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公开(公告)号：US20190060516A1
公开(公告)日：2019-02-28
申请号：US15753269
申请日：2016-08-17
发明人： Russell Martin , Hai-quan Mao
IPC分类号： A61L27/18 , A61L27/58 , A61L27/52 , A61L27/48 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/36 , A61L27/56 , A61L27/54 , D01D5/00 , D06M15/03
摘要： The presently disclosed composition and methods are provided for an in situ forming nanofiber-hydrogel composite, which is formed using non-covalent binding schemes between the fiber surface and hydrogel-forming polymers. A method for healing a soft tissue defect can include applying the said composite material to a soft tissue defect.
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公开(公告)号：US20230338612A1
公开(公告)日：2023-10-26
申请号：US17873980
申请日：2022-07-26
发明人： Russell Martin , Hai-quan Mao
IPC分类号： A61L27/18 , A61L27/48 , A61L27/52 , A61L27/54 , D06M15/03 , A61L29/08 , A61L29/06 , A61K31/00 , A61L29/16 , D06M14/32 , A61L27/28 , D06M15/15 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/36 , A61L27/56 , A61L27/58 , D01D5/00
CPC分类号： A61L27/18 , A61L27/48 , A61L27/52 , A61L27/54 , D06M15/03 , A61L29/085 , A61L29/06 , A61K31/00 , A61L29/16 , D06M14/32 , A61L27/28 , D06M15/15 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/3633 , A61L27/56 , A61L27/58 , D01D5/0046 , A61L2400/06 , A61L2400/12 , A61L2430/34 , D06M2101/32
摘要： The presently disclosed composition and methods are provided for an in situ forming nanofiber-hydrogel composite, which is formed using non-covalent binding schemes between the fiber surface and hydrogel-forming polymers. A method for healing a soft tissue defect can include applying the said composite material to a soft tissue defect.
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公开(公告)号：US10471181B2
公开(公告)日：2019-11-12
申请号：US15753274
申请日：2016-08-17
发明人： Russell Martin , Sashank Reddy , Justin Sacks , Xiaowei Li , Brian Honewee Cho , Hai-quan Mao
IPC分类号： A61L27/48 , A61L27/52 , A61L27/54 , A61L27/58 , A61F2/00 , A61F2/12 , A61L27/36 , A61L27/56 , A61L31/12 , A61L31/14 , A61L31/16
摘要： The presently disclosed composition and methods are provided for a hydrogel or nanofiber-hydrogel composite integrated with a surgical scaffold or mesh. A surgical scaffold device comprised of laminar composite is disclosed for the purpose of reducing foreign body response, managing tissue-materials interface, and improving the integration of the surgical mesh with the surrounding tissue of a subject.
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公开(公告)号：US20180243481A1
公开(公告)日：2018-08-30
申请号：US15753274
申请日：2016-08-17
发明人： Russell Martin , Sashank Reddy , Justin Sacks , Xiaowei Li , Brian Honewee Cho , Hai-quan Mao
CPC分类号： A61L27/48 , A61F2/0063 , A61F2/12 , A61F2210/0061 , A61F2250/0067 , A61L27/3633 , A61L27/52 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/129 , A61L31/148 , A61L31/16 , A61L2300/64 , A61L2430/04 , A61L2430/34 , C08L5/08 , C08L89/00 , C08L67/04
摘要： The presently disclosed composition and methods are provided for a hydrogel or nanofiber-hydrogel composite integrated with a surgical scaffold or mesh. A surgical scaffold device comprised of laminar composite is disclosed for the purpose of reducing foreign body response, managing tissue-materials interface, and improving the integration of the surgical mesh with the surrounding tissue of a subject.
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公开(公告)号：US20180243480A1
公开(公告)日：2018-08-30
申请号：US15753272
申请日：2016-08-17
发明人： Russell Martin , Hai-quan Mao , Sashank Reddy , Justin Sacks , Xiaowei Li , Brian Honewee Cho
CPC分类号： A61L27/48 , A61K35/28 , A61K38/08 , A61K39/395 , A61L27/3604 , A61L27/3608 , A61L27/38 , A61L27/3834 , A61L27/52 , A61L27/54 , A61L27/56 , A61L27/58 , A61L27/60 , A61L2400/06 , A61L2430/34 , C12N5/0667 , C12N2513/00 , C12N2533/30 , C12N2533/90
摘要： The presently disclosed composition and methods are provided for a nanofiber-hydrogel composite containing adipose cell binding moieties. A method for healing a soft tissue defect can include applying an adipose cell-binding composite material to a soft tissue defect in combination with exogenous adipose-derived cells or endogenous cells recruited from the surrounding tissue.
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