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1.发明申请COMPOSITION AND A METHOD FOR PRODUCING CONTRAST AGENT USING THE COMPOSITION 审中-公开组合物和使用该组合物生产对比剂的方法公开(公告)号：US20120052011A1
公开(公告)日：2012-03-01
申请号：US13205246
申请日：2011-08-08
申请人： Tatsuki Fukui , Satoshi Yuasa , Kouichi Kato
发明人： Tatsuki Fukui , Satoshi Yuasa , Kouichi Kato
CPC分类号： A61K49/0034 , A61K49/0032
摘要： A composition including a hydrophilic dye having a sulfonate group and a hydrophobic solvent, wherein the composition includes at least one of a nicotinic acid derivative and a tiamine derivative, can form densely accumulated particles and the like since the composition includes a hydrophilic dye that is likely to dissolve in a hydrophobic solvent.
摘要翻译： 包含具有磺酸盐基团和疏水性溶剂的亲水性染料的组合物，其中所述组合物包含烟酸衍生物和硫胺素衍生物中的至少一种可以形成致密聚集的颗粒等，因为该组合物包含可能的亲水性染料 溶解在疏水性溶剂中。
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公开(公告)号：US20130209367A1
公开(公告)日：2013-08-15
申请号：US13817711
申请日：2011-08-23
申请人： Shinzaburo Ito , Masato Minami , Tatsuki Fukui , Kouichi Kato , Fumio Yamauchi , Yoshinori Tomida , Satoshi Yuasa , Tetsuya Yano , Satoshi Ogawa , Kengo Kanazaki , Atsushi Takahashi , Daisuke Sasaguri , Hiroyuki Aoki
发明人： Shinzaburo Ito , Masato Minami , Tatsuki Fukui , Kouichi Kato , Fumio Yamauchi , Yoshinori Tomida , Satoshi Yuasa , Tetsuya Yano , Satoshi Ogawa , Kengo Kanazaki , Atsushi Takahashi , Daisuke Sasaguri , Hiroyuki Aoki
CPC分类号： A61K49/0093 , A61K9/5153 , A61K49/0034 , A61K49/0052 , A61K49/225 , B82Y15/00 , B82Y30/00
摘要： There is provided an ICG-loaded polymer nanoparticle that is dynamically stable, prevents the leakage of contained ICG and the resulting discoloration, and has a high molar absorbance coefficient. The particle contains a hydrophilic dye having a sulfonate group and a hydrophobic polymer, and the particle further contains at least one of a lipid having a positively charged region, a nicotinic acid derivative and a thiamine derivative.
摘要翻译： 提供了一种负载ICG的聚合物纳米颗粒，其动态稳定，防止所含ICG的泄漏和所得的变色，并具有高的摩尔吸光系数。 该颗粒含有具有磺酸盐基团和疏水性聚合物的亲水性染料，并且该颗粒还含有具有带正电荷区域的脂质，烟酸衍生物和硫胺衍生物中的至少一种。
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公开(公告)号：US20120052017A1
公开(公告)日：2012-03-01
申请号：US13205233
申请日：2011-08-08
申请人： Kouichi Kato , Satoshi Yuasa , Tatsuki Fukui
发明人： Kouichi Kato , Satoshi Yuasa , Tatsuki Fukui
CPC分类号： A61K49/0034 , A61K49/0032 , A61K49/0071
摘要： A contrast agent for optical imaging is produced by preparing a composition containing a hydrophilic dye having a sulfonate group, a hydrophobic solvent, a lipid having a positively charged site, and a polymerizable monomer or a prepolymer, dispersing the composition into water, and polymerizing the polymerizable monomer or the prepolymer.
摘要翻译： 用于光学成像的造影剂通过制备含有具有磺酸酯基的亲水性染料，疏水性溶剂，具有带正电荷位点的脂质和可聚合单体或预聚物的组合物来制备，将组合物分散在水中， 可聚合单体或预聚物。
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公开(公告)号：US09610367B2
公开(公告)日：2017-04-04
申请号：US13817711
申请日：2011-08-23
申请人： Shinzaburo Ito , Masato Minami , Tatsuki Fukui , Kouichi Kato , Fumio Yamauchi , Yoshinori Tomida , Satoshi Yuasa , Tetsuya Yano , Satoshi Ogawa , Kengo Kanazaki , Atsushi Takahashi , Daisuke Sasaguri , Hiroyuki Aoki
发明人： Shinzaburo Ito , Masato Minami , Tatsuki Fukui , Kouichi Kato , Fumio Yamauchi , Yoshinori Tomida , Satoshi Yuasa , Tetsuya Yano , Satoshi Ogawa , Kengo Kanazaki , Atsushi Takahashi , Daisuke Sasaguri , Hiroyuki Aoki
CPC分类号： A61K49/0093 , A61K9/5153 , A61K49/0034 , A61K49/0052 , A61K49/225 , B82Y15/00 , B82Y30/00
摘要： There is provided an ICG-loaded polymer nanoparticle that is dynamically stable, prevents the leakage of contained ICG and the resulting discoloration, and has a high molar absorbance coefficient. The particle contains a hydrophilic dye having a sulfonate group and a hydrophobic polymer, and the particle further contains at least one of a lipid having a positively charged region, a nicotinic acid derivative and a thiamine derivative.
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5.发明授权公开(公告)号：US08652441B2
公开(公告)日：2014-02-18
申请号：US12893074
申请日：2010-09-29
申请人： Tatsuki Fukui , Fumio Yamauchi , Satoshi Yuasa , Sachiko Inoue
发明人： Tatsuki Fukui , Fumio Yamauchi , Satoshi Yuasa , Sachiko Inoue
CPC分类号： C07D209/58 , A61K41/00 , A61K49/0032 , A61K49/0036 , A61K49/0093 , C07D209/60 , C07D209/62 , C07D487/22 , C09B23/0033 , C09B23/0066 , C09B23/086 , C09B47/0673
摘要： A method of detecting a contrast agent for photoacoustic imaging provides a high signal intensity. In a contrast agent for photoacoustic imaging, each particle containing an inorganic material supports at least an organic dye having an absorption coefficient in the near infrared region by means of chemical bonding.
摘要翻译： 检测光声成像造影剂的方法提供高信号强度。 在用于光声成像的造影剂中，含有无机材料的每个颗粒通过化学键合至少支持在近红外区域具有吸收系数的有机染料。
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公开(公告)号：US20110081294A1
公开(公告)日：2011-04-07
申请号：US12893074
申请日：2010-09-29
申请人： Tatsuki Fukui , Fumio Yamauchi , Satoshi Yuasa , Sachiko Inoue
发明人： Tatsuki Fukui , Fumio Yamauchi , Satoshi Yuasa , Sachiko Inoue
IPC分类号： A61K49/00 , C07D209/04 , C09B5/00 , C07D209/58 , A61P43/00
CPC分类号： C07D209/58 , A61K41/00 , A61K49/0032 , A61K49/0036 , A61K49/0093 , C07D209/60 , C07D209/62 , C07D487/22 , C09B23/0033 , C09B23/0066 , C09B23/086 , C09B47/0673
摘要： A method of detecting a contrast agent for photoacoustic imaging provides a high signal intensity. In a contrast agent for photoacoustic imaging, each particle containing an inorganic material supports at least an organic dye having an absorption coefficient in the near infrared region by means of chemical bonding.
摘要翻译： 检测光声成像造影剂的方法提供高信号强度。 在用于光声成像的造影剂中，含有无机材料的每个颗粒通过化学键合至少支持在近红外区域具有吸收系数的有机染料。
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7.发明申请公开(公告)号：US20100233610A1
公开(公告)日：2010-09-16
申请号：US12783975
申请日：2010-05-20
申请人： Tatsuki Fukui , Takashi Kenmoku , Ako Kusakari , Chieko Mihara , Tetsuya Yano , Norikazu Fujimoto
发明人： Tatsuki Fukui , Takashi Kenmoku , Ako Kusakari , Chieko Mihara , Tetsuya Yano , Norikazu Fujimoto
CPC分类号： C08F8/34 , C07C309/15 , C07C309/51 , C07C309/69 , C07C309/76 , C08F8/14 , C08F212/08 , C08F220/58 , C08F2220/585 , G03G9/08726 , G03G9/097 , C08F220/14
摘要： A polymer is provided in which a sulfonic group or a derivative thereof is introduced. The polymer includes a unit represented by the following chemical formula (1): wherein R represents -A1-SO2R1; A1 is selected from an alkylene group, a heterocyclic ring, an aromatic ring; and —SO2R1 is a sulfonic group or of a derivative of a sulfonic acid.
摘要翻译： 提供其中引入了磺酸基或其衍生物的聚合物。 聚合物包括由下列化学式（1）表示的单元：其中R表示-A1-SO2R1; A1选自亚烷基，杂环，芳香环， 和-SO 2 R 1是磺酸基或磺酸衍生物。
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8.发明申请POLYMER HAVING A SULFONIC GROUP OR A SULFONATE GROUP AND AN AMIDE GROUP AND METHOD OF PRODUCING SAME 审中-公开具有磺基或亚磺酸基的聚合物及其生产方法公开(公告)号：US20100121023A1
公开(公告)日：2010-05-13
申请号：US12560852
申请日：2009-09-16
申请人： Tatsuki Fukui , Takashi Kenmoku , Ako Kusakari , Chieko Mihara , Tetsuya Yano , Norikazu Fujimoto
发明人： Tatsuki Fukui , Takashi Kenmoku , Ako Kusakari , Chieko Mihara , Tetsuya Yano , Norikazu Fujimoto
IPC分类号： C08G69/26
CPC分类号： C08F8/34 , C07C309/15 , C07C309/51 , C07C309/69 , C07C309/76 , C08F8/14 , C08F212/08 , C08F220/58 , C08F2220/585 , G03G9/08726 , G03G9/097 , C08F220/14
摘要： A polymer is provided in which a sulfonic group or a derivative thereof is introduced. The polymer includes a unit represented by the following chemical formula (1): wherein R represents -A1-SO2R1; Al is selected from an alkylene group, a heterocyclic ring, an aromatic ring; and —SO2R1 is a sulfonic group or of a derivative of a sulfonic acid.
摘要翻译： 提供其中引入了磺酸基或其衍生物的聚合物。 聚合物包括由下列化学式（1）表示的单元：其中R表示-A1-SO2R1; Al选自亚烷基，杂环，芳香环， 和-SO 2 R 1是磺酸基或磺酸衍生物。
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9.发明申请Charge control agent, toner, image forming method, and image forming apparatus 失效电荷控制剂，调色剂，成像方法和成像设备公开(公告)号：US20090202927A1
公开(公告)日：2009-08-13
申请号：US10585642
申请日：2005-06-09
申请人： Tetsuya Yano , Takashi Kenmoku , Tatsuki Fukui , Ako Kusakari , Chieko Mihara
发明人： Tetsuya Yano , Takashi Kenmoku , Tatsuki Fukui , Ako Kusakari , Chieko Mihara
CPC分类号： C08G63/6882 , C08G63/06 , C08G63/6852
摘要： To provide: a charge control agent having negative chargeability, which contributes to environmental conservation and the like to an increased degree, has high performance (high charge amount, quick rise-up of charge, excellent stability with time, and high environmental stability), and has improved dispersibility; a toner for developing an electrostatic charge image containing the charge control agent; and an image forming method and an image forming apparatus each using the toner for developing an electrostatic charge image. A charge control agent for controlling a charged state of powder, characterized by including one or more units each represented by the following chemical formula (1) in a molecule.
摘要翻译： 为了提供：具有负电荷性的电荷控制剂，其有助于提高环境保护等，具有高性能（高充电量，充电快速上升，优异的稳定性和高环境稳定性）， 并具有改善的分散性; 用于显影含有电荷控制剂的静电荷图像的调色剂; 以及各自使用用于显影静电荷图像的调色剂的图像形成方法和图像形成装置。 一种用于控制粉末的带电状态的电荷控制剂，其特征在于在分子中包含一个或多个由以下化学式（1）表示的单元。
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10.发明授权Polyhydroxyalkanoate having ester group, carboxyl group, and sulfonic group, and method of producing the same 失效具有酯基，羧基和磺酸基的聚羟基链烷酸酯及其制造方法公开(公告)号：US07553922B2
公开(公告)日：2009-06-30
申请号：US10579805
申请日：2005-06-09
申请人： Takashi Kenmoku , Chieko Mihara , Tatsuki Fukui , Ako Kusakari , Tetsuya Yano
发明人： Takashi Kenmoku , Chieko Mihara , Tatsuki Fukui , Ako Kusakari , Tetsuya Yano
IPC分类号： C08G12/34
CPC分类号： C08G63/6882 , C08G63/6852 , C08G63/912
摘要： A novel polyhydroxyalkanoate having a reactive functional group in a molecule and a method of producing the same; and a novel polyhydroxyalkanoate having a new function obtained by chemically modifying the polyhydroxyalkanoate having a reactive functional group and a method of producing the same. A polyhydroxyalkanoate containing units having a carboxyl group, an amide group, and a sulfonic group in a molecule is induced.
摘要翻译： 分子中具有反应性官能团的新型聚羟基链烷酸酯及其制造方法， 和具有通过化学改性具有反应性官能团的聚羟基链烷酸酯获得的新功能的新型聚羟基链烷酸酯及其制备方法。 诱导分子中含有羧基，酰胺基和磺酸基的单元的聚羟基链烷酸酯。
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