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    Monomer protein with bone morphogenetic activity and medicinal agent containing the same for preventing and treating diseases of cartilage and bone
    4.
    发明授权
    Monomer protein with bone morphogenetic activity and medicinal agent containing the same for preventing and treating diseases of cartilage and bone 失效
    具有骨形态发生活性的单体蛋白和含有预防和治疗软骨和骨骼疾病的药物

    公开(公告)号：US07638129B2

    公开(公告)日：2009-12-29

    申请号：US11758878

    申请日：2007-06-06

    申请人： Shinji Kawai ,  Michio Kimura ,  Yoshifumi Muraki ,  Mieko Katsuura

    发明人： Shinji Kawai ,  Michio Kimura ,  Yoshifumi Muraki ,  Mieko Katsuura

    IPC分类号： A61K38/18 ,  C07K14/435

    CPC分类号： C07K14/51 ,  A61K38/00

    摘要： This invention provides for a protein of the TGF-β superfamily in which the cysteine involved in the normal formation of homodimers is changed to another amino acid. These mutant proteins, as monomers, display higher bone morphogenetic activity than the wild-type protein dimers. Also provided is a method for producing and isolating these monomers by plasmid driven expression in various host systems including E. coli. In addition, the invention discloses the use of an agent containing purified monomers in preventing and treating diseases and problems affecting bone and/or cartilage.

    摘要翻译： 本发明提供了TGF-β超家族的蛋白质，其中参与同型二聚体正常形成的半胱氨酸改变为另一种氨基酸。 这些突变蛋白，作为单体，显示比野生型蛋白二聚体更高的骨形态发生活性。 还提供了通过在包括大肠杆菌的各种宿主系统中的质粒驱动表达来产生和分离这些单体的方法。 此外，本发明公开了含有纯化单体的药剂在预防和治疗疾病和影响骨和/或软骨的问题中的用途。

    ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR, METHOD FOR PRODUCING THE SAME, IMAGE FORMING PROCESS, IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE
    6.
    发明申请
    ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR, METHOD FOR PRODUCING THE SAME, IMAGE FORMING PROCESS, IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE 有权
    电子照相机，其制造方法，图像形成工艺，图像形成装置和工艺盒

    公开(公告)号：US20080063962A1

    公开(公告)日：2008-03-13

    申请号：US11850394

    申请日：2007-09-05

    申请人： Tetsuya TOSHINE ,  Chiaki Tanaka ,  Michio Kimura ,  Tomoyuki Shimada ,  Nozomu Tamoto ,  Yoshiki Yanagawa ,  Hiromi Tada

    发明人： Tetsuya TOSHINE ,  Chiaki Tanaka ,  Michio Kimura ,  Tomoyuki Shimada ,  Nozomu Tamoto ,  Yoshiki Yanagawa ,  Hiromi Tada

    IPC分类号： G03G15/02 ,  G03G5/00

    CPC分类号： G03G5/051 ,  G03G5/0514 ,  G03G5/0517 ,  G03G5/0521 ,  G03G5/0525 ,  G03G5/0532 ,  G03G5/0535 ,  G03G5/0578 ,  G03G5/14786 ,  G03G5/14791 ,  G03G5/14795

    摘要： The present invention provides an electrophotographic photoconductor capable of reducing latent electrostatic image stability defects caused by adhesion/adsorption of an electric discharge product formed by a charger in an image forming process, degradation of charge transportability and cleaning defects caused when removing a residual toner. The electrophotographic photoconductor has a conductive substrate, and a photosensitive layer which contains at least a binder, a charge generating material and a charge transporting material and is formed on the substrate, wherein the photosensitive layer contains an injection material composed of at least any one of one wax selected from paraffin waxes, Fisher-Tropsh waxes, polyolefin waxes and a polyorganosiloxane compound in an area from the surface of the photosensitive layer to 50% of the thickness thereof in the thickness direction of the electrophotographic photoconductor, and the content of the injection material is 3% by mass or more to the content of the binder.

    摘要翻译： 本发明提供了一种电子照相感光体，其能够降低在图像形成过程中由充电器形成的放电产物的附着/吸附引起的静电潜像稳定性缺陷，电荷输送性降低和清除残留调色剂时引起的清洁缺陷。 电子照相感光体具有导电性基材和至少含有粘合剂，电荷产生材料和电荷输送材料并形成在基材上的感光层，其中感光层含有由以下的至少一种构成的注入材料： 在感光层的表面至电子照相感光体的厚度方向的50％的范围内，选自石蜡，Fisher-Tropsh蜡，聚烯烃蜡和聚有机硅氧烷化合物的一种蜡，以及注射用量 材料相对于粘合剂的含量为3质量％以上。

    Zinc-containing sustained-release composition, its preparation, and method for producing the same
    7.
    发明申请
    Zinc-containing sustained-release composition, its preparation, and method for producing the same 失效
    含锌缓释组合物及其制备方法及其制备方法

    公开(公告)号：US20060210629A1

    公开(公告)日：2006-09-21

    申请号：US10555191

    申请日：2004-04-01

    申请人： Michio Kimura ,  Tomoko Eto ,  Yutaka Mizushima

    发明人： Michio Kimura ,  Tomoko Eto ,  Yutaka Mizushima

    IPC分类号： A61K39/395 ,  A61K38/21 ,  A61K38/19 ,  A61K38/18 ,  A61K9/22 ,  A61K33/32

    CPC分类号： C07K16/241 ,  A61K9/0019 ,  A61K9/10 ,  A61K33/30 ,  A61K38/193 ,  A61K38/212 ,  A61K38/27 ,  A61K45/06 ,  A61K47/02 ,  A61K2300/00

    摘要： With a simple and high-yield production method, a zinc-containing sustained-release composition capable of stabilizing a physiologically active protein or peptide, typically G-CSF by precipitation and retaining drug efficacy for several days in a living body owing to its sustained releasability is provided. Concretely, a zinc-containing sustained-release composition produced by forming a precipitate by mixing a physiologically active protein or peptide, a water-soluble zinc salt, a water-soluble carbonate and/or a water soluble phosphate aqueous solution. The zinc-containing sustained-release composition may be administered as a zinc-containing sustained preparation by adding a pharmaceutically acceptable additive as is necessary.

    摘要翻译： 通过简单且高产量的生产方法，能够通过沉淀稳定生理活性蛋白质或肽，通常为G-CSF的锌含量缓释组合物，由于其具有持续的释放性，在活体中保持药物疗效几天 被提供。 具体地说，通过混合生理活性蛋白质或肽，水溶性锌盐，水溶性碳酸盐和/或水溶性磷酸盐水溶液形成沉淀物而制备的含锌缓释组合物。 含锌持续释放组合物可以通过根据需要添加药学上可接受的添加剂作为含锌缓释制剂施用。

    Process for preparing halogenated benzene derivatives
    8.
    发明授权
    Process for preparing halogenated benzene derivatives 失效
    卤代苯衍生物的制备方法

    公开(公告)号：US4962245A

    公开(公告)日：1990-10-09

    申请号：US313074

    申请日：1989-02-21

    申请人： Takashi Kanai ,  Michio Kimura ,  Yoshio Noguchi

    发明人： Takashi Kanai ,  Michio Kimura ,  Yoshio Noguchi

    IPC分类号： C07C17/38 ,  C07C17/389 ,  C07C25/02

    CPC分类号： C07C25/02 ,  C07C17/38 ,  C07C17/389

    摘要： By a process for preparing halogenated benzene derivatives comprising distilling or stripping a mixture of the isomers of a halogenated benzene derivative containing a hydrogen halide to remove the hydrogen halide from the isomeric mixture of the halogenated benzene derivative and then contacting with a zeolite adsorbent for selectivity separating the desired isomer of the halogenated benzene derivative, it is possible to prevent from degrading the zeolite adsorbent. And it is possible to separate selectively industrially an desired isomer of the halogenated benzene derivative for a long time without reduction of productivity and to separate selectively the desired isomer in high purity.

    Image forming apparatus
    9.
    发明授权
    Image forming apparatus 有权
    图像形成装置

    公开(公告)号：US08798487B2

    公开(公告)日：2014-08-05

    申请号：US13348062

    申请日：2012-01-11

    申请人： Tomoharu Asano ,  Takaaki Ikegami ,  Michio Kimura

    发明人： Tomoharu Asano ,  Takaaki Ikegami ,  Michio Kimura

    IPC分类号： G03G15/00

    CPC分类号： G03G15/5037 ,  G03G15/553 ,  G03G21/1671

    摘要： An image forming apparatus having an image bearing member, a charger to charge the surface of the image bearing member, an irradiator to irradiate the image bearing member to form the latent image, a developing device to develop the latent electrostatic image with toner to obtain a visible image, a transfer device to transfer the visible image to a transfer medium by a transfer bias applied to a transfer area between the image bearing member and the transfer member, and a voltage detector to measure a first surface voltage and a second surface voltage under different conditions, and a life expectancy identification device to identify whether or when the expected working life of the image bearing member has come to the end based on a comparison of the first surface voltage and the second surface voltage.

    摘要翻译： 一种具有图像承载部件的图像形成装置，对图像承载部件的表面充电的充电器，用于照射图像承载部件以形成潜像的照射器，用调色剂显影静电潜像的显影装置， 可见图像，通过施加到图像承载部件和转印部件之间的转印区域的转印偏压将可见图像转印到转印介质的转印装置，以及电压检测器，用于测量第一表面电压和第二表面电压 不同的条件，以及预期寿命识别装置，用于基于第一表面电压和第二表面电压的比较来确定图像承载部件的预期使用寿命是否或何时已经到了最后。