摘要:
The in vivo circulating life and/or absorption of cationic therapeutic proteins, including but not limited to basic proteins such as NT-3 and BDNF, can be increased by generating analogs that have a lower isoelectric point and, preferably, also a lower protein charge relative to the protein of native sequence.
摘要:
A method for making a thin dielectric layer is disclosed which is useful in fabricating semiconductor devices, particularly transistors and DRAM cell devices. The method comprises a two-steps, i.e., (i) growing a base layer of dielectric material on a substrate having a thickness in excess of the desired thickness for the layer, and (ii) etching back the base layer to the desired thickness. With these two steps, a thin dielectric layer of less than 20 Å may be provided having substantial uniformity across its surface with a standard deviation in surface contours of less than 0.7 Å.
摘要:
A wire management device for storing an earphone wire having a signal terminal and a pair of speakers includes an elongated frame having first and second ends, the frame having a first channel to hold a first wrapped part of the wire, first and second beaks respectively arranged at the first and second ends of the frame to stay the terminal of the wire, and first and second wings respectively branching from neighboring positions of the first and second ends the frame, the first and second wings are, respectively, bent toward the first and second ends of the frame for wrapping the wire, wherein at least one of the wings includes a clamping portion to clamp a last wrapped part of the wire.
摘要:
A wire management device for storing an earphone wire having a signal terminal and a pair of speakers includes an elongated frame having first and second ends, the frame having a first channel to hold a first wrapped part of the wire, first and second beaks respectively arranged at the first and second ends of the frame to stay the terminal of the wire, and first and second wings respectively branching from neighboring positions of the first and second ends the frame, the first and second wings are, respectively, bent toward the first and second ends of the frame for wrapping the wire, wherein at least one of the wings includes a clamping portion to clamp a last wrapped part of the wire.
摘要:
The present invention relates to certain biologically active peptides and polypeptides which can be used as therapeutics or prophylactics against diseases or disorders linked to NGF as the causative agent. In one aspect of the present invention, pharmacologically active polypeptides comprising peptides linked to one or more Fc domains are provided.
摘要:
A novel metalloproteinase inhibitor, analogs thereof, polynucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders caused by excessive amounts of metalloproteinase are also disclosed.
摘要:
The present invention concerns fusion of Fc domains with biologically active peptides and a process for preparing pharmaceutical agents using biologically active peptides. In this invention, pharmacologically active compounds are prepared by a process comprising: a) selecting at least one peptide that modulates the activity of a protein of interest; and b) preparing a pharmacologic agent comprising an Fc domain covalently linked to at least one amino acid of the selected peptide. Linkage to the vehicle increases the half-life of the peptide, which otherwise would be quickly degraded in vivo. The preferred vehicle is an Fc domain. The peptide can be selected, for example, by phage display, E. coli display, ribosome display, RNA-peptide screening, yeast-based screening, chemical-peptide screening, rational design, or protein structural analysis.
摘要:
An extraordinary magnetoresistive device EMR having a discontinuous shunt structure. The discontinuous shunt structure improves the linearity of response of the EMR device. The EMR device includes a EMR heterostructure that includes an EMR active layer. The heterostructure can include first, second and third semiconductor layers, with the second layer being sandwiched between the first and third layers. The middle, or second semiconductor layer provides a two dimensional electron gas. The heterostructure has first and second opposed sides, with a pair of voltage leads and a pair of current leads connected with the first side of the structure. The discontinuous shunt structure is connected with the second side of the structure and may be in the form of a series of discontinuous, electrically conductive elements, such as semi-spherical gold elements.
摘要:
The present invention broadly relates to the field of protein modification, and, more specifically, the attachment of water soluble polymers to novel erythropoietin stimulating protein (NESP).
摘要:
The present invention broadly relates to the field of protein modification, and, more specifically, the attachment of water soluble polymers to novel erythropoietin stimulating protein (NESP).