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公开(公告)号：US10199208B2
公开(公告)日：2019-02-05
申请号：US15060474
申请日：2016-03-03
摘要： An apparatus for separating ions includes an electrode arrangement having a length extending between first and second ends. The first end is configured to introduce a beam of ions into an ion transmission space of the arrangement. An electronic controller applies an RF potential and a DC potential to an electrode of the electrode arrangement, for generating a ponderomotive RF electric field and a mass-independent DC electric field. The application of the potentials is controlled such that a ratio of the strength of the ponderomotive RF electric field to the strength of the mass-independent DC electric field varies along the length of the electrode arrangement. The generated electric field supports extraction of ions having different m/z values at respective different positions along the length of the electrode arrangement. Ions are extracted in one of increasing and decreasing sequential order of m/z ratio with increasing distance from the first end.
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公开(公告)号：US11988635B2
公开(公告)日：2024-05-21
申请号：US17744408
申请日：2022-05-13
IPC分类号： G01N27/622
CPC分类号： G01N27/622
摘要： An ion mobility analyser is disclosed having a gas flow directed along the ion travel axis and a set of electrodes to which DC voltages are applied to establish a DC field. The opposing forces of the gas flow and DC field cause ions to be trapped within a separation region in axial regions determined by their ion mobilities. A gas recirculator, having inlet and outlet ends respectively located downstream and upstream of the separation region, supplies at least fifty percent of the gas flow within the separation region, thereby reducing vacuum pumping requirements.
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公开(公告)号：US10510525B2
公开(公告)日：2019-12-17
申请号：US16245023
申请日：2019-01-10
摘要： An apparatus for separating ions includes an electrode arrangement having a length extending between first and second ends. The first end is configured to introduce a beam of ions into an ion transmission space of the arrangement. An electronic controller applies an RF potential and a DC potential to an electrode of the electrode arrangement, for generating a ponderomotive RF electric field and a mass-independent DC electric field. The application of the potentials is controlled such that a ratio of the strength of the ponderomotive RF electric field to the strength of the mass-independent DC electric field varies along the length of the electrode arrangement. The generated electric field supports extraction of ions having different m/z values at respective different positions along the length of the electrode arrangement. Ions are extracted in one of increasing and decreasing sequential order of m/z ratio with increasing distance from the first end.
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公开(公告)号：US10663428B2
公开(公告)日：2020-05-26
申请号：US16024462
申请日：2018-06-29
申请人： Thermo Finnigan LLC
发明人： Mikhail V. Ugarov
摘要： A system for analyzing a sample includes a source; a mobility separator configured to separate ions based on a mobility in a gas; a plurality of ion channels; and a mass analyzer. The mobility separator includes a two-dimensional grid of electrodes spanning a passage between first and second walls. The first and second walls include an inlet aperture and a plurality of exit apertures, respectively. The two-dimensional grid of electrodes configured to generate an electric field within the passage. The plurality of ion channels arranged adjacent to the plurality of exit apertures. Movement of ions between the inlet aperture and the plurality of exit apertures are governed by the electric field and a gas flow through the passage between to the first and second walls such that the ions are sorted and directed to different channels based on their respective mobility.
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公开(公告)号：US11011362B2
公开(公告)日：2021-05-18
申请号：US16576515
申请日：2019-09-19
申请人： Thermo Finnigan LLC
发明人： Mikhail V. Ugarov
摘要： A mass spectrometer includes an ion source, an ion guide, a first gate, first and second mass filters, a fragmentation cell, a detector, and a controller. The ion source is configured to produce an ion beam from a sample. The first and second mass filters are configured to selectively transmit ions within a mass-to-charge range and reject ions outside of the mass-to-charge range. The detector is configured to measure the intensity of the transmitted ion beam. The controller is configured to close the first ion gate to prevent ions from entering the first mass filter, switch a first quadrupole voltage of the first mass filter to a voltage of a first transition, and open the first ion gate to allow ions to enter the first mass filter, the opening offset from the switching by at least the time required to adjust the voltage of the first mass filter.
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公开(公告)号：US10663430B2
公开(公告)日：2020-05-26
申请号：US16058892
申请日：2018-08-08
申请人： Thermo Finnigan LLC
发明人： Mikhail V. Ugarov
摘要： A system for analyzing a sample includes a source configured to generate ions from constituent components of the sample; a mobility separator configured to separate ions received from the source based on the mobility in a gas; a plurality of ion channels arranged adjacent to the plurality of exit apertures of the mobility separator such that ions from the mobility separator are directed to different channels according to their respective mobility; a mass analyzer configured to determine the mass-to-charge ratio of the ions; and a controller. The controller is configured to identify retention time windows with minimum overlap of ions with similar mobility and sets of ions within the retention time windows; adjust mobility separation parameters for specific sets of ions to optimize separation of compounds; and quantify a plurality of target analytes.
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公开(公告)号：US20240222105A1
公开(公告)日：2024-07-04
申请号：US18148313
申请日：2022-12-29
申请人： THERMO FINNIGAN LLC
发明人： Mikhail V. Ugarov
CPC分类号： H01J49/282 , H01J49/022 , H01J49/0422 , H01J49/165
摘要： Systems, devices, and methods for in-source ion separation are provided. An ion separator includes an ion transfer conduit fluidically upstream of and coupled with one or more components of an analytical instrument. The ion separator includes a gas conduit, fluidically upstream of and coupled with the ion transfer conduit, the gas conduit defining an internal volume. The ion separator also includes electronic circuitry defining an active surface exposed to the internal volume, the electronic circuitry being configured to energize the active surface. Embodiments of the present disclosure provide improved analysis of material samples based at least in part on in-source separation of relatively light ions from relatively heavy ions entrained in a gas flow.
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公开(公告)号：US11119070B2
公开(公告)日：2021-09-14
申请号：US16878205
申请日：2020-05-19
申请人： Thermo Finnigan LLC
发明人： Mikhail V. Ugarov
IPC分类号： G01N27/622 , H01J49/06 , H01J49/10 , G01N27/624
摘要： A system for analyzing a sample includes a source; a mobility separator configured to separate ions based on a mobility in a gas; a plurality of ion channels; and a mass analyzer. The mobility separator includes a two-dimensional grid of electrodes spanning a passage between first and second walls. The first and second walls include an inlet aperture and a plurality of exit apertures, respectively. The two-dimensional grid of electrodes configured to generate an electric field within the passage. The plurality of ion channels arranged adjacent to the plurality of exit apertures. Movement of ions between the inlet aperture and the plurality of exit apertures are governed by the electric field and a gas flow through the passage between to the first and second walls such that the ions are sorted and directed to different channels based on their respective mobility.
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公开(公告)号：US11107667B1
公开(公告)日：2021-08-31
申请号：US16988291
申请日：2020-08-07
申请人： Thermo Finnigan LLC
发明人： Mikhail V. Ugarov , Oleg Silivra
摘要： A mass spectrometer includes an ion source configured to ionize a sample to produce ions; a mass analyzer configured to separate the ions based on their mass-to-charge ratio; a detector configured to detect ions; an ion optics component configured to direct ions along at least part of the path from the ion source to the mass analyzer to the detector; and a controller. The controller is configured to switch the source at a first time from a first polarity source voltage to a second polarity source voltage; and switch the detector or the ion optics component at a second time from a first voltage to a second voltage, the second time being offset from the first time, the first voltage being the first polarity detector voltage or the first polarity ion optics voltage and the second voltage being the second polarity detector voltage or the second polarity ion optics voltage.
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公开(公告)号：US20230307221A1
公开(公告)日：2023-09-28
申请号：US17705177
申请日：2022-03-25
申请人： Thermo Finnigan LLC
发明人： Mikhail V. Ugarov
CPC分类号： H01J49/063 , H01J49/0031
摘要： It is proposed to improve transmission of ions along the curved path of an ion guide by changing the separation between adjacent multipole rods in the plane of curvature. As the separation increases along the length of the device, the ion confinement in the plane of curvature decreases. At the same time, the external field penetration from the electrodes outside of the main ion guide increases which can be used to create additional DC field gradients to facilitate ion confinement and motion through the ion guide.
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