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公开(公告)号：US12220694B2
公开(公告)日：2025-02-11
申请号：US17122470
申请日：2020-12-15
Applicant: TECAN TRADING AG
Inventor： Michael Keller , Thomas Geiges
IPC: B01L3/02
Abstract: Pipetting device for pipetting a liquid driven by a gaseous working medium, the pipetting device having at least one pipette connector adapted to attach a pipette at a connection opening at least one pressurizing and/or suctioning pressure source, a gas flow connection between said connection opening and at least one pressure source, a flow restriction defining at least a section of said gas flow connection, a first sensor configured to measure a quantity indicative of the temperature of the flow restriction. The invention is further directed to a gas flow connection element for a pipetting device and to a method of pipetting a liquid volume.
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公开(公告)号：US11249099B2
公开(公告)日：2022-02-15
申请号：US16359265
申请日：2019-03-20
Applicant: TECAN TRADING AG
Inventor： Anja Wolter , Michael Keller
Abstract: A liquid class including control parameters for controlling a laboratory automation device when handling a liquid of a liquid type assigned to the liquid class with a pipette tip of a pipette tip type assigned to the liquid class, and a method for optimizing the liquid class. The method can include initializing a genetic algorithm with a start liquid class by generating a set of liquid classes by modifying control parameters of the start liquid class. The method can further include optimizing the liquid class iteratively with the genetic algorithm by applying liquid classes from the set of liquid classes to the laboratory automation device, which performs at least one aspiration and dispensing measurement for each applied liquid class, as well as additional method acts.
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公开(公告)号：US11992833B2
公开(公告)日：2024-05-28
申请号：US17295624
申请日：2019-12-20
Applicant: TECAN TRADING AG
Inventor： Adrian Sager , Philipp Ott , Patrick Kinney , Hagen Reinhardt , Michael Keller , Sujata Iyer
CPC classification number: B01L3/0275 , B01L3/0279 , B03C1/01 , B03C1/32 , G01N35/10 , B01L3/0217 , B01L2200/023 , B01L2200/025 , B01L2200/026 , B01L2300/0832 , B01L2300/0858 , B01L2300/18 , B01L2400/0478 , G01N2035/103
Abstract: A pipette tip extension attachable to a pipette tip having a proximal end, a distal end, and an exterior wall extending between the proximal end and the distal end is disclosed. The exterior wall has an outer side and an inner side and forms at the proximal end a reception aperture for inserting a pipette tip, and at the distal end a dispense aperture. The pipette tip extension further has an inner cavity, a distance element connected to the inner side of the exterior wall, and a constriction element.
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Patent Agency Ranking
公开(公告)号：US20240201219A1
公开(公告)日：2024-06-20
申请号：US18528347
申请日：2023-12-04
Applicant: Tecan Trading AG
Inventor： Michael Keller , Thomas Geiges , Volfgang Vilaj
CPC classification number: G01N35/1009 , G01N11/00 , G01N13/02 , G01N2013/0208
Abstract: A method for determining physical parameters of a liquid to be aspirated and/or dispensed by a laboratory automation device comprises: picking up of a pipette with the laboratory automation device; lowering the pipette into a sample container with the laboratory automation device, the sample container containing the liquid; aspirating and dispensing air and liquid with the laboratory automation device in such a way, that a liquid level in the pipette solely rises in a first step and solely lowers in a second step, such that an interior surface of the pipette is wetted with liquid solely one time; and during aspirating and dispensing air and liquid, measuring a pressure curve in the pipette and determining the physical parameters from the pressure curve, the physical parameters comprising at least one of a surface tension, a wetting angle and a viscosity.
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公开(公告)号：US20190293672A1
公开(公告)日：2019-09-26
申请号：US16359265
申请日：2019-03-20
Applicant: TECAN TRADING AG
Inventor： Anja Wolter , Michael Keller
Abstract: A liquid class including control parameters for controlling a laboratory automation device when handling a liquid of a liquid type assigned to the liquid class with a pipette tip of a pipette tip type assigned to the liquid class, and a method for optimizing the liquid class. The method can include initializing a genetic algorithm with a start liquid class by generating a set of liquid classes by modifying control parameters of the start liquid class. The method can further include optimizing the liquid class iteratively with the genetic algorithm by applying liquid classes from the set of liquid classes to the laboratory automation device, which performs at least one aspiration and dispensing measurement for each applied liquid class, as well as additional method acts.
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公开(公告)号：US20240201209A1
公开(公告)日：2024-06-20
申请号：US18543685
申请日：2023-12-18
Applicant: Tecan Trading AG
Inventor： Michael Keller , Christina Bauer , Guido Schuster , Simon Walser
IPC: G01N35/00
CPC classification number: G01N35/00623 , G01N2035/00653
Abstract: A method for classifying a specific pipetting procedure of a laboratory automation device comprises: determining a plurality of pressure curves of a plurality of pipetting procedures, which are equivalent to the specific pipetting procedure; determining a median curve from the plurality of pressure curves, wherein for each time point of the median curve, a median value of the values of the plurality of pressure curves at this time point is calculated; determining a median curve range containing the median curve; controlling the laboratory automation device to perform the specific pipetting procedure and measuring a specific pressure curve during the specific pipetting procedure; determining a deviation value of the specific pressure curve with respect to the median curve range, wherein the deviation value is indicative of the specific pressure curve leaving the median range; and classifying the specific pipetting procedure as erroneous, when the deviation value is greater than a threshold.
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公开(公告)号：US20240402207A1
公开(公告)日：2024-12-05
申请号：US18733603
申请日：2024-06-04
Applicant: Tecan Trading AG
Inventor： Michael Keller , Thomas Geiges
IPC: G01N35/10
Abstract: A method for aspirating a liquid with a laboratory automation device comprises: lowering a pipette of the laboratory automation device into a vessel containing the liquid; during lowering, generating an underpressure or overpressure in the pipette with a pressure generating device of the laboratory automation device and measuring a pressure in a pressure distribution system interconnecting the pressure generating device with the pipette; detecting a liquid surface of the liquid in the vessel by evaluating a pressure change of the pressure; calculating a compensation volume from compartment volumes of compartments of the pressure distribution system and/or of the pipette and from pressure losses between the compartments; and aspirating the liquid from the vessel into the pipette by controlling the pressure generating device to aspirate a specific volume altered by the compensation volume.
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公开(公告)号：US20240201208A1
公开(公告)日：2024-06-20
申请号：US18527954
申请日：2023-12-04
Applicant: Tecan Trading AG
Inventor： Michael Keller , Thomas Geiges , Volfgang Vilaj
CPC classification number: G01N35/00584 , G01N35/04 , G01N2035/0434
Abstract: A method for determining physical parameters of an unknown liquid to be aspirated and/or dispensed by a laboratory automation device comprises: determining physical parameters of a pipette, the physical parameters including geometric parameters of the pipette, which at least include a tip radius of an orifice of the pipette; aspirating and/or dispensing the unknown liquid with a pipette of the laboratory automation device and measuring a measured pressure curve in the pipette during aspirating and/or dispensing; determining the physical parameters of the unknown liquid by minimizing an objective function depending on a difference between a simulated pressure curve and the measured pressure curve, wherein the simulated pressure curve simulates a pressure in the pipette during aspirating and/or dispensing and is calculated based on a physical model of the laboratory automation device including the physical parameters of the pipette.
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