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    Process for the hydrogenation of imines
    10.
    发明申请
    Process for the hydrogenation of imines 审中-公开
    亚胺氢化方法

    公开(公告)号：US20070213540A1

    公开(公告)日：2007-09-13

    申请号：US11371084

    申请日：2006-03-09

    申请人： Juan Jose Perea ,  Thomas Riermeier ,  Axel Monsees ,  Renat Kadyrov

    发明人： Juan Jose Perea ,  Thomas Riermeier ,  Axel Monsees ,  Renat Kadyrov

    IPC分类号： C07D333/42 ,  C07C209/44

    CPC分类号： C07C209/52 ,  C07B2200/07 ,  C07C211/48

    摘要： The present invention relates to a process for the hydrogenation of an imines with hydrogen in the presence of iridium catalysts. In particular, the present invention relates to a process for the hydrogenation of imines with hydrogen under elevated pressure in the presence of an iridium catalyst and with or without an inert solvent, wherein the reaction mixture comprises a phosphonium chloride, bromide or iodide in the presence of an acid, which can be an organic or inorganic acid soluble or insoluble in the reaction mixture. Suitable imines are especially those that contain at least one group. If the groups are substituted asymetrically and are thus compounds having a prochiral ketitine group, it is possible in the process according to the invention for mixtures of optical isomers or pure optical isomers to be formed if enantioselective or diastereoselective iridium catatalysts are used.

    摘要翻译： 本发明涉及在铱催化剂存在下用氢氢化亚胺的方法。 特别地，本发明涉及在铱催化剂和惰性溶剂的存在下在高压下用氢气氢化亚胺的方法，其中反应混合物在存在下包含氯化鏻，溴化物或碘化鏻 的酸，其可以是可溶于或不溶于反应混合物的有机或无机酸。 合适的亚胺尤其是含有至少一个基团的亚胺。 如果这些基团被非对称取代，并且因此是具有前手性酮亚胺基团的化合物，则在本发明的方法中，如果使用对映选择性或非对映选择性铱催化剂，则可以形成光学异构体或纯的光学异构体的混合物。