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1.发明授权公开(公告)号：US07399468B2
公开(公告)日：2008-07-15
申请号：US11586579
申请日：2006-10-26
申请人： Thomas Luther , Martin Mueller , Sybille Albrecht , Viktor Magdolen , Olaf Wilhelm , Manfred Schmitt , Nadja Harbeck
发明人： Thomas Luther , Martin Mueller , Sybille Albrecht , Viktor Magdolen , Olaf Wilhelm , Manfred Schmitt , Nadja Harbeck
IPC分类号： A61K39/395 , A61K39/00 , C07K5/00
CPC分类号： C07K16/28 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07K16/2896 , C07K2317/565 , C07K2317/622 , G01N33/574 , G01N33/57492 , G01N33/582
摘要： The invention concerns a method and a reagent kit for detecting cells in a biological sample using a double-fluorescence technique and the diagnostic and therapeutic application of amino acid sequence-specific antibodies against the urokinase receptor having a high affinity for tumour cell-expressed receptors.
摘要翻译： 本发明涉及一种用于使用双荧光技术检测生物样品中的细胞的方法和试剂盒，以及针对对肿瘤细胞表达受体具有高亲和力的尿激酶受体的氨基酸序列特异性抗体的诊断和治疗应用。
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公开(公告)号：US20070066798A1
公开(公告)日：2007-03-22
申请号：US11586579
申请日：2006-10-26
申请人： Manfred Schmitt , Viktor Magdolen , Thomas Luther , Sybille Albrecht , Martin Muller , Olaf Wilhelm , Nadja Harbeck
发明人： Manfred Schmitt , Viktor Magdolen , Thomas Luther , Sybille Albrecht , Martin Muller , Olaf Wilhelm , Nadja Harbeck
IPC分类号： C12Q1/68 , C07K14/00 , C07K16/00 , A61K38/00 , C07K17/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00
CPC分类号： C07K16/28 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07K16/2896 , C07K2317/565 , C07K2317/622 , G01N33/574 , G01N33/57492 , G01N33/582
摘要： The invention concerns a method and a reagent kit for detecting cells in a biological sample using a double-fluorescence technique and the diagnostic and therapeutic application of amino acid sequence-specific antibodies against the urokinase receptor having a high affinity for tumour cell-expressed receptors.
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公开(公告)号：US07407751B2
公开(公告)日：2008-08-05
申请号：US10679951
申请日：2003-10-06
CPC分类号： C07K14/705 , A61K2039/505 , C07K16/30 , C07K16/3015 , C07K16/3069 , C07K2317/34
摘要： This invention relates to the production of specific antibodies for the detection of human tumor associated urokinase-type plasminogen activator receptor (uPAR) deletion variants in biological samples as well as to their diagnostic and therapeutic application.
摘要翻译： 本发明涉及生物样品中用于检测人肿瘤相关尿激酶型纤溶酶原激活物受体（uPAR）缺失变体的特异性抗体的产生及其诊断和治疗应用。
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公开(公告)号：US08461321B2
公开(公告)日：2013-06-11
申请号：US12164881
申请日：2008-06-30
CPC分类号： C07K14/705 , A61K2039/505 , C07K16/30 , C07K16/3015 , C07K16/3069 , C07K2317/34
摘要： This invention relates to the production of specific antibodies for the detection of human tumor associated urokinase-type plasminogen activator receptor (uPAR) deletion variants in biological samples as well as to their diagnostic and therapeutic application.
摘要翻译： 本发明涉及生物样品中用于检测人肿瘤相关尿激酶型纤溶酶原激活物受体（uPAR）缺失变体的特异性抗体的产生及其诊断和治疗应用。
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公开(公告)号：US20090202504A1
公开(公告)日：2009-08-13
申请号：US12164881
申请日：2008-06-30
IPC分类号： A61K48/00 , C07H21/04 , C12N15/12 , C12N5/10 , C12P21/02 , A61K31/7088 , C12Q1/68 , C12Q1/02 , A61P35/00
CPC分类号： C07K14/705 , A61K2039/505 , C07K16/30 , C07K16/3015 , C07K16/3069 , C07K2317/34
摘要： This invention relates to the production of specific antibodies for the detection of human tumor associated urokinase-type plasminogen activator receptor (uPAR) deletion variants in biological samples as well as to their diagnostic and therapeutic application.
摘要翻译： 本发明涉及生物样品中用于检测人肿瘤相关尿激酶型纤溶酶原激活物受体（uPAR）缺失变体的特异性抗体的产生及其诊断和治疗应用。
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6.发明授权公开(公告)号：US07157238B2
公开(公告)日：2007-01-02
申请号：US09926323
申请日：2000-12-13
申请人： Manfred Schmitt , Frank Noack , Henner Graeff , Nadja Harbeck
发明人： Manfred Schmitt , Frank Noack , Henner Graeff , Nadja Harbeck
IPC分类号： G01N33/574
CPC分类号： C07K16/28 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07K16/2896 , C07K2317/565 , C07K2317/622 , G01N33/574 , G01N33/57492 , G01N33/582
摘要： The invention concerns a method and a reagent kit for detecting cells in a biological sample using a double-fluorescence technique and the diagnostic and therapeutic application of amino acid sequence-specific antibodies against the urokinase receptor having a high affinity for tumour cell-expressed receptors.
摘要翻译： 本发明涉及一种用于使用双荧光技术检测生物样品中的细胞的方法和试剂盒，以及针对对肿瘤细胞表达受体具有高亲和力的尿激酶受体的氨基酸序列特异性抗体的诊断和治疗应用。
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公开(公告)号：US06528619B1
公开(公告)日：2003-03-04
申请号：US09402641
申请日：2000-01-10
申请人： Markus Bürgle , Heinrich Graeff , Horst Kessler , Viktor Magdolen , Bernhard König , Marcus Koppitz , Christoph Riemer , Manfred Schmitt , Ulrich Weidle
发明人： Markus Bürgle , Heinrich Graeff , Horst Kessler , Viktor Magdolen , Bernhard König , Marcus Koppitz , Christoph Riemer , Manfred Schmitt , Ulrich Weidle
IPC分类号： C07K708
CPC分类号： C12N9/6462 , C12Y304/21073
摘要： The present invention provides peptides as inhibitors of the binding of urokinase to the urokinase receptor. The peptides have the general structural formula (I): X1-[X2]n-X3-X4-K-Y-F-X5-X6-I-X7-W-[X8]m (I) in which X1, X2, X3, X4, X5, X6, X7 and X8 each denote an aminocarboxylic acid, n and m are each independently 0 or 1, K denotes an aminocarboxylic acid with a lysine side chain, Y denotes an aminocarboxylic acid with a tyrosine side chain, F denotes an aminocarboxylic acid with a phenyl-alanine side chain, I denotes an aminocarboxylic acid with an isoleucine side chain, W denotes an aminocarboxylic acid with a tryptophan side chain, and the monomeric building blocks are linked by —CONR1— or —NR1CO— bonds where R1 in each case independently denotes hydrogen, methyl or ethyl, and pharmaceutically compatible salts and derivatives thereof.
摘要翻译： 本发明提供肽作为尿激酶与尿激酶受体结合的抑制剂。 肽具有通式结构式（I）：其中X 1，X 2，X 3，X 4，X 5，X 6，X 7和X 8各自表示氨基羧酸，n和m各自独立地为0或1，K表示氨基羧酸， 赖氨酸侧链，Y表示具有酪氨酸侧链的氨基羧酸，F表示具有苯基 - 丙氨酸侧链的氨基羧酸，I表示具有异亮氨酸侧链的氨基羧酸，W表示具有色氨酸侧链的氨基羧酸， 并且单体结构单元通过-CONR1-或-NR1CO-键连接，其中R 1在每种情况下独立地表示氢，甲基或乙基，以及其药学上相容的盐和衍生物。
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公开(公告)号：US06872702B1
公开(公告)日：2005-03-29
申请号：US09402464
申请日：1999-04-14
申请人： Horst Kessler , Heinrich Graeff , Manfred Schmitt , Viktor Magdolen , Olaf G. Wilhelm , Christoph Riemer , Markus Bürgle
发明人： Horst Kessler , Heinrich Graeff , Manfred Schmitt , Viktor Magdolen , Olaf G. Wilhelm , Christoph Riemer , Markus Bürgle
IPC分类号： A61K38/00 , A61K38/04 , A61K38/49 , A61P9/00 , A61P9/10 , A61P19/10 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07K7/00 , C07K7/06 , C07K14/47 , C12N9/72 , A61K38/12
CPC分类号： C12N9/6462 , C12Y304/21073
摘要： The present invention concerns peptides as inhibitors of the binding of urokinase to the urokinase receptor. These peptides, which are preferably cyclic, are suitable as pharmaceutical agents for diseases that are mediated by urokinase and its receptor.
摘要翻译： 本发明涉及作为尿激酶与尿激酶受体结合的抑制剂的肽。 这些优选环状的肽适合作为由尿激酶及其受体介导的疾病的药剂。
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公开(公告)号：US08720202B2
公开(公告)日：2014-05-13
申请号：US13390590
申请日：2010-08-03
CPC分类号： F01N5/02 , F02B29/0412 , F02B37/013 , F02M26/08 , F02M26/10 , F02M26/34 , Y02T10/146 , Y02T10/16
摘要： An internal combustion engine having an exhaust gas recirculation device for recirculating exhaust gas of the internal combustion engine to a fresh-air side of the internal combustion engine. For this purpose, it is provided that the exhaust gas recirculation device has at least one compressor for compressing the exhaust gas supplied to the fresh-air side of the internal combustion engine.
摘要翻译： 具有排气再循环装置的内燃机，其用于将内燃机的废气再循环到内燃机的新鲜空气侧。 为此，排气再循环装置具有至少一个用于压缩供给内燃机的新鲜空气侧的废气的压缩机。
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公开(公告)号：US20120144825A1
公开(公告)日：2012-06-14
申请号：US13377247
申请日：2010-06-22
IPC分类号： F02B37/04
CPC分类号： F02M25/0707 , F01K23/065 , F01N5/02 , F02B37/00 , F02B37/013 , F02G5/02 , F02M26/05 , F02M37/18 , Y02T10/144 , Y02T10/16
摘要： A device for utilizing the waste heat of an internal combustion includes a single-stage or multi-stage supercharging device, which is designed as an exhaust-gas turbocharger in particular. The single-stage or multi-stage supercharging device is assigned an additional supercharging device including an expansion machine acted upon by an auxiliary circuit, in particular a steam circuit.
摘要翻译： 用于利用内燃余热的装置包括特别设计为排气涡轮增压器的单级或多级增压装置。 单级或多级增压装置被分配附加的增压装置，其包括由辅助电路特别是蒸汽回路作用的膨胀机。
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