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123 条记录 (耗时 0.03 秒)

    One-stage reductive amination
    3.
    发明授权
    One-stage reductive amination 失效
    一步还原胺化

    公开(公告)号：US08415500B2

    公开(公告)日：2013-04-09

    申请号：US12808268

    申请日：2008-12-10

    申请人： Tobias Staeb ,  Thilo Hahn ,  Wolfgang Siegel

    发明人： Tobias Staeb ,  Thilo Hahn ,  Wolfgang Siegel

    IPC分类号： C07C211/27 ,  C07C209/62

    CPC分类号： C07C209/26 ,  C07B2200/07 ,  C07C209/62 ,  C07C211/07 ,  C07C211/27

    摘要： A process for preparing amines of the formula I, by reacting a carbonyl compound of the formula II with an amine of the formula III where R1 and R2 are different and are each an organic radical which has from 1 to 20 carbon atoms and may optionally also comprise heteroatoms, R3 is a C1-C6-alkyl group and R4 is an aryl group which may be partly or fully halogenated and/or may bear from one to three radicals from the group of cyano, nitro, C1-C6-alkyl, C1-C6-haloalkyl, hydroxyl, C1-C6-hydroxyalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, hydroxycarbonyl, C1-C6-alkoxycarbonyl, C1-C6-alkylamino, di(C1-C6-alkyl)amino, aryl and aryl(C1-C6-alkyl); and * represents the S or R configuration, and ** represents the S and/or R configuration; which comprises performing the reaction in the presence of a heterogeneous imination catalyst, of a hydrogenation catalyst and of hydrogen.

    摘要翻译： 一种制备式I的胺的方法，通过使式II的羰基化合物与式III的胺反应，其中R 1和R 2不同，并且各自是具有1至20个碳原子的有机基团， 包括杂原子，R 3是C 1 -C 6烷基，R 4是可以部分或完全卤化的和/或可以从氰基，硝基，C 1 -C 6 - 烷基，C 1〜 C 1 -C 6 - 卤代烷基，羟基，C 1 -C 6羟基烷基，C 1 -C 6 - 烷氧基，C 1 -C 6 - 卤代烷氧基，羟基羰基，C 1 -C 6 - 烷氧基羰基，C 1 -C 6烷基氨基， 和芳基（C 1 -C 6 - 烷基）; 和*表示S或R构型，**表示S和/或R构型; 其包括在非均相模拟催化剂，氢化催化剂和氢气存在下进行反应。

    ONE-STAGE REDUCTIVE AMINATION
    4.
    发明申请
    ONE-STAGE REDUCTIVE AMINATION 失效
    一级减少化学

    公开(公告)号：US20100274054A1

    公开(公告)日：2010-10-28

    申请号：US12808268

    申请日：2008-12-10

    申请人： Tobias Staeb ,  Thilo Hahn ,  Wolfgang Siegel

    发明人： Tobias Staeb ,  Thilo Hahn ,  Wolfgang Siegel

    IPC分类号： C07C211/27 ,  C07C209/62

    CPC分类号： C07C209/26 ,  C07B2200/07 ,  C07C209/62 ,  C07C211/07 ,  C07C211/27

    摘要： A process for preparing amines of the formula I, by reacting a carbonyl compound of the formula II with an amine of the formula III where R1 and R2 are different and are each an organic radical which has from 1 to 20 carbon atoms and may optionally also comprise heteroatoms, R3 is a C1-C6-alkyl group and R4 is an aryl group which may be partly or fully halogenated and/or may bear from one to three radicals from the group of cyano, nitro, C1-C6-alkyl, C1-C6-haloalkyl, hydroxyl, C1-C6-hydroxyalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, hydroxycarbonyl, C1-C6-alkoxycarbonyl, C1-C6-alkylamino, di(C1-C6-alkyl)amino, aryl and aryl(C1-C6-alkyl); and * represents the S or R configuration, and ** represents the S and/or R configuration; which comprises performing the reaction in the presence of a heterogeneous imination catalyst, of a hydrogenation catalyst and of hydrogen.

    摘要翻译： 一种制备式I的胺的方法，通过使式II的羰基化合物与式III的胺反应，其中R 1和R 2不同，并且各自是具有1至20个碳原子的有机基团， 包括杂原子，R 3是C 1 -C 6烷基，R 4是可以部分或完全卤化的和/或可以从氰基，硝基，C 1 -C 6 - 烷基，C 1〜 C 1 -C 6 - 卤代烷基，羟基，C 1 -C 6羟基烷基，C 1 -C 6 - 烷氧基，C 1 -C 6 - 卤代烷氧基，羟基羰基，C 1 -C 6 - 烷氧基羰基，C 1 -C 6烷基氨基， 和芳基（C 1 -C 6 - 烷基）; 和*表示S或R构型，**表示S和/或R构型; 其包括在非均相模拟催化剂，氢化催化剂和氢气存在下进行反应。

    METHOD FOR PRODUCING LINEAR PENTENENITRILE
    8.
    发明申请
    METHOD FOR PRODUCING LINEAR PENTENENITRILE 有权
    生产线性胆固醇的方法

    公开(公告)号：US20120178958A1

    公开(公告)日：2012-07-12

    申请号：US13361783

    申请日：2012-01-30

    申请人： Tim Jungkamp ,  Robert Baumann ,  Michael Bartsch ,  Gerd Haderlein ,  Hermann Luyken ,  Jens Scheidel ,  Tobias Aechtner ,  Peter Pfab ,  Petra Deckert ,  Wolfgang Siegel ,  Peter Baßler

    发明人： Tim Jungkamp ,  Robert Baumann ,  Michael Bartsch ,  Gerd Haderlein ,  Hermann Luyken ,  Jens Scheidel ,  Tobias Aechtner ,  Peter Pfab ,  Petra Deckert ,  Wolfgang Siegel ,  Peter Baßler

    IPC分类号： C07C253/30

    CPC分类号： C07C253/30 ,  C07C253/10 ,  Y02P20/582 ,  C07C255/07

    摘要： A method for producing 3-pentenenitrile is provided that includes: (a) isomerizing an educt stream containing 2-methyl-3-butenenitrile on at least one dissolved or dispersed isomerisation catalyst to form a stream (1), which contains the isomerisation catalyst(s), 2-methyl-3-butenenitrile, 3-pentenenitrile and (Z)-2-methyl-2-butenenitrile; (b) distilling the stream (1) to obtain a stream (2) as the overhead product, which contains 2-methyl-3-butenenitrile, 3-pentenenitrile and (Z)-2-methyl-2-butenenitrile and a stream (3) as the bottom product, which contains the isomerisation catalyst(s); (c) distilling the stream (2) to obtain a stream (4) as the overhead product, which is enriched with (Z)-2-methyl-2-butenenitrile in comparison to stream (2), and a stream (5) as the bottom product, which is enriched with 3-pentenenitrile and 2-methyl-3-butenenitrile in comparison to stream (2); (d) distilling stream (5) to obtain a stream (6) as the bottom product, which contains 3-pentenenitrile and a stream (7) as the head product containing 2-methyl-3-butenenitrile.

    摘要翻译： 提供了一种制备3-戊烯腈的方法，其包括：（a）在至少一种溶解或分散的异构化催化剂上异构化含有2-甲基-3-丁烯腈的流出物流以形成含有异构化催化剂（ s），2-甲基-3-丁烯腈，3-戊烯腈和（Z）-2-甲基-2-丁烯腈; （b）蒸馏物流（1）以获得作为塔顶产物的物流（2），其含有2-甲基-3-丁烯腈，3-戊烯腈和（Z）-2-甲基-2-丁烯腈和流（ 3）作为含有异构化催化剂的底部产物; （c）与料流（2）相比，蒸馏物流（2）以获得作为塔顶产物的物流（4），其与（2）相比富含（Z）-2-甲基-2-丁烯腈， 作为与料流（2）相比富含3-戊烯腈和2-甲基-3-丁烯腈的底部产物; （d）蒸馏物流（5），得到作为底物的物流（6），其含有3-戊烯腈和作为含有2-甲基-3-丁烯腈的头部产物的物流（7）。