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    Production process of an antithrombogenic and antiadhesive material for medical use
    4.
    发明授权
    Production process of an antithrombogenic and antiadhesive material for medical use 失效
    用于医疗用途的抗血栓形成和抗粘附材料的生产工艺

    公开(公告)号：US4690973A

    公开(公告)日：1987-09-01

    申请号：US885782

    申请日：1986-07-15

    申请人： Yasuharu Noishiki ,  Kazuhiko Kodaira ,  Masayasu Furuse ,  Teruo Miyata ,  Takeaki Miyamoto ,  Hiraku Ito

    发明人： Yasuharu Noishiki ,  Kazuhiko Kodaira ,  Masayasu Furuse ,  Teruo Miyata ,  Takeaki Miyamoto ,  Hiraku Ito

    IPC分类号： A61L33/10 ,  A61L33/00 ,  A61M25/00 ,  C08H1/06 ,  C08L89/04 ,  C08L89/06

    CPC分类号： A61L33/0023 ,  Y10S128/08

    摘要： This invention concerns a production process of an antithrombogenic and antiadhesive material which can favorably be used as artificial blood vessels, artificial valves, grafting patches for cardiovascular organs, artificial heart catheters and so on. The gist of this invention is constructed substantially of subjecting glycidyltrialkylammonium halide such as glycidyltrimethylammonium chloride to the reaction with a material comprising pure collagen or collagen and other components like mucopolysaccharide in order to introduce a cationic quaternary functional group in collagen molecules of the material and then subjecting heparin to the ionic combination with the cationic functional group introduced. Meanwhile, in advance of the above chemical treatment, the material is prepared from dog's blood vessel by removing proteins except collagen, from cow's Achilles tendon by crushing into powder, from human amnion by rinsing in distilled water or from polyester knit tube by coating its inside with powdered collagen, for example.

    摘要翻译： 本发明涉及可有利地用作人造血管，人造瓣膜，心血管器官接枝片，人造心导管等的抗血栓形成和抗粘附材料的生产方法。 本发明的要点基本上是将缩水甘油三烷基铵卤化物如缩水甘油基三甲基氯化铵与含有纯胶原或胶原和其他组分如粘多糖的材料进行反应，以便在材料的胶原分子中引入阳离子季铵官能团， 肝素与阳离子官能团的离子组合引入。 同时，在上述化学处理之前，通过从牛的跟腱中除去胶原蛋白之外的蛋白质从狗的血管中制备，通过粉碎，从人羊膜中通过在蒸馏水中冲洗或从聚酯针织管中涂覆其内部制备材料 以胶原蛋白粉为例。

    Method for producing sustained release formulation
    9.
    发明授权
    Method for producing sustained release formulation 失效
    缓释制剂的制备方法

    公开(公告)号：US4849141A

    公开(公告)日：1989-07-18

    申请号：US946075

    申请日：1986-12-24

    申请人： Keiji Fujioka ,  Shigeji Sato ,  Yoshio Sasaki ,  Teruo Miyata ,  Masayasu Furuse ,  Hiromi Naito

    发明人： Keiji Fujioka ,  Shigeji Sato ,  Yoshio Sasaki ,  Teruo Miyata ,  Masayasu Furuse ,  Hiromi Naito

    IPC分类号： A61K9/16 ,  A61K9/20 ,  A61K9/22

    CPC分类号： A61K9/2063 ,  A61K9/1658 ,  A61K9/2018 ,  Y10S514/801

    摘要： A method for preparing a sustained release formulation utilizing collagen and/or gelatin as a carrier, which comprises the steps:(i) preparing a uniform and high concentrated mixture with respect to the collagen and/or gelatin by blending an active ingredient, said collagen and/or gelatin, and water or an admixture consisting of water and a hydrophilic organic solvent under one of the conditions selected from:(A) the pH of the mixture is kept below 5 and the salt concentration of the mixture is retained below fiber-forming concentration;(B) chemically modified collagen and/or gelatin is employed; and(C) glucose is added to the mixture;(ii) molding the resultant mixture; and(iii) gradually eliminating the solvent from the molded product.

    摘要翻译： 用于制备利用胶原和/或明胶作为载体的持续释放制剂的方法，其包括以下步骤：（i）通过混合活性成分制备相对于胶原和/或明胶的均匀和高浓缩混合物，所述胶原蛋白 和/或明胶，以及水或由水和亲水性有机溶剂组成的混合物，其中选自以下的条件之一：（A）混合物的pH保持在5以下，混合物的盐浓度保持在纤维 - 形成浓度; （B）使用化学改性的胶原和/或明胶; 和（C）将葡萄糖加入到混合物中; （ii）模制所得混合物; 和（iii）逐渐从成型产品中除去溶剂。