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1.发明申请Polypeptides and Biosynthetic Pathways for the Production of Monatin and Its Precursors 有权用于生产莫纳甜及其前体的多肽和生物合成途径公开(公告)号：US20090117625A1
公开(公告)日：2009-05-07
申请号：US12124014
申请日：2008-05-20
申请人： Timothy W. Abraham , Douglas C. Cameron , Paula M. Hicks , Sara C. McFarlan , Jim Millis , John Rosazza , Lishan Zhao , David P. Weiner
发明人： Timothy W. Abraham , Douglas C. Cameron , Paula M. Hicks , Sara C. McFarlan , Jim Millis , John Rosazza , Lishan Zhao , David P. Weiner
IPC分类号： C12N9/02
CPC分类号： C12P17/10 , C12N9/0006 , C12N9/0014 , C12N9/0016 , C12N9/1096 , C12N15/52
摘要： Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.
摘要翻译： 提供可用于从葡萄糖，色氨酸，吲哚-3-乳酸，吲哚-3-丙酮酸和2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸制备莫纳甜的方法和组合物 。 还公开了制备吲哚-3-丙酮酸和2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸中间体的方法。 提供的组合物包括核酸分子，多肽，化学结构和细胞。 方法包括体外和体内过程，体外方法包括化学反应。
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公开(公告)号：US08435765B2
公开(公告)日：2013-05-07
申请号：US12124014
申请日：2008-05-20
申请人： Timothy W. Abraham , Douglas C. Cameron , Paula M. Hicks , Sara C. McFarlan , James R. Millis , John Rosazza , David P. Weiner , Lishan Zhao
发明人： Timothy W. Abraham , Douglas C. Cameron , Paula M. Hicks , Sara C. McFarlan , James R. Millis , John Rosazza , David P. Weiner , Lishan Zhao
CPC分类号： C12P17/10 , C12N9/0006 , C12N9/0014 , C12N9/0016 , C12N9/1096 , C12N15/52
摘要： Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.
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公开(公告)号：US08372989B2
公开(公告)日：2013-02-12
申请号：US10979821
申请日：2004-11-03
申请人： Timothy W. Abraham , Douglas C. Cameron , Paula M. Hicks , Sara C. McFarlan , John Rosazza , Lishan Zhao , David P. Weiner
发明人： Timothy W. Abraham , Douglas C. Cameron , Paula M. Hicks , Sara C. McFarlan , John Rosazza , Lishan Zhao , David P. Weiner
IPC分类号： C07D209/18 , C12P13/22 , C12P21/06 , C07H21/04 , C12N9/10
CPC分类号： C12P17/10 , C12N9/0006 , C12N9/0014 , C12N9/0016 , C12N9/1096 , C12N15/52
摘要： Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.
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4.发明申请公开(公告)号：US20090130285A1
公开(公告)日：2009-05-21
申请号：US12271655
申请日：2008-11-14
申请人： Timothy W. Abraham , Douglas C. Cameron , Melanie J. Goulson , Paula M. Hicks , Michael G. Lindley , Sara C. McFarlan , James R. Millis , John Rosazza , Lishan Zhao , David P. Weiner
发明人： Timothy W. Abraham , Douglas C. Cameron , Melanie J. Goulson , Paula M. Hicks , Michael G. Lindley , Sara C. McFarlan , James R. Millis , John Rosazza , Lishan Zhao , David P. Weiner
IPC分类号： A23L1/236
摘要： The present invention relates to novel beverage compositions comprising monatin and methods for making such compositions. The present invention also relates to beverage compositions comprising specific monatin stereoisomers, specific blends of monatin stereoisomers, and/or monatin produced via a biosynthetic pathway in vivo (e.g., inside cells) or in vitro.
摘要翻译： 本发明涉及包含莫纳甜的新型饮料组合物和制备这种组合物的方法。 本发明还涉及包含特定莫纳甜立体异构体，莫纳甜立体异构体的特异性共混物和/或通过体内生物合成途径（例如细胞内）或体外产生的莫纳甜的饮料组合物。
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5.发明授权Polypeptides and biosynthetic pathways for the production of monatin and its precursors 有权用于生产莫纳甜及其前体的多肽和生物合成途径公开(公告)号：US07572607B2
公开(公告)日：2009-08-11
申请号：US11114922
申请日：2005-04-26
申请人： Paula M. Hicks , Sara C. McFarlan , Timothy W. Abraham , Douglas C. Cameron , James R. Millis , John Rosazza , Lishan Zhao , David Paul Weiner
发明人： Paula M. Hicks , Sara C. McFarlan , Timothy W. Abraham , Douglas C. Cameron , James R. Millis , John Rosazza , Lishan Zhao , David Paul Weiner
摘要： Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.
摘要翻译： 提供可用于从葡萄糖，色氨酸，吲哚-3-乳酸，吲哚-3-丙酮酸和2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸制备莫纳甜的方法和组合物 。 还公开了制备吲哚-3-丙酮酸和2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸中间体的方法。 提供的组合物包括核酸分子，多肽，化学结构和细胞。 方法包括体外和体内过程，体外方法包括化学反应。
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公开(公告)号：US08206955B2
公开(公告)日：2012-06-26
申请号：US10969245
申请日：2004-10-21
申请人： Sara C. McFarlan , Paula M. Hicks , Mary Jo Zidwick , Fernando A. Sanchez-Riera , Douglas C. Cameron , Mervyn L. deSouza , John Rosazza , Steven J. Gort , Timothy W. Abraham
发明人： Sara C. McFarlan , Paula M. Hicks , Mary Jo Zidwick , Fernando A. Sanchez-Riera , Douglas C. Cameron , Mervyn L. deSouza , John Rosazza , Steven J. Gort , Timothy W. Abraham
CPC分类号： C12N9/88 , C12P17/10 , Y02P20/582
摘要： Methods and compositions that can be used to make monatin or salt thereof from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.
摘要翻译： 可用于从葡萄糖，色氨酸，吲哚-3-乳酸，吲哚-3-丙酮酸和2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸制备莫纳甜或其盐的方法和组合物 ，提供。 还公开了制备吲哚-3-丙酮酸和2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸中间体的方法。 提供的组合物包括核酸分子，多肽，化学结构和细胞。 方法包括体外和体内过程，体外方法包括化学反应。
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公开(公告)号：US07326549B2
公开(公告)日：2008-02-05
申请号：US10472317
申请日：2002-03-19
CPC分类号： C12N9/0069 , C12N15/52 , C12P17/04
摘要： The invention provides methods and materials related to the production of organic products such as glucuronic acid, ascorbic acid, and glucaric acid. Specifically, the invention provides cells, methods for culturing cells, isolated nucleic acid molecules, and methods and materials for producing various organic products such as glucuronic acid, ascorbic acid, and glucaric acid.
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公开(公告)号：US20080187984A1
公开(公告)日：2008-08-07
申请号：US11986988
申请日：2007-11-26
CPC分类号： C12N9/0069 , C12N15/52 , C12P17/04
摘要： The invention provides methods and materials related to the production of organic products such as glucuronic acid, ascorbic acid, and glucaric acid. Specifically, the invention provides cells, methods for culturing cells, isolated nucleic acid molecules, and methods and materials for producing various organic products such as glucuronic acid, ascorbic acid, and glucaric acid.
摘要翻译： 本发明提供了与生产有机产物如葡萄糖醛酸，抗坏血酸和葡糖二酸有关的方法和材料。 具体地，本发明提供细胞，培养细胞的方法，分离的核酸分子，以及用于生产各种有机产物如葡萄糖醛酸，抗坏血酸和葡糖二酸的方法和材料。
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9.发明授权公开(公告)号：US08685118B2
公开(公告)日：2014-04-01
申请号：US11795052
申请日：2006-01-10
摘要： A wax comprises a metathesis product and/or a product that resembles, at least in part, a product which may be formed from a metathesis reaction. The wax may be used to form articles, for example, candles (container candles, votive candles, and/or a pillar candles), crayons, fire logs, or tarts. The wax commonly includes other components in addition to the metathesis product.
摘要翻译： 蜡包括复分解产物和/或类似于至少部分类似于可由复分解反应形成的产物的产物。 蜡可以用于形成制品，例如蜡烛（容器蜡烛，献色蜡烛和/或支柱蜡烛），蜡笔，火记录或挞。 除了复分解产物之外，蜡通常还包括其它组分。
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公开(公告)号：US08440783B2
公开(公告)日：2013-05-14
申请号：US12226696
申请日：2007-04-27
申请人： Timothy W. Abraham , Jeff Malsam , Xiuguang A. Guo , Milhail Ionescu , Ivan J. Javni , Zoran S. Petrovic
发明人： Timothy W. Abraham , Jeff Malsam , Xiuguang A. Guo , Milhail Ionescu , Ivan J. Javni , Zoran S. Petrovic
IPC分类号： C08G69/28
CPC分类号： C08G18/36 , C08G18/7621 , C08G2101/00
摘要： Enhanced oligomeric polyols are reported. The enhanced oligomeric polyols may be prepared by a method comprising the steps of: (a) providing an oligomeric polyol that comprises at least one glycerol fatty acid ester having at least one glycerol fatty acid ester bond; wherein at least 5% of the ethyldenyl groups (*C═C*) in the glycerol fatty acid ester are substituted with a bonding structure selected from the group consisting of: C-*C—C*-C; O-*C—C*-O; C=*C—C*-C, and mixtures thereof, where * is used to denote the original carbon atoms in the ethylidenyl group; and (b) cleaving at least a portion of the glycerol fatty acid ester bonds to form the enhanced oligomeric polyol. The enhanced oligomeric polyols are useful in making polymers such as polyurethanes.
摘要翻译： 报道了增强低聚多元醇。 增强的低聚多元醇可以通过包括以下步骤的方法制备：（a）提供包含至少一种具有至少一种甘油脂肪酸酯键的甘油脂肪酸酯的低聚多元醇; 其中所述甘油脂肪酸酯中的至少5％的乙烯基（* C = C *）被选自以下的键合结构取代：C- * C-C * -C; O- * C-C * -O; C = * C-C * -C及其混合物，其中*用于表示亚乙基中的原始碳原子; 和（b）切割甘油脂肪酸酯键的至少一部分以形成增强的低聚多元醇。 增强的低聚多元醇可用于制备聚合物如聚氨酯。
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