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    Chromanylascorbic acid derivatives their preparation and use
    2.
    发明授权
    Chromanylascorbic acid derivatives their preparation and use 失效
    色甘酸抗坏血酸衍生物，其制备和用途

    公开(公告)号：US5962701A

    公开(公告)日：1999-10-05

    申请号：US912785

    申请日：1997-08-18

    申请人： Thomas Rosenau ,  Wolf-Dieter Habicher ,  Harald Streicher

    发明人： Thomas Rosenau ,  Wolf-Dieter Habicher ,  Harald Streicher

    IPC分类号： A23L1/30 ,  A23L1/302 ,  A61K8/00 ,  A61K8/49 ,  A61K8/67 ,  A61K31/35 ,  A61K31/375 ,  A61P43/00 ,  A61Q19/00 ,  C07D407/12 ,  C08K5/15 ,  C08K5/1545 ,  C09K15/08 ,  C09K15/32 ,  C07D307/62

    CPC分类号： C07D407/12 ,  A61K31/375

    摘要： Chromanylascorbic acid derivatives of the general formula I ##STR1## where R.sup.1 is an organic radical having 1 to 12 C atoms, in particular a methyl group,R.sup.2 is an organic radical having 8 to 30 C atoms, which is unsubstituted or substituted by functional groups, in particular the phytyl 30 radical, andR.sup.3 is the --PO.sub.3 H.sub.2 -- radical or a glycosidyl radical,R.sup.3, R.sup.4 and R.sup.5 are hydrogen, or an alkyl or acyl group having 1 to 20 C atoms, in particular hydrogen, andR.sup.6 is hydrogen or an acyl radical,their preparation by reacting the corresponding 5-chloromethyl- or 5-bromomethylchroman derivatives with the alkali metal or alkaline earth metal salts of ascorbic acid or the ascorbic acid derivatives corresponding to the formula I, and the use of the compounds according to the invention as pharmaceutical or cosmetic active compounds or food supplements, as bioantioxidants and for the stabilization of organic substances, in particular of foods, such as synthetic or natural fats and oils, or pharmaceutical preparations, but also of plastics, against the harmful action of oxygen, light and/or heat are described.

    摘要翻译： 其中R1是具有1至12个碳原子的有机基团，特别是甲基，R 2是具有8至30个碳原子的有机基团，其是未取代的或被官能团取代的通式I的色甘烷抗坏血酸衍生物，特别是 植酰基30基团，R3为-PO3H2-基或糖基，R3，R4和R5为氢，或具有1-20个碳原子的烷基或酰基，特别是氢，R6为氢或酰基 通过使相应的5-氯甲基或5-溴甲基苯并二氢吡喃衍生物与抗坏血酸的碱金属或碱土金属盐或对应于式I的抗坏血酸衍生物反应制备，以及使用根据本发明的化合物 作为药物或化妆品活性化合物或食品补充剂，作为生物抗氧化剂和稳定有机物质，特别是食品，如合成或天然脂肪和油，或药物p 描述了对氧，光和/或热的有害作用的补偿，也是塑料的补偿。

    Preparation of chromanyl derivatives
    3.
    发明授权
    Preparation of chromanyl derivatives 失效
    苯并二氢吡喃衍生物的制备

    公开(公告)号：US5917060A

    公开(公告)日：1999-06-29

    申请号：US992539

    申请日：1997-12-17

    申请人： Thomas Rosenau ,  Wolf-Dieter Habicher

    发明人： Thomas Rosenau ,  Wolf-Dieter Habicher

    IPC分类号： C07D311/72 ,  C07C311/04

    CPC分类号： C07D311/72

    摘要： A process for the preparation of chromanyl derivatives of the formula I ##STR1## where R.sup.1 is hydrogen, C.sub.1 -C.sub.8 -alkyl, aryl, aralkyl, Si(R.sup.4).sub.3, C(.dbd.O)R.sup.4 or C.sub.1 -C.sub.4 -alkoxymethyl,R.sup.2 and R.sup.3 are hydrogen or C.sub.1 -C.sub.3 -alkyl, andR.sup.4 is C.sub.1 -C.sub.8 -alkyl or aryl,which comprises decarboxylating 5-carboxychromanyl derivatives of the formula II ##STR2## where the substituents R.sup.1 to R.sup.3 are as defined above and 5-carboxylchromanyl derivatives of the formula II.

    摘要翻译： 其中R 1是氢，C 1 -C 8 - 烷基，芳基，芳烷基，Si（R 4）3，C（= O）R 4或C 1 -C 4烷氧基甲基，R 2和R 3是式I的苯并二氢吡喃衍生物的方法 氢或C 1 -C 3 - 烷基，R 4是C 1 -C 8 - 烷基或芳基，其包括式II的脱羧的5-羧基苯并二氢吡喃基衍生物，其中取代基R 1至R 3如上定义，和式II的5-羧基苯并二氢吡喃基衍生物。