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公开(公告)号：US09403763B2
公开(公告)日：2016-08-02
申请号：US14365389
申请日：2012-12-14
申请人： Dana-Farber Cancer Institute, Inc. , The Trustees of the University of Pennsylvania , The United States of America As Represented By The Secretary, Department of Health and Human Services , Bryn Mawr College , The Johns Hopkins University , The Trustees of Columbia University in the City of New York
发明人： Joseph Sodroski , Judith M. LaLonde , Amos B. Smith, III , Peter D. Kwong , Young Do Kwon , David M. Jones , Alexander W. Sun , Joel R. Courter , Takahiro Soeta , Toyoharu Kobayashi , Amy M. Princiotto , Xueling Wu , John R. Mascola , Arne Schon , Ernesto Freire , Navid Madani , Matthew Le-Khac , Wayne A. Hendrickson , Jongwoo Park
IPC分类号： C07C237/06 , A61K31/167 , A61K31/185 , C07C279/16 , C07D233/88 , C07D235/02 , C07D235/06 , C07D271/07 , C07D207/335 , C07D207/34 , C07D209/88 , C07D209/94 , C07D307/52 , C07C279/12 , C07C233/56 , C07C237/22
CPC分类号： C07C279/16 , A61K31/167 , A61K31/185 , C07C233/56 , C07C237/06 , C07C237/22 , C07C279/12 , C07C2601/14 , C07C2602/08 , C07D207/335 , C07D207/34 , C07D209/88 , C07D209/94 , C07D233/88 , C07D235/02 , C07D235/06 , C07D271/07 , C07D307/52
摘要： Described herein are small-molecule mimics of CD4, which both enter the Phe43 cavity and target Asp368 of gp120, the HIV-1 envelope protein. Also described herein are methods of using these compounds to inhibit the transmission or progression of HIV infection. These compounds exhibit antiviral potency greater than that of a known antiviral, NBD-556, with 100% breadth against clade B and C viruses. Importantly, the compounds do not activate HIV infection of CD4-negative, CCR5-positive cells, in contrast to NBD-556.
摘要翻译： 本文描述的是CD4的小分子模拟物，其都进入Phe43腔，并且gp120的靶标Asp368（HIV-1包膜蛋白）。 本文还描述了使用这些化合物抑制HIV感染的传播或进展的方法。 这些化合物显示出比已知的抗病毒剂NBD-556的抗病毒效力更大，对于进化枝B和C病毒具有100％的广度。 重要的是，与NBD-556相比，化合物不能激活CD4阴性CCR5阳性细胞的HIV感染。
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公开(公告)号：US20140350113A1
公开(公告)日：2014-11-27
申请号：US14365389
申请日：2012-12-14
申请人： Dana-Farber Cancer Institute, Inc. , The Trustees of the University of Pennsylvania , United States of Americas as Represented By The Secretary, Department of Health and Human Services , Bryn Mawr College , The Johns Hopkins University , The Trustees of Columbia University in the City of New York
发明人： Joseph Sodroski , Judith M. LaLonde , Amos B. Smith, III , Peter D. Kwong , Young Do Kwon , David M. Jones , Alexander W. Sun , Joel R. Courter , Takahiro Soeta , Toyoharu Kobayashi , Amy M. Princiotto , Xueling Wu , John R. Mascola , Ame Schon , Emesto Freire , Navid Madani , Matthew Le-Khac , Wayne A. Hendrickson
IPC分类号： C07C279/16 , C07C237/06
CPC分类号： C07C279/16 , A61K31/167 , A61K31/185 , C07C233/56 , C07C237/06 , C07C237/22 , C07C279/12 , C07C2601/14 , C07C2602/08 , C07D207/335 , C07D207/34 , C07D209/88 , C07D209/94 , C07D233/88 , C07D235/02 , C07D235/06 , C07D271/07 , C07D307/52
摘要： Described herein are small-molecule mimics of CD4, which both enter the Phe43 cavity and target Asp368 of gp120, the HIV-1 envelope protein. Also described herein are methods of using these compounds to inhibit the transmission or progression of HIV infection. These compounds exhibit antiviral potency greater than that of a known antiviral, NBD-556, with 100% breadth against clade B and C viruses. Importantly, the compounds do not activate HIV infection of CD4-negative, CCR5-positive cells, in contrast to NBD-556.
摘要翻译： 本文描述的是CD4的小分子模拟物，其都进入Phe43腔，并且gp120的靶标Asp368（HIV-1包膜蛋白）。 本文还描述了使用这些化合物抑制HIV感染的传播或进展的方法。 这些化合物显示出比已知的抗病毒剂NBD-556的抗病毒效力更大，对于进化枝B和C病毒具有100％的广度。 重要的是，与NBD-556相比，化合物不能激活CD4阴性CCR5阳性细胞的HIV感染。
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公开(公告)号：US11235056B2
公开(公告)日：2022-02-01
申请号：US16496912
申请日：2018-03-26
IPC分类号： A61K39/21 , C07K14/005 , C12N7/00 , C07K14/16 , A61K39/00
摘要： Embodiments of immunogens based on the outer domain of HIV-1 gp120 and methods of their use and production are disclosed. Nucleic acid molecules encoding the immunogens are also provided. In several embodiments, the immunogens can be used to prime an immune response to gp120 in a subject, for example, to treat or prevent an HIV-1 infection in the subject.
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公开(公告)号：US11969466B2
公开(公告)日：2024-04-30
申请号：US18314052
申请日：2023-05-08
发明人： John R. Mascola , Jeffrey C. Boyington , Hadi M. Yassine , Peter D. Kwong , Barney S. Graham , Masaru Kanekiyo
IPC分类号： A61K39/145 , A61K39/12 , C07K14/005 , C07K14/47 , C12N7/00 , A61K39/00
CPC分类号： A61K39/145 , A61K39/12 , C07K14/005 , C07K14/47 , C12N7/00 , A61K2039/55555 , A61K2039/55566 , A61K2039/6031 , C07K2319/00 , C12N2760/16122 , C12N2760/16134
摘要： Vaccines that elicit broadly protective anti-influenza antibodies. Some vaccines comprise nanoparticles that display HA trimers from influenza virus on their surface. The nanoparticles are fusion proteins comprising a monomeric subunit (e.g., ferritin) joined to the stem region of an influenza HA protein. The fusion proteins self-assemble to form the HA-displaying nanoparticles. The vaccines comprise only the stem region of an influenza HA protein joined to a trimerization domain. Also provided are fusion proteins, and nucleic acid molecules encoding such proteins, and assays using nanoparticles of the invention to detect anti-influenza antibodies.
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公开(公告)号：US10363301B2
公开(公告)日：2019-07-30
申请号：US15313265
申请日：2015-05-27
发明人： John R. Mascola , Jeffrey C. Boyington , Hadi M. Yassine , Peter D. Kwong , Barney S. Graham , Masaru Kanekiyo
IPC分类号： A61K39/145 , C12N7/00 , A61K39/12 , C07K14/005 , C07K14/47 , A61K39/00
摘要： Vaccines that elicit broadly protective anti-influenza antibodies. Some vaccines comprise nanoparticles that display HA trimers from influenza virus on their surface. The nanoparticles are fusion proteins comprising a monomeric subunit (e.g., ferritin) joined to the stem region of an influenza HA protein. The fusion proteins self-assemble to form the HA-displaying nanoparticles. The vaccines comprise only the stem region of an influenza HA protein joined to a trimerization domain. Also provided are fusion proteins, and nucleic acid molecules encoding such proteins, and assays using nanoparticles of the invention to detect anti-influenza antibodies.
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公开(公告)号：US09783595B2
公开(公告)日：2017-10-10
申请号：US15226744
申请日：2016-08-02
发明人： Mark Connors , Jinghe Huang , Leo B. Laub , Peter Kwong , Gary Nabel , John R. Mascola , Baoshan Zhang , Rebecca S. Rudicell , Ivelin Georgiev , Yongping Yang , Jiang Zhu , Gilad Ofek
CPC分类号： C07K16/1063 , A61K39/42 , A61K45/06 , A61K49/0004 , A61K2039/505 , C07K16/00 , C07K16/1045 , C07K2317/14 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , G01N33/56972 , G01N33/56983 , G01N33/56988 , G01N2333/161
摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to the HIV-1 gp41 membrane-proximal external region (MPER). Also disclosed are compositions including the disclosed antibodies that specifically bind gp41, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of HIV-1 in a biological sample, or detecting an HIV-1 infection or diagnosing AIDS in a subject. In additional, the broad neutralization breadth of the disclosed antibodies makes them ideal for treating a subject with an HIV infection. Thus, disclosed are methods of treating and/or preventing HIV infection.
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公开(公告)号：US12053520B2
公开(公告)日：2024-08-06
申请号：US17587817
申请日：2022-01-28
IPC分类号： A61K39/21 , C07K14/005 , C07K14/16 , C12N7/00 , A61K39/00
CPC分类号： A61K39/21 , C07K14/005 , C07K14/162 , C12N7/00 , C12Y205/01078 , A61K2039/5258 , A61K2039/55555 , C07K2319/00 , C12N2740/16023 , C12N2740/16043 , C12N2740/16111 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171
摘要： Embodiments of immunogens based on the outer domain of HIV-1 gp120 and methods of their use and production are disclosed. Nucleic acid molecules encoding the immunogens are also provided. In several embodiments, the immunogens can be used to prime an immune response to gp120 in a subject, for example, to treat or prevent an HIV-1 infection in the subject.
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8.发明授权公开(公告)号：US11149082B2
公开(公告)日：2021-10-19
申请号：US16342962
申请日：2017-10-17
申请人： UNIVERSITY OF MARYLAND, COLLEGE PARK , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , INTERNATIONAL AIDS VACCINE INITIATIVE
发明人： Javier Guenaga , Yuxing Li , James Steinhardt , John R. Mascola
摘要： The present disclosure relates to multispecific antibodies targeting the human immunodeficiency virus-1 (HIV-1) envelope, methods for their production, pharmaceutical compositions containing said antibodies and uses thereof in treatment and prevention of HIV infection.
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公开(公告)号：US10047148B2
公开(公告)日：2018-08-14
申请号：US15699902
申请日：2017-09-08
发明人： Mark Connors , Jinghe Huang , Leo B. Laub , Peter Kwong , Gary Nabel , John R. Mascola , Baoshan Zhang , Rebecca S. Rudicell , Ivelin Georgiev , Yongping Yang , Jiang Zhu , Gilad Ofek
IPC分类号： A61K39/395 , C07K16/00 , A61K39/42 , C07K16/10 , A61K39/00 , G01N33/569 , A61K45/06 , A61K49/00
摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to the HIV-1 gp41 membrane-proximal external region (MPER). Also disclosed are compositions including the disclosed antibodies that specifically bind gp41, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of HIV-1 in a biological sample, or detecting an HIV-1 infection or diagnosing AIDS in a subject. In additional, the broad neutralization breadth of the disclosed antibodies makes them ideal for treating a subject with an HIV infection. Thus, disclosed are methods of treating and/or preventing HIV infection.
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公开(公告)号：US11793871B2
公开(公告)日：2023-10-24
申请号：US17742201
申请日：2022-05-11
发明人： Jeffrey C. Boyington , Barney S. Graham , John R. Mascola , Hadi M. Yassine , Kizzmekia S. Corbett , Syed M. Moin , Lingshu Wang , Masaru Kanekiyo
IPC分类号： A61K39/145 , C07K14/005 , C07K14/195 , A61K39/12 , A61P31/16 , A61K39/00
CPC分类号： A61K39/145 , A61K39/12 , A61P31/16 , C07K14/005 , C07K14/195 , A61K2039/55555 , C07K2319/00 , C12N2760/16122 , C12N2760/16134
摘要： Vaccines that elicit broadly protective anti-influenza antibodies. The vaccines comprise nanoparticles that display HA trimers from Group 2 influenza virus on their surface. The nanoparticles are fusion proteins comprising a monomeric subunit (e.g., ferritin) joined to stabilized stem regions of Group 2 influenza virus HA proteins. The fusion proteins self-assemble to form the HA-displaying nanoparticles. Also provided are fusion proteins, and nucleic acid molecules encoding such proteins, and assays using nanoparticles of the invention to detect anti-influenza antibodies.
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