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    Cavernous nerve stimulation via unidirectional propagation of action potentials
    3.
    发明授权
    Cavernous nerve stimulation via unidirectional propagation of action potentials 有权
    通过动作电位的单向传播进行海绵体神经刺激

    公开(公告)号：US07203548B2

    公开(公告)日：2007-04-10

    申请号：US10176743

    申请日：2002-06-20

    申请人： Todd K Whitehurst ,  James P McGivern ,  Rafael Carbunaru ,  Matthew I Haller ,  Tom Xiaohai He ,  Kerry Bradley

    发明人： Todd K Whitehurst ,  James P McGivern ,  Rafael Carbunaru ,  Matthew I Haller ,  Tom Xiaohai He ,  Kerry Bradley

    IPC分类号： A61N1/05 ,  A61N1/18

    CPC分类号： A61N1/0556 ,  A61N1/0551 ,  A61N1/36071 ,  A61N1/37205

    摘要： Methods of using unidirectionally propagating action potentials (UPAPs) for cavernous nerve stimulation and for certain disorders are provided. Stimulators capable of creating such UPAPs include, but are not limited to, miniature implantable stimulators (i.e., microstimulators), possibly with programmably configurable electrodes. In one aspect, a method includes providing at least one implantable stimulator with at least two electrodes, disposing the electrodes to apply stimulation that unidirectionally propagates action potentials along a cavernous nerve; and applying the stimulation to the cavernous nerve, thereby treating erectile dysfunction while limiting side effects of bidirectional stimulation.

    摘要翻译： 提供了使用单向传播动作电位（UPAP）用于海绵神经刺激和某些疾病的方法。 能够产生这种UPAP的刺激器包括但不限于微型可植入刺激器（即，微型刺激器），可能具有可编程配置的电极。 一方面，一种方法包括：提供至少一个可植入的刺激器，其具有至少两个电极，设置所述电极以施加沿着海绵体神经单向传播动作电位的刺激; 并将刺激施加到海绵状神经，从而治疗勃起功能障碍，同时限制双向刺激的副作用。

    Methods for treating gastrointestinal disorders
    5.
    发明授权
    Methods for treating gastrointestinal disorders 有权
    治疗胃肠道疾病的方法

    公开(公告)号：US08452407B2

    公开(公告)日：2013-05-28

    申请号：US11192750

    申请日：2005-07-29

    申请人： Todd K Whitehurst ,  James P McGivern ,  Rafael Carbunaru

    发明人： Todd K Whitehurst ,  James P McGivern ,  Rafael Carbunaru

    IPC分类号： A61N1/00 ,  A61N1/375 ,  A61N1/36

    CPC分类号： A61N1/375 ,  A61N1/36007 ,  A61N1/372 ,  A61N1/37205

    摘要： A small implantable stimulator(s) having at least two electrodes is implanted adjacent to a gastrointestinal nerve and/or muscle for the stimulation treatment of gastrointestinal disorders, including gastrointestinal motility, sphincteric disorders, and/or eating disorders. The stimulator provides a means of stimulating tissue at a stimulation site when desired, and may be implanted via a minimal surgical procedure.

    摘要翻译： 具有至少两个电极的小植入式刺激器邻近胃肠神经和/或肌肉植入，用于刺激治疗胃肠道疾病，包括胃肠蠕动，括肠功能障碍和/或进食障碍。 刺激器提供了在需要时在刺激部位刺激组织的手段，并且可以通过最小的外科手术植入。

    Thrombolysis and chronic anticoagulation therapy
    7.
    发明授权
    Thrombolysis and chronic anticoagulation therapy 失效
    溶栓和慢性抗凝治疗

    公开(公告)号：US07308303B2

    公开(公告)日：2007-12-11

    申请号：US10285803

    申请日：2002-11-01

    申请人： Todd K Whitehurst ,  Kelly H McClure ,  James R Thacker

    发明人： Todd K Whitehurst ,  Kelly H McClure ,  James R Thacker

    IPC分类号： A61N1/00 ,  A61M5/00

    CPC分类号： A61M5/14276 ,  A61M2205/3507 ,  A61M2205/3523 ,  A61M2205/8243 ,  A61M2230/04 ,  A61M2230/205 ,  A61M2230/30 ,  A61N1/362 ,  A61M2230/005

    摘要： Thrombolytic and/or anticoagulation therapy of the present invention includes implantation of the discharge portion(s) of a catheter and, optionally, one or more electrodes on a lead, adjacent tissue(s) to be stimulated. Stimulation pulses, i.e., drug infusion pulses and optional electrical pulses, are supplied by a stimulator implanted remotely, and through the catheter or lead, which is tunneled subcutaneously between the stimulator and stimulation site. Stimulation sites include the coronary arteries, coronary veins, cerebral arteries, other blood vessels, chambers of the heart, mesenteric vessels, deep vessels of the leg, and other locations. Disclosed treatments include drugs used for chronic treatment and/or prevention of thromboembolic disease, for acute treatment of thromboembolic disease, for acute treatment of thrombosis, and combinations of these. The invention reduces or eliminates the incidence of thromboembolic disease and related morbidities, improve symptoms resulting from thromboembolic disease, and improve patient quality of life.

    摘要翻译： 本发明的血栓溶解和/或抗凝治疗包括将导管的放电部分和可选的一个或多个电极植入在待刺激的邻近组织上。 刺激脉冲，即药物输注脉冲和可选的电脉冲由远程植入的刺激器，以及通过在刺激器和刺激部位之间皮下隧穿的导管或引线提供。 刺激部位包括冠状动脉，冠状动脉，脑动脉，其他血管，心脏腔，肠系膜血管，腿部深血管等位置。 公开的治疗包括用于慢性治疗和/或预防血栓栓塞性疾病，用于急性治疗血栓栓塞症，用于急性治疗血栓形成的药物及其组合的药物。 本发明减少或消除了血栓栓塞性疾病和相关疾病的发生，改善了血栓栓塞性疾病引起的症状，并改善了患者的生活质量。

    Fixation device for implantable microdevices
    8.
    发明授权
    Fixation device for implantable microdevices 有权
    可植入微型装置的固定装置

    公开(公告)号：US07054692B1

    公开(公告)日：2006-05-30

    申请号：US10146332

    申请日：2002-05-15

    申请人： Todd K Whitehurst ,  James P McGivern

    发明人： Todd K Whitehurst ,  James P McGivern

    IPC分类号： A61N1/05

    CPC分类号： A61N1/375 ,  A61N1/37205 ,  A61N1/3756

    摘要： A fixation device fixes the position of an implantable microminiature device residing proximally to a target site such as a nerve or a muscle. In one embodiment, the device comprises a sheath and a means for attaching the device to adjacent tissue. The means for attaching may be any one of several embodiments including one or more grasping members, a combination of grasping members and one or more helices, or an extension adapted to accept a suture. In another embodiment, the fixation device comprises an assembly residing in the implantation pathway, behind the stimulation device, thus preventing retreat of the stimulation device in the pathway. In a preferred use, the fixation device fixes the position of a microstimulator component of a Peripheral Nerve Stimulation (PNS) system.

    摘要翻译： 固定装置将位于近端的可植入微型装置的位置固定到诸如神经或肌肉的目标部位。 在一个实施例中，该装置包括护套和用于将该装置附接到相邻组织的装置。 用于附接的装置可以是包括一个或多个抓握构件，抓握构件和一个或多个螺旋的组合的几个实施例中的任一个或适于接纳缝合线的延伸部。 在另一个实施例中，固定装置包括驻留在植入通路中的组件，位于刺激装置后面，从而防止刺激装置在路径中的后退。 在优选的使用中，固定装置固定外围神经刺激（PNS）系统的微型激励器部件的位置。

    Treatment of hypertension
    10.
    发明授权
    Treatment of hypertension 有权
    治疗高血压

    公开(公告)号：US07155284B1

    公开(公告)日：2006-12-26

    申请号：US10346538

    申请日：2003-01-16

    申请人： Todd K Whitehurst ,  Kelly H. McClure ,  James R Thacker ,  James P McGivern

    发明人： Todd K Whitehurst ,  Kelly H. McClure ,  James R Thacker ,  James P McGivern

    IPC分类号： A61N1/18

    CPC分类号： A61N1/36117 ,  A61N1/36135 ,  A61N1/37205 ,  A61N1/37211 ,  A61N1/3787

    摘要： Treatment of hypertension includes implantation of the discharge portion(s) of a catheter and/or electrical stimulation electrode(s) adjacent the tissue(s) to be stimulated. Stimulation pulses, i.e., drug infusion pulses and/or electrical pulses, are supplied by one or more implanted stimulators, through the catheter and possibly also a lead, tunneled subcutaneously between the stimulator and stimulation site. A microstimulator(s) may also/instead deliver electrical stimulation pulses. Stimulation sites include the carotid sinus and carotid body, among other locations. Treatments include drugs used for acute and/or chronic treatment of hypertension. In a number of embodiments, a need for or response to treatment is sensed, and the electrical and/or infusion pulses adjusted accordingly.

    摘要翻译： 高血压的治疗包括植入邻近待刺激的组织的导管和/或电刺激电极的放电部分。 刺激脉冲，即药物输注脉冲和/或电脉冲由一个或多个注入的刺激器通过导管提供，并且可能还包括引线，在刺激器和刺激部位之间皮下隧穿。 微型激励器也可以/替代地递送电刺激脉冲。 刺激部位包括颈动脉窦和颈动脉体等。 治疗包括用于急性和/或慢性治疗高血压的药物。 在多个实施例中，感测对治疗的需要或响应，并且相应地调整电和/或输注脉冲。