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公开(公告)号：US06900033B2
公开(公告)日：2005-05-31
申请号：US10158825
申请日：2002-06-03
申请人： Tom J. Parry , Les Sekut , Craig A. Rosen , Vivian R. Albert , Indrajit Sanyal , Lili Huang , Charles R. Wescott
发明人： Tom J. Parry , Les Sekut , Craig A. Rosen , Vivian R. Albert , Indrajit Sanyal , Lili Huang , Charles R. Wescott
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , C07K14/001 , C07K2319/00
摘要： Binding polypeptides comprising specific amino acid sequences are disclosed that specifically bind ACE-2 protein or ACE-2-like polypeptides. The binding polypeptides can be used in methods of the invention for detecting, isolating, or purifying ACE-2 protein or ACE-2-like polypeptides in solutions or mixtures, or biological samples. The invention also relates to nucleic acid molecules encoding these ACE-2 binding polypeptides, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention also relates to methods and compositions for detecting, diagnosing, prognosing, preventing, treating or ameliorating a disease or disorder associated with aberrant ACE-2 or ACE-2 receptor expression or inappropriate function of ACE-2 or ACE-2 receptor, comprising use of ACE-2 binding polypeptides or fragments or variants thereof, that specifically bind to ACE-2.
摘要翻译： 公开了包含特异性氨基酸序列的结合多肽，其特异性结合ACE-2蛋白或ACE-2样多肽。 结合多肽可用于本发明的方法中用于在溶液或混合物或生物样品中检测，分离或纯化ACE-2蛋白或ACE-2样多肽。 本发明还涉及编码这些ACE-2结合多肽的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。 本发明还涉及用于检测，诊断，预后，预防，治疗或改善与异常ACE-2或ACE-2受体表达或ACE-2或ACE-2受体的不适当功能相关的疾病或病症的方法和组合物， 包括使用特异性结合ACE-2的ACE-2结合多肽或其片段或变体。
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公开(公告)号：US09505823B2
公开(公告)日：2016-11-29
申请号：US11835114
申请日：2007-08-07
申请人： Adam C. Bell , Craig A. Rosen , Indrajit Sanyal , Qinghai Zhao
发明人： Adam C. Bell , Craig A. Rosen , Indrajit Sanyal , Qinghai Zhao
CPC分类号： C07K14/62 , A61K38/28 , C07K14/765 , C07K2319/35 , C12N15/62
摘要： Disclosed are fusion proteins that include albumin fused to a polypeptide that has insulin activity. The fusion proteins may include albumin fused to insulin or an insulin analog. In particular, the fusions proteins may include albumin fused to a single chain insulin analog. The fusion proteins may exhibit extended insulin activity in vivo or in vitro relative to insulin that is not fused to albumin. The fusion proteins may be formulated as aerosol compositions.
摘要翻译： 公开了融合蛋白，其包括与具有胰岛素活性的多肽融合的白蛋白。 融合蛋白可包括与胰岛素或胰岛素类似物融合的白蛋白。 特别地，融合蛋白可以包括与单链胰岛素类似物融合的白蛋白。 融合蛋白可以在体内或体外相对于不与白蛋白融合的胰岛素表现出延长的胰岛素活性。 融合蛋白可以配制成气溶胶组合物。
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公开(公告)号：US5939300A
公开(公告)日：1999-08-17
申请号：US674887
申请日：1996-07-03
CPC分类号： C12N9/0065 , C12Q1/30 , A01K2217/05
摘要： Catalase enzymes derived from bacteria from the genera Alcaligenes (Deleya) and Microscilla are disclosed. The enzymes are produced from native or recombinant host cells and can be utilized to destroy or detect hydrogen peroxide, e.g., in production of glyoxylic acid and in glucose sensors, and in processes where hydrogen peroxide is used as a bleaching or antibacterial agent, e.g. in contact lens cleaning, in bleaching steps in pulp and paper preparation and in the pasteurization of dairy products.
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公开(公告)号：US20050202494A1
公开(公告)日：2005-09-15
申请号：US11096819
申请日：2005-04-01
申请人： Jay Short , Dan Robertson , Indrajit Sanyal , Robert Adhikari , Eric Mathur
发明人： Jay Short , Dan Robertson , Indrajit Sanyal , Robert Adhikari , Eric Mathur
CPC分类号： C12N9/0065 , A01K2217/05 , C12Q1/30
摘要： The invention relates to catalases and to polynucleotides encoding the catalases. In addition methods of designing new catalases and method of use thereof are also provided. The catalases have increased activity and stability at increased pH and temperature.
摘要翻译： 本发明涉及过氧化氢酶和编码该过氧化氢酶的多核苷酸。 另外还提供了设计新的过氧化氢酶的方法及其使用方法。 过氧化氢酶在增加的pH和温度下具有增加的活性和稳定性。
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公开(公告)号：US6074860A
公开(公告)日：2000-06-13
申请号：US951844
申请日：1997-10-16
CPC分类号： C12N9/0065 , C12Q1/30 , A01K2217/05
摘要： Catalase enzymes derived from bacteria from the genera Alcaligenes (Deleya) and Microscilla are disclosed. The enzymes are produced from native or recombinant host cells and can be utilized to destroy or detect hydrogen peroxide, e.g., in production of glyoxylic acid and in glucose sensors, and in processes where hydrogen peroxide is used as a bleaching or antibacterial agent, e.g. in contact lens cleaning, in bleaching steps in pulp and paper preparation and in the pasteurization of dairy products.
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公开(公告)号：US20080057004A1
公开(公告)日：2008-03-06
申请号：US11835114
申请日：2007-08-07
申请人： Adam Bell , Craig Rosen , Indrajit Sanyal , Qinghai Zhao
发明人： Adam Bell , Craig Rosen , Indrajit Sanyal , Qinghai Zhao
CPC分类号： C07K14/62 , A61K38/28 , C07K14/765 , C07K2319/35 , C12N15/62
摘要： Disclosed are fusion proteins that include albumin fused to a polypeptide that has insulin activity. The fusion proteins may include albumin fused to insulin or an insulin analog. In particular, the fusions proteins may include albumin fused to a single chain insulin analog. The fusion proteins may exhibit extended insulin activity in vivo or in vitro relative to insulin that is not fused to albumin. The fusion proteins may be formulated as aerosol compositions.
摘要翻译： 公开了融合蛋白，其包括与具有胰岛素活性的多肽融合的白蛋白。 融合蛋白可包括与胰岛素或胰岛素类似物融合的白蛋白。 特别地，融合蛋白可以包括与单链胰岛素类似物融合的白蛋白。 融合蛋白可以在体内或体外相对于不与白蛋白融合的胰岛素表现出延长的胰岛素活性。 融合蛋白可以配制成气溶胶组合物。
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公开(公告)号：US20070253973A1
公开(公告)日：2007-11-01
申请号：US11714918
申请日：2007-03-07
申请人： Craig Rosen , Adam Bell , Indrajit Sanyal
发明人： Craig Rosen , Adam Bell , Indrajit Sanyal
CPC分类号： C07K14/4715 , A61K39/00 , A61K2039/6031 , C07K2319/31 , Y02A50/388 , Y02A50/39 , Y02A50/464 , Y02A50/466 , Y02A50/484
摘要： The invention relates generally to fusion proteins comprising at least one therapeutic protein or vaccine antigen and alpha fetoprotein. The therapeutic protein or vaccine antigen can be, for example, a peptide, antibody, fragment thereof, or variant thereof. The therapeutic protein or vaccine antigen is fused to alpha-fetoprotein, an alpha-fetoprotein fragment, or an alpha-fetoprotein variant. Also encompassed by the invention are nucleic acids encoding the fusion proteins of the invention, vectors comprising such nucleic acids, and host cells transformed with such nucleic acids and/or vectors. Methods of making and using the fusion proteins, nucleic acids, vectors, and host cells are also encompassed by the invention.
摘要翻译： 本发明一般涉及包含至少一种治疗性蛋白质或疫苗抗原和甲胎蛋白的融合蛋白。 治疗性蛋白质或疫苗抗原可以是例如肽，抗体，其片段或其变体。 治疗性蛋白质或疫苗抗原与甲胎蛋白，甲胎蛋白片段或甲胎蛋白变体融合。 本发明还包括编码本发明的融合蛋白的核酸，包含该核酸的载体和用这种核酸和/或载体转化的宿主细胞。 制备和使用融合蛋白，核酸，载体和宿主细胞的方法也包括在本发明中。
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公开(公告)号：US06410290B1
公开(公告)日：2002-06-25
申请号：US09412347
申请日：1999-10-05
IPC分类号： C12N908
CPC分类号： C12N9/0065 , A01K2217/05 , C12Q1/30
摘要： Catalase enzymes derived from bacteria from the genera Alcaligenes (Deleya) and Microscilla are disclosed. The enzymes are produced from native or recombinant host cells and can be utilized to destroy or detect hydrogen peroxide, e.g., in production of glyoxylic acid and in glucose sensors, and in processes where hydrogen peroxide is used as a bleaching or antibacterial agent, e.g. in contact lens cleaning, in bleaching steps in pulp and paper preparation and in the pasteurization of dairy products.
摘要翻译： 公开了源自产碱杆菌属（Deleya）和Microscilla的细菌的过氧化氢酶。 酶由天然或重组宿主细胞产生，可用于破坏或检测过氧化氢，例如在生产乙醛酸和葡萄糖传感器时，以及过氧化氢用作漂白剂或抗菌剂的过程。 在隐形眼镜清洁中，在纸浆和纸制备中的漂白步骤和乳制品的巴氏消毒中。
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