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    Monomer protein with bone morphogenetic activity and medicinal agent containing the same for preventing and treating diseases of cartilage and bone
    1.
    发明授权
    Monomer protein with bone morphogenetic activity and medicinal agent containing the same for preventing and treating diseases of cartilage and bone 失效
    具有骨形态发生活性的单体蛋白和含有预防和治疗软骨和骨骼疾病的药物

    公开(公告)号：US07638129B2

    公开(公告)日：2009-12-29

    申请号：US11758878

    申请日：2007-06-06

    申请人： Shinji Kawai ,  Michio Kimura ,  Yoshifumi Muraki ,  Mieko Katsuura

    发明人： Shinji Kawai ,  Michio Kimura ,  Yoshifumi Muraki ,  Mieko Katsuura

    IPC分类号： A61K38/18 ,  C07K14/435

    CPC分类号： C07K14/51 ,  A61K38/00

    摘要： This invention provides for a protein of the TGF-β superfamily in which the cysteine involved in the normal formation of homodimers is changed to another amino acid. These mutant proteins, as monomers, display higher bone morphogenetic activity than the wild-type protein dimers. Also provided is a method for producing and isolating these monomers by plasmid driven expression in various host systems including E. coli. In addition, the invention discloses the use of an agent containing purified monomers in preventing and treating diseases and problems affecting bone and/or cartilage.

    摘要翻译： 本发明提供了TGF-β超家族的蛋白质，其中参与同型二聚体正常形成的半胱氨酸改变为另一种氨基酸。 这些突变蛋白，作为单体，显示比野生型蛋白二聚体更高的骨形态发生活性。 还提供了通过在包括大肠杆菌的各种宿主系统中的质粒驱动表达来产生和分离这些单体的方法。 此外，本发明公开了含有纯化单体的药剂在预防和治疗疾病和影响骨和/或软骨的问题中的用途。

    Monomer protein with bone morphogenetic activity and medicinal agent containing the same for preventing and treating diseases of cartilage and bone
    2.
    发明授权
    Monomer protein with bone morphogenetic activity and medicinal agent containing the same for preventing and treating diseases of cartilage and bone 有权
    具有骨形态发生活性的单体蛋白和含有预防和治疗软骨和骨骼疾病的药物

    公开(公告)号：US07235241B2

    公开(公告)日：2007-06-26

    申请号：US10751451

    申请日：2004-01-06

    申请人： Shinji Kawai ,  Michio Kimura ,  Yoshifumi Muraki ,  Mieko Katsuura

    发明人： Shinji Kawai ,  Michio Kimura ,  Yoshifumi Muraki ,  Mieko Katsuura

    IPC分类号： A61K38/18 ,  C07K14/475 ,  C12N1/20 ,  C12P21/06 ,  C07H21/04

    CPC分类号： C07K14/51 ,  A61K38/00

    摘要： This invention provides for a protein of the TGF-β superfamily in which the cysteine involved in the normal formation of homodimers is changed to another amino acid. These mutant proteins, as monomers, display higher bone morphogenetic activity than the wild-type protein dimers. Also provided is a method for producing and isolating these monomers by plasmid driven expression in various host systems including E. coli. In addition, the invention discloses the use of an agent containing purified monomers in preventing and treating diseases and problems affecting bone and/or cartilage.

    摘要翻译： 本发明提供了TGF-β超家族的蛋白质，其中参与同型二聚体正常形成的半胱氨酸改变为另一种氨基酸。 这些突变蛋白，作为单体，显示比野生型蛋白二聚体更高的骨形态发生活性。 还提供了通过在包括大肠杆菌的各种宿主系统中的质粒驱动表达来产生和分离这些单体的方法。 此外，本发明公开了含有纯化单体的药剂在预防和治疗疾病和影响骨和/或软骨的问题中的用途。

    Bone morphogenetic protein antagonist based on the mature protein
    7.
    发明授权
    Bone morphogenetic protein antagonist based on the mature protein 有权
    基于成熟蛋白的骨形态发生蛋白拮抗剂

    公开(公告)号：US07132397B1

    公开(公告)日：2006-11-07

    申请号：US09806368

    申请日：1999-10-04

    申请人： Mieko Katsuura ,  Michio Kimura

    发明人： Mieko Katsuura ,  Michio Kimura

    IPC分类号： A61K38/18 ,  C07K14/51

    CPC分类号： C07K14/51 ,  A61K38/00

    摘要： The purpose is to provide a mature protein having an antagonistic activity against bone morphogenetic proteins. The mature protein having an antagonistic activity against bone morphogenetic proteins is obtained by converting at least one residue among methionine residues or tryptophane residues existing in the amino acid sequence of mature human MP52 (SEQ ID No 1) to a hydrophilic residue by chemical modification, or replacing said residues with a hydrophilic amino acid residue or a polar amino acid residue. The chemical modification for said methionine residue is performed by an oxidization reaction or an alkylation reaction. The chemical modification for said tryptophane residue is performed by an allylsulphenylation reaction. Or a mature protein having an antagonistic activity against bone morphogenetic proteins is obtained by converting at least one residue of tryptophane residues existing in the amino acid sequences of mature human BMP-2 (SEQ ID No 2), mature human BMP-4 (SEQ ID No 3), and mature human BMP-7 (SEQ ID No 4) to a hydrophilic residue by chemical modification, or replacing said residues with a hydrophilic amino acid residue or a polar amino acid residue.

    摘要翻译： 目的是提供对骨形态发生蛋白具有拮抗作用的成熟蛋白质。 通过化学修饰将成熟人MP52（SEQ ID No.1）的氨基酸序列中存在的甲硫氨酸残基或色氨酸残基中的至少一个残基转化成亲水性残基，获得对骨形态发生蛋白具有拮抗作用的成熟蛋白质，或 用亲水氨基酸残基或极性氨基酸残基取代所述残基。 所述甲硫氨酸残基的化学修饰通过氧化反应或烷基化反应进行。 所述色氨酸残基的化学修饰通过烯丙基苯基化反应进行。 或者通过转化成熟人BMP-2（SEQ ID No 2），成熟人BMP-4（SEQ ID No.2）的氨基酸序列中存在的色氨酸残基的至少一个残基，获得对骨形态发生蛋白具有拮抗活性的成熟蛋白质 No.3）和成熟的人BMP-7（SEQ ID No 4）通过化学修饰与亲水性残基反应，或用亲水氨基酸残基或极性氨基酸残基替代所述残基。

    ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR, METHOD FOR PRODUCING THE SAME, IMAGE FORMING PROCESS, IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE
    10.
    发明申请
    ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR, METHOD FOR PRODUCING THE SAME, IMAGE FORMING PROCESS, IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE 有权
    电子照相机，其制造方法，图像形成工艺，图像形成装置和工艺盒

    公开(公告)号：US20080063962A1

    公开(公告)日：2008-03-13

    申请号：US11850394

    申请日：2007-09-05

    申请人： Tetsuya TOSHINE ,  Chiaki Tanaka ,  Michio Kimura ,  Tomoyuki Shimada ,  Nozomu Tamoto ,  Yoshiki Yanagawa ,  Hiromi Tada

    发明人： Tetsuya TOSHINE ,  Chiaki Tanaka ,  Michio Kimura ,  Tomoyuki Shimada ,  Nozomu Tamoto ,  Yoshiki Yanagawa ,  Hiromi Tada

    IPC分类号： G03G15/02 ,  G03G5/00

    CPC分类号： G03G5/051 ,  G03G5/0514 ,  G03G5/0517 ,  G03G5/0521 ,  G03G5/0525 ,  G03G5/0532 ,  G03G5/0535 ,  G03G5/0578 ,  G03G5/14786 ,  G03G5/14791 ,  G03G5/14795

    摘要： The present invention provides an electrophotographic photoconductor capable of reducing latent electrostatic image stability defects caused by adhesion/adsorption of an electric discharge product formed by a charger in an image forming process, degradation of charge transportability and cleaning defects caused when removing a residual toner. The electrophotographic photoconductor has a conductive substrate, and a photosensitive layer which contains at least a binder, a charge generating material and a charge transporting material and is formed on the substrate, wherein the photosensitive layer contains an injection material composed of at least any one of one wax selected from paraffin waxes, Fisher-Tropsh waxes, polyolefin waxes and a polyorganosiloxane compound in an area from the surface of the photosensitive layer to 50% of the thickness thereof in the thickness direction of the electrophotographic photoconductor, and the content of the injection material is 3% by mass or more to the content of the binder.

    摘要翻译： 本发明提供了一种电子照相感光体，其能够降低在图像形成过程中由充电器形成的放电产物的附着/吸附引起的静电潜像稳定性缺陷，电荷输送性降低和清除残留调色剂时引起的清洁缺陷。 电子照相感光体具有导电性基材和至少含有粘合剂，电荷产生材料和电荷输送材料并形成在基材上的感光层，其中感光层含有由以下的至少一种构成的注入材料： 在感光层的表面至电子照相感光体的厚度方向的50％的范围内，选自石蜡，Fisher-Tropsh蜡，聚烯烃蜡和聚有机硅氧烷化合物的一种蜡，以及注射用量 材料相对于粘合剂的含量为3质量％以上。