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    Object having a microbicide coating, method for the production thereof and use of the same
    1.
    发明授权
    Object having a microbicide coating, method for the production thereof and use of the same 有权
    具有杀微生物剂涂层的物体，其制造方法及其用途

    公开(公告)号：US07279173B2

    公开(公告)日：2007-10-09

    申请号：US10415396

    申请日：2001-07-13

    申请人： Thomas Schiestel ,  Hermann Schirra ,  Helmut Schmidt ,  Detmar Buxmann

    发明人： Thomas Schiestel ,  Hermann Schirra ,  Helmut Schmidt ,  Detmar Buxmann

    IPC分类号： A01N25/10 ,  A01N59/16

    CPC分类号： C09D183/08 ,  C09D4/00 ,  C09D5/14 ,  C09D183/02 ,  C09D183/04 ,  C08G77/00 ,  C08L2666/52

    摘要： A microbicidally coated article, especially a container, having on at least part of it a coating comprising an organically modified inorganic matrix comprising silver colloids which is obtainable by application of a coating composition comprising a) a hydrolysate or condensate based on at least one hydrolysable silane with at least one non-hydrolysable substituent and b) a silver compound to the surface of the article and treatment with heat and/or radiation to form the silver colloid coating. Articles coated in accordance with the invention are therefore particularly suitable for purposes of disinfection, preservation, cosmetic, pharmaceutical or medical purposes. Articles from the pharmaceutical or medical sector, especially containers for pharmaceuticals or articles or components which come into contact with the human body and are required to be free from germs, are preferred fields of application.

    摘要翻译： 一种杀微生物涂覆的制品，特别是容器，其至少部分具有包含有机改性的无机基质的涂层，其包含银胶体，其可通过施用涂料组合物获得，所述涂料组合物包含：a）基于至少一种可水解硅烷的水解产物或缩合物 与至少一种不可水解的取代基和b）一种银化合物到制品的表面并用热和/或辐射进行处理以形成银胶体涂层。 因此，根据本发明涂覆的制品特别适用于消毒，保存，化妆品，医药或医疗目的。 优选的药物或医疗领域的药物，尤其是与人体接触并被要求不含细菌的药物或制品或成分的容器。

    Nanostructured forms and layers and method for producing them using stable water-soluble precursors
    3.
    发明授权
    Nanostructured forms and layers and method for producing them using stable water-soluble precursors 有权
    纳米结构形式和层以及使用稳定的水溶性前体制备它们的方法

    公开(公告)号：US06620514B1

    公开(公告)日：2003-09-16

    申请号：US09647971

    申请日：2000-10-06

    申请人： Ertugrul Arpac ,  Gerhard Jonschker ,  Hermann Schirra ,  Helmut Schmidt

    发明人： Ertugrul Arpac ,  Gerhard Jonschker ,  Hermann Schirra ,  Helmut Schmidt

    IPC分类号： B32B904

    CPC分类号： C09D4/00 ,  C03C1/008 ,  C03C14/00 ,  C03C17/009 ,  C03C2214/12 ,  C09D183/04 ,  Y10T428/2995 ,  Y10T428/31663 ,  C08G77/04 ,  C08G77/00 ,  C08L2666/54

    摘要： A process for preparing a composition for producing nanostructured mouldings and layers comprises contacting an aqueous and/or alcoholic sol of a compound of an element selected from silicon sand metals of the main groups and transition groups of the Periodic Table with species possessing hydrolysable alkoxy groups and comprising at least one organically modified alkoxysilane or a precondensate derived therefrom, under conditions which lead to (further) hydrolysis of the species, and subsequent removal of the alcohol formed and any alcohol already present originally. The process is characterized in that the alcohol is removed in an amount such that the residual alcohol content of the composition is not more than 20% by weight.

    摘要翻译： 制备纳米结构模制品和层的组合物的方法包括使选自主体的硅砂金属和周期表的过渡基团的元素的化合物的水溶液和/或醇溶胶与具有可水解烷氧基的物质接触， 包括至少一种有机改性的烷氧基硅烷或由其衍生的预缩合物，在导致（进一步）水解该物质的条件下，随后除去所形成的醇和任何已经存在的醇。 该方法的特征在于，以使得组合物的残余醇含量不超过20重量％的量除去醇。

    Self-crosslinking compositions based on fluorine-containing polycondensates
    4.
    发明授权
    Self-crosslinking compositions based on fluorine-containing polycondensates 有权
    基于含氟缩聚物的自交联组合物

    公开(公告)号：US06630205B2

    公开(公告)日：2003-10-07

    申请号：US10148520

    申请日：2002-05-31

    申请人： Stefan Brueck ,  Christoph Lesniak ,  Hermann Schirra ,  Helmut Schmidt

    发明人： Stefan Brueck ,  Christoph Lesniak ,  Hermann Schirra ,  Helmut Schmidt

    IPC分类号： B05D302

    CPC分类号： C09D183/08 ,  C08G77/22 ,  C08G77/24 ,  C08G77/26 ,  C08L2666/54 ,  C08L83/00

    摘要： The invention relates to a method for coating a substrate according to which a self-crosslinking coating composition is produced on the basis of a) at least one hydrolysable silane with at least one nonhydrolysable substituent, said silane having one or more electrophilic groups X on at least one nonhydrolysable substitutent, b) at least one hydrolysable silane with at least one nonhydrolysable substituent, said silane having one or more nucleophilic groups Y on at least one nonhydrolysable substituent, c) at least one hydrolysable silane with at least one nonhydrolysable carbonic group that has an average of 2 to 30 fluorine atoms that are bound to one or more aliphatic carbon atoms that are separated from the silicon atom by at least two atoms. The silanes (a), (b) and/or (c) are optionally precondensed and either the silanes (a) may be completely or partially replaced by organic compounds with at least two groups X or the silanes (b) may be completely or partially replaced by organic compounds with at least two groups Y. The self-crosslinking coating composition is then applied to a substrate and allowed to cure at ambient temperature (below 40° C.) to form a coating.

    摘要翻译： 本发明涉及一种涂覆基材的方法，根据该方法，基于以下方式制备自交联涂料组合物：a）至少一种具有至少一个不可水解取代基的可水解硅烷，所述硅烷具有一个或多个亲电基团X 至少一种不可水解取代基，b）至少一种具有至少一个不可水解取代基的可水解硅烷，所述硅烷在至少一个不可水解取代基上具有一个或多个亲核基团Y，c）至少一种具有至少一个不可水解碳酸基的可水解硅烷， 具有平均2至30个氟原子，其结合于通过至少两个原子与硅原子分离的一个或多个脂族碳原子。 硅烷（a），（b）和/或（c）任选地被预稠化，并且硅烷（a）可以被具有至少两个X基团的有机化合物完全或部分替代，或者硅烷（b）可以是完全或 部分地被具有至少两个基团Y的有机化合物取代。然后将自交联涂料组合物施加到基底上并使其在环境温度（低于40℃）下固化以形成涂层。

    Nanoscale particles having an iron oxide-containing core enveloped by at least two shells
    5.
    发明授权
    Nanoscale particles having an iron oxide-containing core enveloped by at least two shells 失效
    具有包含至少两个壳的含氧化铁芯的纳米级颗粒

    公开(公告)号：US06979466B2

    公开(公告)日：2005-12-27

    申请号：US10391356

    申请日：2003-03-17

    申请人： Christoph Lesniak ,  Thomas Schiestel ,  Helmut Schmidt ,  Andreas Jordan

    发明人： Christoph Lesniak ,  Thomas Schiestel ,  Helmut Schmidt ,  Andreas Jordan

    IPC分类号： A61K9/16 ,  A61K41/00 ,  A61P35/00 ,  A61K9/51

    CPC分类号： A61K41/0052

    摘要： The invention relates to nanoscale particles suited especially for use in tumor therapy by hyperthermia. Said particles comprise a (preferably superparamagnetic) iron oxide-containing core and at least two shells surrounding said core. The (innermost) shell adjoining the core is an envelope which comprises groups capable of forming cationic groups and is broken down by human or animal tissue at such a slow rate as to allow for association of the core surrounded by said envelope with the surface of cells and/or for absorption of said core into the inside of cells. The outer shell(s) consist(s) of species having neutral and/or anionic groups which allow the nanoscale particles to appear to the outside as having a neutral or negative charge and which are broken down by human or animal tissue more rapidly than the innermost shell—and in so doing uncover the shells underneath—but still sufficiently slowly so as to ensure that the nanoscale particles are adequately distributed in a tissue infiltrated with same particles in a particular point.

    摘要翻译： 本发明涉及特别适用于通过高热治疗肿瘤治疗的纳米级颗粒。 所述颗粒包含（优选超顺磁性）含氧化铁的芯和围绕所述芯的至少两个壳。 与核心相邻的（最内侧）壳是包含能够形成阳离子基团并且以如此慢的速率被人或动物组织分解以允许由所述包膜包围的核与细胞表面缔合的基团 和/或用于将所述核吸收到细胞内部。 外壳由具有中性和/或阴离子基团的物质组成，其允许纳米级颗粒以外面的形式出现在外部，具有中性或负电荷，并且比人或动物组织更快地分解 最内层的壳体，并且在其中露出壳下面，但是仍然足够缓慢，以便确保纳米级颗粒在特定的点上适当地分布在渗透有相同颗粒的组织中。

    Process for preparing agglomerate-free nanoscalar iron oxide particles with a hydrolysis resistant coating
    6.
    发明授权
    Process for preparing agglomerate-free nanoscalar iron oxide particles with a hydrolysis resistant coating 有权
    用耐水解涂层制备无团聚的纳米级氧化铁颗粒的方法

    公开(公告)号：US06183658B2

    公开(公告)日：2001-02-06

    申请号：US09171065

    申请日：1998-10-09

    申请人： Christoph Lesniak ,  Thomas Schiestel ,  Rüdiger Nass ,  Helmut Schmidt

    发明人： Christoph Lesniak ,  Thomas Schiestel ,  Rüdiger Nass ,  Helmut Schmidt

    IPC分类号： C09D1700

    CPC分类号： B82Y30/00 ,  C01G49/02 ,  C01P2004/64 ,  C01P2006/80 ,  C01P2006/90 ,  C09C1/24 ,  C09C3/006 ,  C09C3/045 ,  C09C3/12 ,  Y10T428/2995

    摘要： A process for preparing an agglomerate-free suspension of nanosize iron-containing oxide particles coated in a stable manner comprises preparing an aqueous suspension of nanosize iron-containing oxide particles which are partially or completely in the form of agglomerates; adding a trialkoxysilane and a water-miscible polar organic solvent which has a boiling point at least 10° C. higher than the boiling point of water; treating the resulting suspension with ultrasound until at least 70% of the particles present are in the range of ±20% of the average particle diameter; removing the water by distillation under the action of ultrasound; and separating the non-disintegrated agglomerates.

    摘要翻译： 制备以稳定方式包被的纳米尺寸含铁氧化物颗粒的无附聚物悬浮液的方法包括制备部分或全部为附聚物形式的纳米级含铁氧化物颗粒的水性悬浮液; 加入沸点比水的沸点高至少10℃的三烷氧基硅烷和水混溶性极性有机溶剂; 用超声波处理所得到的悬浮液，直到存在的颗粒的至少70％在平均粒径的±20％的范围内; 在超声波作用下通过蒸馏除去水分; 并分离未崩解的附聚物。

    Nanoscale particles having an iron oxide-containing core enveloped by at least two shells
    7.
    发明授权
    Nanoscale particles having an iron oxide-containing core enveloped by at least two shells 有权
    具有包含至少两个壳的含氧化铁芯的纳米级颗粒

    公开(公告)号：US06541039B1

    公开(公告)日：2003-04-01

    申请号：US09446438

    申请日：1999-12-20

    申请人： Christoph Lesniak ,  Thomas Schiestel ,  Helmut Schmidt ,  Andreas Jordan

    发明人： Christoph Lesniak ,  Thomas Schiestel ,  Helmut Schmidt ,  Andreas Jordan

    IPC分类号： A61K3326

    CPC分类号： A61K41/0052

    摘要： The invention relates to nanoscale particles suited especially for use in tumor therapy by hyperthermia. Said particles comprise a (preferably superparamagnetic) iron oxide-containing core and at least two shells surrounding said core. The (innermost) shell adjoining the core is an envelope which comprises groups capable of forming cationic groups and is broken down by human or animal tissue at such a slow rate as to allow for association of the core surrounded by said envelope with the surface of cells and/or for absorption of said core into the inside of cells. The outer shell(s) consist(s) of species having neutral and/or anionic groups which allow the nanoscale particles to appear to the outside as having a neutral or negative charge and which are broken down by human or animal tissue more rapidly than the innermost shell—and in so doing uncover the shells underneath—but still sufficiently slowly so as to ensure that the nanoscale particles are adequately distributed in a tissue infiltrated with same particles in a particular point.

    摘要翻译： 本发明涉及特别适用于通过高热治疗肿瘤治疗的纳米级颗粒。 所述颗粒包含（优选超顺磁性）含氧化铁的芯和围绕所述芯的至少两个壳。 与核心相邻的（最内侧）壳是包含能够形成阳离子基团并且以如此慢的速率被人或动物组织分解以允许由所述包膜包围的核与细胞表面缔合的基团 和/或用于将所述核吸收到细胞内部。 外壳由具有中性和/或阴离子基团的物质组成，其允许纳米级颗粒以外面的形式出现在外部，具有中性或负电荷，并且比人或动物组织更快地分解 最内层的壳体，并且在其中露出壳下面，但是仍然足够缓慢，以便确保纳米级颗粒在特定的点上适当地分布在渗透有相同颗粒的组织中。

    Metallic articles having vitreous or glass-ceramic pigmented protective layers having a high chemical resistance
    8.
    发明授权
    Metallic articles having vitreous or glass-ceramic pigmented protective layers having a high chemical resistance 有权
    具有玻璃状或玻璃 - 陶瓷着色保护层的具有高耐化学性的金属制品

    公开(公告)号：US09534297B2

    公开(公告)日：2017-01-03

    申请号：US13140608

    申请日：2009-12-23

    申请人： Helmut Schmidt ,  Carsten Schmidt ,  Thomas Dembski

    发明人： Helmut Schmidt ,  Carsten Schmidt ,  Thomas Dembski

    IPC分类号： B32B15/04 ,  C23C18/12

    CPC分类号： C23C18/1241 ,  C23C18/1208 ,  Y02T50/67 ,  Y10T428/256 ,  Y10T428/257

    摘要： Metallic substrates with a vitreous or glass-ceramic pigmented protective layer are obtainable by applying an alkali metal silicate-containing coating sol to the substrate or a surface thereof and thermally densifying the layer thus obtained, said alkali metal silicate-containing coating sol comprising an oxidic pigment of at least one element selected from the third and fourth main or subgroups of the Periodic Table of the chemical elements and the transition metals Fe, Co, Ni, Cu, Zn, Nb and Ta.

    摘要翻译： 具有玻璃状或玻璃陶瓷着色保护层的金属基材可以通过将碱金属硅酸盐的涂层溶胶涂布在基材或其表面上并使由此获得的层热致密化而获得，所述含碱金属硅酸盐的涂料溶胶包含氧化 选自化学元素周期表第三和第四主族或亚组中的至少一种元素的颜料和过渡金属Fe，Co，Ni，Cu，Zn，Nb和Ta。