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公开(公告)号:US20190085014A1
公开(公告)日:2019-03-21
申请号:US16149114
申请日:2018-10-01
发明人: Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
IPC分类号: C07H19/14 , C12Q1/6869 , C07H21/00 , C12Q1/686 , C12Q1/6872 , C12Q1/6876 , C07H19/10 , C12Q1/68 , C12Q1/6874 , C40B40/00
CPC分类号: C12Q1/6869 , C07B2200/11 , C07H19/10 , C07H19/14 , C07H21/00 , C12Q1/68 , C12Q1/686 , C12Q1/6872 , C12Q1/6874 , C12Q1/6876 , C12Q2525/117 , C12Q2525/186 , C12Q2535/101 , C12Q2535/122 , C12Q2563/107 , C12Q2565/501 , C40B40/00
摘要: This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose.
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公开(公告)号:US20190031705A1
公开(公告)日:2019-01-31
申请号:US16150185
申请日:2018-10-02
发明人: Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
IPC分类号: C07H19/14 , C12Q1/6869 , C07H19/10 , C12Q1/6874 , C12Q1/6876 , C12Q1/6872 , C12Q1/68 , C12Q1/686
CPC分类号: C12Q1/6869 , C07B2200/11 , C07H19/10 , C07H19/14 , C07H21/00 , C12Q1/68 , C12Q1/686 , C12Q1/6872 , C12Q1/6874 , C12Q1/6876 , C12Q2525/117 , C12Q2525/186 , C12Q2535/101 , C12Q2535/122 , C12Q2563/107 , C12Q2565/501 , C40B40/00
摘要: This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose.
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公开(公告)号:US09725480B2
公开(公告)日:2017-08-08
申请号:US15167917
申请日:2016-05-27
发明人: Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
CPC分类号: C07H19/14 , C07B2200/11 , C07H19/10 , C07H21/00 , C12Q1/68 , C12Q1/686 , C12Q1/6869 , C12Q1/6872 , C12Q1/6874 , C12Q1/6876 , C12Q2525/117 , C12Q2535/101 , C12Q2535/122 , C12Q2563/107 , C40B40/00 , C12Q2565/501 , C12Q2525/186
摘要: This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analog after the nucleotide analog is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogs which comprise unique labels attached to the nucleotide analog through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose.
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公开(公告)号:US10435742B2
公开(公告)日:2019-10-08
申请号:US16150185
申请日:2018-10-02
发明人: Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
IPC分类号: C12Q1/68 , C07H19/14 , C12Q1/6869 , C07H21/00 , C12Q1/686 , C12Q1/6874 , C12Q1/6872 , C07H19/10 , C12Q1/6876 , C40B40/00
摘要: This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose.
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公开(公告)号:US10407459B2
公开(公告)日:2019-09-10
申请号:US16149114
申请日:2018-10-01
发明人: Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
IPC分类号: C07H19/14 , C12Q1/68 , C07H21/00 , C12Q1/686 , C12Q1/6874 , C12Q1/6872 , C12Q1/6869 , C07H19/10 , C12Q1/6876 , C40B40/00
摘要: This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose.
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公开(公告)号:US20190085016A1
公开(公告)日:2019-03-21
申请号:US16200549
申请日:2018-11-26
发明人: Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
IPC分类号: C07H19/14 , C12Q1/68 , C12Q1/6874 , C07H19/10 , C12Q1/6876 , C07H21/00 , C12Q1/6869 , C12Q1/6872 , C12Q1/686 , C40B40/00
摘要: This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose.
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公开(公告)号:US20190031706A1
公开(公告)日:2019-01-31
申请号:US16150191
申请日:2018-10-02
发明人: Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
IPC分类号: C07H19/14 , C12Q1/6869 , C07H19/10 , C12Q1/6874 , C12Q1/6876 , C12Q1/6872 , C12Q1/68 , C12Q1/686
CPC分类号: C12Q1/6869 , C07B2200/11 , C07H19/10 , C07H19/14 , C07H21/00 , C12Q1/68 , C12Q1/686 , C12Q1/6872 , C12Q1/6874 , C12Q1/6876 , C12Q2525/117 , C12Q2525/186 , C12Q2535/101 , C12Q2535/122 , C12Q2563/107 , C12Q2565/501 , C40B40/00
摘要: This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose.
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公开(公告)号:US09868985B2
公开(公告)日:2018-01-16
申请号:US15647657
申请日:2017-07-12
发明人: Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
CPC分类号: C07H19/14 , C07B2200/11 , C07H19/10 , C07H21/00 , C12Q1/68 , C12Q1/686 , C12Q1/6869 , C12Q1/6872 , C12Q1/6874 , C12Q1/6876 , C12Q2525/117 , C12Q2535/101 , C12Q2535/122 , C12Q2563/107 , C40B40/00 , C12Q2565/501 , C12Q2525/186
摘要: This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analog after the nucleotide analog is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogs which comprise unique labels attached to the nucleotide analog through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose.
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公开(公告)号:US20170313737A1
公开(公告)日:2017-11-02
申请号:US15647657
申请日:2017-07-12
发明人: Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
CPC分类号: C07H19/14 , C07B2200/11 , C07H19/10 , C07H21/00 , C12Q1/68 , C12Q1/686 , C12Q1/6869 , C12Q1/6872 , C12Q1/6874 , C12Q1/6876 , C12Q2525/117 , C12Q2535/101 , C12Q2535/122 , C12Q2563/107 , C40B40/00 , C12Q2565/501 , C12Q2525/186
摘要: This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose.
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公开(公告)号:US09719139B2
公开(公告)日:2017-08-01
申请号:US15380311
申请日:2016-12-15
发明人: Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
CPC分类号: C07H19/14 , C07B2200/11 , C07H19/10 , C07H21/00 , C12Q1/68 , C12Q1/686 , C12Q1/6869 , C12Q1/6872 , C12Q1/6874 , C12Q1/6876 , C12Q2525/117 , C12Q2535/101 , C12Q2535/122 , C12Q2563/107 , C40B40/00 , C12Q2565/501 , C12Q2525/186
摘要: This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analog after the nucleotide analog is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogs which comprise unique labels attached to the nucleotide analog through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose.
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