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19 条记录 (耗时 0.022 秒)

    Isoquinoline derivatives or salts thereof
    1.
    发明授权
    Isoquinoline derivatives or salts thereof 失效
    异喹啉衍生物或其盐

    公开(公告)号：US06573279B1

    公开(公告)日：2003-06-03

    申请号：US09980402

    申请日：2001-12-03

    申请人： Toshihiro Watanabe ,  Akio Kakefuda ,  Toshio Okazaki ,  Noriyuki Masuda ,  Koichi Wada

    发明人： Toshihiro Watanabe ,  Akio Kakefuda ,  Toshio Okazaki ,  Noriyuki Masuda ,  Koichi Wada

    IPC分类号： A61K3147

    CPC分类号： C07D401/06 ,  C07D405/14

    摘要： The compound of the present invention relates to a drug, particularly to a novel isoquinoline derivative or its salt having an If current inhibitory effect without serious side effects such as convulsion and also to a drug, particularly a cardiac rate lowering agent, containing the compound as the active ingredient. Namely, the compound has a current If inhibitory effect and is particularly useful as a cardiac rate lowering agent for preventing ischemic heart diseases such as angina and cardiac infarction and circulatory diseases such as congestive cardiac insufficiency and arrhythmia (supraventricular arrhythmia). The present invention relates to dialkoxy-1,2,3,4-tetrahydroquinoline-2-carbonylpiperidino-3,4-dialkoxypropaneanilide derivatives, etc.

    摘要翻译： 本发明的化合物涉及一种药物，特别是涉及一种新颖的异喹啉衍生物或其盐，其具有无剧烈反应的If电流抑制作用，还涉及含有化合物的药物，特别是心率降低剂 活性成分。 也就是说，该化合物具有电流If抑制作用，并且特别可用作用于预防心绞痛和心肌梗死以及诸如充血性心功能不全和心律失常（室上性心律不齐）的循环系统疾病的心脏病降低剂。 本发明涉及二烷氧基-1,2,3,4-四氢喹啉-2-羰基哌啶子基-3,4-二烷氧基丙酰苯胺衍生物等

    Pyrazolotriazole derivatives
    3.
    发明授权
    Pyrazolotriazole derivatives 失效
    吡唑并三唑衍生物

    公开(公告)号：US5475114A

    公开(公告)日：1995-12-12

    申请号：US199281

    申请日：1994-03-01

    申请人： Toshio Okazaki ,  Akira Suga ,  Toshihiro Watanabe ,  Kazumi Kikuchi ,  Osamu Inagaki ,  Isao Yanagisawa

    发明人： Toshio Okazaki ,  Akira Suga ,  Toshihiro Watanabe ,  Kazumi Kikuchi ,  Osamu Inagaki ,  Isao Yanagisawa

    IPC分类号： C07D487/04 ,  C07D471/08 ,  A61K31/41

    CPC分类号： C07D487/04

    摘要： This invention relates to a pyrazolotriazole derivative represented by the general formula: ##STR1## wherein each symbol means as follows; R.sup.1, R.sup.3 and R.sup.4 : one of them represents hydrogen, tetrazolylated biphenylmethyl or lower alkyl,R.sup.2 : hydrogen, tetrazolylated biphenylmethyl, cycloalkyl or lower alkyl, andR.sup.5 and R.sup.6 : these may be the same or different from each other, and each represents hydrogen, halogen, tetrazolylated biphenylmethyl, formyl, carboxyl, esterified carboxyl, cycloalkyl, lower alkoxy, lower alkoxycarbonyl, or lower alkyl which may be substituted with hydroxyl, formyl or carboxyl,provided that at least one of R.sup.1 to R.sup.6 is tetrazolylated biphenylmethyl, and the broken lines mean that the pyrazolotriazole ring forms three double bonds, or a pharmaceutically acceptable salt thereof, and to a process for the production thereof, wherein the above compound (I) is useful for treating various diseases caused by the physiological function of angiotensin II.

    摘要翻译： PCT No.PCT / JP92 / 01090 Sec。 371日期1994年3月1日 102（e）1994年3月1日PCT提交1992年8月27日PCT公布。 出版物WO93 / 05044 日本1993年3月18日。本发明涉及由以下通式表示的吡唑并三唑衍生物：其中每个符号表示如下： R1，R3和R4：其中一个表示氢，四唑基化联苯甲基或低级烷基，R2：氢，四唑基化联苯甲基，环烷基或低级烷基，R5和R6：它们可以相同或不同，并且各自表示氢 卤素，四唑基化联苯甲基，甲酰基，羧基，酯化羧基，环烷基，低级烷氧基，低级烷氧基羰基或可被羟基，甲酰基或羧基取代的低级烷基，条件是R 1至R 6中的至少一个为四唑基化联苯基甲基， 虚线意味着吡唑并三唑环形成三个双键，或其药学上可接受的盐及其制备方法，其中上述化合物（I）可用于治疗由血管紧张素II的生理功能引起的各种疾病。

    Tying band cluster
    5.
    发明授权
    Tying band cluster 失效
    类型带集群

    公开(公告)号：US5119528A

    公开(公告)日：1992-06-09

    申请号：US653330

    申请日：1991-02-11

    申请人： Mamoru Ono ,  Toshio Okazaki ,  Tomohiro Ikeda

    发明人： Mamoru Ono ,  Toshio Okazaki ,  Tomohiro Ikeda

    IPC分类号： B60R16/02 ,  B29C45/00 ,  B65D63/10 ,  B65D63/12 ,  B65D69/00 ,  F16B2/08 ,  F16L3/233 ,  H02G3/30

    CPC分类号： B65D63/1063 ,  B29C45/0003 ,  B65D69/00 ,  F16L3/233 ,  H02G3/26 ,  B29L2031/7276 ,  B65D2563/108 ,  Y10T24/1498

    摘要： A tying band cluster consists of a plurality of tying bands connected in series, end to end, in longitudinal direction. Each of the tying bands has a head portion, a projecting piece formed at one end of the head portion, and a major portion of a band body formed at the other end of the head portion. When a tying band is formed, the projecting piece of the current tying band is fused with the free end of the major portion of the previous tying band. Because the major portion of the previous tying band is left in the molding dies when the next tying band is formed, the major portion of the previous tying band is kept heated and can therefore be fused completely with the projecting piece of the tying band currently being formed. This ensures a solid connection between the tying bands.

    摘要翻译： 绑带组由多个捆扎带组成，其沿着纵向方向串联连接。 每个捆扎带具有头部，形成在头部的一端的突出片，以及形成在头部的另一端的带体的主要部分。 当形成捆扎带时，当前捆绑带的突出片与先前绑扎带的主要部分的自由端熔合。 因为当形成下一个捆扎带时，先前捆扎带的主要部分留在成型模具中，所以先前捆扎带的主要部分被保持加热，并且因此可以与目前为止的捆扎带的突出部分完全融合 形成。 这确保了捆绑带之间的牢固连接。

    Grommet
    7.
    发明授权
    Grommet 失效
    索环

    公开(公告)号：US4912287A

    公开(公告)日：1990-03-27

    申请号：US400683

    申请日：1989-08-30

    申请人： Mamoru Ono ,  Ichiro Kudo ,  Toshio Okazaki ,  Ichiro Yasue

    发明人： Mamoru Ono ,  Ichiro Kudo ,  Toshio Okazaki ,  Ichiro Yasue

    IPC分类号： H01B17/58 ,  H02G3/08 ,  H02G3/22

    CPC分类号： H02G3/083

    摘要： Disclosed herein is a grommet for supporting a bundle of electric wires which passes a fixing hole formed in a partition panel. The grommet comprises an elastic member and a rigid member to be assembled with the elastic member. The elastic member has a wire securing portion in which the bundle of the electrical wires is secured, a sealing lip to be in contact with the partition panel and a fitting portion having an outer periphery on which a concave portion is formed. The rigid member has a lock portion to be locked with the partition panel and a fitted portion to be fitted onto the fitting portion of the elastic member. The fitted portion has an inner periphery on which a convex portion to be engaged with the concave portion of the fitting portion of the elastic member when the elastic member is assembled with the rigid member is formed. The grommet can realize easy and stable composition of the elastic portion and the rigid portion with high sealability.

    摘要翻译： 这里公开了一种用于支撑通过形成在分隔板中的固定孔的电线束的索环。 索环包括弹性构件和与弹性构件组装的刚性构件。 弹性构件具有电线固定部，电线束被固定在该电线固定部分中，与分隔板接触的密封唇部和具有形成有凹部的外周的嵌合部。 刚性构件具有与分隔板锁定的锁定部分和装配在弹性构件的装配部分上的装配部分。 嵌合部具有内周，弹性部件与刚性部件组装时，形成有与弹性部件的嵌合部的凹部卡合的凸部。 索环可以实现弹性部分和刚性部分的容易且稳定的组合，具有高密封性。

    Branch wire protector
    8.
    发明授权
    Branch wire protector 失效
    支线保护器

    公开(公告)号：US4797512A

    公开(公告)日：1989-01-10

    申请号：US137662

    申请日：1987-12-24

    申请人： Fumio Kumagai ,  Toshio Okazaki

    发明人： Fumio Kumagai ,  Toshio Okazaki

    IPC分类号： H02G3/04 ,  H01B7/00 ,  H02G15/18 ,  H02G3/02

    CPC分类号： H02G15/18 ,  B60R16/0215 ,  Y10S285/903

    摘要： To increase strength of a branch wire protector including a T-shaped semicylindrical member with a trunk portion and a branch portion; a trunk semicylindrical member with a semicylindrical base portion; a branch semicylindrical member; and locking member for locking the trunk and branch semicylindrical members to the T-shaped semicylindrical member, a clinch projection member is formed at an inner end surface of the branch semicylindrical member and a mated clinch hole is formed in the semicylindrical base portion of the trunk semicylindrical member.

    摘要翻译： 提高包括具有主体部分和分支部分的T形半圆柱形部件的分支线保护器的强度; 具有半圆柱形基部的躯干半圆柱形构件; 分支半圆柱体; 以及用于将躯干和分支半圆柱形构件锁定到T形半圆柱构件的锁定构件，在分支半圆柱构件的内端面处形成有夹紧突起构件，并且在躯干的半圆柱形基部中形成配合的钳口 半圆柱体。

    Wire harness and method of manufacturing the same
    9.
    发明授权
    Wire harness and method of manufacturing the same 有权
    线束及其制造方法

    公开(公告)号：US09403495B2

    公开(公告)日：2016-08-02

    申请号：US13822824

    申请日：2011-07-26

    申请人： Hiroki Gotou ,  Toshio Okazaki

    发明人： Hiroki Gotou ,  Toshio Okazaki

    IPC分类号： B60R16/02 ,  H02G3/04 ,  H01B13/012

    CPC分类号： B60R16/0215 ,  H01B13/01263 ,  H02G3/0468 ,  Y10T29/49117

    摘要： There are provided a wire harness and a manufacturing method thereof which can reduce number of components and which does not require an electric wire to be formed longer than necessary. A wire harness includes an electric wire and a tubular corrugated tube made of synthetic resin and arranged to receive the electric wire to protect the electric wire. The corrugated tube is bent at an appropriate section when wired on an automobile. The corrugated tube includes recessed grooves and protrusions arranged alternately along a longitudinal direction. The adjacent protrusions of the appropriate section on the inward side are attached to each other by welding. The appropriate section is bent in a non-restorable fashion in a direction in which the appropriate section is bent when wired in the automobile.

    摘要翻译： 提供一种线束及其制造方法，其可以减少部件的数量，并且不需要形成比需要更长的电线。 线束包括电线和由合成树脂制成的管状波纹管，并布置成接收电线以保护电线。 当布线在汽车上时，波纹管在适当的部分弯曲。 波纹管包括沿着纵向交替布置的凹槽和突起。 内侧的适当部分的相邻突起通过焊接彼此附接。 适当的部分以不可恢复的方式弯曲成在汽车中布线时适当部分弯曲的方向。