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    Production process of an antithrombogenic and antiadhesive material for medical use
    2.
    发明授权
    Production process of an antithrombogenic and antiadhesive material for medical use 失效
    用于医疗用途的抗血栓形成和抗粘附材料的生产工艺

    公开(公告)号：US4690973A

    公开(公告)日：1987-09-01

    申请号：US885782

    申请日：1986-07-15

    申请人： Yasuharu Noishiki ,  Kazuhiko Kodaira ,  Masayasu Furuse ,  Teruo Miyata ,  Takeaki Miyamoto ,  Hiraku Ito

    发明人： Yasuharu Noishiki ,  Kazuhiko Kodaira ,  Masayasu Furuse ,  Teruo Miyata ,  Takeaki Miyamoto ,  Hiraku Ito

    IPC分类号： A61L33/10 ,  A61L33/00 ,  A61M25/00 ,  C08H1/06 ,  C08L89/04 ,  C08L89/06

    CPC分类号： A61L33/0023 ,  Y10S128/08

    摘要： This invention concerns a production process of an antithrombogenic and antiadhesive material which can favorably be used as artificial blood vessels, artificial valves, grafting patches for cardiovascular organs, artificial heart catheters and so on. The gist of this invention is constructed substantially of subjecting glycidyltrialkylammonium halide such as glycidyltrimethylammonium chloride to the reaction with a material comprising pure collagen or collagen and other components like mucopolysaccharide in order to introduce a cationic quaternary functional group in collagen molecules of the material and then subjecting heparin to the ionic combination with the cationic functional group introduced. Meanwhile, in advance of the above chemical treatment, the material is prepared from dog's blood vessel by removing proteins except collagen, from cow's Achilles tendon by crushing into powder, from human amnion by rinsing in distilled water or from polyester knit tube by coating its inside with powdered collagen, for example.

    摘要翻译： 本发明涉及可有利地用作人造血管，人造瓣膜，心血管器官接枝片，人造心导管等的抗血栓形成和抗粘附材料的生产方法。 本发明的要点基本上是将缩水甘油三烷基铵卤化物如缩水甘油基三甲基氯化铵与含有纯胶原或胶原和其他组分如粘多糖的材料进行反应，以便在材料的胶原分子中引入阳离子季铵官能团， 肝素与阳离子官能团的离子组合引入。 同时，在上述化学处理之前，通过从牛的跟腱中除去胶原蛋白之外的蛋白质从狗的血管中制备，通过粉碎，从人羊膜中通过在蒸馏水中冲洗或从聚酯针织管中涂覆其内部制备材料 以胶原蛋白粉为例。

    Antithrombogenic medical material and method of preparing same
    6.
    发明授权
    Antithrombogenic medical material and method of preparing same 失效
    抗凝血药物及其制备方法

    公开(公告)号：US4833200A

    公开(公告)日：1989-05-23

    申请号：US889654

    申请日：1986-07-25

    申请人： Yasuharu Noishiki ,  Teruo Miyata

    发明人： Yasuharu Noishiki ,  Teruo Miyata

    IPC分类号： A61K38/16 ,  A61K38/17 ,  A61L33/00 ,  C08L5/10

    CPC分类号： A61L33/0029 ,  C08L5/10 ,  Y10S514/801 ,  Y10S514/822

    摘要： An antithrombogenic medical material with a remarkable antithrombogenic property and histocompatibility as well as sufficient physical strength, formed by fixing a heparinized collagen to a synthetic polymer material is provided. And a method of preparing an antithrombogenic medical material is provided, wherein a synthetic polymer material is subjected to a coating or impregnating treatment with a collagen-containing solution, followed by heparinization of the collagen, and the heparinized collagen is fixed to the synthetic polymer material. This method allows manufacturing of antithrombogenic medical material with ease.

    摘要翻译： 本发明提供具有抗凝血性能和组织相容性以及通过将肝素化胶原固定在合成高分子材料上形成的充分体力的抗血栓形成的医用材料。 提供一种制备抗血栓形成的医药材料的方法，其中合成聚合物材料用含胶原的溶液进行包衣或浸渍处理，然后将胶原蛋白肝素化，并将肝素化胶原蛋白固定在合成聚合物材料 。 该方法容易制造抗血栓形成的医用材料。

    Medical material
    7.
    发明授权
    Medical material 失效
    医疗材料

    公开(公告)号：US4695281A

    公开(公告)日：1987-09-22

    申请号：US478773

    申请日：1983-03-25

    申请人： Teruo Miyata ,  Yasuharu Noishiki

    发明人： Teruo Miyata ,  Yasuharu Noishiki

    IPC分类号： A61F2/00 ,  A61L27/24 ,  A61L27/36 ,  A61L33/00 ,  C08H1/06 ,  A61F2/02 ,  A61F2/06

    CPC分类号： C08H1/06 ,  A61L27/24 ,  A61L27/36 ,  A61L33/0082 ,  A61F2310/00365 ,  Y10S623/917

    摘要： The medical material according to this invention contains collagen, which as been chemically modified by saccinylation of thermal --NH.sub.2 groups of said chains attached to poly peptide chains of the collagen so that the --NH.sub.2 groups are converted into groups having --COOH groups. This succinylation can be carried out by reacting succinic anhydride with the --NH.sub.2 groups of the collagen. Since the above medical material has excellent compatibility with living bodies, especially, with blood, it is suitable to use it as a replacement material for tissues and/or organs which are kept in contact with blood at their surfaces, namely, is suitable for use in artificial blood vessels, artificial valves, some parts of artificial hearts which are kept in contact with blood at said parts, etc. and as a patching material for hearts.

    摘要翻译： 根据本发明的医疗材料包含胶原蛋白，其通过连接到胶原的多肽链的所述链的热-NH 2基团的凝血化而被化学修饰，使得-NH 2基团转化为具有-COOH基团的基团。 该琥珀酰化可以通过使琥珀酸酐与胶原的-NH 2基团反应来进行。 由于上述医用材料与生物体，特别是血液具有良好的相容性，因此适合用作与其表面保持与血液接触的组织和/或器官的替代材料，即适合使用 在人造血管，人造瓣膜，与所述部分血液保持接触的人造心脏的一些部分等，以及作为心脏的修补材料。

    Medical materials
    8.
    发明授权
    Medical materials 失效
    医疗材料

    公开(公告)号：US4704131A

    公开(公告)日：1987-11-03

    申请号：US661258

    申请日：1984-10-15

    申请人： Yasuharu Noishiki ,  Teruo Miyata

    发明人： Yasuharu Noishiki ,  Teruo Miyata

    IPC分类号： A61L33/10 ,  A61L33/00 ,  A61F2/04 ,  A01N1/02 ,  A61F2/06

    CPC分类号： A61L33/0029 ,  Y10S128/08 ,  Y10S623/916

    摘要： The medical material contains heparinized collagen in which heparin has been bonded to protamine covalently fixed on collagen, and, owing to its excellent compatibility with living bodies, especially, its superb antithrombotic property, can be suitably used as a substituent material for tissues or organs which are brought into direct contact with blood, namely, as aritificial vessels, artificial valves and patching materials for cardiovascular organs, and the above medical material is also suitable as a membrane having anti-adhesion effects. The medical material is obtained by immersing and treating a natural or artificial material successively in an aqueous protamine solution, an aqueous glutaraldehyde solution and an aqueous heparin solution.

    摘要翻译： 医用材料含有肝素化胶原蛋白，其中肝素已被共价固定在胶原上的鱼精蛋白结合，并且由于其与活体的相容性优异，特别是其极好的抗血栓性质，可以适合用作组织或器官的取代基材料 与血液直接接触，即作为人造血管，人造瓣膜和心血管器官的修补材料，上述医用材料也适合作为具有抗粘连作用的膜。 通过将天然或人造材料依次浸入鱼精蛋白水溶液，戊二醛水溶液和肝素水溶液中而获得医疗材料。

    MEDICAL MATERIAL, ARTIFICIAL TOOTH ROOT, AND METHOD OF PRODUCING MEDICAL MATERIAL
    9.
    发明申请
    MEDICAL MATERIAL, ARTIFICIAL TOOTH ROOT, AND METHOD OF PRODUCING MEDICAL MATERIAL 审中-公开
    医用材料，人造牙根和生产医用材料的方法

    公开(公告)号：US20090215009A1

    公开(公告)日：2009-08-27

    申请号：US11816811

    申请日：2006-02-23

    申请人： Yasuharu Noishiki ,  Yoshinori Kuboki ,  Yasuo Seki ,  Hiroyuki Shiota

    发明人： Yasuharu Noishiki ,  Yoshinori Kuboki ,  Yasuo Seki ,  Hiroyuki Shiota

    IPC分类号： A61C19/00 ,  A61K9/00 ,  A61K35/12 ,  A61K35/28 ,  A61K38/16 ,  A61K31/715 ,  A61K38/43 ,  A61K38/14 ,  A61P43/00 ,  B05D1/18

    CPC分类号： A61L27/12 ,  A61L27/56

    摘要： [Problems] To provide a medical material having such a structure that enables even diffusion and distribution in the material of a sufficient amount a substance necessary for a medical treatment.[Means for Solving Problems] A medical material 10 composed of a porous three-dimensional construct 11, which is a rectangular parallelepiped having a porosity of from 20 to 97% and pores 12, 13, 14 and 15 provided in the main body. From this pore 12, a substance such as calcium phosphate or ceramics apatite and/or a physiologically active cell, tissue or protein and a substance suitable for exerting the functions thereof are introduced.

    摘要翻译： [问题]提供具有这样的结构的医疗材料，其能够在材料中均匀地扩散和分布足量的药物所需的物质。 解决问题的手段由主体中设置有孔隙率为20〜97％的长方体的多孔性三维构造体11和孔12,13,14,15组成的医疗用材料10。 从该孔12中，引入磷酸钙或陶瓷磷灰石等物质和/或生理活性细胞，组织或蛋白质以及适用于其功能的物质。

    Prosthesis containing bioabsorbable materials insolubilized without chemical reagents and method of making the same
    10.
    发明授权
    Prosthesis containing bioabsorbable materials insolubilized without chemical reagents and method of making the same 失效
    含有不含化学试剂的生物可吸收材料的假体及其制造方法

    公开(公告)号：US5986168A

    公开(公告)日：1999-11-16

    申请号：US928752

    申请日：1997-09-12

    申请人： Yasuharu Noishiki

    发明人： Yasuharu Noishiki

    IPC分类号： A61L27/00 ,  A61F2/06 ,  A61L27/20 ,  A61L27/22 ,  A61L27/34 ,  A61L27/36 ,  A61L27/38 ,  A61L27/56 ,  A61L27/58 ,  A61F2/02

    CPC分类号： A61L27/3691 ,  A61L27/20 ,  A61L27/22 ,  A61L27/34 ,  A61L27/38 ,  A61L27/56 ,  A61L27/58 ,  Y02P20/582

    摘要： The present invention relates to a prosthesis comprising one or more bioabsorbable substances insolubilized and/or immobilized in place by a physical method which excludes chemical reagents. A growth factor can be bound to the bioabsorbable substance for simulating growth of, for example, fibroblast and endothelial cells, around and into the prosthesis. The invention can include a porous fabric substrate having the bioabsorbable substance(s) insolubilized and immobilized therewithin by one or more of the physical methods. The physical method can include entanglement, dry-up, thermal crosslinkng, gamma irradiation, ultraviolet irradiation, or swelling up by hyper hydration with electric charge. The invention excludes the use of conventional chemical reagents, such as glutaraldehyde or formaldehyde, which are toxic. Since the invention does not use the chemical reagents of the prior art, it can avoid the toxicity and foreign body reaction problems associated therewith. The prosthesis of the invention does not have blood leakage and provides an excellent antithrombogenicity by rapid completion of neointima formation with endothelial cell lining at an early stage after implantation.

    摘要翻译： 本发明涉及一种假体，其包含一种或多种通过不包括化学试剂的物理方法不溶化和/或固定在适当位置的生物可吸收物质。 生长因子可以结合生物可吸收物质，用于模拟假体周围的成纤维细胞和内皮细胞的生长。 本发明可以包括具有生物可吸收物质的多孔织物基质，所述生物可吸收物质通过一种或多种物理方法不溶解并固定在其中。 物理方法可以包括缠结，干燥，热交联，γ照射，紫外线照射或通过电荷高水合膨胀。 本发明不包括使用有毒的常规化学试剂如戊二醛或甲醛。 由于本发明不使用现有技术的化学试剂，因此可以避免与之相关的毒性和异物反应问题。 本发明的假体不具有血液渗漏，并且通过在植入后的早期快速完成与内皮细胞衬里的新内膜形成而提供优异的抗血栓形成。