公开(公告)号：US06474229B2

公开(公告)日：2002-11-05

申请号：US09824756

申请日：2001-04-04

申请人： Tetsuo Yano ,  Yasunori Ohta ,  Tetsuya Kudoh

发明人： Tetsuo Yano ,  Yasunori Ohta ,  Tetsuya Kudoh

IPC分类号： B44C124

CPC分类号： B44B5/0066

摘要： A marking device includes a marking mechanism, a marking portion moving mechanism, and a pressure adjusting circuit. The marking mechanism marks a surface to be processed, of an object to be marked, by reciprocating a marking portion. The marking portion moving mechanism moves the marking portion in two-dimensional directions along the surface to be processed. The pressure adjusting circuit keeps a constant pressure which the marking portion applies to the surface to be processed. The marking mechanism includes a cam mechanism for linearly reciprocating the marking portion by following a cam which is rotated by a driving member.

摘要翻译： 标记装置包括标记机构，标记部分移动机构和压力调节电路。 标记机构通过使标记部分往复运动而标记待加工物体的待标记物体。 标记部移动机构沿着被处理面向二维方向移动标记部。 压力调节电路保持标记部分施加到被处理表面的恒定压力。 标记机构包括用于通过跟随由驱动构件旋转的凸轮使标记部线性往复运动的凸轮机构。

公开(公告)号：US20120329846A1

公开(公告)日：2012-12-27

申请号：US13431183

申请日：2012-03-27

申请人： Hideki Matsumoto ,  Tomohisa Okutsu ,  Tomoko Takeda ,  Hideki Suzuki ,  Tetsuo Yano ,  Masaki Hashimoto ,  Miho Ono ,  Manabu Suzuki

发明人： Hideki Matsumoto ,  Tomohisa Okutsu ,  Tomoko Takeda ,  Hideki Suzuki ,  Tetsuo Yano ,  Masaki Hashimoto ,  Miho Ono ,  Manabu Suzuki

IPC分类号： A61K31/198 ,  C07D233/64 ,  C07C323/58 ,  C07D209/16 ,  C07C229/24 ,  A61P29/00 ,  C07C229/36 ,  A61K31/4172 ,  A61K31/195 ,  A61K31/405 ,  A61P1/00 ,  C07C229/26 ,  C07C229/08

CPC分类号： A61K31/198 ,  A61K31/405 ,  A61K31/4172 ,  Y02A50/411 ,  A61K2300/00

摘要： Disclosed is an agent for use in the treatment or prevention of inflammatory bowel disease. Also disclosed is an agent for inhibiting the production of TNF-α. A therapeutic or prophylactic agent for inflammatory bowel disease comprising at least one amino acid selected from the group consisting of lysine, histidine, phenylalanine, methionine, tryptophan, glutamine, glycine, cysteine, cystine and threonine, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day; and a TNF-α production inhibitor comprising an amino acid selected from the group consisting of histidine, phenylalanine and tryptophan, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day.

摘要翻译： 公开了用于治疗或预防炎症性肠病的药剂。 还公开了抑制TNF-α产生的药剂。 包含至少一种选自赖氨酸，组氨酸，苯丙氨酸，甲硫氨酸，色氨酸，谷氨酰胺，甘氨酸，半胱氨酸，胱氨酸和苏氨酸的氨基酸的炎症性肠病治疗或预防剂，所述氨基酸以 每日0.1〜4000mg / kg; 和包含选自组氨酸，苯丙氨酸和色氨酸的氨基酸的TNF-α产生抑制剂，所述氨基酸以每天0.1至4000mg / kg的剂量施用。

公开(公告)号：US20070249717A1

公开(公告)日：2007-10-25

申请号：US11740541

申请日：2007-04-26

申请人： Tetsuo Yano ,  Masaki Hashimoto ,  Smriga Miroslav ,  Hisayuki Uneyama ,  Kunio Torii

发明人： Tetsuo Yano ,  Masaki Hashimoto ,  Smriga Miroslav ,  Hisayuki Uneyama ,  Kunio Torii

IPC分类号： A61K31/198

CPC分类号： A61K31/198 ,  A23L33/175

摘要： The present invention provides an agent for the prophylaxis or treatment of visceral pain associated with gastrointestinal tract diseases, which contains lysine. Using the prophylactic or therapeutic agent, gastrointestinal tract diseases accompanying visceral pain, such as intestinal disorder, irritable bowel syndrome, functional dyspepsia, gastro esophageal disease, functional abdominal pain syndrome, ulcerative colitis and Crohn's disease and the like can be lo treated or prevented. In addition, pharmaceutical agent, food and drink and dietary supplement for the prophylaxis or treatment of visceral pain associated with such gastrointestinal tract diseases are provided. They are highly effective for visceral pain associated with gastrointestinal tract diseases as compared to existing pharmaceutical agents, show reduced side effects, and are highly effective.

摘要翻译： 本发明提供了用于预防或治疗与包含赖氨酸的胃肠道疾病相关的内脏疼痛的药剂。 使用预防或治疗剂，可以治疗或预防伴随内脏痛，诸如肠障，肠易激综合征，功能性消化不良，胃食管疾病，功能性腹痛综合征，溃疡性结肠炎和克罗恩病等的胃肠道疾病。 此外，还提供了用于预防或治疗与这种胃肠道疾病相关的内脏痛的药剂，食物和饮料和膳食补充剂。 与现有的药剂相比，它们与胃肠道疾病相关的内脏痛具有高度的效果，显示出减少的副作用，并且是非常有效的。

公开(公告)号：US20070021460A1

公开(公告)日：2007-01-25

申请号：US10557353

申请日：2004-05-19

申请人： Shingo Makino ,  Naoyuki Fukuchi ,  Sayaka Asari ,  Masaki Hashimoto ,  Tetsuo Yano ,  Youji Yamada ,  Munetaka Tokumasu ,  Masataka Shoji ,  Itsuya Tanabe ,  Shinichi Fujita ,  Hideki Matsumoto

发明人： Shingo Makino ,  Naoyuki Fukuchi ,  Sayaka Asari ,  Masaki Hashimoto ,  Tetsuo Yano ,  Youji Yamada ,  Munetaka Tokumasu ,  Masataka Shoji ,  Itsuya Tanabe ,  Shinichi Fujita ,  Hideki Matsumoto

IPC分类号： C07D211/26 ,  C07D211/28 ,  A61K31/445

CPC分类号： C07D211/70

摘要： The present invention provides a piperidine derivative represented by the following formula or analogs thereto, which are used for agents for treating or preventing various diseases related to 5-HT7.

摘要翻译： 本发明提供由下式表示的哌啶衍生物或其类似物，其用于治疗或预防与5-HT7相关的各种疾病的药剂。

公开(公告)号：US06465756B2

公开(公告)日：2002-10-15

申请号：US09790534

申请日：2001-02-23

申请人： Yasuhiro Tanaka ,  Shosuke Miyaki ,  Tetsuo Yano

发明人： Yasuhiro Tanaka ,  Shosuke Miyaki ,  Tetsuo Yano

IPC分类号： B23K2600

CPC分类号： B44B5/0066

摘要： A laser beam 7 from an engravement portion softening mechanism 6 of an apparatus is condensed onto an engravement portion on an engravement surface of a workpiece 1 for softening the engravement portion. When the hardness of the engravement portion is lowered, a pen tip 2 of the apparatus is applied to the engravement portion. Thus, it is possible to reduce reliably wear and damage of the pen tip 2 which results from engraving a hard workpiece, and to prolong the useful life of the pen tip 2, so that the durability and the reliability of the apparatus are improved.

摘要翻译： 来自设备的雕刻部分软化机构6的激光束7被冷凝到工件1的雕刻表面上的雕刻部分上，用于软化雕刻部分。 当雕刻部分的硬度降低时，该装置的笔尖2被施加到雕刻部分。 因此，可以可靠地减少由刻印硬质工件引起的笔尖2的磨损和损伤，并且延长笔尖2的使用寿命，从而提高了装置的耐久性和可靠性。

公开(公告)号：US08796485B2

公开(公告)日：2014-08-05

申请号：US13079273

申请日：2011-04-04

申请人： Masayuki Sugiki ,  Toru Okamatsu ,  Sayaka Asari ,  Yayoi Kawato ,  Toshihiro Hatanaka ,  Tetsuo Yano ,  Yukie Seki ,  Naohiro Miyamura ,  Hiroaki Nagasaki ,  Yuzuru Eto ,  Reiko Yasuda

发明人： Masayuki Sugiki ,  Toru Okamatsu ,  Sayaka Asari ,  Yayoi Kawato ,  Toshihiro Hatanaka ,  Tetsuo Yano ,  Yukie Seki ,  Naohiro Miyamura ,  Hiroaki Nagasaki ,  Yuzuru Eto ,  Reiko Yasuda

IPC分类号： A23L1/228 ,  C07C237/04 ,  C07C309/51 ,  C07F9/40 ,  C07F9/38 ,  A23L1/305

CPC分类号： C07C237/04 ,  A23L27/204 ,  A23L27/22 ,  A23L33/175 ,  C07C309/51 ,  C07F9/3834 ,  C07F9/4018 ,  C07F9/4021

摘要： By searching various kinds of compounds having CaSR agonistic activity, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise the compound. More specifically, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise a glutamic acid derivative having CaSR agonistic activity or pharmaceutically acceptable salts thereof.

摘要翻译： 通过搜索具有CaSR激动活性的各种化合物，本发明提供了各自包含该化合物的CaSR激动剂，药物组合物，用于腹泻和诱导剂的预防或治疗剂。 更具体地，本发明提供了CaSR激动剂，药物组合物，用于腹泻和赋予Kokumi的预防或治疗剂，其各自包含具有CaSR激动活性的谷氨酸衍生物或其药学上可接受的盐。

公开(公告)号：US08168669B2

公开(公告)日：2012-05-01

申请号：US12491698

申请日：2009-06-25

申请人： Hideki Matsumoto ,  Tomohisa Okutsu ,  Tomoko Takeda ,  Hideki Suzuki ,  Tetsuo Yano ,  Masaki Hashimoto ,  Miho Ono ,  Manabu Suzuki

发明人： Hideki Matsumoto ,  Tomohisa Okutsu ,  Tomoko Takeda ,  Hideki Suzuki ,  Tetsuo Yano ,  Masaki Hashimoto ,  Miho Ono ,  Manabu Suzuki

IPC分类号： A61K31/197 ,  A61K31/4172 ,  A61K31/4184

CPC分类号： A61K31/198 ,  A61K31/405 ,  A61K31/4172 ,  Y02A50/411 ,  A61K2300/00

摘要： Disclosed is an agent for use in the treatment or prevention of inflammatory bowel disease. Also disclosed is an agent for inhibiting the production of TNF-α. A therapeutic or prophylactic agent for inflammatory bowel disease comprising at least one amino acid selected from the group consisting of lysine, histidine, phenylalanine, methionine, tryptophan, glutamine, glycine, cysteine, cystine and threonine, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day; and a TNF-α production inhibitor comprising an amino acid selected from the group consisting of histidine, phenylalanine and tryptophan, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day.

摘要翻译： 公开了用于治疗或预防炎症性肠病的药剂。 还公开了抑制TNF-α产生的药剂。 包含至少一种选自赖氨酸，组氨酸，苯丙氨酸，甲硫氨酸，色氨酸，谷氨酰胺，甘氨酸，半胱氨酸，胱氨酸和苏氨酸的氨基酸的炎症性肠病治疗或预防剂，所述氨基酸以 每日0.1〜4000mg / kg; 和包含选自组氨酸，苯丙氨酸和色氨酸的氨基酸的TNF-α产生抑制剂，所述氨基酸以每天0.1至4000mg / kg的剂量施用。

公开(公告)号：US20100105864A1

公开(公告)日：2010-04-29

申请号：US12613727

申请日：2009-11-06

申请人： Junya Yoneda ,  Tetsuo Yano ,  Yukie Seki ,  Yuzuru Eto ,  Yusuke Amino

发明人： Junya Yoneda ,  Tetsuo Yano ,  Yukie Seki ,  Yuzuru Eto ,  Yusuke Amino

IPC分类号： C07K5/08 ,  C07C211/02 ,  C07K2/00 ,  C07K4/00 ,  C07K5/06

CPC分类号： A61K31/137 ,  A61K38/00 ,  C07K5/0215 ,  C07K5/06026 ,  C07K5/06043 ,  C07K5/0606 ,  C07K5/06104 ,  C07K5/06113

摘要： A compound which is able to activate a calcium receptor can be used as an active ingredient of a prophylactic or therapeutic agent for treating diarrhea. The compound can be a peptide such as γ-Glu-X-Gly (X represents an amino acid or an amino acid derivative), γ-Glu-Val-Y (Y represents an amino acid or an amino acid derivative), γ-Glu-Ala, γ-Glu-Gly, γ-Glu-Cys, γ-Glu-Met, γ-Glu-Thr, γ-Glu-Val, γ-Glu-Orn, Asp-Gly, Cys-Gly, Cys-Met, Glu-Cys, Gly-Cys, Leu-Asp, γ-Glu-Met(O), γ-Glu-γ-Glu-Val, γ-Glu-Val-NH2, γ-Glu-Val-ol, γ-Glu-Ser, γ-Glu-Tau, γ-Glu-Cys(S-Me)(O), γ-Glu-Leu, γ-Glu-Ile, γ-Glu-t-Leu, and γ-Glu-Cys(S-Me).

摘要翻译： 能够激活钙受体的化合物可以用作治疗腹泻的预防或治疗剂的活性成分。 该化合物可以是γ-Glu-X-Gly（X表示氨基酸或氨基酸衍生物），γ-Glu-Val-Y（Y表示氨基酸或氨基酸衍生物），γ- Glu-Ala，γ-Glu-Gly，γ-Glu-Cys，γ-Glu-Met，γ-Glu-Thr，γ-Glu-Val，γ-Glu-Orn，Asp-Gly，Cys-Gly， Met，Glu-Cys，Gly-Cys，Leu-Asp，γ-Glu-Met（O），γ-Glu-γ-Glu-Val，γ-Glu-Val-NH2，γ-Glu-Val- -Glu-Ser，γ-Glu-Tau，γ-Glu-Cys（S-Me）（O），γ-Glu-Leu，γ-Glu-Ile，γ-Glu-t-Leu和γ-Glu- Cys（S-Me）。

公开(公告)号：US20080108684A1

公开(公告)日：2008-05-08

申请号：US11968343

申请日：2008-01-02

申请人： HIDEKI MATSUMOTO ,  Tomohisa Okutsu ,  Tomoko Takeda ,  Hideki Suzuki ,  Tetsuo Yano ,  Masaki Hashimoto ,  Miho Ono ,  Manabu Suzuki

发明人： HIDEKI MATSUMOTO ,  Tomohisa Okutsu ,  Tomoko Takeda ,  Hideki Suzuki ,  Tetsuo Yano ,  Masaki Hashimoto ,  Miho Ono ,  Manabu Suzuki

IPC分类号： A61K31/4172 ,  A61K31/405 ,  A61K31/198

CPC分类号： A61K31/198 ,  A61K31/405 ,  A61K31/4172 ,  Y02A50/411 ,  A61K2300/00

摘要： Disclosed is an agent for use in the treatment or prevention of inflammatory bowel disease. Also disclosed is an agent for inhibiting the production of TNF-α. A therapeutic or prophylactic agent for inflammatory bowel disease comprising at least one amino acid selected from the group consisting of lysine, histidine, phenylalanine, methionine, tryptophan, glutamine, glycine, cysteine, cystine and threonine, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day; and a TNF-α production inhibitor comprising an amino acid selected from the group consisting of histidine, phenylalanine and tryptophan, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day.

摘要翻译： 公开了用于治疗或预防炎症性肠病的药剂。 还公开了抑制TNF-α产生的药剂。 包含至少一种选自赖氨酸，组氨酸，苯丙氨酸，甲硫氨酸，色氨酸，谷氨酰胺，甘氨酸，半胱氨酸，胱氨酸和苏氨酸的氨基酸的炎症性肠病治疗或预防剂，所述氨基酸以 每日0.1〜4000mg / kg; 和包含选自组氨酸，苯丙氨酸和色氨酸的氨基酸的TNF-α产生抑制剂，所述氨基酸以每天0.1至4000mg / kg的剂量施用。

公开(公告)号：US4119463A

公开(公告)日：1978-10-10

申请号：US678715

申请日：1976-04-20

申请人： Shigeru Iguchi ,  Tamotu Iwata ,  Tetsuo Yano

发明人： Shigeru Iguchi ,  Tamotu Iwata ,  Tetsuo Yano

IPC分类号： G03C1/04 ,  G03C1/053 ,  G03C1/76 ,  G03C3/00

CPC分类号： G03C1/053

摘要： A photographic binder prepared by heating a mixed aqueous solution of styrene-maleic anhydride copolymer, isobutylene-maleic anhydride copolymer and polyvinyl alcohol in acidic state makes it possible to coat a photographic coating liquid for forming photographic layers in the same manner as in the case of using gelatin and furthermore gives excellent physical properties to the resultant photographic layers.

摘要翻译： 通过在酸性状态下加热苯乙烯 - 马来酸酐共聚物，异丁烯 - 马来酸酐共聚物和聚乙烯醇的混合水溶液制备的照相粘合剂使得可以以与以下相同的方式涂覆用于形成照相层的照相涂布液： 使用明胶，并且还对所得照相层提供优异的物理性能。