公开(公告)号：US20110186428A1

公开(公告)日：2011-08-04

申请号：US12696316

申请日：2010-01-29

申请人： Terry Beaty ,  Henning Groll ,  Harvey Buck ,  Eric Diebold ,  Abner Joseph ,  Randy Riggles

发明人： Terry Beaty ,  Henning Groll ,  Harvey Buck ,  Eric Diebold ,  Abner Joseph ,  Randy Riggles

IPC分类号： G01N33/50

CPC分类号： G01N27/327 ,  G01N27/3272

摘要： The present invention relates to a biosensor. The biosensor includes a support substrate, electrodes positioned on the support substrate, a spacer substrate positioned on the support substrate, and a cover positioned on the spacer substrate. The cover cooperates with the support substrate to define a capillary channel. The electrodes include at least one working electrode defining a working electrode area in the capillary channel. The working electrode is configured to minimize variation in the working electrode area in the capillary channel due to variations in the spacer substrate placement relative to the working electrode.

摘要翻译： 本发明涉及生物传感器。 生物传感器包括支撑基板，位于支撑基板上的电极，位于支撑基板上的间隔基板和位于间隔基板上的盖。 盖与支撑基板配合以限定毛细通道。 电极包括限定毛细通道中的工作电极区域的至少一个工作电极。 工作电极被配置为使得由于间隔基板相对于工作电极的位置的变化而使毛细通道中的工作电极面积的变化最小化。

公开(公告)号：US20050023137A1

公开(公告)日：2005-02-03

申请号：US10871843

申请日：2004-06-18

申请人： Raghbir Bhullar ,  Harvey Buck ,  Brian Hill ,  Paul Walling ,  Terry Beaty ,  David Burke ,  Eric Diebold

发明人： Raghbir Bhullar ,  Harvey Buck ,  Brian Hill ,  Paul Walling ,  Terry Beaty ,  David Burke ,  Eric Diebold

IPC分类号： B01L3/02 ,  C12Q1/00 ,  G01N1/00 ,  G01N27/00 ,  G01N27/30 ,  G01N33/487

CPC分类号： C12M1/00 ,  C12Q1/001 ,  G01N27/3272

摘要： A biosensor having multiple electrical functionalities located both within and outside of the measurement zone in which a fluid sample is interrogated. Incredibly small and complex electrical patterns with high quality edges provide electrical functionalities in the biosensor and also provide the electrical wiring for the various other electrical devices provided in the inventive biosensor. In addition to a measurement zone with multiple and various electrical functionalities, biosensors of the present invention may be provided with a user interface zone, a digital device zone and/or a power generation zone. The inventive biosensors offer improved ease of use and performance, and decrease the computational burden and associated cost of the instruments that read the biosensors by adding accurate yet cost-effective functionalities to the biosensors themselves.

摘要翻译： 具有位于测量区域内和外部的多个电功能的生物传感器，其中询问流体样品。 具有高质量边缘的难以置信的小且复杂的电气图案在生物传感器中提供电功能，并且还为本发明的生物传感器中提供的各种其它电气装置提供电线。 除了具有多个和各种电功能的测量区域之外，本发明的生物传感器可以设置有用户界面区域，数字设备区域和/或发电区域。 本发明的生物传感器提供了改进的易用性和性能，并且通过向生物传感器本身添加准确而成本有效的功能来降低读取生物传感器的仪器的计算负担和相关成本。

公开(公告)号：US20170219510A1

公开(公告)日：2017-08-03

申请号：US15488574

申请日：2017-04-17

申请人： Terry Beaty ,  Harvey Buck ,  Eric Diebold ,  Martin Gerber

发明人： Terry Beaty ,  Harvey Buck ,  Eric Diebold ,  Martin Gerber

IPC分类号： G01N27/327 ,  G01N33/49

摘要： Electrode arrangements for test elements, test elements and methods of determining sample sufficiency, monitoring fill time, establishing fill directions and/or confirming electrode coverage by a sample for test elements are disclosed. The test elements have an electrode-support substrate including a spacer having an edge defining a boundary of a capillary channel. The electrode-support substrate also includes a first electrode pair and a second electrode pair, wherein the first electrode pair is positioned between the second electrode pair. The method includes dosing the test sensor with the fluid sample; applying a signal to the first electrode pair and the second electrode pair, detecting a first response to the signal from the first electrode pair, and detecting a second response to the signal from the second electrode pair; determining a time period between the first response and the second response and then applying a measurement test sequence for an analyte of interest on the fluid sample if the time period is less than a first predetermined threshold.

公开(公告)号：US08439201B2

公开(公告)日：2013-05-14

申请号：US12989833

申请日：2009-05-21

申请人： Eric Mazur ,  Eric Diebold

发明人： Eric Mazur ,  Eric Diebold

IPC分类号： B03B1/00

CPC分类号： B82B3/0071

摘要： The invention provides methods and systems for separating particles that exhibit different Raman characteristics. The method can include introducing nanoparticles, on which Raman-active molecules are adsorbed, into a photopolymerizable resin and exposing to excite Raman active vibrational modes of the molecules to generate Raman-shifted radiation suitable for polymerizing the resin such that the Raman-shifted radiation causes selective polymerization of a resin surrounding nanoparticles if the nanoparticles provide a Raman enhancement factor greater than a threshold. In addition, methods for electrically isolating nanoparticles, or selectively removing one type of nanoparticles from collections, are disclosed. These methods rely on generation of blue-shifted anti-Stokes photons to selectively expose portions of a photoresist covering the nanoparticles to those photons. Such exposure can cause a change in the exposed portions (e.g., polymerize or increase solubility to a developing agent), which can be employed to achieve isolation of the nanoparticles or their selective removal.

摘要翻译： 本发明提供了分离显示不同拉曼特性的颗粒的方法和系统。 该方法可以包括将其上吸附有拉曼活性分子的纳米颗粒引入可光聚合树脂中并暴露于分子的激发拉曼活性振动模式以产生适于聚合树脂的拉曼偏移辐射，使得拉曼位移辐射导致 如果纳米颗粒提供大于阈值的拉曼增强因子，则围绕纳米颗粒的树脂的选择性聚合。 此外，公开了用于电绝缘纳米颗粒或从集合中选择性地除去一种类型的纳米颗粒的方法。 这些方法依赖于产生蓝移的反斯托克斯光子，以选择性地将覆盖纳米颗粒的光刻胶的部分暴露于那些光子。 这种暴露可导致暴露部分的变化（例如，聚合或增加对显影剂的溶解度），其可用于实现纳米颗粒的分离或其选择性去除。

公开(公告)号：US08294891B2

公开(公告)日：2012-10-23

申请号：US12523567

申请日：2008-01-22

申请人： Eric Mazur ,  Eric Diebold

发明人： Eric Mazur ,  Eric Diebold

IPC分类号： G01N21/03 ,  G01J3/44

CPC分类号： G01N21/658 ,  B65D79/02 ,  B65D2203/02 ,  G01N33/02

摘要： In one aspect, a system for use in product packaging is disclosed that includes a polymeric sensing substrate coupled to a package such that a front sensing surface thereof is in contact with a portion of a product, e.g., a fungible product, stored in the package and a back surface thereof is accessible via an environment external to the package. The system further includes a radiation source adapted to direct radiation to the substrate's back surface such that the radiation would interact with one or more molecular species of the product that are in contact with the substrate's sensing surface. The system also includes a detector that is adapted to detect radiation returning from the substrate in response to its illumination by the radiation source. The front surface of the sensing substrate can comprise a plurality of micron-sized or submicron-sized ridges having a discontinuous or continuous metal coating, e.g., a metallic layer with a thickness in a range of about 10 nm to about 1000 nm (and preferably in a range of about 50 nm to about 120 nm), disposed thereon.

摘要翻译： 在一个方面，公开了一种用于产品包装的系统，其包括耦合到包装的聚合物感测衬底，使得其前感测表面与存储在包装中的产品（例如，可替代产品）的一部分接触 并且其后表面可通过包装外部的环境访问。 该系统还包括适于将辐射引导到衬底的背表面的辐射源，使得辐射将与与衬底的感测表面接触的产品的一种或多种分子种类相互作用。 该系统还包括检测器，其适于检测响应于其由辐射源照射的从衬底返回的辐射。 感测基板的前表面可以包括具有不连续或连续金属涂层的多个微米尺寸或亚微米尺寸的脊，例如厚度在约10nm至约1000nm范围内的金属层（优选地， 在约50nm至约120nm的范围内）。

公开(公告)号：US20090046283A1

公开(公告)日：2009-02-19

申请号：US12017720

申请日：2008-01-22

申请人： Eric Mazur ,  Eric Diebold ,  Steven M. Ebstein

发明人： Eric Mazur ,  Eric Diebold ,  Steven M. Ebstein

IPC分类号： G01J3/44 ,  H01L21/00

CPC分类号： B81B1/006 ,  B01L3/5023 ,  B01L3/5027 ,  B01L3/5088 ,  B01L2200/12 ,  B01L2300/165 ,  B81C1/00206 ,  B82Y15/00 ,  B82Y30/00 ,  G01N21/658

摘要： In one aspect, the present invention generally provides methods for fabricating substrates for use in a variety of analytical and/or diagnostic applications. Such a substrate can be generated by exposing a semiconductor surface (e.g., silicon surface) to a plurality of short laser pulses to generate micron-sized, and preferably submicron-sized, structures on the surface. The structured surface can then be coated with a thin metallic layer, e.g., one having a thickness in a range of about 10 nm to about 1000 nm.

摘要翻译： 一方面，本发明通常提供用于制造用于各种分析和/或诊断应用的基底的方法。 可以通过将半导体表面（例如，硅表面）暴露于多个短激光脉冲以在表面上产生微米尺寸且优选亚微米尺寸的结构来产生这种基板。 然后可以用薄金属层涂覆结构化表面，例如具有在约10nm至约1000nm范围内的厚度的金属层。

公开(公告)号：US20110178820A1

公开(公告)日：2011-07-21

申请号：US12818894

申请日：2010-06-18

申请人： Abhishek S. Soni ,  Paul J. Galley ,  Alan Greenburg ,  Steven Bousamra ,  Stefan Weinert ,  Eric Diebold

发明人： Abhishek S. Soni ,  Paul J. Galley ,  Alan Greenburg ,  Steven Bousamra ,  Stefan Weinert ,  Eric Diebold

IPC分类号： G06Q50/00

CPC分类号： G06F19/3456 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/4839 ,  A61B5/7275 ,  G06F19/3418 ,  G06F19/3468 ,  G06F19/3475 ,  G06F19/3481 ,  G06Q50/24 ,  G16H10/20 ,  G16H10/60 ,  G16H15/00

摘要： Embodiments related to a system and method managing the implementation, execution, data collection, data analysis and status reporting of a structured collection procedure running on a portable, hand-held collection device are disclosed. The collection device performing the structured collection procedure has program instructions that when executed by a processor cause the processor to initiate automatically a schedule of events of the structured collection procedure upon one or more entry criteria being met at some unknown time, store in memory patient data collected in accordance to the schedule of events, end automatically the structured collection procedure upon one or more exit criteria being met at some unknown time. Status reporting can be provided throughout the execution of the collection procedure.

摘要翻译： 公开了涉及在便携式手持收集装置上运行的结构化收集过程的实现，执行，数据收集，数据分析和状态报告的系统和方法的实施例。 执行结构化收集过程的收集装置具有当处理器执行时使得处理器在某个未知时间满足一个或多个入口标准时自动启动结构化收集过程的事件调度的程序指令，存储在存储器患者数据中 根据事件进度收集，在一些未知时间满足一个或多个退出条件时自动结束结算收集程序。 整个执行过程中可以提供状态报告。

公开(公告)号：US20110155649A1

公开(公告)日：2011-06-30

申请号：US12989833

申请日：2009-05-21

申请人： Eric Mazur ,  Eric Diebold

发明人： Eric Mazur ,  Eric Diebold

IPC分类号： B82B3/00 ,  B07B13/00 ,  B82Y40/00

CPC分类号： B82B3/0071

摘要： The invention provides methods and systems for separating particles that exhibit different Raman characteristics. The method can include introducing nanoparticles, on which Raman-active molecules are adsorbed, into a photopolymerizable resin and exposing to excite Raman active vibrational modes of the molecules to generate Raman-shifted radiation suitable for polymerizing the resin such that the Raman-shifted radiation causes selective polymerization of a resin surrounding nanoparticles if the nanoparticles provide a Raman enhancement factor greater than a threshold. In addition, methods for electrically isolating nanoparticles, or selectively removing one type of nanoparticles from collections, are disclosed. These methods rely on generation of blue-shifted anti-Stokes photons to selectively expose portions of a photoresist covering the nanoparticles to those photons. Such exposure can cause a change in the exposed portions (e.g., polymerize or increase solubility to a developing agent), which can be employed to achieve isolation of the nanoparticles or their selective removal.

摘要翻译： 本发明提供了分离显示不同拉曼特性的颗粒的方法和系统。 该方法可以包括将其上吸附有拉曼活性分子的纳米颗粒引入可光聚合的树脂中并暴露于分子的激发拉曼活性振动模式以产生适于聚合树脂的拉曼偏移辐射，使得拉曼位移辐射导致 如果纳米颗粒提供大于阈值的拉曼增强因子，则围绕纳米颗粒的树脂的选择性聚合。 此外，公开了用于电绝缘纳米颗粒或从集合中选择性地除去一种类型的纳米颗粒的方法。 这些方法依赖于产生蓝移的反斯托克斯光子，以选择性地将覆盖纳米颗粒的光刻胶的部分暴露于那些光子。 这种暴露可导致暴露部分的变化（例如，聚合或增加对显影剂的溶解度），其可用于实现纳米颗粒的分离或其选择性去除。

公开(公告)号：US20100171948A1

公开(公告)日：2010-07-08

申请号：US12481973

申请日：2009-06-10

申请人： Eric Mazur ,  Eric Diebold ,  Steven Ebstein

发明人： Eric Mazur ,  Eric Diebold ,  Steven Ebstein

IPC分类号： G01J3/44

CPC分类号： B82Y30/00 ,  B01L3/5023 ,  B01L3/5027 ,  B01L3/5088 ,  B01L2200/12 ,  B01L2300/165 ,  B81B1/006 ,  B81C1/00206 ,  B82Y15/00 ,  G01N21/658

摘要： In one aspect, the present invention generally provides methods for fabricating substrates for use in a variety of analytical and/or diagnostic applications. Such a substrate can be generated by exposing a semiconductor surface (e.g., silicon surface) to a plurality of short laser pulses to generate micron-sized, and preferably submicron-sized, structures on the surface. The structured surface can then be coated with a thin metallic layer, e.g., one having a thickness in a range of about 10 nm to about 1000 nm.

摘要翻译： 一方面，本发明通常提供用于制造用于各种分析和/或诊断应用的基底的方法。 可以通过将半导体表面（例如，硅表面）暴露于多个短激光脉冲以在表面上产生微米尺寸且优选亚微米尺寸的结构来产生这种基板。 然后可以用薄金属层涂覆结构化表面，例如具有在约10nm至约1000nm范围内的厚度的金属层。

公开(公告)号：US20090033929A1

公开(公告)日：2009-02-05

申请号：US12017698

申请日：2008-01-22

申请人： Eric Mazur ,  Eric Diebold

发明人： Eric Mazur ,  Eric Diebold

IPC分类号： G01J3/44 ,  B32B3/26 ,  H01L21/44

CPC分类号： G01N21/658 ,  Y10T428/249978

摘要： In one aspect, the present invention provides methods for fabricating substrates for use in a variety of analytical and/or diagnostic applications. Such a substrate can be generated by exposing a semiconductor surface (e.g., silicon surface) to a plurality of short laser pulses to generate micron-sized, and preferably submicron-sized, structures on the surface. The structured surface can then be coated with discontinuous metal coating characterized by one or more metalized surface region and a plurality of surface gaps.

摘要翻译： 一方面，本发明提供用于制造用于各种分析和/或诊断应用的基底的方法。 可以通过将半导体表面（例如，硅表面）暴露于多个短激光脉冲以在表面上产生微米尺寸且优选亚微米尺寸的结构来产生这种基板。 然后可以用不连续金属涂层涂覆结构化表面，其特征在于一个或多个金属化表面区域和多个表面间隙。