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公开(公告)号：US20110009712A1
公开(公告)日：2011-01-13
申请号：US12499738
申请日：2009-07-08
IPC分类号： A61B5/0295 , A61B5/026 , A61B5/02
CPC分类号： A61B5/686 , A61B5/0084 , A61B5/02007 , A61B5/0205 , A61B5/02125 , A61B5/02154 , A61B5/02416 , A61B5/026 , A61B5/0295 , A61B5/04012 , A61B5/0402 , A61B5/0535 , A61B5/0538 , A61B5/1459 , A61B5/4836 , A61B5/7242 , A61B5/746 , A61N1/36521 , A61N1/36557
摘要： Implantable systems, and methods for use therewith, are provided for monitoring for an impending myocardial infarction. A signal indicative of changes in arterial blood volume is obtained. Such a signal can be a photoplethysmography signal or an impedance plethysmography signal. For each of a plurality of periods of time, a metric indicative of the areas under the curve of the signal or number of inflections in the signal is determined. An impending myocardial infarction is monitored for based on changes in the metric indicative of the area under the curve of the signal or number of inflections in the signal, and an alert and/or therapy is triggered in response to an impending myocardial infarction being predicted.
摘要翻译： 可植入系统及其使用方法被提供用于监测即将发生的心肌梗死。 获得表示动脉血容量变化的信号。 这样的信号可以是光谱体积描记信号或阻抗体积描记信号。 对于多个时间段中的每一个，确定指示信号曲线下的区域或信号中的变形数量的度量。 基于指示信号曲线下的面积的度量的变化或信号中的变动数量来监视即将到来的心肌梗死，并且响应于正在预测的即将发生的心肌梗死而触发警报和/或治疗。
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2.发明授权公开(公告)号：US08672855B2
公开(公告)日：2014-03-18
申请号：US12499738
申请日：2009-07-08
IPC分类号： A61B5/0295
CPC分类号： A61B5/686 , A61B5/0084 , A61B5/02007 , A61B5/0205 , A61B5/02125 , A61B5/02154 , A61B5/02416 , A61B5/026 , A61B5/0295 , A61B5/04012 , A61B5/0402 , A61B5/0535 , A61B5/0538 , A61B5/1459 , A61B5/4836 , A61B5/7242 , A61B5/746 , A61N1/36521 , A61N1/36557
摘要： Implantable systems, and methods for use therewith, are provided for monitoring for an impending myocardial infarction. A signal indicative of changes in arterial blood volume is obtained. Such a signal can be a photoplethysmography signal or an impedance plethysmography signal. For each of a plurality of periods of time, a metric indicative of the areas under the curve of the signal or number of inflections in the signal is determined. An impending myocardial infarction is monitored for based on changes in the metric indicative of the area under the curve of the signal or number of inflections in the signal, and an alert and/or therapy is triggered in response to an impending myocardial infarction being predicted.
摘要翻译： 可植入系统及其使用方法被提供用于监测即将发生的心肌梗死。 获得表示动脉血容量变化的信号。 这样的信号可以是光谱体积描记信号或阻抗体积描记信号。 对于多个时间段中的每一个，确定指示信号曲线下的区域或信号中的变形数量的度量。 基于指示信号曲线下的面积的度量的变化或信号中的变动数量来监视即将到来的心肌梗死，并且响应于正在预测的即将发生的心肌梗死而触发警报和/或治疗。
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3.发明授权Devices, systems, and methods for characterizing a tachycardia and/or selecting treatment for a tachycardia using results of a dominant frequency analysis 有权使用主频率分析结果表征心动过速和/或选择治疗心动过速的装置，系统和方法公开(公告)号：US09205274B2
公开(公告)日：2015-12-08
申请号：US13090059
申请日：2011-04-19
IPC分类号： A61B5/0402 , A61N1/39 , A61B5/04 , A61N1/362 , A61B5/0464 , A61B5/00
CPC分类号： A61N1/3962 , A61B5/04014 , A61B5/0464 , A61B5/7257 , A61N1/3622
摘要： Provided herein are implantable systems, and methods for use therewith, for characterizing a tachycardia and/or selecting treatment for a tachycardia using results of a dominant frequency analysis. One or more electrogram (EGM) signal(s) indicative of cardiac electrical activity are obtained. For at least one of the EGM signal(s) a dominant frequency (DF) analysis is performed, and the results of the DF analysis are used to characterize a tachycardia and/or to select treatment for a tachycardia.
摘要翻译： 本文提供的可植入系统及其使用的方法用于表征心动过速和/或使用主频率分析的结果来选择治疗心动过速。 获得指示心脏电活动的一个或多个电描记图（EGM）信号。 对于至少一个EGM信号进行主频（DF）分析，并且DF分析的结果用于表征心动过速和/或选择心动过速的治疗。
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4.发明授权Devices, systems and methods for characterizing a tachycardia and/or selecting treatment for a tachycardia using results of a fractionation analysis 有权用于表征心动过速和/或使用分级分析结果选择治疗心动过速的装置，系统和方法公开(公告)号：US08548587B2
公开(公告)日：2013-10-01
申请号：US13090079
申请日：2011-04-19
IPC分类号： A61N1/365
CPC分类号： A61N1/3962 , A61N1/3622 , A61N1/3702
摘要： Provided herein are implantable systems, and methods for use therewith, for characterizing a tachycardia and/or selecting treatment for a tachycardia using results of a fractionation analysis. One or more electrogram (EGM) signal(s) indicative of cardiac electrical activity are obtained. At least one of the EGM signal(s) is analyzed to determine whether the EGM signal is fractionated, and the results of the analyzing are used to characterize a tachycardia and/or to select treatment for a tachycardia.
摘要翻译： 本文提供了可植入系统及其使用的方法，用于表征心动过速和/或使用分级分析结果选择治疗心动过速。 获得指示心脏电活动的一个或多个电描记图（EGM）信号。 分析至少一个EGM信号以确定EGM信号是否被分级，并且分析结果用于表征心动过速和/或选择心动过速的治疗。
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5.发明申请DEVICES, SYSTEMS AND METHODS FOR CHARACTERIZING A TACHYCARDIA AND/OR SELECTING TREATMENT FOR A TACHYCARDIA USING RESULTS OF A FRACTIONATION ANALYSIS 有权使用分析分析结果表征TACHYCARDIA和/或选择TACHYCARDIA处理的装置，系统和方法公开(公告)号：US20120271368A1
公开(公告)日：2012-10-25
申请号：US13090079
申请日：2011-04-19
IPC分类号： A61N1/365
CPC分类号： A61N1/3962 , A61N1/3622 , A61N1/3702
摘要： Provided herein are implantable systems, and methods for use therewith, for characterizing a tachycardia and/or selecting treatment for a tachycardia using results of a fractionation analysis. One or more electrogram (EGM) signal(s) indicative of cardiac electrical activity are obtained. At least one of the EGM signal(s) is analyzed to determine whether the EGM signal is fractionated, and the results of the analyzing are used to characterize a tachycardia and/or to select treatment for a tachycardia.
摘要翻译： 本文提供了可植入系统及其使用的方法，用于表征心动过速和/或使用分级分析结果选择治疗心动过速。 获得指示心脏电活动的一个或多个电描记图（EGM）信号。 分析至少一个EGM信号以确定EGM信号是否被分级，并且分析结果用于表征心动过速和/或选择心动过速的治疗。
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6.发明申请DEVICES, SYSTEMS, AND METHODS FOR CHARACTERIZING A TACHYCARDIA AND/OR SELECTING TREATMENT FOR A TACHYCARDIA USING RESULTS OF A DOMINANT FREQUENCY ANALYSIS 有权使用主要频率分析结果表征TACHYCARDIA和/或选择TACHYCARDIA处理的设备，系统和方法公开(公告)号：US20120271367A1
公开(公告)日：2012-10-25
申请号：US13090059
申请日：2011-04-19
IPC分类号： A61N1/365
CPC分类号： A61N1/3962 , A61B5/04014 , A61B5/0464 , A61B5/7257 , A61N1/3622
摘要： Provided herein are implantable systems, and methods for use therewith, for characterizing a tachycardia and/or selecting treatment for a tachycardia using results of a dominant frequency analysis. One or more electrogram (EGM) signal(s) indicative of cardiac electrical activity are obtained. For at least one of the EGM signal(s) a dominant frequency (DF) analysis is performed, and the results of the DF analysis are used to characterize a tachycardia and/or to select treatment for a tachycardia.
摘要翻译： 本文提供的可植入系统及其使用的方法用于表征心动过速和/或使用主频率分析的结果来选择治疗心动过速。 获得指示心脏电活动的一个或多个电描记图（EGM）信号。 对于至少一个EGM信号进行主频（DF）分析，并且DF分析的结果用于表征心动过速和/或选择心动过速的治疗。
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7.发明申请公开(公告)号：US20110009755A1
公开(公告)日：2011-01-13
申请号：US12637574
申请日：2009-12-14
申请人： Brian Jeffrey Wenzel , Timothy A. Fayram , Allen J. Keel , Edward Karst , Wenbo Hou , Taraneh Ghaffari Farazi
发明人： Brian Jeffrey Wenzel , Timothy A. Fayram , Allen J. Keel , Edward Karst , Wenbo Hou , Taraneh Ghaffari Farazi
IPC分类号： A61B5/0215
CPC分类号： A61N1/36585 , A61B5/02125 , A61B5/0215 , A61B5/0295 , A61B5/0535 , A61B5/1459 , A61B5/7239 , A61N1/08 , B82Y10/00 , B82Y40/00 , G03F7/0002
摘要： Provided herein are implantable systems, and methods for use therewith, for monitoring a patient's arterial blood pressure while a patient's heart is being paced. A signal (e.g., PPG or IPG signal) indicative of changes in arterial blood volume remote from the patient's heart is obtained using a sensor or electrodes that are implanted remote from the patient's heart. One or more metrics indicative of pulse arrival time (PAT) are determined, where each metric can be determined by determining a time from a paced cardiac event to one or more predetermined features of the signal indicative of changes in arterial blood volume. Based on at the metric(s) indicative of PAT, arterial blood pressure is estimated, which can include determining values indicative of systolic blood pressure, diastolic blood pressure, pulse pressure and/or mean arterial blood pressure, and/or changes in such values.
摘要翻译： 本文提供了可植入系统及其使用的方法，用于在患者的心脏起搏时监测患者的动脉血压。 使用远离患者心脏植入的传感器或电极获得指示远离患者心脏的动脉血容量变化的信号（例如，PPG或IPG信号）。 确定指示脉冲到达时间（PAT）的一个或多个度量，其中可以通过确定从起搏心脏事件到指示动脉血容量变化的信号的一个或多个预定特征的时间来确定每个度量。 基于指示PAT的度量，估计动脉血压，其可以包括确定指示收缩压，舒张压，脉压和/或平均动脉血压的值，和/或这些值的变化 。
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公开(公告)号：US09687656B2
公开(公告)日：2017-06-27
申请号：US12637574
申请日：2009-12-14
申请人： Brian Jeffrey Wenzel , Timothy A. Fayram , Allen J. Keel , Edward Karst , Wenbo Hou , Taraneh Ghaffari Farazi
发明人： Brian Jeffrey Wenzel , Timothy A. Fayram , Allen J. Keel , Edward Karst , Wenbo Hou , Taraneh Ghaffari Farazi
IPC分类号： A61B5/02 , A61N1/365 , A61B5/0215 , A61B5/0295 , A61B5/1459 , A61N1/08 , G03F7/00 , B82Y10/00 , B82Y40/00 , A61B5/021 , A61B5/053 , A61B5/00
CPC分类号： A61N1/36585 , A61B5/02125 , A61B5/0215 , A61B5/0295 , A61B5/0535 , A61B5/1459 , A61B5/7239 , A61N1/08 , B82Y10/00 , B82Y40/00 , G03F7/0002
摘要： Provided herein are implantable systems, and methods for use therewith, for monitoring a patient's arterial blood pressure while a patient's heart is being paced. A signal (e.g., PPG or IPG signal) indicative of changes in arterial blood volume remote from the patient's heart is obtained using a sensor or electrodes that are implanted remote from the patient's heart. One or more metrics indicative of pulse arrival time (PAT) are determined, where each metric can be determined by determining a time from a paced cardiac event to one or more predetermined features of the signal indicative of changes in arterial blood volume. Based on at the metric(s) indicative of PAT, arterial blood pressure is estimated, which can include determining values indicative of systolic blood pressure, diastolic blood pressure, pulse pressure and/or mean arterial blood pressure, and/or changes in such values.
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9.发明申请SYSTEMS AND METHODS FOR CONTROLLING NEUROSTIMULATION OF ACUPUNCTURE SITES USING AN IMPLANTABLE CARDIAC RHYTHM MANAGEMENT DEVICE 有权使用可植入式心脏管理装置控制针刺部位神经细胞的系统和方法公开(公告)号：US20140039238A1
公开(公告)日：2014-02-06
申请号：US13563417
申请日：2012-07-31
CPC分类号： A61N1/36139 , A61B5/0215 , A61B5/042 , A61B5/0538 , A61B5/14532 , A61B5/4818 , A61B5/4836 , A61F7/00 , A61H39/002 , A61H39/06 , A61H2201/5002 , A61H2230/045 , A61H2230/305 , A61N1/3606 , A61N1/36114 , A61N1/36117 , A61N1/3621 , A61N1/3627 , A61N1/3962 , A61N2/02
摘要： Techniques are provided for use with an implantable cardiac rhythm management (CRMD) system equipped to deliver neurostimulation to acupuncture sites within anterior regions of the neck, thorax or abdomen of the patient. Parameters associated with the health of the patient are detected, such as parameters indicative of arrhythmia, heart failure and hypertension.
摘要翻译： 技术提供用于与植入式心律管理（CRMD）系统一起使用，该系统被配备用于向患者的颈部，胸部或腹部前区域内的针灸位置递送神经刺激。 检测与患者健康有关的参数，例如指示心律失常，心力衰竭和高血压的参数。
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公开(公告)号：US08162841B2
公开(公告)日：2012-04-24
申请号：US12474276
申请日：2009-05-29
申请人： Allen J. Keel , Brian Jeffrey Wenzel , Edward Karst , Wenbo Hou , Taraneh Ghaffari Farazi , Timothy A. Fayram , Eric S. Fain , Paul A. Levine
发明人： Allen J. Keel , Brian Jeffrey Wenzel , Edward Karst , Wenbo Hou , Taraneh Ghaffari Farazi , Timothy A. Fayram , Eric S. Fain , Paul A. Levine
IPC分类号： A61B5/02
CPC分类号： A61B5/02158 , A61B5/02125 , A61B5/0295 , A61B5/0452 , A61B5/1459 , A61B2562/0219 , A61N1/36557 , A61N1/36564 , A61N1/36585 , G06F19/00
摘要： Certain embodiments of the present invention are related to an implantable monitoring device to monitor a patient's arterial blood pressure, where the device is configured to be implanted subcutaneously. The device includes subcutaneous (SubQ) electrodes and a plethysmography sensor. Additionally, the device includes an arterial blood pressure monitor configured to determine at least one value indicative of the patient's arterial blood pressure based on at least one detected predetermined feature of a SubQ ECG and at least one detected predetermined feature of a plethysmography signal. Alternative embodiments of the present invention are directed to a non-implantable monitoring device to monitor a patient's arterial blood pressure based on features of a surface ECG and a plethysmography signal obtained from a non-implanted sensor.
摘要翻译： 本发明的某些实施例涉及一种用于监测患者的动脉血压的可植入监测装置，其中该装置被配置为被皮下植入。 该装置包括皮下（SubQ）电极和体积描记传感器。 另外，该装置包括动脉血压监测器，其被配置为基于至少一个检测到的SubQ ECG的预定特征和至少一个检测到的体积描记信号的预定特征来确定指示患者的动脉血压的至少一个值。 本发明的替代实施例涉及一种非植入式监测装置，用于基于从非植入传感器获得的表面ECG和体积描记信号的特征来监测患者的动脉血压。
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