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    Cholesterol detection reagent
    1.
    发明申请
    Cholesterol detection reagent 审中-公开
    胆固醇检测试剂

    公开(公告)号：US20060110781A1

    公开(公告)日：2006-05-25

    申请号：US10516072

    申请日：2003-05-30

    申请人： Toshihide Kobayashi ,  Satoshi Sato ,  Yoshio Hamashima

    发明人： Toshihide Kobayashi ,  Satoshi Sato ,  Yoshio Hamashima

    IPC分类号： C12Q1/00 ,  C12Q1/60

    CPC分类号： G01N33/92

    摘要： An object of the present invention is to provide a novel cholesterol detection reagent comprising a substance which can specifically binds to cholesterol to detect it, and a method for detecting cholesterol using the reagent. The present invention provides a cholesterol detection reagent comprising a polyethylene glycol cholesteryl ether which may be labeled.

    摘要翻译： 本发明的目的是提供一种胆固醇检测试剂，其包含能够特异性结合胆固醇进行检测的物质，以及使用该试剂检测胆固醇的方法。 本发明提供一种胆固醇检测试剂，其包含可标记的聚乙二醇胆固醇醚。

    Oxazolines
    4.
    发明授权
    Oxazolines 失效
    恶唑啉

    公开(公告)号：US4220766A

    公开(公告)日：1980-09-02

    申请号：US868422

    申请日：1978-01-10

    申请人： Teruji Tsuji ,  Mitsuru Yoshioka ,  Shoichiro Uyeo ,  Yoshio Hamashima ,  Ikuo Kikkawa ,  Wataru Nagata

    发明人： Teruji Tsuji ,  Mitsuru Yoshioka ,  Shoichiro Uyeo ,  Yoshio Hamashima ,  Ikuo Kikkawa ,  Wataru Nagata

    IPC分类号： C07D498/04 ,  C07D499/00 ,  C07D505/00 ,  C07D285/16 ,  C07D491/04

    CPC分类号： C07D505/00 ,  C07D499/00 ,  Y02P20/582

    摘要： Useful intermediates for preparing a 1-dethia-1-oxacephalosporin and represented by the following formula: ##STR1## (wherein R is a monovalent group resulting from the elimination of the carbonyl function of an acyl group derived from a carboxylic or carbonic acid;COB is carboxy or protected carboxy; andX is hydrogen or a nucleophilic group)are prepared from the corresponding penicillin 1-oxides of the following formula: ##STR2## (wherein R, COB, and X are as defined above) by heating, if required in the presence of the desulfurizing reagent, or by exchanging the X group with another one under the condition of an appropriate nucleophilic substitution.

    摘要翻译： 用于制备1-脱硫-1-氧杂环孢菌素并由下式表示的有用的中间体：其中R是由消除衍生自羧酸或碳酸的酰基的羰基官能团产生的一价基团; COB 是羧基或被保护的羧基; X是氢或亲核基团）由相应的下式的青霉素1-氧化物制备：如果需要，通过加热，其中R，COB和X如上所定义 在脱硫试剂的存在下，或者通过在适当的亲核取代条件下与另一种X基团交换X基团。

    Azetidinone intermediates for cephalosporin analogs
    6.
    发明授权
    Azetidinone intermediates for cephalosporin analogs 失效
    氮杂环丁酮中间体用于头孢菌素类似物

    公开(公告)号：US4592865A

    公开(公告)日：1986-06-03

    申请号：US589670

    申请日：1984-03-13

    申请人： Masayuki Narisada ,  Hiroshi Onoue ,  Teruji Tsuji ,  Yasuhiro Nishitani ,  Mitsuru Yoshioka ,  Yoshio Hamashima ,  Wataru Nagata

    发明人： Masayuki Narisada ,  Hiroshi Onoue ,  Teruji Tsuji ,  Yasuhiro Nishitani ,  Mitsuru Yoshioka ,  Yoshio Hamashima ,  Wataru Nagata

    IPC分类号： C07D205/08 ,  C07D205/085 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12 ,  C07D505/00 ,  C07F9/568 ,  C07D498/04

    CPC分类号： C07F9/5683 ,  C07D205/085 ,  C07D505/00

    摘要： Intermediates of the following formula are useful for the synthesis of 1-oxacephalosporins. Their preparation from penicillins and the transformation process to make 1-oxacephalosporins are disclosed. The compounds are of the formula: ##STR1## wherein A is amino or a selected acylamino;COB is carboxy or a selected protected-carboxy;X is halogen or the group ORin which R is a group represented by following formulas: ##STR2## wherein Nu is a selected nucleophilic group; R.sup.1 is a group of the following formula: ##STR3## in which Hal is halogen or alkylsulfonyloxy and R.sup.2 is alkyl or aryl; andY is hydrogen or methoxy; with the proviso that when R is propargyl or 2-oxopropyl andR.sup.1 is ##STR4## A is in the 3.alpha.-configuration and Y is 3.beta.-hydrogen or A is in the 3.beta.-configuration and Y is 3.alpha.-methoxy.

    摘要翻译： 下列配方的中间体可用于合成1-氧杂七环素。 公开了它们从青霉素的制备和制备1-氧杂七环素的转化过程。 化合物具有下式：其中A是氨基或选择的酰氨基; COB是羧基或选择的保护羧基; X是卤素或基团OR，其中R是由下式表示的基团：CH2CCH，CH2CCNu，CH2CHCH2，＆lt; IMAGE＆gt;＆gt;其中Nu是选择的亲核基团; R1是下式的基团：其中Hal是卤素或烷基磺酰氧基，R2是烷基或芳基的 Y为氢或甲氧基; 条件是当R为炔丙基或2-氧代丙基且R 1为A 3构型时，Y为3个β-氢，或A为3个β-构型，Y为3个α-甲氧基。

    Malonyloxacephemcarboxylic acid derivatives
    8.
    发明授权
    Malonyloxacephemcarboxylic acid derivatives 失效
    恶唑烷四羧酸衍生物

    公开(公告)号：US4569993A

    公开(公告)日：1986-02-11

    申请号：US679006

    申请日：1984-12-06

    申请人： Masayuki Narisada ,  Fumihiko Watanabe ,  Yoshio Hamashima

    发明人： Masayuki Narisada ,  Fumihiko Watanabe ,  Yoshio Hamashima

    IPC分类号： A61K31/535 ,  A61P31/04 ,  C07D505/00 ,  C07D498/04

    CPC分类号： C07D505/00 ,  Y02P20/55

    摘要： An antibacterial 7beta-substituted malonamido-7alpha-methoxy-3-tetrazolylthiomethyl-1-dethia-1-oxa-3-cephem-4-carboxylic acid and its derivative represented by the following formula: ##STR1## (wherein R.sup.1 is alkyl, hydroxyaryl, or thienyl;R.sup.2 and R.sup.4 each is hydrogen, light metal or a carboxy-protecting group; andR.sup.3 is optionally protected hydroxyalkyl, carbamoylalkyl, dialkylaminoalkyl, or sulfamoylalkyl)are disclosed.

    摘要翻译： 一种抗菌的7-取代的丙二酰-7α-甲氧基-3-四唑基硫甲基-1-脱硫-1-氧杂-3-环己基-4-羧酸及其衍生物由下式表示：其中R1是烷基， 羟基芳基或噻吩基; R2和R4各自为氢，轻金属或羧基保护基; R3为任选保护的羟烷基，氨基甲酰基烷基，二烷基氨基烷基或氨磺酰基烷基）。

    1-Oxadethiacepham compounds
    9.
    发明授权
    1-Oxadethiacepham compounds 失效
    1-氧杂十八胺化合物

    公开(公告)号：US4533730A

    公开(公告)日：1985-08-06

    申请号：US543940

    申请日：1983-10-19

    申请人： Mitsuru Yoshioka ,  Uyeo Shoichiro ,  Yoshio Hamashima ,  Ikuo Kikkawa ,  Teruji Tsuji ,  Wataru Nagata

    发明人： Mitsuru Yoshioka ,  Uyeo Shoichiro ,  Yoshio Hamashima ,  Ikuo Kikkawa ,  Teruji Tsuji ,  Wataru Nagata

    IPC分类号： C07D498/04 ,  C07D498/20 ,  C07D505/00

    CPC分类号： C07D505/00

    摘要： Intermediates for preparing an antibacterial 1-dethia-1-oxacephalosporins which are represented by the following formula: ##STR1## wherein R is a monovalent group (minus the carbonyl) from an acyl derived from a carboxylic or carbonic acid;Y.sup.1 is a divalent group of the following formula: ##STR2## wherein COB is carboxy or protected carboxy;X is hydrogen or a nucleophilic group; andZ is a leaving groupare prepared from a compound of the following formula; ##STR3## wherein R and Y.sup.1 are as defined above by the action of an acid. The new compounds of this invention shown by the following formula: ##STR4## wherein A is amino or substituted amino;E is hydrogen or methoxy; andY is a divalent group of the following formula: ##STR5## in which COB, X, and Z are as defined above are convertible into other compounds of the same formula by applying conventional methods in .beta.-lactam chemistry.

    摘要翻译： 用于制备由下式表示的抗菌1-脱氧-1-氧杂头孢菌素的中间体：其中R是衍生自羧酸或碳酸的酰基的一价基团（减去羰基）; Y1是下式的二价基团：其中COB是羧基或被保护的羧基; X是氢或亲核基团; 并且Z为离去基团由下式的化合物制备： 其中R和Y1如上所定义，通过酸的作用。 本发明的新化合物由下式表示：其中A是氨基或取代的氨基; E是氢或甲氧基; 并且Y是下式的二价基团：其中COB，X和Z如上定义的 + TR 可通过在β-内酰胺化学中应用常规方法转化为相同式的其它化合物。

    1-Oxadethiacepham compounds
    10.
    发明授权
    1-Oxadethiacepham compounds 失效
    1-氧杂十八胺化合物

    公开(公告)号：US4504659A

    公开(公告)日：1985-03-12

    申请号：US543939

    申请日：1983-10-19

    申请人： Mitsuru Yoshioka ,  Uyeo Shoichiro ,  Yoshio Hamashima ,  Ikuo Kikkawa ,  Teruji Tsuji ,  Wataru Nagata

    发明人： Mitsuru Yoshioka ,  Uyeo Shoichiro ,  Yoshio Hamashima ,  Ikuo Kikkawa ,  Teruji Tsuji ,  Wataru Nagata

    IPC分类号： C07D498/04 ,  C07D498/20 ,  C07D505/00

    CPC分类号： C07D505/00

    摘要： Intermediates for preparing an antibacterial 1-dethia-1-oxacephalosporins which are represented by the following formula: ##STR1## wherein R is a monovalent group (minus the carbonyl) from an acyl derived from a carboxylic or carbonic acid;Y.sup.1 is a divalent group of the following formula: ##STR2## wherein COB is carboxy or protected carboxy;X is hydrogen or a nucleophilic group; andZ is a leaving groupare prepared from a compound of the following formula: ##STR3## wherein R and Y.sup.1 are as defined above by the action of an acid.

    摘要翻译： 用于制备由下式表示的抗菌1-脱氧-1-氧杂头孢菌素的中间体：其中R是衍生自羧酸或碳酸的酰基的一价基团（减去羰基）; Y1是下式的二价基团：其中COB是羧基或被保护的羧基; X是氢或亲核基团; 并且Z是离去基团由下式的化合物制备：其中R和Y1如上所定义，通过酸的作用。