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公开(公告)号：US07988991B2
公开(公告)日：2011-08-02
申请号：US10469612
申请日：2002-03-07
IPC分类号： A61F13/02
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K31/216 , A61K31/48 , A61K47/32
摘要： A patch agent of the present invention comprises a support, and an adhesive layer laid on the support and containing an adhesive base and a drug, wherein the adhesive base contains an acrylic polymer substantially having no carboxyl and no hydroxyl in molecules thereof, and a rubber-based polymer, so as to achieve sufficiently high skin permeability of the drug and preparation properties. Accordingly, the present invention enables administration of the drug through skin to be implemented with drug administration effect at a sufficiently high level and on a stable basis.
摘要翻译： 本发明的贴剂包括载体和铺设在载体上并含有粘合剂基质和药物的粘合剂层，其中所述粘合剂基底含有基本上不含羧基的丙烯酸聚合物，并且在其分子中不含羟基，并且橡胶 的聚合物，以达到足够高的药物的皮肤渗透性和制备性能。 因此，本发明能够以足够高的水平和稳定的基础通过皮肤进行药物给药作用的施用。
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公开(公告)号：US20080038328A1
公开(公告)日：2008-02-14
申请号：US11597517
申请日：2005-05-30
IPC分类号： A61K9/70 , A61K31/216 , A61K31/445 , A61K31/48 , A61K47/12 , A61K47/30
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K47/12
摘要： The patch preparation of the present invention is a patch preparation comprising a backing and an adhesive layer provided on the backing; wherein, the adhesive layer contains (A) a volatile organic acid and (B) a basic drug; the molar concentration ratio [(MA)/(MB)] between the molar concentration (MA) of the component (A) and the molar concentration (MB) of the component (B) in the adhesive layer is 0.5 or more; and the component (B) contains a basic drug formed as an ion pair with an anion component.
摘要翻译： 本发明的贴片制剂是一种贴片制剂，其包括背衬和设置在背衬上的粘合剂层; 其中粘合剂层含有（A）挥发性有机酸和（B）碱性药物; 组分（A）的摩尔浓度（M SUB A）之间的摩尔浓度比[（M SUB）/（M B B）] 粘合剂层中组分（B）的摩尔浓度（M B B）为0.5以上; 并且组分（B）含有形成为具有阴离子组分的离子对的碱性药物。
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公开(公告)号：USRE45936E1
公开(公告)日：2016-03-22
申请号：US12108934
申请日：2008-04-24
CPC分类号： A61K9/7061 , A61K9/7069
摘要： An adhesive which comprises aqueous and nonaqueous polymers suitable for holding an lipophilic drug, etc., and has tackiness and cohesiveness which are sufficient for the plaster of a patch; and a patch employing the adhesive. The adhesive contains a polymer which comprises one or more kinds of acrylic or methacrylic monomer units, at least one kind of the monomer units having a hydroxy group, and which has been crosslinked with a boron compound.
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4.发明申请Patch for External Use with Elevated Content of Absorption Promoter in Pressure-Sensitive Adhesive Base 审中-公开吸附促进剂在压敏粘合剂基质中含量高的外用补片公开(公告)号：US20080226697A1
公开(公告)日：2008-09-18
申请号：US11578892
申请日：2005-04-21
IPC分类号： A61K9/70 , A61K31/216
CPC分类号： A61K9/7053 , A61K9/7061 , A61K31/216 , A61K47/12 , A61K47/32
摘要： A pressure-sensitive adhesive composition for transdermal absorption which contains a drug and a transdermal absorption promoter for the drug, characterized by further containing polyvinylpyrrolidone so as to stabilize the transdermal absorption promoter contained in the adhesive composition. Thus, the transdermal absorption promoter can be prevented from vaporization or degradation and a patch for external use containing the transdermal absorption promoter at a high concentration in using can be provided.
摘要翻译： 一种用于透皮吸收的压敏粘合剂组合物，其包含用于药物的药物和透皮吸收促进剂，其特征在于进一步含有聚乙烯吡咯烷酮以稳定粘合剂组合物中所含的经皮吸收促进剂。 因此，可以防止透皮吸收促进剂的蒸发或降解，并且可以提供在使用中含有高浓度的含有透皮吸收促进剂的外用贴片。
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公开(公告)号：US20070144928A1
公开(公告)日：2007-06-28
申请号：US10580014
申请日：2004-11-12
申请人： Naruhito Higo , Tetsuro Tateishi , Takeshi Ito
发明人： Naruhito Higo , Tetsuro Tateishi , Takeshi Ito
CPC分类号： A61F15/001 , A61J1/067 , B65D75/30 , B65D77/26
摘要： A packaging bag 1 according to the present invention comprises a pair of packaging films 7x, 7y that are disposed facing one another, and are sealed together around a perimeter thereof so as to form a housing portion 9 housing a plaster. On one of the packaging films 7x is provided a protrusion 10 that protrudes toward the other packaging film 7y. When the plaster 2 is packaged, only the protrusion 10 of the packaging film 7x contacts a plaster body 5. The portion contacted by the protrusion 10 is a portion, on the inside of the plaster body 5, that excludes an outer periphery of the plaster body 5. Therefore, even if adhesive sticks out of the outer periphery of the plaster body 5, this adhesive does not contact the packaging film 7x. As a result, the plaster 2 can be easily removed from the packaging bag 1.
摘要翻译： 根据本发明的包装袋1包括一对彼此相对设置并且围绕其周边密封在一起的包装膜7x，7y，以形成容纳石膏的壳体部分9。 在其中一个包装薄膜7x上设置有朝向另一个包装膜7y突出的突起10。 当石膏2被包装时，只有包装膜7 x的突起10接触石膏体5。 由突起10接触的部分是石膏体5的内部排除石膏体5的外周的部分。 因此，即使粘合剂从膏体5的外周伸出，该粘合剂也不会与包装膜7 x接触。 结果，可以容易地从包装袋1中取出石膏2。
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公开(公告)号：US07785622B2
公开(公告)日：2010-08-31
申请号：US10527710
申请日：2003-09-12
申请人： Takeshi Ito , Tetsuro Tateishi , Naruhito Higo
发明人： Takeshi Ito , Tetsuro Tateishi , Naruhito Higo
IPC分类号： A61K31/445 , A61K9/70
CPC分类号： A61K31/4453 , A61K9/7053 , A61K9/7076
摘要： An adhesive patch for percutaneous fentanyl administration which is easily produced, has long-term continuity, and is excellent in adhesion and conformability to the skin. The adhesive patch comprises a backing layer and a pressure-sensitive adhesive layer formed on one side thereof, wherein the pressure-sensitive adhesive layer comprises fentanyl as an active ingredient, a pressure-sensitive adhesive base, and a tackifier resin, the pressure-sensitive adhesive base comprising polyisobutylene and a styrene/isoprene/styrene block copolymer, the proportion of the polyisobutylene in the adhesive base being, 8 to 15 wt. %, and the ratio of the concentration of the polyisobutylene to that of the styrene/isoprene/styrene block copolymer being from 2:3 to 3:2.
摘要翻译： 用于经皮芬太尼给药的粘合贴剂易于生产，具有长期的连续性，并且具有优异的粘附性和对皮肤的适应性。 粘合贴剂包括背衬层和在其一侧形成的压敏粘合剂层，其中压敏粘合剂层包含芬太尼作为活性成分，压敏粘合剂基底和增粘树脂，压敏粘合剂层 包含聚异丁烯和苯乙烯/异戊二烯/苯乙烯嵌段共聚物的粘合剂基料，粘合剂基质中聚异丁烯的比例为8〜15wt。 ％，聚异丁烯与苯乙烯/异戊二烯/苯乙烯嵌段共聚物的浓度比例为2：3〜3：2。
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7.发明授权Patch with improved anchoring properties between a substrate and an adhesive 有权具有改善的衬底和粘合剂之间的锚固性能的贴片公开(公告)号：US07754236B2
公开(公告)日：2010-07-13
申请号：US10517468
申请日：2003-06-06
申请人： Tatsuaki Suzuki , Tetsuro Tateishi , Naruhito Higo
发明人： Tatsuaki Suzuki , Tetsuro Tateishi , Naruhito Higo
IPC分类号： A61F13/00
CPC分类号： A61K9/7053 , A61K9/7076 , A61K31/4468 , Y10T428/2852 , Y10T428/2883
摘要： The present invention relates to a patch which is free from any migration of a drug into a substrate and has favorable anchoring properties between the substrate and adhesive layer, in which the drug containing adhesive layer firmly adheres onto the substrate and which gives no adhesion residue when applied to the skin and then peeled off. Namely, a patch comprising a substrate made of a polyester-based film and a drug-containing adhesive layer laminated thereon wherein the surface roughness (also known as “the central line mean roughness” or “Ra”) of the polyester-based film surface in the side in contact with the adhesive layer is from 0.05 to 0.8 μm is provided.
摘要翻译： 本发明涉及一种贴剂，其不含任何药物迁移到基质中，并且在基材和粘合剂层之间具有良好的锚定性能，其中含药物的粘合剂层牢固地粘附到基底上，并且当不含粘合剂残留物时不产生粘附残留 应用于皮肤，然后剥离。 即，将由聚酯系薄膜构成的基材和层叠有药物的粘合剂层的贴剂形成，其中聚酯类薄膜表面的表面粗糙度（也称为“中心线平均粗糙度”或“Ra”） 在与粘合剂层接触的一侧为0.05〜0.8μm。
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8.发明申请公开(公告)号：US20070128262A1
公开(公告)日：2007-06-07
申请号：US10587660
申请日：2005-01-31
申请人： Satoshi Amano , Sachiko Honma , Tetsuro Tateishi , Naruhito Higo
发明人： Satoshi Amano , Sachiko Honma , Tetsuro Tateishi , Naruhito Higo
IPC分类号： A61K9/70 , A61K31/138
CPC分类号： A61K31/138 , A61L15/58
摘要： The patch-containing pouch 100 of the present invention is a pouch 1 housing in its interior a patch 2 which has a pressure-sensitive adhesive layer 22 laminated on at least one side of a support 21 and has a release film 23 attached to the pressure-sensitive adhesive layer 22, wherein the pressure-sensitive adhesive layer 22 contains a drug represented by general formula (1) or a pharmaceutically acceptable salt thereof, and at least a portion of the inner surface 31a or 31b of the pouch 1 in contact with the patch 2 is made of polyacrylonitrile. [where R represents 2-isopropoxyethoxymethyl, carbamoylmethyl or 2-methoxyethyl.]
摘要翻译： 本发明的含有补片的袋100是在其内部容纳有贴片2的袋1，贴片2具有层压在支撑体21的至少一侧上的压敏粘合剂层22，并且具有附接到压力的剥离膜23 敏感性粘合剂层22，其中粘合剂层22含有由通式（1）表示的药物或其药学上可接受的盐，并且袋1的内表面31a或31b的至少一部分在 贴片2的接触由聚丙烯腈制成。 [其中R表示2-异丙氧基乙氧基甲基，氨基甲酰基甲基或2-甲氧基乙基]
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公开(公告)号：US20060165763A1
公开(公告)日：2006-07-27
申请号：US10525644
申请日：2003-08-07
申请人： Takeshi Ito , Tetsuro Tateishi , Naruhito Higo
发明人： Takeshi Ito , Tetsuro Tateishi , Naruhito Higo
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K31/221 , A61K47/12 , A61K47/32
摘要： A patch comprising a backing layer and an adhesive layer disposed on the backing layer and compounded with an adhesive agent and oxybutynin and/or a pharmaceutically acceptable salt thereof, wherein the adhesive agent comprises an acrylic polymer substantially free of both carboxyl group and hydroxyl group and a rubber polymer, in which weight ratio of content of the acrylic polymer to content of the rubber polymer is from 1:4 to 1:19.
摘要翻译： 一种贴剂，其包括背衬层和设置在背衬层上并与粘合剂和奥昔布宁和/或其药学上可接受的盐复合的粘合剂层，其中所述粘合剂包含基本上不含羧基和羟基的丙烯酸聚合物， 橡胶聚合物，其中丙烯酸类聚合物的含量与橡胶聚合物的含量的重量比为1:4至1:19。
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公开(公告)号：US20050266063A1
公开(公告)日：2005-12-01
申请号：US11141727
申请日：2005-05-31
IPC分类号： A61K9/70
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7069 , A61K9/7076
摘要： The present invention relates an adhesive patch comprising a backing layer and an adhesive layer that contains a drug, wherein the adhesive layer contains a mixed adhesive base containing a hydrocarbon rubber and a silicon-containing polymer. The adhesive patch of the invention shows extremely superior skin absorbability of a drug in a preparation, reduced skin irritation, and excellent aging stability of the drug in the preparation, and can achieve easiness of drug-taking methods and improvement in compliance.
摘要翻译： 本发明涉及包含背衬层和含有药物的粘合剂层的粘合贴剂，其中粘合剂层含有含有烃橡胶和含硅聚合物的混合粘合剂基料。 本发明的贴剂在制剂中显示出极好的药物在皮肤吸收性，皮肤刺激性降低，以及药物优良的老化稳定性，并且可以实现药物吸收方法的容易性和依从性的提高。
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