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公开(公告)号：US09738922B2
公开(公告)日：2017-08-22
申请号：US14578125
申请日：2014-12-19
申请人： Timothy H. Bestor , John R. Edwards , Jingyue Ju , Xiaoxu Li
发明人： Timothy H. Bestor , John R. Edwards , Jingyue Ju , Xiaoxu Li
CPC分类号： C12Q1/6806 , C07H19/23 , C12Q1/6827 , C12Q1/6874 , C12Q2521/125 , C12Q2527/125 , C12Q2537/164
摘要： This invention provides methods of derivatizing a double-stranded DNA comprising contacting double-stranded DNA with a CpG methyltransferase and an s-adenosylmethionine analog. This invention also provides methods of sequencing DNA to determine methylation patterns.
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公开(公告)号：US20150148240A1
公开(公告)日：2015-05-28
申请号：US14578125
申请日：2014-12-19
申请人： Timothy H. Bestor , John R. Edwards , Jingyue Ju , Xiaoxu Li
发明人： Timothy H. Bestor , John R. Edwards , Jingyue Ju , Xiaoxu Li
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C07H19/23 , C12Q1/6827 , C12Q1/6874 , C12Q2521/125 , C12Q2527/125 , C12Q2537/164
摘要： This invention provides methods of derivatizing a double-stranded DNA comprising contacting double-stranded DNA with a CpG methyltransferase and an s-adenosylmethionine analog. This invention also provides methods of sequencing DNA to determine methylation patterns.
摘要翻译： 本发明提供衍生双链DNA的方法，包括使双链DNA与CpG甲基转移酶和s-腺苷甲硫氨酸类似物接触。 本发明还提供了测序DNA以测定甲基化模式的方法。
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公开(公告)号：US20110177508A1
公开(公告)日：2011-07-21
申请号：US13055208
申请日：2009-07-22
申请人： Timothy H. Bestor , John R. Edwards , Jingyue Ju , Xiaoxu Li
发明人： Timothy H. Bestor , John R. Edwards , Jingyue Ju , Xiaoxu Li
CPC分类号： C12Q1/6806 , C07H19/23 , C12Q1/6827 , C12Q1/6874 , C12Q2521/125 , C12Q2527/125 , C12Q2537/164
摘要： This invention provides methods of derivatizing a double-stranded DNA comprising contacting double-stranded DNA with a CpG methyltransferase and an s-adenosylmethionine analog. This invention also provides methods of sequencing DNA to determine methylation patterns. This invention also provides neobases and methods of sequencing for methylation patterns using neobases.
摘要翻译： 本发明提供衍生双链DNA的方法，包括使双链DNA与CpG甲基转移酶和s-腺苷甲硫氨酸类似物接触。 本发明还提供了测序DNA以测定甲基化模式的方法。 本发明还提供了新基因和使用新碱基测序甲基化模式的方法。
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公开(公告)号：US10337049B2
公开(公告)日：2019-07-02
申请号：US14973637
申请日：2015-12-17
申请人： Timothy H. Bestor , Jingyue Ju , Xiaoxu Li , James J. Russo
发明人： Timothy H. Bestor , Jingyue Ju , Xiaoxu Li , James J. Russo
IPC分类号： C12Q1/68 , C12Q1/6806 , C07H19/16 , C07H19/167 , C12Q1/6874 , C12N9/10 , C12P19/34 , C12Q1/6827
摘要： The present invention provides a method of determining whether cytosine residues present at a predetermined positions within a single strand of a double stranded DNA of known sequence are methylated as well as compounds for carrying out this method.
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公开(公告)号：US20160355542A1
公开(公告)日：2016-12-08
申请号：US14973637
申请日：2015-12-17
申请人： Timothy H. Bestor , Jingyue Ju , Xiaoxu Li , James J. Russo
发明人： Timothy H. Bestor , Jingyue Ju , Xiaoxu Li , James J. Russo
CPC分类号： C12Q1/6806 , C07H19/16 , C07H19/167 , C12N9/1007 , C12P19/34 , C12Q1/6827 , C12Q1/6874 , C12Y201/01 , C12Q2535/101 , C12Q2535/122 , C12Q2563/101 , C12Q2565/631 , C12Q2563/167 , C12Q2563/107
摘要： The present invention provides a method of determining whether cytosine residues present at a predetermined positions within a single strand of a double stranded DNA of known sequence are methylated as well as compounds for carrying out this method.
摘要翻译： 本发明提供了确定存在于已知序列的双链DNA的单链内的预定位置处的胞嘧啶残基是否被甲基化的方法以及用于实施该方法的化合物。
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公开(公告)号：US20200063194A1
公开(公告)日：2020-02-27
申请号：US16499997
申请日：2018-04-03
申请人： Jingyue Ju , Timothy H. Bestor , James J. Russo , Steffen Jockusch , Xiaoxu Li
发明人： Jingyue Ju , Timothy H. Bestor , James J. Russo , Steffen Jockusch , Xiaoxu Li
IPC分类号： C12Q1/6827 , C12N9/10
摘要： The subject invention provides a method of determining whether a cytosine at a predefined position within a single strand of a double-stranded DNA of known sequence is hydroxymethylated.The invention also provides a method of determining whether a cytosine at a predefined position within a single strand of a double-stranded DNA of known sequence is unmethylated.The invention further provides a method of determining whether a cytosine at a predefined position within a single strand of a double-stranded DNA of known sequence is methylated but not hydroxymethylated.The invention also provides a method of determining whether a cytosine present at a predefined position within a single strand of a double-stranded DNA of known sequence, and within a CpG site, is unmethylated.
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7.发明申请FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS 有权通过使用可清除的荧光核反应终止子合成的四色DNA序列公开(公告)号：US20120021408A1
公开(公告)日：2012-01-26
申请号：US13023283
申请日：2011-02-08
申请人： Jingyue Ju , Dae Hyun Kim , Lanrong Bi , Qinglin Meng , Xiaoxu Li
发明人： Jingyue Ju , Dae Hyun Kim , Lanrong Bi , Qinglin Meng , Xiaoxu Li
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q1/6823 , C12Q2565/631 , C12Q2523/107 , C12Q2523/319
摘要： This invention provides a process for sequencing single-stranded DNA by employing a nanopore and modified nucleotides.
摘要翻译： 本发明提供了通过使用纳米孔和修饰的核苷酸对单链DNA进行测序的方法。
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8.发明申请公开(公告)号：US20220177959A1
公开(公告)日：2022-06-09
申请号：US17436513
申请日：2020-03-05
申请人： Jingyue Ju , Carl W. Fuller , Shiv Kumar , Sergey Kalachikov , Xiaoxu Li , Irina Morozova , James Russo , Steffen Jockusch
发明人： Jingyue Ju , Carl W. Fuller , Shiv Kumar , Sergey Kalachikov , Xiaoxu Li , Irina Morozova , James Russo , Steffen Jockusch
IPC分类号： C12Q1/6869
摘要： Disclosed herein are highly accurate approaches for single molecule electronic nanopore-based SBS.
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公开(公告)号：US11085076B2
公开(公告)日：2021-08-10
申请号：US15763364
申请日：2016-09-28
申请人： Jingyue Ju , Xiaoxu Li , Xin Chen , Zengmin Li , Shiv Kumar , Shundi Shi , Cheng Guo , Jianyi Ren , Min-Kang Hsieh , Minchen Chien , Chuanjuan Tao , Ece Erturk , Sergey Kalachikov , James J. Russo
发明人： Jingyue Ju , Xiaoxu Li , Xin Chen , Zengmin Li , Shiv Kumar , Shundi Shi , Cheng Guo , Jianyi Ren , Min-Kang Hsieh , Minchen Chien , Chuanjuan Tao , Ece Erturk , Sergey Kalachikov , James J. Russo
IPC分类号： C12Q1/68 , C07H19/10 , C07H19/14 , C07H19/20 , C12Q1/6869
摘要： Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.
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10.发明申请FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS 有权通过使用可清除的荧光核反应终止子合成的四色DNA序列公开(公告)号：US20140315191A1
公开(公告)日：2014-10-23
申请号：US14242487
申请日：2014-04-01
申请人： Jingyue Ju , Dae Hyun Kim , Lanrong Bi , Qinglin Meng , Xiaoxu Li
发明人： Jingyue Ju , Dae Hyun Kim , Lanrong Bi , Qinglin Meng , Xiaoxu Li
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q1/6823 , C12Q2565/631 , C12Q2523/107 , C12Q2523/319
摘要： This invention provides a process for sequencing single-stranded DNA employing modified nucleotides.
摘要翻译： 本发明提供了使用修饰的核苷酸测序单链DNA的方法。
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