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公开(公告)号：US07563599B2
公开(公告)日：2009-07-21
申请号：US10839799
申请日：2004-05-06
申请人： Toshihiko Ohtomo , Koh Sato , Masayuki Tsuchiya
发明人： Toshihiko Ohtomo , Koh Sato , Masayuki Tsuchiya
CPC分类号： C07K16/3053 , A61K38/00 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2319/00
摘要： The present invention discloses reshaped antibody to human medulloblastoma cells comprising: (A) an L chain comprising: (1) a human L chain C region, and (2) an L chain V region comprising human L chain FRs and L chain CDRs of mouse monoclonal antibody ONS-M21 to human medulloblastoma cells; and, (B) an H chain containing: (1) a human H chain C region, and (2) an H chain V region comprising human H chain FRs and H chain CDRs of mouse monoclonal antibody ONS-M21 to human medulloblastoma cells. Since the majority of this reshaped human antibody is derived from a human antibody and mouse CDRs have a low level of antigenicity, the reshaped human antibody of the present invention has a low level of antigenicity in humans, and is therefore expected to be useful as a therapeutic agent and diagnostic tool for brain tumors such as medulloblastoma which strongly express antigen that is recognized by this antibody.
摘要翻译： 本发明公开了对人成神经管细胞瘤细胞重整的抗体，其包含：（A）L链，其包含：（1）人L链C区，和（2）包含人L链FR和L链CDR的L链V区 单克隆抗体ONS-M21给人成神经管细胞瘤细胞; 和（B）包含以下物质的H链：（1）人H链C区，和（2）包含人H链FR的H链V区和小鼠单克隆抗体ONS-M21的H链CDR至人成神经管细胞瘤细胞。 由于这种重构的人抗体的大部分来自人抗体，小鼠CDR具有低水平的抗原性，所以本发明的重构人（人源化）抗体在人中具有低水平的抗原性，因此预期为 可用作用于脑肿瘤如成神经管细胞瘤的治疗剂和诊断工具，其能强烈表达被该抗体识别的抗原。
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公开(公告)号：US20050249726A1
公开(公告)日：2005-11-10
申请号：US10839799
申请日：2004-05-06
申请人： Toshihiko Ohtomo , Koh Sato , Masayuki Tsuchiya
发明人： Toshihiko Ohtomo , Koh Sato , Masayuki Tsuchiya
IPC分类号： A61K38/00 , A61K39/395 , C07H21/04 , C07K16/30 , C07K16/44 , C12N5/06 , C12P21/06 , C12P21/08
CPC分类号： C07K16/3053 , A61K38/00 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2319/00
摘要： The present invention discloses reshaped antibody to human medulloblastoma cells comprising: (A) an L chain comprising: (1) a human L chain C region, and (2) an L chain V region comprising human L chain FRs and L chain CDRs of mouse monoclonal antibody ONS-M21 to human medulloblastoma cells; and, (B) an H chain containing: (1) a human H chain C region, and (2) an H chain V region comprising human H chain FRs and H chain CDRs of mouse monoclonal antibody ONS-M21 to human medulloblastoma cells. Since the majority of this reshaped human antibody is derived from a human antibody and mouse CDRs have a low level of antigenicity, the reshaped human antibody of the present invention has a low level of antigenicity in humans, and is therefore expected to be useful as a therapeutic agent and diagnostic tool for brain tumors such as medulloblastoma which strongly express antigen that is recognized by this antibody.
摘要翻译： 本发明公开了对人成神经管细胞瘤细胞重整的抗体，其包含：（A）L链，其包含：（1）人L链C区，和（2）包含人L链FR和L链CDR的L链V区 单克隆抗体ONS-M21给人成神经管细胞瘤细胞; 和（B）包含以下物质的H链：（1）人H链C区，和（2）包含人H链FR的H链V区和小鼠单克隆抗体ONS-M21的H链CDR至人成神经管细胞瘤细胞。 由于这种重构的人抗体的大部分来自人抗体，小鼠CDR具有低水平的抗原性，所以本发明的重构人（人源化）抗体在人中具有低水平的抗原性，因此预期为 可用作用于脑肿瘤如成神经管细胞瘤的治疗剂和诊断工具，其能强烈表达被该抗体识别的抗原。
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公开(公告)号：US06214973B1
公开(公告)日：2001-04-10
申请号：US08646265
申请日：1996-09-09
申请人： Toshihiko Ohtomo , Koh Sato , Masayuki Tsuchiya
发明人： Toshihiko Ohtomo , Koh Sato , Masayuki Tsuchiya
IPC分类号： C07K1600
CPC分类号： C07K16/3053 , A61K38/00 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2319/00
摘要： The present invention discloses reshaped antibody to human medulloblastoma cells comprising: (A) an L chain comprising: (1) a human L chain C region, and (2) an L chain V region comprising human L chain FRs and L chain CDRs of mouse monoclonal antibody ONS-M21 to human medulloblastoma cells; and, (B) an H chain containing: (1) a human H chain C region, and (2) an H chain V region comprising human H chain FRs and H chain CDRs of mouse monoclonal antibody ONS-M21 to human medulloblastoma cells. Since the majority of this reshaped human antibody is derived from a human antibody and mouse CDRs have a low level of antigenicity, the reshaped human antibody of the present invention has a low level of antigenicity in humans, and is therefore expected to be useful as a therapeutic agent and diagnostic tool for brain tumors such as medulloblastoma which strongly express antigen that is recognized by this antibody.
摘要翻译： 本发明公开了对人成神经管细胞瘤细胞重整的抗体，其包含：（A）L链，其包含：（1）人L链C区，和（2）包含人L链FR和L链CDR的L链V区 单克隆抗体ONS-M21给人成神经管细胞瘤细胞; 和（B）包含以下物质的H链：（1）人H链C区，和（2）包含人H链FR的H链V区和小鼠单克隆抗体ONS-M21的H链CDR至人成神经管细胞瘤细胞。 由于这种重整的人抗体的大部分来自人抗体，小鼠CDR具有低水平的抗原性，所以本发明的重构人抗体在人体中具有低水平的抗原性，因此预期可用作 用于脑肿瘤如成神经管细胞瘤的治疗剂和诊断工具，其能强烈表达由该抗体识别的抗原。
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公开(公告)号：US20080009038A1
公开(公告)日：2008-01-10
申请号：US10582413
申请日：2004-12-10
CPC分类号： C07K16/00 , C07K16/18 , C07K2317/622 , C07K2317/75
摘要： Anti-human Mp1 antibodies were isolated and purified, and then single-chain anti-human Mp1 antibodies were prepared using genetic engineering techniques. The antibodies were found to exhibit a high agonistic activity. This shows that the activity of an antibody can be enhanced by making the antibody into a single-chain polypeptide that comprises two or more heavy chain variable regions and two or more light chain variable regions linked via linkers.
摘要翻译： 分离和纯化抗人Mp1抗体，然后使用遗传工程技术制备单链抗人Mp1抗体。 发现抗体表现出高的激动作用。 这表明通过将抗体制成包含两个或多个重链可变区和通过接头连接的两个或更多个轻链可变区的单链多肽，可以增强抗体的活性。
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公开(公告)号：US06699974B2
公开(公告)日：2004-03-02
申请号：US09269921
申请日：1999-04-01
申请人： Koichiro Ono , Toshihiko Ohtomo , Masayuki Tsuchiya , Yasushi Yoshimura , Yasuo Koishihara , Masaaki Kosaka
发明人： Koichiro Ono , Toshihiko Ohtomo , Masayuki Tsuchiya , Yasushi Yoshimura , Yasuo Koishihara , Masaaki Kosaka
IPC分类号： C07K1680
CPC分类号： C07K16/2896 , A61K38/00 , C07K16/3061 , C07K2317/24 , C07K2317/732 , C07K2317/734 , C07K2319/00
摘要： A reshaped human anti-HM 1.24 antibody comprising: (A) an L chain comprising (1) the C region of a human L chain, and (2) the V region of an L chain comprising the FR of a human L chain and the CDR of the L chain of a mouse anti-HM 1.24 monoclonal antibody; and (B) an H chain comprising (1) the C region of a human H chain, and (2) the V region of an H chain comprising the FR of a human H chain and the CDR of the H chain of a mouse anti-HM 1.24 monoclonal antibody. Since most of this reshaped human antibody is derived from human antibody and the CDR has a low antigenicity, the reshaped human antibody of the present invention has a low antigenicity and, therefore, is expected to be-used for medical treatment.
摘要翻译： 重构人抗HM 1.24抗体，其包含：（A）包含（1）人L链的C区的L链，和（2）包含人L链的FR的L链的V区和 小鼠抗HM 1.24单克隆抗体的L链的CDR; 和（B）包含（1）人H链的C区的H链，和（2）包含人H链的FR的H链的V区和小鼠抗体的H链的CDR -HM 1.24单克隆抗体。由于大部分重整人抗体衍生自人抗体，CDR具有低抗原性，本发明的重构人抗体具有低抗原性，因此预期用于医学 治疗。
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公开(公告)号：US06551840B2
公开(公告)日：2003-04-22
申请号：US10158895
申请日：2002-06-03
IPC分类号： G01N33566
CPC分类号： G01N33/68 , G01N2333/495
摘要： A method for screening substances that inhibit binding between a TAK1 polypeptide and a TAB1 polypeptide, which comprises contacting the TAB1 polypeptide to the TAK1 polypeptide and a test sample and then detecting or determining the TAK1 polypeptide that is bound to the TAB1 polypeptide.
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公开(公告)号：US20120015436A1
公开(公告)日：2012-01-19
申请号：US13225999
申请日：2011-09-06
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/24 , C07K16/2866 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/622 , C07K2317/73 , C07K2319/00
摘要： The invention relates to a modified antibody which contains two or more H chain V regions and two or more L chain V regions of monoclonal antibody and can transduce a signal into cells by crosslinking TPO receptor to thereby exert TPO agonist action. The modified antibody can be used as a TPO signal transduction agonist and, therefore, useful as a remedy for various diseases such as platelet-reduction-related blood diseases, thrombopenia following chemotherapy for cancer or leukemia, etc.
摘要翻译： 本发明涉及含有两个或多个H链V区和两个或更多个单克隆抗体的L链V区的修饰抗体，并且可通过交联TPO受体将信号转导进入细胞从而发挥TPO激动剂作用。 修饰的抗体可用作TPO信号转导激动剂，因此可用作各种疾病如血小板减少相关血液疾病，癌症或白血病化疗后的血小板减少症等的补救。
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公开(公告)号：US20090311718A1
公开(公告)日：2009-12-17
申请号：US12497131
申请日：2009-07-02
申请人： Naoshi Fukushima , Masayuki Tsuchiya , Shinsuke Uno , Toshihiko Ohtomo , Naohiro Yabuta , Hiroyuki Tsunod
发明人： Naoshi Fukushima , Masayuki Tsuchiya , Shinsuke Uno , Toshihiko Ohtomo , Naohiro Yabuta , Hiroyuki Tsunod
CPC分类号： C07K16/2869 , A61K38/00 , A61K2039/505 , C07K16/24 , C07K16/28 , C07K16/2866 , C07K16/3061 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/622 , C07K2317/73 , C07K2319/00
摘要： The invention relates to a modified antibody which contains two or more H chain V regions and two or more L chain V regions of monoclonal antibody and can transduce a signal into cells by crosslinking a cell surface molecule(s) to thereby serve as an agonist. The modified antibody can be used as a signal transduction agonist and, therefore, useful as a preventive and/or remedy for various diseases such as cancer, inflammation, hormone disorders and blood diseases.
摘要翻译： 本发明涉及含有两个或更多个H链V区和两个或多个单克隆抗体的L链V区的修饰抗体，并且可以通过交联细胞表面分子从而将信号转导入细胞，从而用作激动剂。 修饰的抗体可以用作信号转导激动剂，因此可用作各种疾病如癌症，炎症，激素失调和血液疾病的预防和/或补救。
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9.发明申请Methods of Screening Compounds Inhibiting Signal Transduction Through Inflammatory Cytokines 失效筛选化合物抑制信号转导通过炎症细胞因子的方法公开(公告)号：US20080160541A1
公开(公告)日：2008-07-03
申请号：US12026932
申请日：2008-02-06
IPC分类号： G01N33/53
CPC分类号： C12N9/1205 , A61K38/00 , C07K14/47 , C12Q1/48 , G01N33/573 , G01N2500/02
摘要： Revealed are that the actions of inflammatory cytokine and the production of inflammatory cytokines such as IL-1 and TNF induced by an inflammatory stimulus as well as the production of other inflammatory cytokines such as IL-6 induced by the former class of inflammatory cytokines are all suppressed by inhibiting the signal transduction through TAK1.
摘要翻译： 显示炎症细胞因子的作用以及由炎症刺激诱导的炎性细胞因子如IL-1和TNF的产生，以及由前一类炎性细胞因子诱导的其它炎性细胞因子如IL-6的产生都是 通过抑制通过TAK1的信号转导来抑制。
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公开(公告)号：US06908750B2
公开(公告)日：2005-06-21
申请号：US10423007
申请日：2003-04-25
IPC分类号： A61K38/00 , C07K14/47 , C07K14/705 , C07K16/30 , C12N15/12 , C12N15/00 , C07H21/04 , C12N15/63 , C12N15/85
CPC分类号： C07K14/4748 , A01K2217/05 , A61K38/00 , C07K14/705 , C07K16/3061
摘要： There are provided a genomic DNA comprising 4 exons encoding the amino acid sequence as set forth in SEQ ID NO: 2 and 3 introns ligating them, and a splicing variant of said genomic DNA; as well as a DNA having the base sequence as set forth in SEQ ID NO: 4 and a promoter activity and the fragment thereof, and uses thereof.
摘要翻译： 提供了包含编码SEQ ID NO：2所示的氨基酸序列的4个外显子和3个与其连接的内含子的基因组DNA和所述基因组DNA的剪接变体; 以及具有SEQ ID NO：4所示的碱基序列和启动子活性及其片段的DNA及其用途。
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