，通过检测NRF2异常来确定mTOR相关癌症药物的功效的预测方法。 此外，本发明提供癌症的预后预测方法，具体地，通过检测NRF2异常来预测癌症的预测方法。 此外，本发明提供靶向NRF2的新型抗癌剂。

公开(公告)号：US10337071B2

公开(公告)日：2019-07-02

申请号：US13055697

申请日：2009-07-15

申请人： Tatsuhiro Shibata ,  Shigeru Saito

发明人： Tatsuhiro Shibata ,  Shigeru Saito

IPC分类号： G01N33/00 ,  C12Q1/6886 ,  C07H21/00

摘要： The present invention provides a marker which can be used as an indicator for efficacy prediction of an mTOR related anticancer agent or prognostic prediction, and a novel anticancer agent. The present invention provides a method for efficacy evaluation of a cancer drug, and, specifically, a prediction method for the efficacy of an mTOR-related cancer drug by detecting NRF2 abnormality. In addition, the present invention provides a prognostic prediction method for cancer, and, specifically, a prediction method for the prognosis of cancer by detecting NRF2 abnormality. Furthermore, the present invention provides a novel anticancer agent that targets NRF2.

公开(公告)号：US07956815B2

公开(公告)日：2011-06-07

申请号：US11969762

申请日：2008-01-04

申请人： Masataka Ohira ,  Wuqiong Luo ,  Makoto Taroumaru ,  Amane Miura ,  Shigeru Saito ,  Masazumi Ueba ,  Takashi Ohira

发明人： Masataka Ohira ,  Wuqiong Luo ,  Makoto Taroumaru ,  Amane Miura ,  Shigeru Saito ,  Masazumi Ueba ,  Takashi Ohira

IPC分类号： H01Q9/04 ,  H01Q9/00

CPC分类号： H01Q9/42 ,  H01Q21/061 ,  H01Q21/205

摘要： A low-profile antenna structure can control its directivity with great flexibility. Excited elements 11 and 12 are symmetrically arranged on a y-axis, whereas parasitic elements 13 and 14 are symmetrically arranged on an x-axis, with respect to an origin. The excited elements, as well as the parasitic elements, each have an inverted-F antenna structure and are a distance of λ/4 apart from each other. Feed circuits 21 and 22 are respectively connected to and feed signals to the excited elements 11 and 12, such that phases of the signals to be fed are different from each other by a desired degree. Variable reactors 23 and 24 (i) are respectively connected to the parasitic elements 13 and 14, and (ii) in accordance with reactance values thereof, can each change an electrical length of the corresponding one of the parasitic elements.

摘要翻译： 低调的天线结构可以灵活地控制其方向性。 激励元件11和12对称地布置在y轴上，而寄生元件13和14相对于原点对称地布置在x轴上。 激励元件以及寄生元件各自具有倒F型天线结构，并且彼此间隔为λ/ 4。 馈电电路21和22分别连接到激励元件11和12并将信号馈送到激励元件11和12，使得要被馈送的信号的相位彼此不同所需的程度。 可变电抗器23和24（i）分别连接到寄生元件13和14，并且（ii）根据其电抗值可以各自改变相应的一个寄生元件的电长度。

公开(公告)号：US20100098743A1

公开(公告)日：2010-04-22

申请号：US12528103

申请日：2008-02-21

申请人： Toshio Nikaido ,  Motonori Okabe ,  Toshiko Yoshida ,  Shunro Endo ,  Nakamasa Hayashi ,  Shigeru Saito

发明人： Toshio Nikaido ,  Motonori Okabe ,  Toshiko Yoshida ,  Shunro Endo ,  Nakamasa Hayashi ,  Shigeru Saito

IPC分类号： A61K9/00 ,  A61K45/00 ,  A61P43/00

CPC分类号： A61L27/3604

摘要： An object is to overcome the disadvantages of a conventional lyophilized amniotic membrane or the like which causes damages in a cell membrane or an amniotic membrane tissue and is therefore not suitable for use as a substitute membrane for a membrane tissue in a living body, and to provide a novel medical substitute membrane composed of a dried amniotic membrane, which can be used as a substitute membrane for a membrane tissue in a living body. The dried amniotic membrane is produced by drying a fresh amniotic membrane, which envelopes an embryo of an animal including human, and can be used as a substitute membrane for a membrane tissue in a living body; the dried amniotic membrane is dehydrated and dried so that the dried amniotic membrane can be stored in a dry air in a sterile state; when hydrated again by immersing in water or a buffer solution, the amniotic membrane still has an epithelial cell, a basement membrane and a connective tissue which constitute the fresh amniotic membrane. The dried amniotic membrane is useful as a medical substitute membrane for a membrane tissue in a living body such as a dura mater, a meninx, a pericardium, a pleura and a peritoneum.

摘要翻译： 本发明的目的在于克服在细胞膜或羊膜组织中引起损伤的常规冻干羊膜等的缺点，因此不适合用作生物体中的膜组织的替代膜， 提供由干燥羊膜构成的新型医用替代膜，其可以用作活体中的膜组织的替代膜。 干燥的羊膜通过干燥包裹人的动物的胚胎的新鲜的羊膜来制造，可以用作生物体中的膜组织的替代膜; 将干燥的羊膜脱水干燥，使干燥的羊膜能够以无菌状态储存在干燥空气中; 当通过浸入水或缓冲溶液中再次水合时，羊膜仍具有构成新鲜羊膜的上皮细胞，基底膜和结缔组织。 干燥的羊膜可用作诸如硬脑膜，meninx，心包膜，胸膜和腹膜的活体中的膜组织的医用替代膜。

公开(公告)号：US20090288649A1

公开(公告)日：2009-11-26

申请号：US12468320

申请日：2009-05-19

申请人： Hayato Matsuda ,  Shigeru Saito

发明人： Hayato Matsuda ,  Shigeru Saito

IPC分类号： F02B25/06

CPC分类号： F01M13/00 ,  F01M13/04 ,  F02M25/06 ,  Y02T10/121

摘要： In a blowby gas treatment system for a multiple cylinder engine, in which: a first cylinder and a second cylinder are provided to the engine; a first fuel supply device that always operates during operation of the engine is connected to the first cylinder; and a second fuel supply device that is capable of stopping an operation thereof during the operation of the engine is connected to the second cylinder, first and second branch pipes of an intake manifold are connected to the first and second cylinders, and a blowby gas outlet of a breather chamber and a blowby gas inlet opening into the first branch pipe communicate with each other via a breather pipe, the breather chamber collecting a blowby gas of the engine. Accordingly, when any of the cylinders is stopped, it is possible to easily prevent a blowby gas from flowing toward the stopped cylinder.

摘要翻译： 在用于多缸发动机的窜气处理系统中，其中：向发动机提供第一气缸和第二气缸; 在发动机运转中始终运行的第一燃料供给装置连接到第一气缸; 并且能够在发动机运转期间停止其操作的第二燃料供给装置与第二气缸连接，进气歧管的第一和第二分支管连接到第一和第二气缸，并且排气口 通气室和通过第一分支管的窜气入口开口经由通气管彼此连通，通气室收集发动机的窜气。 因此，当任何气缸停止时，可以容易地防止窜气流向停止的气缸。

公开(公告)号：US20090127929A1

公开(公告)日：2009-05-21

申请号：US12269903

申请日：2008-11-13

申请人： Mototsugu Sawada ,  Shigeru Saito

发明人： Mototsugu Sawada ,  Shigeru Saito

IPC分类号： B60T8/88

CPC分类号： B60T8/90 ,  B60T8/1766 ,  B60T8/885 ,  B60T2270/406

摘要： A brake control apparatus includes a braking force applying apparatus for applying a braking force to each of a plurality of wheels adapted to a vehicle, a braking force testing device for testing the braking force of a predetermined malfunction test subject wheel by controlling the braking force applied thereto to be reduced or maintained for a predetermined time on the basis of a test actuation pattern while the braking force applied to each wheel is increased, a wheel speed detecting device for detecting a wheel speed of each of the plurality of the wheels including the malfunction test subject wheel, and a malfunction detecting device for detecting a malfunctioning state, in a case where changes of the wheel speed of the malfunction test subject wheel towards acceleration is not detected while the braking force testing device testing the braking force applied to the malfunction test subject wheel.

摘要翻译： 制动控制装置包括：制动力施加装置，用于对适用于车辆的多个车轮中的每一个施加制动力;制动力测试装置，用于通过控制施加的制动力来测试预定故障测试对象轮的制动力 在施加到每个车轮的制动力增加的同时，基于测试致动模式减小或维持预定时间;车轮速度检测装置，用于检测包括故障的多个车轮中的每一个的车轮速度 测试对象轮和用于检测故障状态的故障检测装置，在制动力测试装置测试施加到故障测试的制动力的同时，在故障测试对象轮对加速度的车轮速度的变化未被检测的情况下 主题轮。

公开(公告)号：US20070203870A1

公开(公告)日：2007-08-30

申请号：US11459153

申请日：2006-07-21

申请人： Shigeru Saito

发明人： Shigeru Saito

IPC分类号： G06N7/02

CPC分类号： G06F17/10

摘要： The invention has the object of obtaining, at a high rate of success, graphs indicating the relationships between variables indicating the states of observed items which are the subjects of data mining, and improving the reliability of the outputted graphs. A method for generating a graph showing the relationships between variables comprises a step S2 of establishing a number of graphs to be generated, a step S5 of randomly establishing an order of variables X forming the set of all variables V, a step S6 of performing a process of reconstructing a graph showing the relationships between variables, and a step S10 of outputting a comprehensive graph including all edges existing in any of the graphs generated with each graph generation. In the graph reconstruction process, an inverse matrix of the correlation coefficient matrix is calculated, and the operation of determining the conditional independence relating to two variables which are the subject of the conditional independence determination is skipped if any of the diagonal elements relating to the two variables is greater than a predetermined threshold value.

摘要翻译： 本发明的目的是以高成功率获得指示数据挖掘对象的观察项目状态的变量之间的关系的图形，并提高输出图形的可靠性。 用于生成表示变量之间的关系的图形的方法包括建立要生成的图形数的步骤S2;随机地建立形成所有变量V的集合的变量X的阶数的步骤S 5，步骤S6 执行重建表示变量之间的关系的图表的过程，以及输出包括存在于利用每个图形生成生成的任何图表中的所有边缘的综合图形的步骤S10。 在图重建处理中，计算相关系数矩阵的逆矩阵，并且如果与两个对象相关的任何对角元素跳过，则跳过确定与条件独立性确定的对象的两个变量相关的条件独立性的操作 变量大于预定阈值。

公开(公告)号：US06871002B1

公开(公告)日：2005-03-22

申请号：US09685059

申请日：2000-10-05

申请人： Shigeru Saito

发明人： Shigeru Saito

IPC分类号： H04H20/00 ,  H04H20/16 ,  H04H40/18 ,  H04J3/00 ,  H04N5/44 ,  H04N5/91 ,  H04N7/08 ,  H04N7/081 ,  H04N7/00

CPC分类号： H04N21/4334 ,  H04H20/16 ,  H04H40/18 ,  H04N21/4335 ,  H04N21/4349 ,  H04N21/643

摘要： This DSM-CC carousel receiver has a DSM-CC section receiving section for receiving a transport stream of MPEG2 (Moving Picture Experts Group-2) and extracting what forming a DSM-CC section, a DSM-CC section analysis section for judging whether the DSM-CC section extracted is DDB configuring the DII unobtained module, a temporary module information setting section for setting temporary module information for the DDB when it is judged to be DDB, which configures the DII unobtained module, by the DSM-CC section analysis section, and a writing section for writing the DDB configuring the DII unobtained module into the storage section according to the temporary module information determined by the temporary module information setting section.

摘要翻译： 该DSM-CC转盘接收机具有用于接收MPEG2（运动图像专家组-2）的传输流并提取构成DSM-CC部分的DSM-CC部分接收部分，DSM-CC部分分析部分，用于判断是否 提取的DSM-CC部分是配置DII不可获取模块的DDB，临时模块信息设置部分，用于当DSM-CC部分析部分被判定为DDB时，用于设置DDB的临时模块信息，其构成DII未获得的模块 以及写入部分，用于根据由临时模块信息设置部分确定的临时模块信息将配置DII未获得模块的DDB写入存储部分。

公开(公告)号：US06598070B1

公开(公告)日：2003-07-22

申请号：US09447552

申请日：1999-11-23

申请人： Shigeru Saito

发明人： Shigeru Saito

IPC分类号： G06F1515

CPC分类号： H04N21/4349 ,  H04L29/06 ,  H04L67/06 ,  H04L69/329 ,  H04N7/16 ,  H04N7/17318 ,  H04N21/235 ,  H04N21/23614 ,  H04N21/4334 ,  H04N21/4348 ,  H04N21/435 ,  H04N21/8126

摘要： A data sending/receiving system, data receiving device and data receiving method enable technique of efficient data; reception to be provided in such a way that even though when the system receives data whose file-name, file-size and so forth are unknown, the system determines temporary file-name and/or file-size with possible bounds, before implementing storing processing. A sending device converts file to be sent into packet data, and adds identification information of the file and position information of the packet data in relation to the file to respective packets. A receiving device generates a temporary file-name and a temporary file-size according to an identification information, before storing packet data associated with the temporary file-name in storage device.

摘要翻译： 数据发送/接收系统，数据接收装置和数据接收方法使数据有效的技术; 接收以这样的方式提供，即使当系统接收到其文件名，文件大小等未知的数据时，系统在实现存储之前确定具有可能边界的临时文件名和/或文件大小 处理。 发送装置将要发送的文件转换为分组数据，并将文件的识别信息和与文件相关的分组数据的位置信息添加到各个分组。 接收装置在将与临时文件名相关联的分组数据存储在存储装置中之前，根据识别信息生成临时文件名和临时文件大小。

公开(公告)号：US06448444B1

公开(公告)日：2002-09-10

申请号：US09839201

申请日：2001-04-23

申请人： Hiroshi Ikegami ,  Keiichi Izumi ,  Masaya Suzuki ,  Noriyasu Sakamoto ,  Shigeru Saito

发明人： Hiroshi Ikegami ,  Keiichi Izumi ,  Masaya Suzuki ,  Noriyasu Sakamoto ,  Shigeru Saito

IPC分类号： C07C25132

摘要： Oxime compounds of formula (1) wherein R1, R2, and R3 are independently halogen, C1-C3 alkyl, C1-C3 halolalkyl, C1-C3 alkoxy, C1-C3 haloalkoxy, nitro, or cyano; R4 is 3,3-dihalogeno-2-propenyl; a is an integer of 0 to 2; Y is oxygen, sulfur, or NH; Z is oxygen, sulfur, or NR5 wherein R5 is hydrogen, acetyl, or C1-C3 alkyl; and X is of formula (2) insecticidal/acaricidal agents containing them as active ingredients; and intermediates for their production.