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22 条记录 (耗时 0.079 秒)

    Methods and compositions for modulating ACE-2 activity
    1.
    发明授权
    Methods and compositions for modulating ACE-2 activity 有权
    调节ACE-2活性的方法和组合物

    公开(公告)号：US06900033B2

    公开(公告)日：2005-05-31

    申请号：US10158825

    申请日：2002-06-03

    申请人： Tom J. Parry ,  Les Sekut ,  Craig A. Rosen ,  Vivian R. Albert ,  Indrajit Sanyal ,  Lili Huang ,  Charles R. Wescott

    发明人： Tom J. Parry ,  Les Sekut ,  Craig A. Rosen ,  Vivian R. Albert ,  Indrajit Sanyal ,  Lili Huang ,  Charles R. Wescott

    IPC分类号： A61K38/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  A61K38/16 ,  C12N5/06 ,  C12N9/64 ,  C12P21/02

    CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K7/08 ,  C07K14/001 ,  C07K2319/00

    摘要： Binding polypeptides comprising specific amino acid sequences are disclosed that specifically bind ACE-2 protein or ACE-2-like polypeptides. The binding polypeptides can be used in methods of the invention for detecting, isolating, or purifying ACE-2 protein or ACE-2-like polypeptides in solutions or mixtures, or biological samples. The invention also relates to nucleic acid molecules encoding these ACE-2 binding polypeptides, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention also relates to methods and compositions for detecting, diagnosing, prognosing, preventing, treating or ameliorating a disease or disorder associated with aberrant ACE-2 or ACE-2 receptor expression or inappropriate function of ACE-2 or ACE-2 receptor, comprising use of ACE-2 binding polypeptides or fragments or variants thereof, that specifically bind to ACE-2.

    摘要翻译： 公开了包含特异性氨基酸序列的结合多肽，其特异性结合ACE-2蛋白或ACE-2样多肽。 结合多肽可用于本发明的方法中用于在溶液或混合物或生物样品中检测，分离或纯化ACE-2蛋白或ACE-2样多肽。 本发明还涉及编码这些ACE-2结合多肽的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。 本发明还涉及用于检测，诊断，预后，预防，治疗或改善与异常ACE-2或ACE-2受体表达或ACE-2或ACE-2受体的不适当功能相关的疾病或病症的方法和组合物， 包括使用特异性结合ACE-2的ACE-2结合多肽或其片段或变体。

    Methods of treating cancer using antibodies that immunospecifically bind to trail receptors
    2.
    发明授权
    Methods of treating cancer using antibodies that immunospecifically bind to trail receptors 有权
    使用免疫特异性结合尾静脉受体的抗体治疗癌症的方法

    公开(公告)号：US07361341B2

    公开(公告)日：2008-04-22

    申请号：US11391384

    申请日：2006-03-29

    申请人： Theodora W. Salcedo ,  Steven M. Ruben ,  Craig A. Rosen ,  Vivian R. Albert ,  Claire Dobson ,  Tristan Vaughan

    发明人： Theodora W. Salcedo ,  Steven M. Ruben ,  Craig A. Rosen ,  Vivian R. Albert ,  Claire Dobson ,  Tristan Vaughan

    IPC分类号： A61K39/395 ,  G01N33/53 ,  C12P21/04 ,  C12P21/08 ,  C07K16/00 ,  C07H21/04

    CPC分类号： C07K16/2878 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/73

    摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.

    摘要翻译： 本发明涉及免疫特异性结合TRAIL受体TR4的抗体和相关分子。 这样的抗体具有例如用于治疗癌症和其它增殖性疾病的用途。 本发明还涉及编码抗TR4抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。 本发明涉及用于检测，诊断，治疗或改善疾病或病症，特别是癌症和其它过度增殖性疾病的方法和组合物，包括向动物，优选人类施用有效量的一种或多种抗体或片段或变体 或相关分子，其免疫特异性结合TRAIL受体TR4。