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1.发明申请Patch for External Use with Elevated Content of Absorption Promoter in Pressure-Sensitive Adhesive Base 审中-公开吸附促进剂在压敏粘合剂基质中含量高的外用补片公开(公告)号：US20080226697A1
公开(公告)日：2008-09-18
申请号：US11578892
申请日：2005-04-21
IPC分类号： A61K9/70 , A61K31/216
CPC分类号： A61K9/7053 , A61K9/7061 , A61K31/216 , A61K47/12 , A61K47/32
摘要： A pressure-sensitive adhesive composition for transdermal absorption which contains a drug and a transdermal absorption promoter for the drug, characterized by further containing polyvinylpyrrolidone so as to stabilize the transdermal absorption promoter contained in the adhesive composition. Thus, the transdermal absorption promoter can be prevented from vaporization or degradation and a patch for external use containing the transdermal absorption promoter at a high concentration in using can be provided.
摘要翻译： 一种用于透皮吸收的压敏粘合剂组合物，其包含用于药物的药物和透皮吸收促进剂，其特征在于进一步含有聚乙烯吡咯烷酮以稳定粘合剂组合物中所含的经皮吸收促进剂。 因此，可以防止透皮吸收促进剂的蒸发或降解，并且可以提供在使用中含有高浓度的含有透皮吸收促进剂的外用贴片。
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公开(公告)号：US07034083B2
公开(公告)日：2006-04-25
申请号：US10502474
申请日：2003-01-24
IPC分类号： C08F8/00
CPC分类号： A61K9/7061
摘要： An adhesive which comprises aqueous and nonaqueous polymers suitable for holding an lipophilic drug, etc., and has tackiness and cohesiveness which are sufficient for the plaster of a patch; and a patch employing the adhesive. The adhesive contains a polymer which comprises one or more kinds of acrylic or methacrylic monomer units, at least one kind of the monomer units having a hydroxy group, and which has been crosslinked with a boron compound.
摘要翻译： 一种粘合剂，其包含适于保持亲脂性药物的水性和非水性聚合物等，并且具有足够的贴剂粘贴性和粘性; 和使用粘合剂的贴剂。 粘合剂含有包含一种或多种丙烯酸或甲基丙烯酸单体单元，至少一种具有羟基的单体单元并且已经与硼化合物交联的聚合物。
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公开(公告)号：USRE45936E1
公开(公告)日：2016-03-22
申请号：US12108934
申请日：2008-04-24
CPC分类号： A61K9/7061 , A61K9/7069
摘要： An adhesive which comprises aqueous and nonaqueous polymers suitable for holding an lipophilic drug, etc., and has tackiness and cohesiveness which are sufficient for the plaster of a patch; and a patch employing the adhesive. The adhesive contains a polymer which comprises one or more kinds of acrylic or methacrylic monomer units, at least one kind of the monomer units having a hydroxy group, and which has been crosslinked with a boron compound.
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公开(公告)号：US08420117B2
公开(公告)日：2013-04-16
申请号：US12831190
申请日：2010-07-06
CPC分类号： A61K9/7053 , A61K47/12
摘要： A patch formulation for external use where a basic drug, an organic acid and an organic acid salt are combined as essential components is disclosed. The basic drug is preferably in the form of its acid addition salt. The organic acid is preferably a carboxylic acid having carbon atoms of 2 to 7, and more preferably at least one acid selected from the group consisting of acetic, lactic, tartaric, citric, malic, benzoic and salicylic acids. The organic acid salt is preferably a metal salt of a carboxylic acid, and more preferably sodium acetate.
摘要翻译： 公开了将碱性药物，有机酸和有机酸盐组合为必需成分的外用贴剂。 碱性药物优选为其酸加成盐的形式。 有机酸优选为碳原子数为2〜7的羧酸，更优选为选自乙酸，乳酸，酒石酸，柠檬酸，苹果酸，苯甲酸和水杨酸中的至少一种酸。 有机酸盐优选为羧酸的金属盐，更优选为乙酸钠。
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公开(公告)号：US20050053646A1
公开(公告)日：2005-03-10
申请号：US10502474
申请日：2003-01-24
CPC分类号： A61K9/7061
摘要： An adhesive which comprises aqueous and nonaqueous polymers suitable for holding an lipophilic drug, etc., and has tackiness and cohesiveness which are sufficient for the plaster of a patch; and a patch employing the adhesive. The adhesive contains a polymer which comprises one or more kinds of acrylic or methacrylic monomer units, at least one kind of the monomer units having a hydroxy group, and which has been crosslinked with a boron compound.
摘要翻译： 一种粘合剂，其包含适于保持亲脂性药物的水性和非水性聚合物等，并且具有足够的贴剂粘贴性和粘性; 和使用粘合剂的贴剂。 粘合剂含有包含一种或多种丙烯酸或甲基丙烯酸单体单元，至少一种具有羟基的单体单元并且已经与硼化合物交联的聚合物。
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公开(公告)号：US20110027365A1
公开(公告)日：2011-02-03
申请号：US12831190
申请日：2010-07-06
IPC分类号： A61K9/14 , A61P25/20 , A61P25/16 , A61P23/02 , A61P25/06 , A61P29/00 , A61P9/06 , A61P25/04 , A61P1/08 , A61K31/433 , A61K31/24
CPC分类号： A61K9/7053 , A61K47/12
摘要： A patch formulation for external use where a basic drug, an organic acid and an organic acid salt are combined as essential components is disclosed. The basic drug is preferably in the form of its acid addition salt. The organic acid is preferably a carboxylic acid having carbon atoms of 2 to 7, and more preferably at least one acid selected from the group consisting of acetic, lactic, tartaric, citric, malic, benzoic and salicylic acids. The organic acid salt is preferably a metal salt of a carboxylic acid, and more preferably sodium acetate.
摘要翻译： 公开了将碱性药物，有机酸和有机酸盐组合为必需成分的外用贴剂。 碱性药物优选为其酸加成盐的形式。 有机酸优选为碳原子数为2〜7的羧酸，更优选为选自乙酸，乳酸，酒石酸，柠檬酸，苹果酸，苯甲酸和水杨酸中的至少一种酸。 有机酸盐优选为羧酸的金属盐，更优选为乙酸钠。
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7.发明申请Process for production of pressure-sensitive adhesive moldings comprising crosslinked polymers as the main component 审中-公开用于生产包含交联聚合物作为主要成分的压敏粘合剂模制品的方法公开(公告)号：US20050119385A1
公开(公告)日：2005-06-02
申请号：US10502412
申请日：2003-01-24
CPC分类号： C09J133/04 , A61K9/7061 , A61K47/12 , A61L15/24 , A61L15/58 , C08J5/00 , C08L2312/00 , C08L33/08
摘要： The invention provides a process for production of pressure-sensitive adhesive shaped products which enables proper shaping of a tacky polymer through proper control of the rate of crosslinking thereof, specifically, a process for production of pressure-sensitive adhesive shaped products which comprises mixing a polymer bearing hydroxyl or carboxyl groups with one or more crosslinking agents selected from the group consisting of metal alcoholates and boron compounds in the presence of a lower alcohol and then subjecting the obtained mixture to shaping either accompanied with or followed by thermal crosslinking.
摘要翻译： 本发明提供了一种用于生产压敏粘合剂成型产品的方法，其通过适当地控制其交联速率，特别是生产压敏粘合剂成型产品的方法，使粘性聚合物能够适当地成形，该方法包括将聚合物 在低级醇的存在下，使用一种或多种选自金属醇化物和硼化合物的交联剂负载羟基或羧基，然后使所得混合物在伴随或随后进行热交联的条件下进行成型。
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公开(公告)号：US07785622B2
公开(公告)日：2010-08-31
申请号：US10527710
申请日：2003-09-12
申请人： Takeshi Ito , Tetsuro Tateishi , Naruhito Higo
发明人： Takeshi Ito , Tetsuro Tateishi , Naruhito Higo
IPC分类号： A61K31/445 , A61K9/70
CPC分类号： A61K31/4453 , A61K9/7053 , A61K9/7076
摘要： An adhesive patch for percutaneous fentanyl administration which is easily produced, has long-term continuity, and is excellent in adhesion and conformability to the skin. The adhesive patch comprises a backing layer and a pressure-sensitive adhesive layer formed on one side thereof, wherein the pressure-sensitive adhesive layer comprises fentanyl as an active ingredient, a pressure-sensitive adhesive base, and a tackifier resin, the pressure-sensitive adhesive base comprising polyisobutylene and a styrene/isoprene/styrene block copolymer, the proportion of the polyisobutylene in the adhesive base being, 8 to 15 wt. %, and the ratio of the concentration of the polyisobutylene to that of the styrene/isoprene/styrene block copolymer being from 2:3 to 3:2.
摘要翻译： 用于经皮芬太尼给药的粘合贴剂易于生产，具有长期的连续性，并且具有优异的粘附性和对皮肤的适应性。 粘合贴剂包括背衬层和在其一侧形成的压敏粘合剂层，其中压敏粘合剂层包含芬太尼作为活性成分，压敏粘合剂基底和增粘树脂，压敏粘合剂层 包含聚异丁烯和苯乙烯/异戊二烯/苯乙烯嵌段共聚物的粘合剂基料，粘合剂基质中聚异丁烯的比例为8〜15wt。 ％，聚异丁烯与苯乙烯/异戊二烯/苯乙烯嵌段共聚物的浓度比例为2：3〜3：2。
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9.发明授权Patch with improved anchoring properties between a substrate and an adhesive 有权具有改善的衬底和粘合剂之间的锚固性能的贴片公开(公告)号：US07754236B2
公开(公告)日：2010-07-13
申请号：US10517468
申请日：2003-06-06
申请人： Tatsuaki Suzuki , Tetsuro Tateishi , Naruhito Higo
发明人： Tatsuaki Suzuki , Tetsuro Tateishi , Naruhito Higo
IPC分类号： A61F13/00
CPC分类号： A61K9/7053 , A61K9/7076 , A61K31/4468 , Y10T428/2852 , Y10T428/2883
摘要： The present invention relates to a patch which is free from any migration of a drug into a substrate and has favorable anchoring properties between the substrate and adhesive layer, in which the drug containing adhesive layer firmly adheres onto the substrate and which gives no adhesion residue when applied to the skin and then peeled off. Namely, a patch comprising a substrate made of a polyester-based film and a drug-containing adhesive layer laminated thereon wherein the surface roughness (also known as “the central line mean roughness” or “Ra”) of the polyester-based film surface in the side in contact with the adhesive layer is from 0.05 to 0.8 μm is provided.
摘要翻译： 本发明涉及一种贴剂，其不含任何药物迁移到基质中，并且在基材和粘合剂层之间具有良好的锚定性能，其中含药物的粘合剂层牢固地粘附到基底上，并且当不含粘合剂残留物时不产生粘附残留 应用于皮肤，然后剥离。 即，将由聚酯系薄膜构成的基材和层叠有药物的粘合剂层的贴剂形成，其中聚酯类薄膜表面的表面粗糙度（也称为“中心线平均粗糙度”或“Ra”） 在与粘合剂层接触的一侧为0.05〜0.8μm。
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10.发明申请公开(公告)号：US20070128262A1
公开(公告)日：2007-06-07
申请号：US10587660
申请日：2005-01-31
申请人： Satoshi Amano , Sachiko Honma , Tetsuro Tateishi , Naruhito Higo
发明人： Satoshi Amano , Sachiko Honma , Tetsuro Tateishi , Naruhito Higo
IPC分类号： A61K9/70 , A61K31/138
CPC分类号： A61K31/138 , A61L15/58
摘要： The patch-containing pouch 100 of the present invention is a pouch 1 housing in its interior a patch 2 which has a pressure-sensitive adhesive layer 22 laminated on at least one side of a support 21 and has a release film 23 attached to the pressure-sensitive adhesive layer 22, wherein the pressure-sensitive adhesive layer 22 contains a drug represented by general formula (1) or a pharmaceutically acceptable salt thereof, and at least a portion of the inner surface 31a or 31b of the pouch 1 in contact with the patch 2 is made of polyacrylonitrile. [where R represents 2-isopropoxyethoxymethyl, carbamoylmethyl or 2-methoxyethyl.]
摘要翻译： 本发明的含有补片的袋100是在其内部容纳有贴片2的袋1，贴片2具有层压在支撑体21的至少一侧上的压敏粘合剂层22，并且具有附接到压力的剥离膜23 敏感性粘合剂层22，其中粘合剂层22含有由通式（1）表示的药物或其药学上可接受的盐，并且袋1的内表面31a或31b的至少一部分在 贴片2的接触由聚丙烯腈制成。 [其中R表示2-异丙氧基乙氧基甲基，氨基甲酰基甲基或2-甲氧基乙基]
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