公开(公告)号：US5423209A

公开(公告)日：1995-06-13

申请号：US249068

申请日：1994-05-25

申请人： Teruomi Nakaya ,  Masao Ebihara ,  Yoshio Hayashi ,  Seizo Suzuki ,  Naoaki Kuwano ,  Asao Hanzawa ,  Takashi Saitow ,  Mitsuo Usami ,  Toru Iwata

发明人： Teruomi Nakaya ,  Masao Ebihara ,  Yoshio Hayashi ,  Seizo Suzuki ,  Naoaki Kuwano ,  Asao Hanzawa ,  Takashi Saitow ,  Mitsuo Usami ,  Toru Iwata

IPC分类号： G01F1/46 ,  G01P5/16 ,  G01P5/165 ,  G01P13/02 ,  G01C21/00

CPC分类号： G01F1/46 ,  G01P13/025 ,  G01P5/165

摘要： A flight velocity detection system using a truncated pyramid-shape multi-e Pitot probe in which an extreme end portion has a truncated pyramid-shape, a cylindrical hole is provided at the apex thereof, a total pressure tube of a smaller diameter than that of the cylindrical hole is secured at a position by a predetermined length determined by a relationship with the diameter of the cylindrical hole from the extreme end of the cylindrical hole, and groups of pressure holes comprised of a plurality of pressure holes are arranged in each of the truncated pyramid surfaces of the truncated pyramid shape. Items of pressure information detected by the probe are input into a velocity vector processor to convert them into electric signals, and signals are processed using pressure coefficients of the holes of the probe with respect to the velocity vector stored in advance in the velocity vector processor to calculate flight velocity vector (V, .alpha., .beta.) with respect to the probe axis from the pressure information and air density.

摘要翻译： 使用截头棱锥形多孔皮托探头的飞行速度检测系统，其顶端具有截头棱锥形，圆柱形孔设置在其顶点，直径小于 圆柱形孔被固定在与圆柱形孔的前端与圆柱形孔的直径关系确定的预定长度的位置处，并且由多个压力孔组成的一组压力孔布置在 截头棱锥形截面金字塔表面。 由探头检测到的压力信息的项目被输入到速度矢量处理器中以将它们转换为电信号，并且使用相对于预先存储在速度矢量处理器中的速度向量的探针的孔的压力系数来处理信号， 从压力信息和空气密度计算相对于探针轴的飞行速度矢量（V，α，β）。

公开(公告)号：US4749898A

公开(公告)日：1988-06-07

申请号：US13523

申请日：1987-02-11

申请人： Seizo Suzuki ,  Teruomi Nakaya ,  Yoshio Hayashi

发明人： Seizo Suzuki ,  Teruomi Nakaya ,  Yoshio Hayashi

IPC分类号： H02K15/16 ,  B23Q1/54 ,  B25J9/10 ,  B25J9/14 ,  F16C23/10 ,  G05D3/00 ,  H01L21/00 ,  H01L41/09 ,  H02K7/075

CPC分类号： H01L21/67138 ,  B23Q1/5481 ,  B25J9/105 ,  B25J9/108 ,  B25J9/14 ,  F16C23/10 ,  H02K7/075 ,  H02N2/0095 ,  Y10T74/2111

摘要： A superprecision positioning device includes an output shaft rotor, a plurality of eccentric shaft rotors including an inner eccentric shaft rotor and an outer eccentric shaft rotor, and a bearing base cylinder, electrically rotating and driving mechanism portions being provided between the eccentric shaft rotor and the output shaft rotor, and between the outer eccentric shaft rotor and the bearing base cylinder, respectively, whereby the eccentric shaft rotors and the output shaft rotor may be independently rotated and controlled. With this arrangement, movement in three degrees of freedom may be achieved by translational movement and rotation of the output shaft in a two-dimensional surface, and if an axially movable support shaft is inserted in the output shaft, an article being positioned may be moved with four degrees of freedom in total, providing superprecision positioning in units of 1/10 micron.

摘要翻译： 超精度定位装置包括输出轴转子，包括内偏心轴转子和外偏心轴转子的多个偏心轴转子和轴承基座圆筒，电旋转和驱动机构部分设置在偏心轴转子和 输出轴转子和外偏心轴转子与轴承座圆筒之间，由此能够独立地旋转和控制偏心轴转子和输出轴转子。 通过这种布置，可以通过在二维表面中的输出轴的平移运动和旋转来实现三自由度的运动，并且如果轴向可移动的支撑轴插入输出轴中，则定位的物品可以移动 总共具有四个自由度，以1/10微米的单位提供超精密定位。

公开(公告)号：US20070127349A1

公开(公告)日：2007-06-07

申请号：US11560758

申请日：2006-11-16

申请人： Tohru Hotta ,  Yoshio Hayashi ,  Noriyoshi Ooyama ,  Kiyotaka Eizumi

发明人： Tohru Hotta ,  Yoshio Hayashi ,  Noriyoshi Ooyama ,  Kiyotaka Eizumi

IPC分类号： G11B7/00

CPC分类号： G11B7/1381 ,  G11B7/0903 ,  G11B7/1275 ,  G11B7/1353 ,  G11B2007/0006

摘要： An optical pickup apparatus comprising: a diffraction grating including a first grating for diffracting a first laser light beam, and a second grating for diffracting a second laser light beam which is shorter in wavelength than the first laser light beam, the diffraction grating being disposed in a common optical path for guiding the first laser light beam and the second laser light beam to an optical disc; and a photo detector including in a first light receiving area, a main light receiving unit, a front sub-light receiving unit, and a rear sub-light receiving unit that receive reflected light beams, which are reflected by the optical disc, of a main beam, of a front sub-beam, and of a rear sub-beam, respectively, the first laser light beam being diffracted by the diffraction grating into the main beam, the front sub-beam formed in front of the main beam, and the rear sub-beam formed at the back of the main beam, wherein the first grating is set such that the front sub-light receiving unit and the rear sub-light receiving unit in the first light receiving area are disposed at positions which substantially avoid unnecessary diffracted light beam spots which are generated by projecting to the first light receiving area unnecessary diffracted light beams, the unnecessary diffracted light beams generated by the second grating from the first laser light beam.

摘要翻译： 一种光学拾取装置，包括：衍射光栅，包括用于衍射第一激光束的第一光栅和用于衍射比第一激光束波长短的第二激光束的第二光栅，所述衍射光栅设置在 用于将第一激光束和第二激光束引导到光盘的公共光路; 以及光接收单元，其包括在第一受光区域，主光接收单元，前副光接收单元和后副光接收单元中的光检测器，其接收由光盘反射的反射光束， 主子束，前子光束和后副光束，第一激光束被衍射光栅衍射成主光束，形成在主光束前面的前子光束，以及 形成在主光束后部的后副光束，其中第一光栅被设置为使得第一光接收区域中的前子光接收单元和后副光接收单元被设置在基本避免的位置 通过向第一光接收区域投射不需要的衍射光束而产生的不必要的衍射光束点，由第二光栅从第一激光束产生的不需要的衍射光束。

公开(公告)号：US07026322B2

公开(公告)日：2006-04-11

申请号：US10632688

申请日：2003-08-01

申请人： Yoshio Hayashi ,  Michael A. Palladino, Jr. ,  Jennifer Grodberg

发明人： Yoshio Hayashi ,  Michael A. Palladino, Jr. ,  Jennifer Grodberg

IPC分类号： C07D241/06 ,  C07D241/08 ,  A61K31/496 ,  A61K31/00

CPC分类号： C07D403/06 ,  A61K31/496

摘要： Methods of using a compound, its pharmaceutically acceptable salts, and/or its pro-drug esters, in isolated form, to treat cancer, and methods for isolating, for formulating, and for administering the compound, salt, and/or pro-drug ester as an antitumor agent, wherein the compound, salt, or pro-drug ester has the following structure: wherein: R1, R2, R5, R7, and R8 are each separately selected from the group consisting of a hydrogen atom, a halogen atom, and saturated C1-C24 alkyl, unsaturated C1-C24 alkenyl, cycloalkyl, cycloalkenyl, alkoxy, cycloalkoxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, amino, substituted amino, nitro, substituted nitro, phenyl, and substituted phenyl groups, R3, R4, and R6 are each separately selected from the group consisting of a hydrogen atom, a halogen atom, and saturated C1-C12 alkyl, unsaturated C1-C12 alkenyl, cycloalkyl, alkoxy, cycloalkoxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, amino, substituted amino, nitro, and substituted nitro groups, X1 and X2 are separately selected from the group consisting of an oxygen atom, and a sulfur atom, and the dashed bond represents a bond selected from the group consisting of a carbon-carbon single bond and a carbon-carbon double bond. Most preferably, R3 and R4 are hydrogen, and each are involved in hydrogen bonds, and/or the dashed bond is a double bond, such that the chemical backbone of the compound substantially retains a substantially planar conformation.

公开(公告)号：US20050007899A1

公开(公告)日：2005-01-13

申请号：US10830748

申请日：2004-04-23

申请人： Yoshio Hayashi ,  Atsuhiro Hanaoka

发明人： Yoshio Hayashi ,  Atsuhiro Hanaoka

IPC分类号： G11B7/09 ,  G11B7/00 ,  G11B7/095 ,  G11B7/125

CPC分类号： G11B7/0932 ,  G11B7/0956

摘要： An optical head device including a lens holder which holds an objective lens, six wires for supporting the lens holder and a holder support member which movably supports the lens holder by the six wires in a tracking, focusing and tilt direction. The six wires comprise two pairs, each of the pairs comprising a composite wire composed of two wires and a single wire composed of one wire which are respectively disposed on an upper side and a lower side of the lens holder in the focusing direction. The spring constant of the composite wire is set to be approximately equal to a spring constant of the single wire. Alternatively, the six wires may be disposed on the same circumference with respect to a drive center in the tilt direction or the spring constant of one wire of the pair may be set to be smaller than spring constants of the other two wires of the pair.

摘要翻译： 一种光学头装置，包括保持物镜的透镜保持器，用于支撑透镜保持器的六根电线和通过六根电线在跟踪，聚焦和倾斜方向上可移动地支撑透镜架的保持器支撑构件。 六条线包括两对，每对包括由两条线组成的复合线和由聚焦方向分别设置在透镜保持器的上侧和下侧的一根线组成的单根线。 复合线的弹簧常数设定为大致等于单线的弹簧常数。 或者，六根线可以相对于倾斜方向上的驱动中心设置在相同的圆周上，或者该对中的一根线的弹簧常数可以被设置为小于该对中的另外两根线的弹簧常数。

公开(公告)号：US5761174A

公开(公告)日：1998-06-02

申请号：US523147

申请日：1995-09-05

申请人： Tadashi Takeda ,  Yoshio Hayashi ,  Ikuo Kasuga ,  Kazuo Higashiura ,  Noriyuki Satoh ,  Hisahiro Ishihara

发明人： Tadashi Takeda ,  Yoshio Hayashi ,  Ikuo Kasuga ,  Kazuo Higashiura ,  Noriyuki Satoh ,  Hisahiro Ishihara

IPC分类号： G11B7/09 ,  G11B7/135

CPC分类号： G11B7/0916 ,  G11B7/0903 ,  G11B7/0908 ,  G11B7/1353 ,  G11B7/1381

摘要： An optical pickup device includes a light source irradiating a record medium with plural light spots of light emitted therefrom, a plurality of light detecting elelments to which reflected light of the light spots are guided, respectively, to adequately synthesize and compare outputs of said light detecting elements, thereby reading information recorded in tracks of the record medium, and detecting an tracking error and a focusing error, and a hologram element which splits light emitted from the light source into plural beams is disposed in an optical path between the light source and the record medium, said hologram element is split by a split line, said split line elongating in a direction perpendicular to a track of the medium on an optical axis, and a hologram pattern having a diffraction function which is substantially directed in the track direction is disposed on at least one side of said split line, thereby differentiating diffraction conditions on both sides of said split line from each other.

摘要翻译： 一种光学拾取装置包括：一个光源，用于照射具有从其发出的光的多个光点的记录介质，分别引导光点的反射光的多个光检测元件，以充分合成并比较所述光检测的输出 从而读取记录在记录介质的轨道中的信息，并且检测跟踪误差和聚焦误差，并且将从光源发射的光分解成多个光束的全息元件设置在光源和光源之间的光路中 记录介质，所述全息元件被分割线分开，所述分割线在垂直于光轴上的介质的轨道的方向上延伸，并且设置具有基本上指向轨道方向的衍射函数的全息图图案 在所述分割线的至少一侧上，从而使所述分割线的两侧的衍射条件有差异 从彼此。

公开(公告)号：US5401756A

公开(公告)日：1995-03-28

申请号：US190609

申请日：1994-02-02

申请人： Akihiro Yamamoto ,  Shuji Morita ,  Yoshio Hayashi ,  Noboru Yamada ,  Toshihito Kitamura

发明人： Akihiro Yamamoto ,  Shuji Morita ,  Yoshio Hayashi ,  Noboru Yamada ,  Toshihito Kitamura

IPC分类号： C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06 ,  A61K31/405 ,  A61K31/44

CPC分类号： C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06

摘要： Benzamide platelet activating factor antagonists of the following formula (I): ##STR1## wherein ##STR2## B, D: hydrogen atom, etc. E: pyridyl group, etc.n: integer from 0 to 2R.sup.2 : R.sup.3 R.sup.4 N-- etc.(R.sup.3, R.sup.4 : optionally substituted C.sub.6 -C.sub.12 aryl group, etc.) ##STR3## optical antipodes thereof or pharmaceutically acceptable salts thereof, show excellent PAF antagonism and are effective for therapy and prophylaxis of diseases caused by PAF (bronchial asthma, nephritis, shocks, cardiac infarction, cerebral hemorrhage, ulcer, DIC, autoimmune diseases, thrombosis, etc.).

摘要翻译： 下列通式（I）的苯甲酰胺血小板活化因子拮抗剂：其中B，D：氢原子等。E：吡啶基等n：0-2的整数R2：R3R4N- 等等（R3，R4：任选取代的C 6 -C 12芳基等）NCH，CHCH或CH 2 CH 2; 其光学对映体或其药学上可接受的盐显示出优异的PAF拮抗作用，并且有效治疗和预防由PAF引起的疾病（支气管哮喘，肾炎，休克，心肌梗塞，脑出血，溃疡，DIC，自身免疫性疾病，血栓形成等） ）。

公开(公告)号：US5116858A

公开(公告)日：1992-05-26

申请号：US514832

申请日：1990-04-26

申请人： Yoshio Hayashi ,  Yasuhiro Morinaka ,  Masaki Shinoda ,  Hiroyoshi Nishi ,  Kazutoshi Watanabe ,  Nobuko Fukushima

发明人： Yoshio Hayashi ,  Yasuhiro Morinaka ,  Masaki Shinoda ,  Hiroyoshi Nishi ,  Kazutoshi Watanabe ,  Nobuko Fukushima

IPC分类号： A61K31/415 ,  A61P25/28 ,  A61P43/00 ,  C07D233/70

CPC分类号： C07D233/70

摘要： 4-Imidazoline derivatives represented by the formula (I) and/or formula (II): ##STR1## wherein R.sup.1 represents C.sub.1 -C.sub.8 alkyl, C.sub.3 -C.sub.8 alkenyl, C.sub.3 -C.sub.8 alkynyl, C.sub.3 -C.sub.8 cycloalkyl, or optionally substituted aralkyl; R.sup.2 and R.sup.3 independently represent hydrogen, C.sub.3 -C.sub.20 alkyl, C.sub.3 -C.sub.20 alkenyl, C.sub.3 -C.sub.20 alkynyl, C.sub.3 -C.sub.20 alkoxy, C.sub.3 -C.sub.20 alkenyloxy, C.sub.3 -C.sub.20 alkynyloxy, C.sub.3 -C.sub.8 cyloalkyl, C.sub.1 -C.sub.10 alkylthio, or optionally substituted aralkyl or aralkyloxy; R.sup.4 represents C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.8 cycloalkyl, or optionally substituted aralkyl; provided that R.sup.2 and R.sup.3 cannot be hydrogen at the same time, and pharmaceutically acceptable salts thereof. A pharmaceutical formulation containing the compound is also provided.

公开(公告)号：US4699921A

公开(公告)日：1987-10-13

申请号：US763618

申请日：1985-08-08

申请人： Masakatsu Shibasaki ,  Mikiko Sodeoka ,  Yuji Ogawa ,  Toshiaki Mase ,  Akira Ishibashi ,  Daijiro Horii ,  Toshiji Kanayama ,  Katsuhiko Iseki ,  Masaki Shinoda ,  Chiyoko Ishiyama ,  Yoshio Hayashi

发明人： Masakatsu Shibasaki ,  Mikiko Sodeoka ,  Yuji Ogawa ,  Toshiaki Mase ,  Akira Ishibashi ,  Daijiro Horii ,  Toshiji Kanayama ,  Katsuhiko Iseki ,  Masaki Shinoda ,  Chiyoko Ishiyama ,  Yoshio Hayashi

IPC分类号： C07C59/46 ,  A61K31/557 ,  A61P1/04 ,  A61P7/02 ,  A61P9/00 ,  A61P9/08 ,  A61P9/12 ,  C07C51/00 ,  C07C67/00 ,  C07C69/732 ,  C07C405/00

CPC分类号： C07C405/0083 ,  A61K31/557 ,  Y02P20/55

摘要： Disclosed is a pharmaceutical composition having circulation ameliorating effect and antiulcer effect containing a prostaglandin I.sub.2 analogue represented by the formula shown below or a non-toxic salt or a cyclodextrin inclusion compound thereof as the effective ingredient: ##STR1## wherein R.sup.1 represents a hydrogen atom, an alkyl group having 1 to 12 carbon atoms, a cycloalkyl group having 4 to 7 carbon atoms or a phenyl group, A represents a pentyl group, a cyclopentyl group, a cyclohexyl group, a 1-methyl-3-hexynyl group, a 2-methyl-3-hexynyl group, a 1-methylhexyl group, a 2-phenethyl group, a 1,1-dimethylpentyl group, a 2-methylpentyl group, a 1-cyclohexylethyl group, a 2-methylhexyl group, a 1-methyl-3-pentynyl group or a 2,6-dimethyl-5-heptenyl group; the double bond between the carbon atoms at 4- and 5-positions is E or Z or a mixture thereof; the asymmetric center in the substituent represented by A is in the R-configuration or the S-configuration or a mixture thereof.Pharmaceutical compositions containing, as an active ingredient, prostaglandin I.sub.2 analogues of the present invention have potent platelet aggregation inhibiting effect, blood pressure depressing effect, vasodilative effect and antiulcer effect, and are also low in toxicity.

摘要翻译： 本发明公开了一种具有循环改善作用和抗溃疡效果的药物组合物，其含有下述式表示的前列腺素I 2类似物或其无毒性盐或环糊精包合物作为有效成分：其中R 1表示氢原子， 碳原子数1〜12的烷基，碳原子数4〜7的环烷基或苯基，A表示戊基，环戊基，环己基，1-甲基-3-己炔基，2 1-甲基-3-己炔基，1-甲基己基，2-苯乙基，1,1-二甲基戊基，2-甲基戊基，1-环己基乙基，2-甲基己基，1-甲基 -3-戊炔基或2,6-二甲基-5-庚烯基; 4-和5-位的碳原子之间的双键是E或Z或它们的混合物; 由A表示的取代基中的不对称中心是R构型或S-构型或其混合物。 含有本发明的前列腺素I2类似物作为活性成分的药物组合物具有有效的血小板聚集抑制作用，降血压作用，血管扩张作用和抗溃疡作用，毒性也低。

公开(公告)号：US4376816A

公开(公告)日：1983-03-15

申请号：US276870

申请日：1981-06-25

申请人： Yoshio Hayashi ,  Akira Onuma ,  Tetsuo Shiga

发明人： Yoshio Hayashi ,  Akira Onuma ,  Tetsuo Shiga

IPC分类号： G03C1/498 ,  G03C3/00 ,  G03C5/24 ,  B65B35/50 ,  B65D85/48

CPC分类号： G03C3/00 ,  G03C1/49881

摘要： A method for storing sheets of a photothermographic sheet material composed of a high molecular weight compound support and a sensitive emulsion comprising, as the indispendable constituents, an organic silver salt oxidizing agent, a reducing agent for silver ion, a photosensitive silver salt compound or its precursor, and a binder, characterized by inserting paper having smooth surfaces between every two sheets of said photothermographic sheet material. By this method, the photothermographic sheet material can be stored for a long period of time without deterioration of quality.

摘要翻译： 一种用于存储由高分子量化合物载体和感光乳剂组成的光热敏成像片材的片材的方法，其包含作为不可避免的成分的有机银盐氧化剂，银离子还原剂，感光性银盐化合物或其 前体和粘合剂，其特征在于在每两片所述光热敏成像片材之间插入具有光滑表面的纸。 通过该方法，可以长时间保存光热敏照相片材，而不会降低质量。