利索-全球专利检索

  1. Login
  2. Sign Up

Search Results

35 records (took 0.03 seconds)

    3D diffractive optics
    1.
    发明授权
    3D diffractive optics 有权

    公开(公告)号：US11327330B2

    公开(公告)日：2022-05-10

    申请号：US16431412

    申请日：2019-06-04

    Applicant: The Regents of the University of Colorado

    Inventor： Rafael Piestun ,  Haiyan Wang

    IPC: G02B27/42 ,  G02B27/00

    Abstract: Various embodiments provide for the implementation of volumetric diffractive optics equivalent functionality via cascaded planar elements. To illustrate the principle, a design 3D diffractive optics and implement a two-layer continuous phase-only design on a single spatial light modulator (SLM) with a folded system. The system provides dynamic and efficient multiplexing capability. Numerical and experimental results show this approach improves system performance such as diffraction efficiency, spatial/spectral selectivity, and number of multiplexing functions relative to 2D devices while providing dynamic large space-bandwidth relative to current static volume diffractive optics. The limitations and capabilities of dynamic 3D diffractive optics are discussed.

    Methods and systems for three dimensional optical imaging, sensing, particle localization and manipulation
    2.
    发明授权
    Methods and systems for three dimensional optical imaging, sensing, particle localization and manipulation 有权
    用于三维光学成像，感测，粒子定位和操纵的方法和系统

    公开(公告)号：US09560338B2

    公开(公告)日：2017-01-31

    申请号：US14031887

    申请日：2013-09-19

    Applicant: The Regents of the University of Colorado

    Inventor： Rafael Piestun ,  Sean Albert Quirin

    IPC: G06K9/00 ,  H04N13/02 ,  G06T7/00

    CPC classification number: H04N13/204 ,  G06T7/77 ,  G06T2207/10056 ,  G06T2207/10064

    Abstract: Embodiments include methods, systems, and/or devices that may be used to image, obtain three-dimensional information from a scence, and/or locate multiple small particles and/or objects in three dimensions. A point spread function (PSF) with a predefined three dimensional shape may be implemented to obtain high Fisher information in 3D. The PSF may be generated via a phase mask, an amplitude mask, a hologram, or a diffractive optical element. The small particles may be imaged using the 3D PSF. The images may be used to find the precise location of the object using an estimation algorithm such as maximum likelihood estimation (MLE), expectation maximization, or Bayesian methods, for example. Calibration measurements can be used to improve the theoretical model of the optical system. Fiduciary particles/targets can also be used to compensate for drift and other type of movement of the sample relative to the detector.

    Abstract translation: 实施例包括可用于成像，从三角形获取三维信息和/或定位三维的多个小颗粒和/或物体的方法，系统和/或设备。 可以实现具有预定三维形状的点扩散函数（PSF）以获得3D中的高Fisher信息。 PSF可以通过相位掩模，幅度掩模，全息图或衍射光学元件生成。 可以使用3D PSF对小颗粒进行成像。 例如，图像可以用于使用诸如最大似然估计（MLE），期望最大化或贝叶斯方法的估计算法来找到对象的精确位置。 校准测量可用于改善光学系统的理论模型。 受信颗粒/目标也可用于补偿样品相对于检测器的漂移和其他类型的运动。

    3-D Localization And Imaging of Dense Arrays of Particles
    3.
    发明申请
    3-D Localization And Imaging of Dense Arrays of Particles 有权
    粒子密集阵列的3-D定位和成像

    公开(公告)号：US20160048963A1

    公开(公告)日：2016-02-18

    申请号：US14777361

    申请日：2014-03-14

    Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO

    Inventor： Rafael Piestun ,  Anthony Barsic

    IPC: G06T7/00 ,  G06K9/68

    CPC classification number: G06K9/00 ,  G01N21/6458 ,  G02B21/14 ,  G02B21/361 ,  G02B21/367 ,  G06K9/6807 ,  G06T7/73 ,  G06T2200/04 ,  G06T2207/10016 ,  G06T2207/10056 ,  G06T2207/10064 ,  G06T2207/30242

    Abstract: Systems, methods, and computer program products are disclosed to localize and/or image a dense array of particles. In some embodiments, a plurality of particles may be imaged using an imaging device. A plurality of point spread function dictionary coefficients of the image may be estimated using a point spread function dictionary; where the point spread function dictionary can include a plurality of spread function responses corresponding to different particle positions. From the point spread function dictionary coefficients the number of particles in the image can be determined. Moreover location of each particle in the image can be determined from the point spread function dictionary co efficients.

    Abstract translation: 公开了系统，方法和计算机程序产品来定位和/或成像密集的粒子阵列。 在一些实施例中，可以使用成像装置成像多个颗粒。 可以使用点扩散函数字典来估计图像的多个点扩散函数词典系数; 其中点扩散函数字典可以包括对应于不同粒子位置的多个扩展函数响应。 从点扩散函数字典系数可以确定图像中的粒子数。 此外，图像中每个粒子的位置可以从点扩展函数字典有效性确定。

    METHODS AND SYSTEMS FOR THREE DIMENSIONAL OPTICAL IMAGING, SENSING, PARTICLE LOCALIZATION AND MANIPULATION
    5.
    发明申请
    METHODS AND SYSTEMS FOR THREE DIMENSIONAL OPTICAL IMAGING, SENSING, PARTICLE LOCALIZATION AND MANIPULATION 有权
    用于三维光学成像，感测，粒子定位和操作的方法和系统

    公开(公告)号：US20150035946A1

    公开(公告)日：2015-02-05

    申请号：US14465543

    申请日：2014-08-21

    Applicant: The Regents of the University of Colorado, a body corporate

    Inventor： Rafael Piestun ,  Sean Albert Quirin

    IPC: H04N13/02 ,  G06T7/00

    CPC classification number: H04N13/204 ,  G06T7/77 ,  G06T2207/10056 ,  G06T2207/10064

    Abstract: Embodiments include methods, systems, and/or devices that may be used to image, obtain three-dimensional information from a scene, and/or locate multiple small particles and/or objects in three dimensions. A point spread function (PSF) with a predefined three dimensional shape may be implemented to obtain high Fisher information in 3D. The PSF may be generated via a phase mask, an amplitude mask, a hologram, or a diffractive optical element. The small particles may be imaged using the 3D PSF. The images may be used to find the precise location of the object using an estimation algorithm such as maximum likelihood estimation (MLE), expectation maximization, or Bayesian methods, for example. Calibration measurements can be used to improve the theoretical model of the optical system. Fiduciary particles/targets can also be used to compensate for drift and other type of movement of the sample relative to the detector.

    Abstract translation: 实施例包括可以用于图像，从场景获取三维信息和/或定位三维中的多个小粒子和/或对象的方法，系统和/或设备。 可以实现具有预定三维形状的点扩散函数（PSF）以获得3D中的高Fisher信息。 PSF可以通过相位掩模，幅度掩模，全息图或衍射光学元件生成。 可以使用3D PSF对小颗粒进行成像。 例如，图像可以用于使用诸如最大似然估计（MLE），期望最大化或贝叶斯方法的估计算法来找到对象的精确位置。 校准测量可用于改善光学系统的理论模型。 受信颗粒/目标也可用于补偿样品相对于检测器的漂移和其他类型的运动。

    HIGH-SPEED WAVEFRONT OPTIMIZATION
    6.
    发明申请
    HIGH-SPEED WAVEFRONT OPTIMIZATION 有权
    高速波形优化

    公开(公告)号：US20130271592A1

    公开(公告)日：2013-10-17

    申请号：US13670954

    申请日：2012-11-07

    Applicant: The Regents of the University of Colorado

    Inventor： Rafael Piestun ,  Donald Conkey

    IPC: H04N7/18

    CPC classification number: H04N7/18 ,  G01N21/4795 ,  G02B26/06

    Abstract: A wavefront is optimized imaging a sample. A binary off-axis hologram is encoded by selective adoption of states for each mirror of a deformable mirror device, which is illuminated with an incident beam of light. A single diffraction order that has encoded phase-mask information is selected from light reflected from the deformable mirror device and focused onto the sample. Light scattered from the sample is directed to a photodetector. A transmission matrix through the sample is calculated from light received by the photodetector.

    Abstract translation: 波前优化成像样本。 通过选择性地采用用入射光束照射的可变形反射镜装置的每个反射镜的状态来编码二进制离轴全息图。 已经编码相位掩模信息的单个衍射顺序是从可变形反射镜装置反射的光中选出并聚焦到样品上。 从样品散射的光被引导到光电检测器。 通过光电检测器接收的光计算通过样品的透射矩阵。

    3-D localization and imaging of dense arrays of particles
    9.
    发明授权
    3-D localization and imaging of dense arrays of particles 有权

    公开(公告)号：US10657346B2

    公开(公告)日：2020-05-19

    申请号：US15856539

    申请日：2017-12-28

    Applicant: The Regents of the University of Colorado, a body corporate

    Inventor： Rafael Piestun ,  Anthony Barsic

    IPC: G06K9/00 ,  G06T7/73 ,  G02B21/36 ,  G06K9/68 ,  G01N21/64 ,  G02B21/14

    Abstract: Systems, methods, and computer program products are disclosed to localize and/or image a dense array of particles. In some embodiments, a plurality of particles may be imaged using an imaging device. A plurality of point spread function dictionary coefficients of the image may be estimated using a point spread function dictionary; where the point spread function dictionary can include a plurality of spread function responses corresponding to different particle positions. From the point spread function dictionary coefficients the number of particles in the image can be determined. Moreover location of each particle in the image can be determined from the point spread function dictionary coefficients.

    Method and/or system for stabilization, tracking, and/or control of microscopic systems
    10.
    发明授权
    Method and/or system for stabilization, tracking, and/or control of microscopic systems 有权

    公开(公告)号：US10215975B2

    公开(公告)日：2019-02-26

    申请号：US15018684

    申请日：2016-02-08

    Applicant: The Regents of the University of Colorado, a body corporate

    Inventor： Rafael Piestun ,  Wyatt Mohrman ,  Ginni Grover

    IPC: G02B21/16 ,  G02B21/36 ,  G02B21/12 ,  G02B21/24

    Abstract: Some embodiments of the invention include a system comprising a positioning device configured to a hold a sample and adjust a position of a sample in response to receiving a drift compensation signal; a first light source disposed to transilluminate the sample; a second light source disposed to epi-illuminate the sample; an optical system configured to receive light from the sample and generate a three-dimensional point spread function from the light from the sample; an image sensor disposed relative to the optical system that produces an image from the light collected from the sample via the optical system; and logic electrically coupled with the image detector and the positioning device, the logic configured to determine one or more drift compensation values from images imaged by the image detector, and configured to send one or more drift compensation signals to the positioning device.

Patent Agency Ranking