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    Systems and methods for sensing red blood cell hematocrit
    3.
    发明授权
    Systems and methods for sensing red blood cell hematocrit 失效
    用于感测红细胞血细胞比容的系统和方法

    公开(公告)号：US06294094B1

    公开(公告)日：2001-09-25

    申请号：US09389506

    申请日：1999-09-03

    申请人： Matthew R. Muller ,  Michel L. F. Joie ,  Mark R. Vandlik

    发明人： Matthew R. Muller ,  Michel L. F. Joie ,  Mark R. Vandlik

    IPC分类号： B01D1712

    CPC分类号： B01D21/302 ,  A61M1/0236 ,  A61M1/367 ,  A61M1/3696 ,  A61M1/38 ,  A61M2205/128 ,  A61M2205/3393 ,  A61M2230/207 ,  B01D17/0217 ,  B01D21/2444 ,  B01D21/245 ,  B01D21/26 ,  B01D21/262 ,  B01D21/34 ,  B01D2221/08 ,  B01D2221/10

    摘要： Red blood cell sensing systems and methods rely upon straightforward measurement geometries. The systems and methods comprise an incident light source, an optical sensor, and a blood collection tube. The systems and methods hold the blood collection tube a predetermined radial distance from the incident light source where a linear relationship exists between sensed reflected light measured by the optical sensor and red blood cell hematocrit in a range of at least 10 to 90. The systems and methods make possible accurate red blood sensing without use of special optical cuvettes, mirrors, or focusing lenses. The systems and methods also make possible the use of standard transparent plastic tubing, without reliance upon special optical cuvettes.

    摘要翻译： 红细胞感测系统和方法依赖于简单的测量几何。 系统和方法包括入射光源，光学传感器和采血管。 系统和方法将采血管保持与入射光源预定的径向距离，其中在由光学传感器测量的感测反射光与红细胞血细胞比容之间存在线性关系，范围在至少10至90°。系统和 方法可以在不使用特殊的光学比色杯，镜子或聚焦镜片的情况下进行准确的红血传感。 系统和方法也可以使用标准的透明塑料管，而不依赖于特殊的光学比色皿。

    Access disconnect system with optical and other sensors
    5.
    发明授权
    Access disconnect system with optical and other sensors 有权
    具有光学和其他传感器的接入断开系统

    公开(公告)号：US08187184B2

    公开(公告)日：2012-05-29

    申请号：US11859556

    申请日：2007-09-21

    申请人： Matthew R. Muller ,  Luke Beehner ,  William W. Chan ,  James S. Slepicka ,  Atif Yardimci

    发明人： Matthew R. Muller ,  Luke Beehner ,  William W. Chan ,  James S. Slepicka ,  Atif Yardimci

    IPC分类号： A61B5/00

    CPC分类号： A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M5/16831 ,  A61M5/16836 ,  A61M2205/15 ,  A61M2205/3306

    摘要： An optical access disconnect system is useful for detecting the presence of blood. The optical access disconnect system includes one or more optical sensors placed near an access site of a patient, the optical sensors suitable for detecting the presence of blood, especially by detecting a difference in light reflected or absorbed by blood. The optical access disconnect system may also be used as an interlock to assure compliance. A detector may be placed adjacent the access site to detect the access needle, or an object or mark on the access needle or fluid line. A therapy machine, such as a dialysis machine, may be programmed not to start or continue operation unless the needle or fluid line is detected. The detector may be one of the optical sensors, calibrated or adjusted to detect a mark on the needle or access line, or may be another type of detector.

    摘要翻译： 光学接入断开系统可用于检测血液的存在。 光学接入断开系统包括放置在患者进入位置附近的一个或多个光学传感器，适用于检测血液存在的光学传感器，特别是通过检测由血液反射或吸收的光的差异。 光学接入断开系统也可以用作互锁以确保符合性。 检测器可以放置在接近位置附近以检测进入针，或者进入针或流体线上的物体或标记。 除非检测到针或流体管线，否则治疗机器（例如透析机）可被编程为不启动或继续操作。 检测器可以是校准或调整以检测针或接入线上的标记的光学传感器之一，或者可以是另一种类型的检测器。

    Electromagnetic induction access disconnect sensor
    6.
    发明授权
    Electromagnetic induction access disconnect sensor 有权
    电磁感应存取断路传感器

    公开(公告)号：US08114043B2

    公开(公告)日：2012-02-14

    申请号：US12180318

    申请日：2008-07-25

    申请人： Matthew R. Muller

    发明人： Matthew R. Muller

    IPC分类号： A61M37/00

    CPC分类号： A61M1/3653 ,  A61M1/3655 ,  A61M1/3656 ,  A61M1/3661 ,  A61M2205/13 ,  A61M2205/3561 ,  A61M2205/3569 ,  A61M2205/3592

    摘要： A connection of a patient's vascular system to an extracorporeal blood treatment machine is monitored to ensure the patient's safety during a procedure. The procedure may be hemodialysis, apheresis, plasmapheresis, a coronary by-pass operation, or other procedure. To ensure safe electrical connection, a contact and a return are connected via a conductive connection into the extracorporeal blood circuit. A current is then generated between the contact and the return and is monitored by a non-contact sensor near an access site of the patient. If the current or other quantity related to the current changes significantly, a signal is sent to the machine or a controller to notify a caregiver or a medical professional. The signal may also be sent to immediately stop a blood pump or other component of the machine.

    摘要翻译： 监测患者血管系统与体外血液处理机的连接，以确保患者在手术过程中的安全。 该程序可以是血液透析，单采血浆置换术，血浆置换术，冠状动脉旁路手术或其他手术。 为了确保安全的电气连接，接触和返回通过导电连接连接到体外血液回路中。 然后在接触和返回之间产生电流，并由患者接近位置附近的非接触传感器监测。 如果与当前相关的当前或其他数量显着变化，则将信号发送到机器或控制器以通知护理人员或医疗专业人员。 也可以发送信号以立即停止血液泵或机器的其他部件。

    Systems and methods for optically sensing characteristics of a blood flow
    7.
    发明授权
    Systems and methods for optically sensing characteristics of a blood flow 有权
    用于光学感测血流特征的系统和方法

    公开(公告)号：US07420660B2

    公开(公告)日：2008-09-02

    申请号：US11974652

    申请日：2007-10-15

    申请人： Matthew R. Muller

    发明人： Matthew R. Muller

    IPC分类号： G01N33/48

    CPC分类号： G01N21/31 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2205/128 ,  A61M2205/3393 ,  B01D17/0217

    摘要： Systems and methods for optically sensing characteristics of a blood flow provide a light source having a driver circuit that includes a source of constant current and a modulator that modulates the constant current at a selected carrier frequency for transmission to the light source. The systems and methods also include a light sensor for receiving light from the light source and producing a modulated output proportional to received light intensity. A receiver circuit including a bandpass filter is coupled to the light sensor to receive the modulated output and having a center frequency at or near the selected carrier frequency to eliminate frequency components above and below the selected carrier frequency.

    摘要翻译： 用于光学感测血流特性的系统和方法提供了具有包括恒定电流源的驱动器电路的光源和调制选定载波频率处的恒定电流以传输到光源的调制器。 该系统和方法还包括用于接收来自光源的光的光传感器，并且产生与所接收的光强成正比的调制输出。 包括带通滤波器的接收器电路被耦合到光传感器以接收调制输出并且具有处于或接近所选载波频率的中心频率，以消除所选载波频率之上和之下的频率分量。

    Systems and methods for sensing red blood cell hematocrit
    8.
    发明授权
    Systems and methods for sensing red blood cell hematocrit 有权
    用于感测红细胞血细胞比容的系统和方法

    公开(公告)号：US06419822B2

    公开(公告)日：2002-07-16

    申请号：US09901986

    申请日：2001-07-10

    申请人： Matthew R. Muller ,  Michel L. F. Joie ,  Mark R. Vandlik

    发明人： Matthew R. Muller ,  Michel L. F. Joie ,  Mark R. Vandlik

    IPC分类号： B01D1712

    CPC分类号： B01D21/302 ,  A61M1/0236 ,  A61M1/367 ,  A61M1/3696 ,  A61M1/38 ,  A61M2205/128 ,  A61M2205/3393 ,  A61M2230/207 ,  B01D17/0217 ,  B01D21/2444 ,  B01D21/245 ,  B01D21/26 ,  B01D21/262 ,  B01D21/34 ,  B01D2221/08 ,  B01D2221/10

    摘要： Red blood cell sensing systems and methods rely upon straightforward measurement geometries. The systems and methods comprise an incident light source, an optical sensor, and a blood collection tube. The systems and methods hold the blood collection tube a predetermined radial distance from the incident light source where a linear relationship exists between sensed reflected light measured by the optical sensor and red blood cell hematocrit in a range of at least 10 to 90. The systems and methods make possible accurate red blood sensing without use of special optical cuvettes, mirrors, or focusing lenses. The systems and methods also make possible the use of standard transparent plastic tubing, without reliance upon special optical cuvettes.

    摘要翻译： 红细胞感测系统和方法依赖于简单的测量几何。 系统和方法包括入射光源，光学传感器和采血管。 系统和方法将采血管保持与入射光源预定的径向距离，其中在由光学传感器测量的感测反射光与红细胞血细胞比容之间存在线性关系，范围在至少10至90°。系统和 方法可以在不使用特殊的光学比色杯，镜子或聚焦镜片的情况下进行准确的红血传感。 系统和方法也可以使用标准的透明塑料管，而不依赖于特殊的光学比色皿。

    Electromagnetic induction access disconnect systems
    9.
    发明授权
    Electromagnetic induction access disconnect systems 有权
    电磁感应接入断开系统

    公开(公告)号：US08632486B2

    公开(公告)日：2014-01-21

    申请号：US13343484

    申请日：2012-01-04

    申请人： Matthew R. Muller

    发明人： Matthew R. Muller

    IPC分类号： A61M37/00

    CPC分类号： A61M1/3653 ,  A61M1/3655 ,  A61M1/3656 ,  A61M1/3661 ,  A61M2205/13 ,  A61M2205/3561 ,  A61M2205/3569 ,  A61M2205/3592

    摘要： An access disconnect system includes a blood processing machine having a blood pump operable with blood tubing, first and second conductive contacts located in the blood tubing on an arterial tubing side of a blood filter. The first conductive contact is located upstream of the blood pump and the second conductive contact is located downstream of the blood pump. The first and second conductive contacts are positioned and arranged to form a conductive circuit including a vascular system of a patient and the blood processing machine. The system further includes a source of electric current connected to at least one of the first and second conductive contacts and a transmitter for sending a signal indicative of an amount of current flowing through the conductive circuit when the source of electric current is applied.

    摘要翻译： 一种接入断开系统包括具有可与血管连接的血液泵的血液处理机，位于血液过滤器的动脉管侧上的血管中的第一和第二导电触点。 第一导电触点位于血泵的上游，第二导电触点位于血泵的下游。 第一和第二导电触点被定位和布置成形成包括患者的血管系统和血液处理机的导电电路。 该系统还包括连接到第一和第二导电触点中的至少一个的电流源，以及当施加电流源时发送指示流过导电电路的电流量的信号的发射器。

    ELECTROMAGNETIC INDUCTION ACCESS DISCONNECT SYSTEMS
    10.
    发明申请
    ELECTROMAGNETIC INDUCTION ACCESS DISCONNECT SYSTEMS 有权
    电磁感应接入断开系统

    公开(公告)号：US20120101422A1

    公开(公告)日：2012-04-26

    申请号：US13343484

    申请日：2012-01-04

    申请人： Matthew R. Muller

    发明人： Matthew R. Muller

    IPC分类号： A61M1/34

    CPC分类号： A61M1/3653 ,  A61M1/3655 ,  A61M1/3656 ,  A61M1/3661 ,  A61M2205/13 ,  A61M2205/3561 ,  A61M2205/3569 ,  A61M2205/3592

    摘要： An access disconnect system includes a blood processing machine having a blood pump operable with blood tubing, first and second conductive contacts located in the blood tubing on an arterial tubing side of a blood filter. The first conductive contact is located upstream of the blood pump and the second conductive contact is located downstream of the blood pump. The first and second conductive contacts are positioned and arranged to form a conductive circuit including a vascular system of a patient and the blood processing machine. The system further includes a source of electric current connected to at least one of the first and second conductive contacts and a transmitter for sending a signal indicative of an amount of current flowing through the conductive circuit when the source of electric current is applied.

    摘要翻译： 一种接入断开系统包括具有可与血管连接的血液泵的血液处理机，位于血液过滤器的动脉管侧上的血管中的第一和第二导电触点。 第一导电触点位于血泵的上游，第二导电触点位于血泵的下游。 第一和第二导电触点被定位和布置成形成包括患者的血管系统和血液处理机的导电电路。 该系统还包括连接到第一和第二导电触点中的至少一个的电流源，以及当施加电流源时发送指示流过导电电路的电流量的信号的发射器。