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    Benzothiadiazine compounds, and pharmaceutical composition comprising the same
    3.
    发明授权
    Benzothiadiazine compounds, and pharmaceutical composition comprising the same 失效
    苯并噻二嗪化合物和包含它们的药物组合物

    公开(公告)号：US4889851A

    公开(公告)日：1989-12-26

    申请号：US116913

    申请日：1987-11-05

    申请人： Teruo Oku ,  Eishiro Todo ,  Chiyoshi Kasahara ,  Katsuya Nakamura ,  Hiroshi Kayakiri

    发明人： Teruo Oku ,  Eishiro Todo ,  Chiyoshi Kasahara ,  Katsuya Nakamura ,  Hiroshi Kayakiri

    IPC分类号： C07D209/14 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4418 ,  A61K31/54 ,  A61K31/5415 ,  A61P3/00 ,  A61P19/10 ,  A61P29/00 ,  A61P43/00 ,  C07C67/00 ,  C07C301/00 ,  C07C311/39 ,  C07C311/40 ,  C07C311/42 ,  C07C313/00 ,  C07C323/49 ,  C07D209/40 ,  C07D209/86 ,  C07D209/88 ,  C07D213/76 ,  C07D215/38 ,  C07D217/22 ,  C07D233/02 ,  C07D233/88 ,  C07D239/69 ,  C07D249/04 ,  C07D249/08 ,  C07D249/14 ,  C07D249/18 ,  C07D257/04 ,  C07D261/14 ,  C07D263/00 ,  C07D271/00 ,  C07D285/24 ,  C07D295/12 ,  C07D307/52 ,  C07D333/36 ,  C07D417/04 ,  C07D417/06 ,  C07D521/00

    CPC分类号： C07D213/76 ,  C07D239/69 ,  C07D285/24 ,  C07D417/04

    摘要： A compound of the formula: ##STR1## wherein R' is phenyl, phenyl which is substituted with halogen, lower alkyl, lower alkoxy, halo lower alkyl, lower alkylamino, lower alkylthio, phenoxy, carboxy, lower alkoxycarbonyl, carboxy lower alkyl, lower alkoxycarbonyl, lower alkyl, cyclo lower alkyl; lower alkyl which is substituted with carboxy or lower alkoxyoxycarbonyl; or pyrimidinyl, pyridyl or pyridyl which is substituted with lower alkyl;A is lower alkylene;n is an integer of 0 or 1;R.sup.2 is lower alkyl;R.sup.3 is hydrogen; hydroxy; halogen; halo lower alkyl; lower alkyl; lower alkylamino; lower alkanoyl amino; lower alkanoyl lower alkylamino; lower alkoxy; lower alkoxy which is substituted with phenyl, phthalimido, pyranyl, amino, carboxy, lower alkoxycarbonyl, cyclo lower alkyl or cyclo lower alkyl which is substituted with amino lower alkyl or lower alkoxycarbonylamino lower alkyl; or cyclo lower alkyloxy or cyclo lower alkyloxy which is substituted with carboxy or lower alkoxycarbonyl;R.sup.4 is hydrogen or halogen, andR.sup.5 is hydrogen or halogen, with the provisoR.sup.1 is phenyl substituted with lower alkoxy, lower alkylamino, lower alkylthio, phenoxy, carboxy, lower alkoxycarbonyl, carboxyl lower alkyl or lower alkoxycarbonyl lower alkyl; lower alkyl or lower alkyl substituted with carboxy or lower alkoxycarbonyl; pyrimidinyl; pyridyl or pyridyl substituted with lower alkyl, when R.sup.3 is hydrogen or halogen, or a pharmaceutically acceptable salt thereof. The compounds and compositions containing the same are useful in the treatment of bone diseases.

    摘要翻译： 下式的化合物：其中R'是苯基，被卤素取代的苯基，低级烷基，低级烷氧基，卤代低级烷基，低级烷基氨基，低级烷硫基，苯氧基，羧基，低级烷氧基羰基，羧基低级烷基，低级 烷氧基羰基，低级烷基，环低级烷基; 被羧基或低级烷氧基氧基羰基取代的低级烷基; 或被低级烷基取代的嘧啶基，吡啶基或吡啶基; A是低级亚烷基; n为0或1的整数; R2是低级烷基; R3是氢; 羟基; 卤素; 卤代低级烷基; 低级烷基; 低级烷基氨基; 低级烷酰基氨基; 低级烷酰基低级烷基氨基; 低级烷氧基 被苯基，苯二甲酰亚氨基，吡喃基，氨基，羧基，低级烷氧基羰基，环低级烷基或被氨基低级烷基或低级烷氧基羰基氨基低级烷基取代的环低级烷基取代的低级烷氧基; 或被羧基或低级烷氧基羰基取代的环低级烷氧基或环低级烷氧基; R4为氢或卤素，R5为氢或卤素，条件是R1为被低级烷氧基，低级烷基氨基，低级烷硫基，苯氧基，羧基，低级烷氧基羰基，羧基低级烷基或低级烷氧基羰基低级烷基取代的苯基。 被羧基或低级烷氧基羰基取代的低级烷基或低级烷基; 嘧啶基; 吡啶基或吡啶基被低级烷基取代，当R3为氢或卤素时，或其药学上可接受的盐。 含有它们的化合物和组合物可用于治疗骨疾病。

    New aminopiperazine derivatives
    4.
    发明授权
    New aminopiperazine derivatives 失效
    新的氨基哌嗪衍生物

    公开(公告)号：US5250528A

    公开(公告)日：1993-10-05

    申请号：US957759

    申请日：1992-10-08

    申请人： Teruo Oku ,  Eishiro Todo ,  Yoshihiro Yokota ,  Hiroshi Kayakiri ,  Masashi Hashimoto

    发明人： Teruo Oku ,  Eishiro Todo ,  Yoshihiro Yokota ,  Hiroshi Kayakiri ,  Masashi Hashimoto

    IPC分类号： C07D295/28 ,  C07D295/32 ,  A61K31/495 ,  C07D403/06 ,  C07D409/06

    CPC分类号： C07D295/32 ,  C07D295/30

    摘要： This invention relates to new aminopiperazine derivatives having the potentiation of the cholinergic activity and represented by the general formula [I]: ##STR1## wherein R.sup.1 is lower alkyl, aryl, ar(lower)alkoxy or a heterocyclic group, each of which may be substituted with halogen,R.sup.2 is hydrogen or lower alkyl,R.sup.3 is cyclo(lower)alkyl, aryl or ar(lower)-alkyl, each of which may be substituted with halogen,A is ##STR2## or lower alkylene, and Y is ##STR3## and pharmaceutically acceptable salts thereof, to processes for the preparation thereof and to a pharmaceutical composition comprising the same.

    摘要翻译： 本发明涉及具有增强胆碱能活性并由通式[I]表示的新氨基哌嗪衍生物：其中R 1是低级烷基，芳基，芳（低级）烷氧基或杂环基，其各自为 其可以被卤素取代，R 2是氢或低级烷基，R 3是环（低级）烷基，芳基或芳（低级） - 烷基，其各自可以被卤素取代，A是低级亚烷基，和 Y是其和药学上可接受的盐，其制备方法和包含其的药物组合物。