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34 条记录 (耗时 0.023 秒)

    Solid formulation for dialysis and process for producing the same
    2.
    发明申请
    Solid formulation for dialysis and process for producing the same 审中-公开
    用于透析的固体制剂及其制备方法

    公开(公告)号：US20070190161A1

    公开(公告)日：2007-08-16

    申请号：US10588733

    申请日：2005-02-02

    申请人： Toshiya Kai ,  Naohisa Katayama ,  Jun-Ichi Yokoe ,  Makoto Sato

    发明人： Toshiya Kai ,  Naohisa Katayama ,  Jun-Ichi Yokoe ,  Makoto Sato

    IPC分类号： A61K9/14 ,  A61K31/215 ,  A61K31/7004

    CPC分类号： A61K31/19 ,  A61K31/7004 ,  A61K33/14 ,  A61K2300/00

    摘要： The present invention relates to a solid formulation for dialysis and a method for producing the same. The formulation is a mixture of: first particles having a coating layer containing magnesium chloride and sodium acetate on surfaces of sodium chloride particles; and second particles having a coating layer containing calcium chloride and sodium acetate on the surfaces of sodium chloride particles, at least one of the coating layers of the first and second particles further including potassium chloride. In the formulation of the present invention, aggregation or consolidation between particles due to moisture absorption thereof can be suppressed. Besides, the content of each component in the formulation becomes uniform, so as to quickly dissolve in water when used. In addition, the formulation of the present invention is an extremely stable solid formulation in which decomposition of glucose hardly occurs even when a formulation containing electrolyte components and acetic acid further contains glucose.

    摘要翻译： 本发明涉及透析用固体制剂及其制造方法。 该制剂是以下混合物：在氯化钠颗粒表面上具有含有氯化镁和乙酸钠的涂层的第一颗粒; 和在氯化钠颗粒表面上具有含有氯化钙和乙酸钠的涂层的第二颗粒，第一和第二颗粒的​​至少一个涂层还包括氯化钾。 在本发明的制剂中，可以抑制由于其吸湿而导致的颗粒之间的凝集或固结。 此外，配方中的各成分的含量均匀，在使用时迅速溶解于水中。 此外，本发明的制剂是极其稳定的固体制剂，即使含有电解质成分和乙酸的制剂还含有葡萄糖，几乎不发生葡萄糖分解。

    ORALLY-DISINTEGRATING TABLET AND MANUFACTURING METHOD THEREOF
    3.
    发明申请
    ORALLY-DISINTEGRATING TABLET AND MANUFACTURING METHOD THEREOF 审中-公开
    ORALLY-DISINCATTATTING TABLET及其制造方法

    公开(公告)号：US20080254120A1

    公开(公告)日：2008-10-16

    申请号：US12099668

    申请日：2008-04-08

    申请人： Shiho Sakuragi ,  Jun-ichi Yokoe ,  Naohisa Katayama ,  Toshiya Kai

    发明人： Shiho Sakuragi ,  Jun-ichi Yokoe ,  Naohisa Katayama ,  Toshiya Kai

    IPC分类号： A61K9/26

    CPC分类号： A61K9/0056 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2095

    摘要： An orally-disintegrating tablet comprises a principal agent, a sugar alcohol powder and a sugar alcohol granule, wherein the orally-disintegrating tablet has a hardness of 30 N or greater. According to the present invention, a smooth swallowing orally-disintegrating tablet, for which both the mechanical strength and the disintegration properties in the buccal cavity are favorable with using a normal tableting machine and without using special devices and the feeling on the tongue and taste are favorable, is provided.

    摘要翻译： 口腔崩解片包含主剂，糖醇粉和糖醇颗粒，其中口腔崩解片的硬度为30N以上。 根据本发明，使用普通压片机，颊腔的机械强度和崩解性能均匀且不使用特殊的装置和舌头和口感的口感崩解片是平滑吞咽口腔崩解片， 有利的。

    High-Copy-Number, High-Expression Vector Having Methionine Aminopeptidase Gene
    8.
    发明申请
    High-Copy-Number, High-Expression Vector Having Methionine Aminopeptidase Gene 审中-公开
    具有甲硫氨酸氨基肽酶基因的高拷贝数，高表达载体

    公开(公告)号：US20080166769A1

    公开(公告)日：2008-07-10

    申请号：US11921329

    申请日：2006-06-01

    申请人： Tadayuki Uno ,  Yohei Hoashi ,  Naohisa Katayama ,  Toshiya Kai

    发明人： Tadayuki Uno ,  Yohei Hoashi ,  Naohisa Katayama ,  Toshiya Kai

    IPC分类号： C12N15/63 ,  C12N1/21

    CPC分类号： C12N15/70 ,  C07K14/805 ,  C12N15/69 ,  C12P21/02

    摘要： Provided is a high-copy-number, high-expression vector capable of producing a protein having satisfactory functions and activity of the same level as that of a natural form of the protein, in a large quantity and in a simple manner. Also provided is a vector including: (A) a target gene or a cloning site of the target gene, (B) a sequence element necessary for the high copying of the target gene, (C) a sequence element necessary for the expression of the target gene and a methionine aminopeptidase gene; a method of producing the vector; a transformant having the vector introduced therein; and a process for producing a protein using the transformant.

    摘要翻译： 提供了能够以大量和简单的方式产生具有与天然形式的蛋白质相同水平的令人满意的功能和活性的蛋白质的高拷贝数高表达载体。 还提供了载体，其包括：（A）靶基因的靶基因或克隆位点，（B）靶基因的高拷贝所必需的序列元件，（C）表达所需靶序列所需的序列元件 靶基因和甲硫氨酸氨基肽酶基因; 生成载体的方法; 其中引入载体的转化体; 以及使用该转化体生产蛋白质的方法。

    Inclusion compound of porphyrin metal complex and albumin
    10.
    发明申请
    Inclusion compound of porphyrin metal complex and albumin 审中-公开
    卟啉金属络合物和白蛋白的包合物

    公开(公告)号：US20060166861A1

    公开(公告)日：2006-07-27

    申请号：US11337473

    申请日：2006-01-24

    申请人： Yoshinori Kida ,  Ippei Fukutomi ,  Naohisa Katayama ,  Toshiya Kai

    发明人： Yoshinori Kida ,  Ippei Fukutomi ,  Naohisa Katayama ,  Toshiya Kai

    IPC分类号： A61K38/41 ,  C07D487/22 ,  C07K14/765

    CPC分类号： B82Y5/00 ,  A61K47/643 ,  A61K47/6949

    摘要： A novel inclusion compound obtained by including in albumin a tetraphenylporphyrin metal complex represented by the following chemical formula (1) and having 2-position side chains: where R1 is a cyclohexyl group or the like; R2 represents a substituent; M represents a transition metal atom or metal ion belonging to Groups 6 to 10 of the periodic table; X− represents a halogen ion; and the number of X− is obtained by subtracting 2 from a valence of the metal ion.

    摘要翻译： 通过在白蛋白中含有由下列化学式（1）表示的具有2-位侧链的四苯基卟啉金属络合物，其中R1是环己基等，得到的新型包合物; R2表示取代基; M表示属于周期表第6至10族的过渡金属原子或金属离子; X - 表示卤素离子; 并且通过从金属离子的化合价中减去2来获得X 的数量。