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    ACYLAMINOPIPERIDINE COMPOUND
    2.
    发明申请
    ACYLAMINOPIPERIDINE COMPOUND 失效
    ACYLAMINOPIPERIDINE化合物

    公开(公告)号：US20090131666A1

    公开(公告)日：2009-05-21

    申请号：US12294145

    申请日：2007-03-23

    申请人： Toru Kontani ,  Noriyuki Kawano ,  Naoyuki Masuda ,  Koji Kato ,  Hiroshi Nagata ,  Hiroshi Inami ,  Tadashi Terasaka ,  Kazuhiro Yokoyama ,  Takahiro Miyazaki

    发明人： Toru Kontani ,  Noriyuki Kawano ,  Naoyuki Masuda ,  Koji Kato ,  Hiroshi Nagata ,  Hiroshi Inami ,  Tadashi Terasaka ,  Kazuhiro Yokoyama ,  Takahiro Miyazaki

    IPC分类号： C07D401/04

    CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D487/04

    摘要： [Problem] To provide a compound which has an excellent activity to modulate the functions of CCR4 or TARC and/or MDC and can be used for the prevention and/or treatment of various inflammatory diseases, allergic diseases, autoimmune diseases and the like. [Means for Resolution] An acylaminopiperidine compound represented by the formula (I) or a pharmaceutically acceptable salt thereof. [Symbols in the formula represent the following meanings; A: a single bond or C1-C6 alkylene, R1: phenyl which may be substituted, etc., R2: —H or C1-C6 alkyl, R3: —H, C1-C6 alkyl or C3-C8 cycloalkyl, R4: pyrrolidin-2-yl which may be substituted, etc., and D: benzene ring or pyrazole ring].

    摘要翻译： [问题]提供具有优异活性以调节CCR4或TARC和/或MDC功能的化合物，并可用于预防和/或治疗各种炎性疾病，过敏性疾病，自身免疫性疾病等。 [解决方法]由式（I）表示的酰氨基哌啶化合物或其药学上可接受的盐。 [式中的符号表示以下含义： A：单键或C1-C6亚烷基，R1：可被取代的苯基等，R2：-H或C1-C6烷基，R3：-H，C1-C6烷基或C3-C8环烷基，R4：吡咯烷 -2-基，其可以被取代等，D：苯环或吡唑环]。

    Heterocyclic compound, composition and method for inhibiting adenosine deaminase
    9.
    发明授权
    Heterocyclic compound, composition and method for inhibiting adenosine deaminase 失效
    杂环化合物，抑制腺苷脱氨酶的组合物和方法

    公开(公告)号：US06596738B1

    公开(公告)日：2003-07-22

    申请号：US09926134

    申请日：2001-09-07

    申请人： Tadashi Terasaka ,  Nobuo Seki ,  Kiyoshi Tsuji ,  Isao Nakanishi ,  Takayoshi Kinoshita ,  Katsuya Nakamura

    发明人： Tadashi Terasaka ,  Nobuo Seki ,  Kiyoshi Tsuji ,  Isao Nakanishi ,  Takayoshi Kinoshita ,  Katsuya Nakamura

    IPC分类号： A61K314164

    CPC分类号： C07D249/08 ,  C07D231/12 ,  C07D233/56 ,  C07D233/90 ,  C07D249/10 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D413/14 ,  C07D417/06 ,  C07D417/14 ,  C07D471/04 ,  C07F7/1804 ,  Y02P20/55

    摘要： Heterocyclic compounds of the following formula: wherein B is  [wherein R1 is hydrogen or lower alkyl; R2 is hydrogen or lower alkyl; and X is hydrogen or hydroxy protective group], lower alkanoyl or hydroxyimino(lower)alkyl A is lower alkylene; W is heterocyclic or carbocyclic group, each of which may have one or more substituent(s); Z is heterocyclic group selected from the group consisting of imidazolyl, triazolyl,imidazopyridyl and adenyl, each of which may have one or more substituent(s); or a salt thereof, provided that when W is aryl which may have one or more substituent(s), then (i) Z is triazolyl, imidazopyridyl or adenyl, each of which may have one or more substituent(s); (ii) Z is imidazolyl which may have one or more substituent(s) and B is lower alkanoyl or hydroxyimino(lower)alkyl; or (iii) Z is imidazolyl which may have one or more substituent(s) and R1 and R2 are both lower alkyl. or pharmaceutically acceptable salts thereof, which are useful as a medicament.

    摘要翻译： 下式的杂环化合物：其中B是[其中R 1是氢或低级烷基; R 2是氢或低级烷基; 和X是氢或羟基保护基]，低级烷酰基或羟基亚氨基（低级）烷基A是低级亚烷基; W是杂环或碳环基，每一个可以具有一个或多个取代基; Z是选自 咪唑基，三唑基，咪唑并吡啶基和腺嘌呤，其各自可以具有一个或多个取代基;或其盐，条件是当W是可以具有一个或多个取代基的芳基时，则（i）Z是 三唑基，咪唑并吡啶基或腺苷酸，其各自可以具有一个或多个取代基; （ii）Z是可以具有一个或多个取代基的咪唑基，B是低级烷酰基或羟基亚氨基（低级）烷基; 或（iii）Z是可具有一个或多个取代基的咪唑基，R 1和R 2均为低级烷基或其药学上可接受的盐，其可用作药物。