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    Method for transfer of gene into fat cell or progenitor fat cell
    5.
    发明授权
    Method for transfer of gene into fat cell or progenitor fat cell 有权
    将基因转移到脂肪细胞或祖细胞脂肪细胞中的方法

    公开(公告)号：US08835177B2

    公开(公告)日：2014-09-16

    申请号：US11917853

    申请日：2006-06-12

    申请人： Takahiro Marui ,  Tatsuji Enoki ,  Hiroaki Sagawa ,  Ikunoshin Kato

    发明人： Takahiro Marui ,  Tatsuji Enoki ,  Hiroaki Sagawa ,  Ikunoshin Kato

    IPC分类号： C12N15/87 ,  C07K14/78 ,  C12N15/86 ,  C12N15/867

    CPC分类号： C12N15/86 ,  C07K14/78 ,  C12N2533/52 ,  C12N2740/13045 ,  C12N2810/857

    摘要： A method for transferring a gene into a fat cell or progenitor fat cell comprising the step of infecting the fat cell or progenitor cell with a retrovirus vector having a foreign gene in the presence of a substance having both of a retrovirus-binding site and a target cell-binding site in the molecule or a mixture of a substance having a retrovirus-binding site and a substance having a target cell-binding site, the target cell-binding site having a region that can bind to VLA-5 and/or a region that can bind to VLA-4.

    摘要翻译： 一种将基因转移到脂肪细胞或祖细胞脂肪细胞中的方法，包括在具有逆转录病毒结合位点和靶标的物质存在的情况下用具有外来基因的逆转录病毒载体感染所述脂肪细胞或祖细胞的步骤 分子中的细胞结合位点或具有逆转录病毒结合位点的物质与具有靶细胞结合位点的物质的混合物，所述靶细胞结合位点具有能够结合VLA-5的区域和/或 可以结合VLA-4的区域。

    Method For Transfer Of Gene Into Fat Cell Or Progenitor Fat Cell
    7.
    发明申请
    Method For Transfer Of Gene Into Fat Cell Or Progenitor Fat Cell 有权
    将基因转移到脂肪细胞或祖细胞脂肪细胞的方法

    公开(公告)号：US20090162936A1

    公开(公告)日：2009-06-25

    申请号：US11917853

    申请日：2006-06-12

    申请人： Takahiro Marui ,  Tatsuji Enoki ,  Hiroaki Sagawa ,  Ikunoshin Kato

    发明人： Takahiro Marui ,  Tatsuji Enoki ,  Hiroaki Sagawa ,  Ikunoshin Kato

    IPC分类号： C12N15/867

    CPC分类号： C12N15/86 ,  C07K14/78 ,  C12N2533/52 ,  C12N2740/13045 ,  C12N2810/857

    摘要： A method for transferring a gene into a fat cell or progenitor fat cell comprising the step of infecting the fat cell or progenitor cell with a retrovirus vector having a foreign gene in the presence of a substance having both of a retrovirus-binding site and a target cell-binding site in the molecule or a mixture of a substance having a retrovirus-binding site and a substance having a target cell-binding site, the target cell-binding site having a region that can bind to VLA-5 and/or a region that can bind to VLA-4.

    摘要翻译： 一种将基因转移到脂肪细胞或祖细胞脂肪细胞中的方法，包括在具有逆转录病毒结合位点和靶标的物质存在的情况下用具有外来基因的逆转录病毒载体感染所述脂肪细胞或祖细胞的步骤 分子中的细胞结合位点或具有逆转录病毒结合位点的物质与具有靶细胞结合位点的物质的混合物，所述靶细胞结合位点具有能够结合VLA-5的区域和/或 可以结合VLA-4的区域。

    METHOD FOR PRODUCING GAMMA DELTA T CELL POPULATION
    9.
    发明申请
    METHOD FOR PRODUCING GAMMA DELTA T CELL POPULATION 审中-公开
    生产GAMMA DELTA T细胞群体的方法

    公开(公告)号：US20110158954A1

    公开(公告)日：2011-06-30

    申请号：US12450017

    申请日：2008-03-04

    申请人： Mitsuko Ideno ,  Fumiyo Sakai ,  Tatsuji Enoki ,  Ikunoshin Kato

    发明人： Mitsuko Ideno ,  Fumiyo Sakai ,  Tatsuji Enoki ,  Ikunoshin Kato

    IPC分类号： A61K35/12 ,  A61P31/04 ,  A61P31/12 ,  C12N5/0783 ,  C12N15/86 ,  C12N15/867 ,  C12N15/861

    CPC分类号： C12N5/0636 ,  A61K2035/122 ,  C12N2501/58 ,  C12N2501/999 ,  C12N2533/52

    摘要： A method for preparing a γδ T cell population, characterized in that the method includes the step of culturing a cell population containing γδ T cells, in the presence of (a) fibronectin, a fibronectin fragment or a mixture thereof and (b) an activating factor of γδ T cells. According to the present invention, a method for preparing a γδ T cell population is provided. The γδ T cell population obtained by the method is suitably used in, for example, immunotherapy. Therefore, the method of the present invention is expected to greatly contribute to a medical field.

    摘要翻译： 一种制备γδT细胞群体的方法，其特征在于该方法包括在（a）纤连蛋白，纤连蛋白片段或其混合物存在下培养含有γδT细胞的细胞群的步骤，和（b）活化 γδT细胞因子。 根据本发明，提供了制备γδT细胞群体的方法。 通过该方法获得的γδT细胞群适用于例如免疫治疗。 因此，预期本发明的方法对医疗领域有很大贡献。