摘要:
Various sulfonamide-based compounds are able to selectively inhibit the Src family of tyrosine kinases. These compounds are useful in the treatment of various diseases including hyperproliferative diseases, hematologic diseases, osteoporosis, neurological diseases, autoimmune diseases, allergic/immunological diseases, or viral infections.
摘要:
The present invention provides a method of prophylaxis, treatment or inhibition of a cannabinoid receptor-associated disease, disorder or condition in a mammalian subject, the method comprising administering to the subject a compound having the structure of formula I or a pharmaceutically acceptable salt, acid salt, hydrate or stereoisomer thereof, wherein the cannabinoid receptor-associated disease, disorder or condition is pain or an inflammatory disease, disorder or condition, and wherein formula I is as follows: wherein Rb, Rc, Z, Y and m are defined in the specification.
摘要:
The present invention provides methods of prevention and treatment of cannabinoid receptor-associated diseases and conditions, wherein the method includes administering a substituted imidazoheterocyclic compounds having the structure of formula I or a pharmaceutically acceptable salt, acid salt, hydrate, solvate or stereoisomer of a compound having the structure of formula I. The cannabinoid receptor-associated diseases and conditions preventable or treatable by the methods of the present invention include pain, inflammation and pruritis.
摘要:
A method of displaying results of a financial model for forecasting at least one financial variable relating to a client. The method comprises the steps of receiving asset and liability data regarding the client; generating forecasted values for the financial variables over a number of simulations using the asset and liability data; and displaying a topographical chart on a user interface. The topographical chart may be positioned on a plane shown in the user interface. The plane may be defined by a time axis and a value axis for the at least one financial variable, such that a coordinate set on the plane represents the value of the at least one financial variable at a time point. The height of a first point on the topographical chart corresponding to the coordinate set may indicate a portion of the simulations that result in the coordinate set.
摘要:
A zoned heating and cooling system is controlled by a relay panel with a controlling thermostat in a first zone, and an additional thermostat in each additional zone. A relay corresponding to each first and additional zone, a relay to control the mode in which the system operates, and a fan relay, work in conjunction with the thermostats to: turn on system heating or cooling equipment; open dampers to provide conditioned air to those zones which call for heating or cooling; close dampers to block conditioned air from entering the zones which do not call for heating or cooling, when other zones do call; open all dampers when there is no calling; and provide for the manual or automatic control of a system fan.
摘要:
Modular casket hardware which includes a bracket configured to attach to a casket corner wall surface. The bracket is also configured to be oriented with respect to the casket in a first orientation to attach to the casket wall and a second orientation to attach to the casket corner. A bore in the bracket is configured to receive a casket bar when in the first orientation. Tabs on the bracket are configured to at least partially fit within a portion of the casket bar when the bracket is oriented in the second orientation. A bracket cover could also use other bracket type mechanisms to attach and hold the casket bars to the casket which will support the required weight of a casket at the grave site. Once a bracket and bars are attached, the casket will be able to be shipped without the decorative bracket cover installed. The decorative modular casket bracket cover will be able to be added to the casket at any time.
摘要:
The present invention provides substituted imidazoheterocyclic compounds having the structure of formula I Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.
摘要:
The present invention provides substituted imidazoheterocyclic compounds having the structure of formula I Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.
摘要:
A system for watermarking and transferring watermarked material comprises a transaction server, first and second clients, first apparatus for applying a perceptible watermark to the material and second apparatus for removing the watermark. The server, clients and first and second apparatus are linked by one or more communications networks. The system is arranged to implement the steps of: transferring from the transaction server to the first apparatus (i) data for creating a watermark, the creating data including (a) data defining an invertible algorithm and (b) data for creating at least one security key associated with the algorithm and (ii) data for creating a material identifier; using the said first apparatus to apply a material identifier to the material and applying a watermark to the material, using the said creating data; transferring from the first client to the transaction server the said material identifier and data for inverting the algorithm including the said at least one key; transferring the watermarked material to the second apparatus; deriving the said material identifier from the material; transferring the identifier from the second client to the transaction server; subject to predetermined conditions being satisfied, transferring from the transaction server to the second apparatus watermark removal data associated with the said material identifier, the removal data including at least one key and data defining an algorithm for removing the watermark in conjunction with the key; and using the second apparatus to remove the watermark using the said removal data.
摘要:
The fresh flower bouquet system provides cost-effective production of fresh floral bouquets, forming bouquets with symmetrical spacing of individual stems and maintaining the flowers in water and a cut flower hydrating solution without the use of floral foam. The system includes a plastic or metal cap having a grid of holes defined therein, a plastic or glass vase or other container, and a tie-down system, e.g., an elastic or rubber band wrapped around the stems, for bundling the stems together in the container below the cap. When the closure or cap is snapped or threaded on to the container, a secured, self-contained floral bouquet having maximum shelf life because of continuous hydration is formed.