公开(公告)号：US06768291B2

公开(公告)日：2004-07-27

申请号：US10107443

申请日：2002-03-28

申请人： Toshiki Isogai ,  Yasushi Kohno ,  Toshimasa Yamamoto ,  Hiroyuki Wado

发明人： Toshiki Isogai ,  Yasushi Kohno ,  Toshimasa Yamamoto ,  Hiroyuki Wado

IPC分类号： G01N2700

CPC分类号： G01F1/6845

摘要： In a sensor chip for a fluid flow sensor, a thin film portion is formed above a hollow cavity portion while leaving thin film layers formed on the surface of a substrate. A conductor is provided on the inner wall face of a through hole formed to penetrate the substrate to thereby electrically connect a detecting portion constituted by a conductor film in the thin film layers and a substrate conductor portion formed on the rear face side of the through hole. The surface of a circuit board is formed with a control circuit and a base conductor portion electrically connected to the control circuit. The sensor chip and the circuit board are layered and the substrate conductor portion and the base conductor portion are electrically connected.

摘要翻译： 在用于流体流量传感器的传感器芯片中，在中空空腔部分的上方形成薄膜部分，同时留下形成在基板表面上的薄膜层。 在形成为穿透基板的通孔的内壁面上设置有导体，由此将由薄膜层中的导体膜构成的检测部和形成在通孔的背面侧的基板导体部电连接 。 电路板的表面形成有电连接到控制电路的控制电路和基底导体部分。 传感器芯片和电路板被层叠，并且基板导体部分和基底导体部分电连接。

公开(公告)号：US06694811B2

公开(公告)日：2004-02-24

申请号：US10379938

申请日：2003-03-06

申请人： Yasushi Kohno ,  Toshimasa Yamamoto ,  Hiroyuki Wado ,  Tetsuo Yoshioka

发明人： Yasushi Kohno ,  Toshimasa Yamamoto ,  Hiroyuki Wado ,  Tetsuo Yoshioka

IPC分类号： G01F168

CPC分类号： G01F1/6842

摘要： A flow meter is formed with a passage for introducing and carrying air to measure and has a sensing part disposed in the passage for measuring a flow rate of the air. A contraction part is formed on an inner surface of the passage so that the contraction part faces the sensing part. The contraction part narrows the flow of the air flowing near the sensing part. A flat surface of the contraction part is formed in parallel with the surface of the sensing part and at least upstream of the sensing part. Thus, collision of particles against the sensing part and adhesion of contaminants to the sensing pert are inhibited. Meanwhile, the flow rate of the air is measured stably and accurately.

摘要翻译： 流量计形成有用于引入和携带空气进行测量的通道，并且具有设置在通道中的用于测量空气流量的感测部分。 收缩部分形成在通道的内表面上，使得收缩部分面向感测部分。 收缩部分使感应部分附近的空气流动变窄。 收缩部分的平坦表面形成为与感测部分的表面平行并且至少在感测部分的上游。 因此，抑制了颗粒与传感部分的碰撞以及污染物与传感污染物的粘附。 同时，稳定且准确地测量空气的流量。

公开(公告)号：US06602428B2

公开(公告)日：2003-08-05

申请号：US09991986

申请日：2001-11-26

申请人： Hiroyuki Wado ,  Makiko Sugiura ,  Toshimasa Yamamoto ,  Yukihiro Takeuchi ,  Yasushi Kohno

发明人： Hiroyuki Wado ,  Makiko Sugiura ,  Toshimasa Yamamoto ,  Yukihiro Takeuchi ,  Yasushi Kohno

IPC分类号： H01L2100

CPC分类号： G01F1/6845 ,  B81B2201/0264 ,  B81B2203/0127 ,  B81C1/00182 ,  B81C2201/014 ,  B81C2201/0169 ,  G01L9/0042

摘要： A sensor for measuring a physical amount such as an amount of air includes a membrane structure composed of metal stripes sandwiched between first and second insulating layers. A metal layer made of platinum or the like is formed on the first insulating layer and then heat-treated to improve its properties. Then, the metal layer is etched into a form of the metal stripes. The second insulating layer made of a material such as silicon dioxide is formed on the etched metal stripes. Since the metal layer is heat-treated before it is etched into the form of metal stripes, the metal stripes are not deformed by the heat-treatment. The second insulating layer can be formed on the metal stripes without generating cracks in the second insulating layer.

公开(公告)号：US06938473B2

公开(公告)日：2005-09-06

申请号：US10298230

申请日：2002-11-18

申请人： Takao Iwaki ,  Toshiyuki Morishita ,  Yasushi Kohno ,  Hiroyuki Wado ,  Yasushi Goka ,  Makoto Tsunekawa ,  Toshirou Gotou ,  Kiyoyuki Sugiura

发明人： Takao Iwaki ,  Toshiyuki Morishita ,  Yasushi Kohno ,  Hiroyuki Wado ,  Yasushi Goka ,  Makoto Tsunekawa ,  Toshirou Gotou ,  Kiyoyuki Sugiura

IPC分类号： G01F1/684 ,  G01F1/68

CPC分类号： G01F1/6842

摘要： An airflow meter has a membrane type sensor element. The sensor element is supported on a support member so that a sensing surface of the sensor element is in parallel to the airflow direction. The airflow meter has at least one means for protecting the sensor element from dust such as foreign particles. The protecting means is provided with an obstruction member that is disposed upstream or downstream of the sensor element with respect to the airflow direction. The sensor element is hidden behind the obstruction member. The obstruction member has gradually spreading surfaces and gradually converging surfaces along the airflow direction. Alternatively, the protecting means can be provided with a deflector, a cover member, a flow guide member, an inlet or a dust collector.

摘要翻译： 气流计具有膜式传感器元件。 传感器元件支撑在支撑构件上，使得传感器元件的感测表面平行于气流方向。 气流计具有至少一种用于保护传感器元件免受诸如外来颗粒的灰尘的装置。 保护装置设置有相对于气流方向设置在传感器元件的上游或下游的阻塞构件。 传感器元件隐藏在阻塞构件后面。 阻塞构件具有逐渐扩散的表面并沿着气流方向逐渐收敛表面。 或者，保护装置可以设置有偏转器，盖构件，导流构件，入口或集尘器。

公开(公告)号：US08695409B2

公开(公告)日：2014-04-15

申请号：US13596385

申请日：2012-08-28

申请人： Yasushi Kohno ,  Takao Ban ,  Hidehito Tsujii

发明人： Yasushi Kohno ,  Takao Ban ,  Hidehito Tsujii

IPC分类号： G01M15/04

CPC分类号： G01F1/6842 ,  G01F1/698 ,  G01F1/6983 ,  G01F5/00

摘要： An air flow rate measuring apparatus includes a heater and a control circuit. The heater heats a part of an intake air sucked into an engine. The control circuit controls an energization of the heater. The heater has a measuring-mode temperature when a flow rate of the intake air is measured. The control circuit has a heat cleaner which temporarily raises a temperature of the heater higher than the measuring-mode temperature when an energization of the air flow rate measuring apparatus is started.

摘要翻译： 空气流量测量装置包括加热器和控制电路。 加热器加热吸入发动机的进气的一部分。 控制电路控制加热器的通电。 当测量进气的流量时，加热器具有测量模式温度。 控制电路具有在开始空气流量测量装置通电时临时使加热器的温度高于测量模式温度的热清洁器。

公开(公告)号：US20130317065A1

公开(公告)日：2013-11-28

申请号：US13980604

申请日：2012-01-24

申请人： Kazuya Tatani ,  Atsushi Kondo ,  Tatsuhiro Kondo ,  Naohiro Kawamura ,  Shigeki Seto ,  Yasushi Kohno

发明人： Kazuya Tatani ,  Atsushi Kondo ,  Tatsuhiro Kondo ,  Naohiro Kawamura ,  Shigeki Seto ,  Yasushi Kohno

IPC分类号： A61K31/4439 ,  C07D401/14 ,  C07D413/14 ,  C07D405/06 ,  C07D417/06 ,  A61K31/506 ,  A61K31/444 ,  A61K31/427 ,  A61K31/41 ,  A61K31/4245 ,  C07D401/06 ,  C07D405/14 ,  C07D409/14 ,  A61K31/404

CPC分类号： A61K31/4245 ,  A61K31/404 ,  A61K31/41 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  A61K45/06 ,  C07D209/18 ,  C07D401/06 ,  C07D401/14 ,  C07D403/10 ,  C07D405/06 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/06 ,  C07D419/14 ,  A61K2300/00

摘要： The present invention provides a compound represented by the general formula (I) of the present invention, which has EP1 receptor antagonism: wherein A represents a benzene ring, a pyridine ring, or the like; Y1 represents a C1-6 alkylene group or the like; Y2 represents a single bond or the like; Z represents —C(═O)—NHSO2R6, an acidic 5-membered hetero ring group, or the like; R1 represents a hydrogen atom or the like; R2 represents a phenyl group, a 5-membered aromatic heterocyclic group, or the like; R3 represents a halogen atom, a C1-6 alkoxy group, or the like; R4 represents a hydrogen atom, a halogen atom, or the like; R5 represents a hydrogen atom or the like; and R6 represents a C1-6 alkyl group or the like], or a pharmaceutically acceptable salt thereof. Furthermore, the compound (I) of the present invention can be used as an agent for treating or preventing LUTS, in particular, various symptoms of OABs.

摘要翻译： 本发明提供了具有EP1受体拮抗作用的本发明通式（I）表示的化合物：其中A表示苯环，吡啶环等; Y1表示C1-6亚烷基等; Y2表示单键等; Z表示-C（= O）-NHSO 2 R 6，酸性5元杂环基等; R1表示氢原子等; R 2表示苯基，5元芳族杂环基等; R3表示卤素原子，C1-6烷氧基等; R 4表示氢原子，卤素原子等; R5表示氢原子等; R6表示C1-6烷基等〕或其药学上可接受的盐。 此外，本发明的化合物（I）可以用作治疗或预防LUTS，特别是OAB的各种症状的药剂。

公开(公告)号：US20100160335A1

公开(公告)日：2010-06-24

申请号：US12452172

申请日：2008-06-18

申请人： Yasushi Kohno ,  Koji Ochiai ,  Satoshi Takita ,  Akihiko Kojima ,  Tomohiko Eiraku ,  Tetsuya Kishi

发明人： Yasushi Kohno ,  Koji Ochiai ,  Satoshi Takita ,  Akihiko Kojima ,  Tomohiko Eiraku ,  Tetsuya Kishi

IPC分类号： A61K31/50 ,  A61K31/501 ,  C07D403/00

CPC分类号： C07D413/14 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04

摘要： It is to provide a novel pyridazinone derivative represented by the following general formula (1), which is useful as a pharmaceutical and has a phosphodiesterase inhibitory action: wherein R1 represents H or C1-6 alkyl, each of R2 and R3 represents H, X, C1-6 alkoxy, Z represents O or S, and A represents AA or BB, wherein AA represents: and BB represents: wherein R4 represents H or C1-6 alkyl, and each of R5 and R6 represents C1-6 alkyl.

摘要翻译： 提供由以下通式（1）表示的新的哒嗪酮衍生物，其可用作药物并具有磷酸二酯酶抑制作用：其中R1表示H或C1-6烷基，R2和R3各自表示H，X C 1-6烷氧基，Z表示O或S，A表示AA或BB，其中AA表示：BB表示：其中R4表示H或C1-6烷基，R5和R6各自表示C1-6烷基。

公开(公告)号：US07703320B2

公开(公告)日：2010-04-27

申请号：US12120517

申请日：2008-05-14

申请人： Junzo Yamaguchi ,  Yasushi Kohno

发明人： Junzo Yamaguchi ,  Yasushi Kohno

IPC分类号： G01F1/68

CPC分类号： G01F1/692

摘要： According to a flow measuring device, first ranges formed by a first plurality of resistors form a single continuous value range on a flow direction coordinate axis. Thus, the first plurality of resistors is limited from being thermally insulated from one another in the flow direction, and thereby detectivity is improved. Also, second ranges formed by a second plurality of resistors form an other single continuous value range on a longitudinal direction coordinate axis. The other continuous value range includes a position that corresponds to a half length of a heating element in a longitudinal direction. As a result, detection difference is obtained at the position, at which a temperature is most optimally detected, and thereby detectivity is further improved.

摘要翻译： 根据流量测量装置，由第一多个电阻器形成的第一范围在流动方向坐标轴上形成单个连续值范围。 因此，第一多个电阻器被限制为在流动方向上彼此热绝缘，从而提高了检测性。 此外，由第二多个电阻器形成的第二范围在纵向坐标轴上形成另一个单个连续值范围。 另一连续值范围包括对应于加热元件在纵向上的半长度的位置。 结果，在最佳检测温度的位置处获得检测差异，从而进一步提高检测性。

公开(公告)号：US20080275008A1

公开(公告)日：2008-11-06

申请号：US12213187

申请日：2008-06-16

申请人： Yasushi Kohno ,  Kiyoaki Tanaka ,  Kazuhiko Kuriyama ,  Wataru Hori

发明人： Yasushi Kohno ,  Kiyoaki Tanaka ,  Kazuhiko Kuriyama ,  Wataru Hori

IPC分类号： A61K31/662

CPC分类号： C07C47/575 ,  C07C45/71 ,  C07F7/1804 ,  C07F9/3826 ,  C07F9/3882 ,  C07F9/4015 ,  C07F9/4056 ,  C07F9/653

摘要： Aminophosphonic acid derivatives (e.g., 2-amino-5-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]-2-methylpentylphosphonate monoester) are represented by the following general formula (1): and act as effective S1P receptor modulators while posing less side effects.

摘要翻译： 氨基膦酸衍生物（例如2-氨基-5- [4-（3-苄氧基苯硫基）-2-氯苯基] -2-甲基戊基膦酸酯单酯）由以下通式（1）表示：作为有效的S1P受体调节剂， 减少副作用。

公开(公告)号：US5902398A

公开(公告)日：1999-05-11

申请号：US724689

申请日：1996-10-01

申请人： Yasushi Kohno ,  Takeo Hayashi

发明人： Yasushi Kohno ,  Takeo Hayashi

IPC分类号： A01C1/00 ,  A01C1/06 ,  A01H4/00 ,  B05C1/02 ,  B05C11/00 ,  C12M3/00 ,  C12N11/04

CPC分类号： A01H4/006 ,  A01C1/06

摘要： An artificial seed manufacturing apparatus in which enclosures can be inserted into capsules without fail, and the diameter of the capsule can automatically be controlled. This apparatus comprises: an enclosure supply mechanism with a container, a tip, and a driving source; a coating material delivery mechanism with a passage, a pressure plunger, a hollow nozzle plunger, and a stepping motor; and a control unit for controlling the enclosure supply mechanism and the coating material delivery mechanism, comprising: moving distance storing means for erasably storing setting data which are inputted through setting operation to designate moving distance of the pressure plunger; and stepping motor control means for supplying driving pulse, the stepping motor control means allowing the pressure plunger to reciprocate by the moving distance, to the stepping motor based on the data stored in the moving distance storing means.

摘要翻译： 一种人造种子制造装置，其中外壳可以不经故障地插入胶囊中，并且可以自动控制胶囊的直径。 该装置包括：具有容器，尖端和驱动源的机壳供给机构; 具有通道的涂料输送机构，压力柱塞，中空喷嘴柱塞和步进电机; 以及控制单元，用于控制所述外壳供应机构和所述涂料输送机构，包括：移动距离存储装置，用于可移除存储装置，用于通过设定操作输入的设定数据，以指定所述压力柱塞的移动距离; 以及用于提供驱动脉冲的步进电机控制装置，使得压力柱塞能够通过移动距离往复运动的步进电机控制装置基于存储在移动距离存储装置中的数据到步进电机。