公开(公告)号：US08388950B2

公开(公告)日：2013-03-05

申请号：US11917454

申请日：2006-06-14

申请人： Toshinori Ikehara ,  Hideyuki Kishida

发明人： Toshinori Ikehara ,  Hideyuki Kishida

IPC分类号： A61K38/43

CPC分类号： A23K20/174 ,  A23L29/10 ,  A23L33/10 ,  A61K8/355 ,  A61K8/39 ,  A61K9/107 ,  A61K31/122 ,  A61K47/14 ,  A61K47/26 ,  A61Q19/00

摘要： A coenzyme Q10-containing water soluble composition comprises coenzyme Q10, a hydrophilic polyglycerol fatty acid ester, a lipophilic sucrose fatty acid ester and an aqueous phase component and a process for producing the same are disclosed. A coenzyme Q10-containing water-soluble dry powder can be obtained by drying the above-mentioned coenzyme Q10-containing water soluble composition. A food, functional food, beverage, pharmaceutical product, quasi drug, cosmetic, or animal food can be obtained by using the above-mentioned coenzyme Q10-containing water soluble composition or the above-mentioned coenzyme Q10-containing water-soluble dry powder. The coenzyme Q10-containing water soluble composition has a high bioavailability, and maintains a stable emulsion form for a long period of time from refrigeration temperature to room temperature and allows efficient supply.

摘要翻译： 含有辅酶Q10的水溶性组合物包括辅酶Q10，亲水性聚甘油脂肪酸酯，亲脂性蔗糖脂肪酸酯和水相成分及其制造方法。 可以通过干燥上述含有辅酶Q10的水溶性组合物来获得含辅酶Q10的水溶性干粉。 可以通过使用上述含有辅酶Q10的水溶性组合物或上述含有辅酶Q10的水溶性干粉来获得食品，功能性食品，饮料，药物，准药物，化妆品或动物性食品。 含有辅酶Q10的水溶性组合物具有高的生物利用度，并且从制冷温度到室温长时间保持稳定的乳液形式并且可以有效地供应。

公开(公告)号：US20070098761A1

公开(公告)日：2007-05-03

申请号：US10560900

申请日：2004-07-14

申请人： Naoki Arai ,  Hideyuki Kishida ,  Toshinori Ikehara ,  Tatsumasa Mae

发明人： Naoki Arai ,  Hideyuki Kishida ,  Toshinori Ikehara ,  Tatsumasa Mae

IPC分类号： A61K9/48 ,  A61K47/00

CPC分类号： A61K36/484 ,  A23L33/105 ,  A23L33/115 ,  A23V2002/00 ,  A61K9/4858 ,  A61K31/352 ,  A61K31/353 ,  A23V2200/332

摘要： The object of the invention is to provide a composition for prevention and/or amelioration of life-style related disease, and/or a composition for inhibition and/or amelioration of increase in body weight, comprising at least one compound selected from the group consisting of glabrene, glabridin, glabrol, 3′-hydroxy-4′-O-methylglabridin, 4′-O-methylglabridin and hyspaglabridin B as compounds having a PPAR ligand activity effective in amelioration of insulin resistance and in prevention and/or amelioration of life-style related diseases such as visceral fat obesity, type 2 diabetes, hyperlipemia and hypertension, which can be utilized in food and drink such as health food and health functional food (food for specified uses and food with nutrient function), pharmaceutical preparations, non-pharmaceutical preparations, cosmetics etc. At least one compound selected from the group consisting of glabrene, glabridin, glabrol, 3′-hydroxy-4′-O-methylglabridin, 4′-O-methylglabridin and hyspaglabridin B is dissolved in medium-chain fatty acid triglycerides and/or partial glycerides, whereby the stability of the compound(s) is improved and the processability thereof into food and drink, pharmaceutical preparations, non-pharmaceutical preparations, cosmetics etc. is also improved.

摘要翻译： 本发明的目的是提供一种用于预防和/或改善生命方式相关疾病的组合物和/或用于抑制和/或改善体重增加的组合物，其包含至少一种选自以下的化合物： glabrene，glabridin，glabrol，3'-羟基-4'-O-甲基吡咯啶，4'-O-甲基吡咯啶和嗜麦芽窄食idin宾B作为具有有效改善胰岛素抵抗和预防和/或改善生命的PPAR配体活性的化合物 类风湿性关节疾病，如内脏脂肪肥胖，2型糖尿病，高脂血症和高血压，可用于食品和饮料，如保健食品和保健功能食品（特定用途的食品和营养功能食品），药物制剂， 药物制剂，化妆品等。至少一种选自由Glabrene，glabridin，glabrol，3'-羟基-4'-O-甲基吡咯啶，4'-O-甲基吡咯烷和hyspaglab ridin B溶解在中链脂肪酸甘油三酯和/或部分甘油酯中，从而提高了化合物的稳定性，并且其加工成食品和饮料，药物制剂，非药物制剂，化妆品等也是 改进。

公开(公告)号：US20100284983A1

公开(公告)日：2010-11-11

申请号：US11917454

申请日：2006-06-14

申请人： Toshinori Ikehara ,  Hideyuki Kishida

发明人： Toshinori Ikehara ,  Hideyuki Kishida

IPC分类号： A61K31/122 ,  A61K38/43 ,  A61K9/14 ,  A61K8/92 ,  A61Q1/02 ,  A61Q11/00 ,  A61Q19/00 ,  A61P43/00 ,  A23L1/30 ,  A23K1/00 ,  A23L2/52

CPC分类号： A23K20/174 ,  A23L29/10 ,  A23L33/10 ,  A61K8/355 ,  A61K8/39 ,  A61K9/107 ,  A61K31/122 ,  A61K47/14 ,  A61K47/26 ,  A61Q19/00

摘要： A coenzyme Q10-containing water soluble composition comprises coenzyme Q10, a hydrophilic polyglycerol fatty acid ester, a lipophilic sucrose fatty acid ester and an aqueous phase component and a process for producing the same are disclosed. A coenzyme Q10-containing water-soluble dry powder can be obtained by drying the above-mentioned coenzyme Q10-containing water soluble composition. A food, functional food, beverage, pharmaceutical product, quasi drug, cosmetic, or animal food can be obtained by using the above-mentioned coenzyme Q10-containing water soluble composition or the above-mentioned coenzyme Q10-containing water-soluble dry powder. The coenzyme Q10-containing water soluble composition has a high bioavailability, and maintains a stable emulsion form for a long period of time from refrigeration temperature to room temperature and allows efficient supply.

摘要翻译： 含有辅酶Q10的水溶性组合物包括辅酶Q10，亲水性聚甘油脂肪酸酯，亲脂性蔗糖脂肪酸酯和水相成分及其制造方法。 可以通过干燥上述含有辅酶Q10的水溶性组合物来获得含辅酶Q10的水溶性干粉。 可以通过使用上述含有辅酶Q10的水溶性组合物或上述含有辅酶Q10的水溶性干粉来获得食品，功能性食品，饮料，药物，准药物，化妆品或动物性食品。 含有辅酶Q10的水溶性组合物具有高的生物利用度，并且从制冷温度到室温长时间保持稳定的乳液形式并且可以有效地供应。

公开(公告)号：US20130309338A1

公开(公告)日：2013-11-21

申请号：US13982841

申请日：2012-01-31

申请人： Takao Yamaguchi ,  Toshinori Ikehara

发明人： Takao Yamaguchi ,  Toshinori Ikehara

IPC分类号： A61K47/14 ,  A61K36/287 ,  A61K36/484

CPC分类号： A61K36/484 ,  A61K9/0095 ,  A61K9/08 ,  A61K36/287 ,  A61K47/14 ,  A61K2236/00 ,  A61K2300/00

摘要： An object of the present invention is to provide a water-solubilizing preparation that is obtained by convenient steps without use of a special apparatus such as a high-pressure homogenizer, does not impair the original properties of a water-based material even after being added to the material, has high dispersibility and transparency and excellent heat resistance and acid resistance, and can maintain stability. The water-solubilizing preparation of the present invention is a biologically active substance-containing water-solubilizing preparation comprising 1 to 50% by weight of an oily ingredient (A) containing a biologically active substance and oil, 10 to 98% by weight of a polyglycerin fatty acid ester (B) having an HLB value of 12.5 or larger, and 1 to 40% by weight of a surfactant (C) having an HLB value of 7 to 11.8.

摘要翻译： 本发明的目的是提供一种通过方便的步骤而不使用诸如高压均化器的特殊装置获得的水溶性制剂，即使在添加后也不损害水性材料的原始性能 对材料，具有高分散性和透明性，优异的耐热性和耐酸性，并能保持稳定性。 本发明的水溶性制剂是含有1〜50重量％含有生物活性物质和油的油性成分（A）的含有生物活性物质的水溶性制剂，10〜98重量％ HLB值为12.5以上的聚甘油脂肪酸酯（B）和HLB值为7〜11.8的表面活性剂（C）为1〜40重量％。

公开(公告)号：US07897169B2

公开(公告)日：2011-03-01

申请号：US10501669

申请日：2003-01-20

申请人： Yasuyoshi Ueda ,  Shiro Kitamura ,  Tadayoshi Shiraishi ,  Masayuki Abe ,  Takeshi Kawashima ,  Toshinori Ikehara

发明人： Yasuyoshi Ueda ,  Shiro Kitamura ,  Tadayoshi Shiraishi ,  Masayuki Abe ,  Takeshi Kawashima ,  Toshinori Ikehara

IPC分类号： A61K47/00

CPC分类号： A23G9/32 ,  A21D2/14 ,  A23C11/04 ,  A23C19/082 ,  A23D7/0056 ,  A23D7/015 ,  A23D9/007 ,  A23F3/163 ,  A23F5/243 ,  A23L7/111 ,  A23L7/122 ,  A23L7/13 ,  A23L7/165 ,  A23L9/12 ,  A23L9/22 ,  A23L19/03 ,  A23L19/14 ,  A23L23/00 ,  A23L27/60 ,  A23L33/10 ,  A23P20/11 ,  A23P30/40 ,  A23V2002/00 ,  C11B5/0092 ,  A23V2250/314

摘要： To provide a food which suitably supply ubiquinol, a substance indispensable to the living body but is liable to be decreased and fall short of the requirements, through ingestion in the same ways as the ordinary foods in daily living. A ubiquinol-enriched oil/fat-containing food.

摘要翻译： 提供适当地提供泛醌的食物，其通过以与日常生活中的普通食物相同的方式摄取，这是生物体不可缺少但易于降低并且不符合要求的物质。 富含ubiquinol的含油/脂肪的食物。

公开(公告)号：US20050181109A1

公开(公告)日：2005-08-18

申请号：US10501685

申请日：2003-01-20

申请人： Tadayoshi Shiraishi ,  Masayuki Abe ,  Takeshi Kawashima ,  Toshinori Ikehara

发明人： Tadayoshi Shiraishi ,  Masayuki Abe ,  Takeshi Kawashima ,  Toshinori Ikehara

IPC分类号： A21D2/14 ,  A23D7/01 ,  A23D9/007 ,  A23G1/00 ,  A23L1/30 ,  C11B5/00 ,  A23D7/00

CPC分类号： A23G1/30 ,  A21D2/14 ,  A23D7/011 ,  A23D7/013 ,  A23D9/007 ,  A23G1/426 ,  A23L33/10 ,  A23V2002/00 ,  C11B5/0021 ,  A23V2250/314 ,  A23V2250/194

摘要： To provide a ubiquinone supplementation food which is obtained by adding a composition containing ubiquinone and an oil/fat; an edible oil/fat composition which contains ubiquinone; a process for producing a ubiquinone supplementation food which comprises dissolving ubiquinone in an oil/fat under heating, and adding the obtained mixture to a food material; a method for preventing precipitation and/or localization of ubiquinone in a food which comprises producing a food by dissolving ubiquinone in an oil/fat under heating and adding the obtained mixture to a food material; and a method for supplying ubiquinone which comprises ingesting said foods.

摘要翻译： 提供通过添加含有泛醌和油/脂肪的组合物获得的泛醌补充食物; 含有泛醌的食用油/脂肪组合物; 一种生产泛醌补充食品的方法，其包括在加热下将泛醌溶解在油/脂中，并将所得混合物加入到食物中; 一种防止泛醌在食物中的沉淀和/或定位的方法，其包括通过在加热下将泛醌溶解在油/脂中并将所得混合物加入到食物中来生产食物; 以及提供泛醌的方法，其包括摄取所述食物。

公开(公告)号：US07678404B2

公开(公告)日：2010-03-16

申请号：US10501685

申请日：2003-01-20

申请人： Tadayoshi Shiraishi ,  Masayuki Abe ,  Takeshi Kawashima ,  Toshinori Ikehara

发明人： Tadayoshi Shiraishi ,  Masayuki Abe ,  Takeshi Kawashima ,  Toshinori Ikehara

IPC分类号： A23D7/00 ,  A23D9/00 ,  A23L1/30

CPC分类号： A23G1/30 ,  A21D2/14 ,  A23D7/011 ,  A23D7/013 ,  A23D9/007 ,  A23G1/426 ,  A23L33/10 ,  A23V2002/00 ,  C11B5/0021 ,  A23V2250/314 ,  A23V2250/194

摘要： To provide a ubiquinone supplementation food which is obtained by adding a composition containing ubiquinone and an oil/fat; an edible oil/fat composition which contains ubiquinone; a process for producing a ubiquinone supplementation food which comprises dissolving ubiquinone in an oil/fat under heating, and adding the obtained mixture to a food material; a method for preventing precipitation and/or localization of ubiquinone in a food which comprises producing a food by dissolving ubiquinone in an oil/fat under heating and adding the obtained mixture to a food material; and a method for supplying ubiquinone which comprises ingesting said foods.

摘要翻译： 提供通过添加含有泛醌和油/脂肪的组合物获得的泛醌补充食物; 含有泛醌的食用油/脂肪组合物; 一种生产泛醌补充食品的方法，其包括在加热下将泛醌溶解在油/脂中，并将所得混合物加入到食物中; 一种防止泛醌在食物中的沉淀和/或定位的方法，其包括通过在加热下将泛醌溶解在油/脂中并将所得混合物加入到食物中来生产食物; 以及提供泛醌的方法，其包括摄取所述食物。

公开(公告)号：US20090142324A1

公开(公告)日：2009-06-04

申请号：US12364686

申请日：2009-02-03

申请人： Toshinori Ikehara ,  Koji Ogino

发明人： Toshinori Ikehara ,  Koji Ogino

IPC分类号： A61K9/107 ,  A61K31/122

CPC分类号： A23D7/0053 ,  A23L2/52 ,  A23L33/15 ,  A23V2002/00 ,  A23V2250/314 ,  A23V2250/192 ,  A23V2250/5424

摘要： To provide an oil-in-water emulsion composition that prevents separation of coenzyme Q10 and creaming during storage, maintains a stable emulsification state over long term exceeding two weeks, and does not impair flavor or taste. The oil phase of the oil-in-water emulsion composition contains coenzyme Q10, and a complex of an organic acid ester of a monoglyceride and a milk protein is used as the emulsifier.

摘要翻译： 为了提供防止在保存期间分离辅酶Q10和乳化剂的水包油乳液组合物，长期保持稳定的乳化状态超过两周，并且不损害风味或味道。 水包油乳液组合物的油相含有辅酶Q10，使用单酸甘油酯的有机酸酯和乳蛋白质的配合物作为乳化剂。

公开(公告)号：US20050118289A1

公开(公告)日：2005-06-02

申请号：US10508903

申请日：2003-04-04

申请人： Toshinori Ikehara ,  Mikio Kitahara

发明人： Toshinori Ikehara ,  Mikio Kitahara

IPC分类号： A23D9/00 ,  A23L1/221 ,  A23L1/30 ,  A61K36/484 ,  A61P1/06 ,  A61P11/10 ,  A61P25/04 ,  A61K35/78

CPC分类号： A61K36/484 ,  A23L27/11 ,  A23L33/105 ,  A23L33/12 ,  A61K2300/00

摘要： In the present invention, an oil and fat composition containing 10% by weight or more of a specific fat-soluble polyhydric fatty acid ester, in particular, a glycerol fatty acid ester, is used as a solvent for extracting hydrophobic components from licorice. Consequently, it is possible to reduce the production costs for hydrophobic components of licorice which have excellent effects as food and drink, such as health food and food with health claims (food for specified health uses and food with nutrient function claims), pharmaceutical products, etc. It is also possible to improve the stability and handling properties of the resulting composition.

摘要翻译： 在本发明中，使用含有10重量％以上的特定脂溶性多元脂肪酸酯，特别是甘油脂肪酸酯的油脂组合物作为从甘草中提取疏水性成分的溶剂。 因此，可以降低作为食品和饮料具有优异效果的甘草疏水组分的生产成本，例如保健食品和具有健康要求的食品（具体的健康用途的食品和具有营养功能要求的食品），药品， 还可以提高所得组合物的稳定性和操作性能。

公开(公告)号：US20080102131A1

公开(公告)日：2008-05-01

申请号：US11930714

申请日：2007-10-31

申请人： Yozo NAGIRA ,  Toshinori Ikehara ,  Takashi Ueda ,  Shinsuke Akao

发明人： Yozo NAGIRA ,  Toshinori Ikehara ,  Takashi Ueda ,  Shinsuke Akao

IPC分类号： A61K9/14 ,  A61K31/07 ,  A61K31/122 ,  A61K31/20 ,  A61K31/201 ,  A61K31/202 ,  A61K31/355 ,  A61K31/59

CPC分类号： A61K36/484 ,  A61K9/113 ,  A61K9/205 ,  A61K9/2054 ,  A61K31/07 ,  A61K31/122 ,  A61K31/20 ,  A61K31/201 ,  A61K31/202 ,  A61K31/355 ,  A61K31/59

摘要： The present invention provides a particulate composition wherein an oil component (A) comprising a water-insoluble bioactive substance is poly-dispersed while forming a domain in a matrix comprising of a water-soluble excipient based on a water-soluble polymer, and wherein the sphericity of the particulate composition is not less than 0.9 and a method of producing the same. The particulate composition simultaneously has excellent water solubility, workability, tabletability and heat-resistance. It also provides a food, food with nutrient function claims, food for specified health uses, nutritional supplement, nutritional product, animal drug, drink, feed, pet food, cosmetic, pharmaceutical product, therapeutic drug, prophylactic drug and the like, which contain the particulate composition.

摘要翻译： 本发明提供了一种颗粒组合物，其中包含水不溶性生物活性物质的油组分（A）是多分散的，同时在包含基于水溶性聚合物的水溶性赋形剂的基质中形成结构域，并且其中 颗粒组合物的球形度不小于0.9及其制备方法。 颗粒组合物同时具有优异的水溶性，可加工性，可压片性和耐热性。 它还提供食物，具有营养功能的食物，特定健康用途的食物，营养补充剂，营养产品，动物药物，饮料，饲料，宠物食品，化妆品，药​​物，治疗药物，预防药物等，其含有 颗粒组成。