公开(公告)号：US20050255165A1

公开(公告)日：2005-11-17

申请号：US11187505

申请日：2005-07-22

申请人： Timothy King ,  Charles Patrick

发明人： Timothy King ,  Charles Patrick

IPC分类号： A61K9/14 ,  A61K9/16 ,  A61K9/50 ,  B01J13/02

CPC分类号： A61K9/1647 ,  B01J13/02 ,  Y10T428/2985

摘要： A cost-effective, scalable technique for producing microspheres loaded with biologically active solid proteins is provided. The microspheres degrade over time and release biologically active VEGF, as demonstrated by the proliferation of HUVECs in vitro compared to negative controls. A defined concentration of microspheres can deliver a quantifiable level of VEGF with known release kinetics. The invention can be used with other growth factors and applied to tissue engineering applications such as the regeneration of peripheral nerve, bone, adipose tissue, and solid organs. The method of the invention includes the steps of dissolving a polymer with an organic solvent to produce a polymer solution; adding a biologically effective amount of a bioactive substance to the solution to produce a mixture of the polymer and the bioactive substance; vibrating the mixture to produce a bioactive substance-polymer complex; emulsifying the mixture to produce an emulsion comprising the bioactive substance-polymer complex; and extracting the organic solvent from the emulsion to produce microspheres comprising the polymer-bioactive substance complex, wherein the bioactivity of the bioactive substance is usefully preserved.

摘要翻译： 提供了一种用于生产负载有生物活性固体蛋白质的微球的成本有效的可扩展技术。 随着时间的推移，微球降解并释放生物活性的VEGF，与阴性对照相比，体外HUVECs的增殖所证实。 确定的微球浓度可以用已知的释放动力学递送可量化的VEGF水平。 本发明可与其他生长因子一起使用，适用于组织工程应用，如周围神经，骨骼，脂肪组织和实体器官的再生。 本发明的方法包括以下步骤：用有机溶剂溶解聚合物以产生聚合物溶液; 向该溶液中加入生物有效量的生物活性物质以产生聚合物和生物活性物质的混合物; 振动混合物以产生生物活性物质 - 聚合物复合物; 乳化混合物以产生包含生物活性物质 - 聚合物复合物的乳液; 并从乳液中提取有机溶剂以产生包含聚合物 - 生物活性物质复合物的微球，其中生物活性物质的生物活性被有效地保留。

公开(公告)号：US10104331B2

公开(公告)日：2018-10-16

申请号：US14836239

申请日：2015-08-26

申请人： Marc R. Amling ,  Timothy King ,  Grant deGoede ,  Lisa Blake

发明人： Marc R. Amling ,  Timothy King ,  Grant deGoede ,  Lisa Blake

IPC分类号： A62B1/04 ,  H04N5/77 ,  H04N13/02 ,  H04N13/239 ,  A61B1/00 ,  A61B1/04 ,  G01C11/04 ,  H04N9/804

摘要： A video imaging system, and more particularly, a modular video imaging system having a control module connectable to multiple input modules. The input modules each capable of receiving differing types of image data from different types of cameras including stereoscopic camera configurations and processing the image data into a format recognizable by the control module. The control unit providing general functions such as user interface and general image processing that is not camera specific including the generation of a 3D image stream formed by combining two image streams.

公开(公告)号：US20140037165A1

公开(公告)日：2014-02-06

申请号：US14048913

申请日：2013-10-08

申请人： Timothy King ,  Thomas Prescher ,  Kim Barnhill

发明人： Timothy King ,  Thomas Prescher ,  Kim Barnhill

IPC分类号： A61B5/00 ,  G06T7/00 ,  G01R33/54 ,  A61B6/03 ,  A61B8/08 ,  A61B6/00

CPC分类号： A61B5/748 ,  A61B1/0005 ,  A61B5/0077 ,  A61B5/742 ,  A61B6/032 ,  A61B6/52 ,  A61B8/52 ,  G01R33/54 ,  G06T7/0012

摘要： A system for indicating an area of interest on an image, including a source of image data, an image processing unit, a user interface, and a destination, which may be a display. The image data may be ultrasound, X-ray, magnetic resonance imaging, nuclear magnetic resonance imaging, magnetic resonance tomography, computed tomography or surgical image data. The image processing unit may be configured to receive the image data from the source and combine it with a desired overlay pattern selected from a plurality of overlay patterns for indicating an area of interest on the image, which is then displayed on the display. The overlay pattern may include a key with coordinates or labels. Properties of the overlay pattern and the image data may be adjusted independently or automatically.

摘要翻译： 一种用于指示图像的感兴趣区域的系统，包括图像数据源，图像处理单元，用户界面和目的地，其可以是显示器。 图像数据可以是超声，X射线，磁共振成像，核磁共振成像，磁共振断层摄影，计算机断层扫描或手术图像数据。 图像处理单元可以被配置为从源接收图像数据并将其与从多个覆盖图案中选择的期望的覆盖图案组合，以指示图像上的感兴趣区域，然后显示在显示器上。 覆盖图案可以包括具有坐标或标签的键。 覆盖图案和图像数据的属性可以单独或自动调整。

公开(公告)号：US20120209123A1

公开(公告)日：2012-08-16

申请号：US13289554

申请日：2011-11-04

申请人： Timothy King

发明人： Timothy King

IPC分类号： A61B6/00

CPC分类号： A61B1/0005 ,  A61B5/0077 ,  A61B5/1128 ,  A61B5/7485 ,  A61B2562/0219

摘要： A system for identifying an area of interest on a surgical image, including a source of surgical image data, which may be a camera, an image processing unit, which may be a camera control unit, and a destination, which may be a display. The image processing unit is configured to receive the surgical image data and combine it with an overlay pattern for identifying an area of interest, which is then displayed on the display. The overlay may include a key with coordinates or labels. Properties of the overlay and the key may be customized and adjusted.

摘要翻译： 一种用于识别手术图像上的感兴趣区域的系统，包括可以是照相机的手术图像数据源，可以是相机控制单元的图像处理单元和可以是显示器的目的地。 图像处理单元被配置为接收手术图像数据并将其与用于识别感兴趣区域的覆盖图案组合，然后将其显示在显示器上。 覆盖可以包括具有坐标或标签的键。 可以定制和调整覆盖层和键的属性。

公开(公告)号：US07417836B2

公开(公告)日：2008-08-26

申请号：US11847071

申请日：2007-08-29

申请人： Ronald A. Bax ,  Rudy Rusali ,  Timothy King

发明人： Ronald A. Bax ,  Rudy Rusali ,  Timothy King

IPC分类号： H02H3/00

CPC分类号： H01H83/14 ,  H01H3/001 ,  H01H83/04 ,  H01H83/144 ,  H02H1/06 ,  H02H3/04 ,  H02H3/05 ,  H02H3/105 ,  H02H3/32 ,  H02H3/33 ,  H02H3/347 ,  H02H7/09

摘要： The aircraft applicable current imbalance detection and circuit interrupter interrupts an electrical circuit when a current imbalance is sensed. The current imbalance detection and circuit interrupter includes a housing, power supplies, a sensor system for sensing a current imbalance at the line side of the electrical circuit, a logic controller and a power controller including a power relay having contacts capable of surviving carry-break and make-carry-break types of ground fault conditions at anticipated current levels. At power up, the device performs a test to confirm that none of the relay contacts have failed in a closed position, and to check whether a switching FET which controls the relay coil has shorted.

摘要翻译： 当感测到电流不平衡时，飞机适用的电流不平衡检测和电路断路器中断电路。 电流不平衡检测和电路断路器包括壳体，电源，用于感测电路线路侧的电流不平衡的传感器系统，逻辑控制器和功率控制器，其包括具有能够存活携带断点的触点的功率继电器 以及预期目前水平的接地故障类型。 上电时，器件进行测试以确认没有继电器触点在闭合位置发生故障，并检查控制继电器线圈的开关FET是否短路。

公开(公告)号：US20070291427A1

公开(公告)日：2007-12-20

申请号：US11846962

申请日：2007-08-29

申请人： Ronald Bax ,  Rudy Rusali ,  Timothy King

发明人： Ronald Bax ,  Rudy Rusali ,  Timothy King

IPC分类号： H02H3/00

CPC分类号： H01H83/14 ,  H01H3/001 ,  H01H83/04 ,  H01H83/144 ,  H02H1/06 ,  H02H3/04 ,  H02H3/05 ,  H02H3/105 ,  H02H3/32 ,  H02H3/33 ,  H02H3/347 ,  H02H7/09

摘要： The aircraft applicable current imbalance detection and circuit interrupter interrupts an electrical circuit when a current imbalance is sensed. The current imbalance detection and circuit interrupter includes a housing, power supplies, a sensor system for sensing a current imbalance at the line side of the electrical circuit, a logic controller and a power controller including a power relay having contacts capable of surviving carry-break and make-carry-break types of ground fault conditions at anticipated current levels. At power up, the device performs a test to confirm that none of the relay contacts have failed in a closed position, and to check whether a switching FET which controls the relay coil has shorted.

公开(公告)号：US20060276372A1

公开(公告)日：2006-12-07

申请号：US11372353

申请日：2006-03-09

申请人： Samuel Lockwood ,  Geoff Nadolski ,  Dean Frey ,  Mark McLaws ,  Timothy King ,  David Burdick

发明人： Samuel Lockwood ,  Geoff Nadolski ,  Dean Frey ,  Mark McLaws ,  Timothy King ,  David Burdick

IPC分类号： A61K38/16 ,  A61K31/7034 ,  A61K31/7072 ,  A61K31/66 ,  A61K31/192 ,  A61K31/195 ,  A61K31/185 ,  A61K31/12 ,  A61K31/13

CPC分类号： A61K31/01 ,  A61K31/12 ,  A61K31/13 ,  A61K31/185 ,  A61K31/192 ,  A61K31/195 ,  A61K31/215 ,  A61K31/6615 ,  A61K31/7024 ,  A61K38/16

摘要： A method and system used for treating proliferative disorders using carotenoids, carotenoid analogs, and/or carotenoid derivatives. The method and system may be used for chemoprevention and/or chemotherapy. The method and system may induce apoptosis in target cells, tissues, and/or organs. The analog, derivative, or intermediate may be administered to a cell, a group of cells, a tissue, an organ or a subject, such that at least a portion of the undesirable consequences of the proliferative disorder are thereby reduced.

摘要翻译： 用于使用类胡萝卜素，类胡萝卜素类似物和/或类胡萝卜素衍生物治疗增殖性疾病的方法和系统。 该方法和系统可用于化学预防和/或化疗。 该方法和系统可诱导靶细胞，组织和/或器官中的细胞凋亡。 可以将类似物，衍生物或中间体施用于细胞，细胞组织，组织，器官或受试者，从而减少增殖性疾病的不良后果的至少一部分。

公开(公告)号：US20050067519A1

公开(公告)日：2005-03-31

申请号：US10675839

申请日：2003-09-30

申请人： Timothy King

发明人： Timothy King

IPC分类号： A47K10/38 ,  B65H18/00 ,  B65H18/08 ,  B65H18/28 ,  B65H20/26 ,  B65H35/00 ,  B65H35/04 ,  B65H35/08

CPC分类号： B65H35/0006 ,  B65H20/26 ,  B65H35/04

摘要： A double-wound center-feed roll is disclosed which is formed from at least two webs each having lines of weakness which allow the webs to be separated into a plurality of sheets. The lines of weakness of one web are offset from those of the other such that in use the sheets can be dispensed singly from alternate webs. A first portion of the webs at the center of the roll is lightly bonded together while a second portion of the webs on the outside of the roll remains unbonded. The center-feed roll of the present invention reduces the occurrence of both web orientation reversal and streaming dispensing problems.

公开(公告)号：US20150182107A1

公开(公告)日：2015-07-02

申请号：US14573457

申请日：2014-12-17

申请人： Timothy King ,  Klaus-Martin Irion ,  Werner Goebel

发明人： Timothy King ,  Klaus-Martin Irion ,  Werner Goebel

IPC分类号： A61B1/06 ,  A61B1/05

CPC分类号： A61B1/0607 ,  A61B1/0005 ,  A61B1/043 ,  A61B1/05 ,  A61B1/0638

摘要： Still image display of a recent video image of tissue as a reference still image prior to a switch in the mode of illumination of the tissue. The still image is displayed concurrently with live video of the tissue under a different mode of illumination, to facilitate discrimination between healthy and diseased tissue. When a practitioner switches a light source from a “first light” to a “second light”, the second light video may be frozen/captured and displayed as a reference still image as a PIP, and the second light live video is displayed concurrently. The second light can be infrared and/or near infrared light. The second light can include structured light to project a structured light pattern to facilitate structure measurements. The second light source is configured with a numerical aperture greater than the first light source.

摘要翻译： 在组织的照射模式切换之前，将组织的最近视频图像的静止图像显示为参考静止图像。 在不同的照明模式下，静止图像与组织的实时视频同时显示，以便于健康和患病组织之间的区分。 当从业者将光源从“第一光”切换到“第二光”时，第二光视频可以被冻结/捕获并作为参考静止图像显示为PIP，并且第二实况视频被同时显示。 第二根灯可以是红外线和/或近红外线。 第二个光可以包括结构化的光以投射结构化的光图案以促进结构测量。 第二光源配置有大于第一光源的数值孔径。

公开(公告)号：US20140253703A1

公开(公告)日：2014-09-11

申请号：US13793232

申请日：2013-03-11

申请人： Timothy King

发明人： Timothy King

IPC分类号： A61B1/00

CPC分类号： A61B1/00057 ,  G06F19/00 ,  G06F19/321 ,  G16H30/20

摘要： A system and method for diagnosing problems in a medical imaging system. In some implementations, problems with the medical imaging system are determined by encoding information into an image relating to system settings or other data, and using the information to diagnose possible problems with the image and/or the medical imaging system.

摘要翻译： 一种用于诊断医学成像系统中的问题的系统和方法。 在一些实施方式中，通过将信息编码成与系统设置或其他数据相关的图像，以及使用该信息来诊断图像和/或医学成像系统的可能问题来确定医学成像系统的问题。